LeishMANIAdb
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Mpv17-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Mpv17-like protein
Gene product:
Mpv17 / PMP22 family - putative
Species:
Leishmania infantum
UniProt:
E9AHM7_LEIIN
TriTrypDb:
LINF_330007900
Length:
355

Annotations

Annotations by Jardim et al.

Membrane associated proteins, PMP22

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

E9AHM7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHM7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 191 195 PF00656 0.385
CLV_NRD_NRD_1 120 122 PF00675 0.295
CLV_NRD_NRD_1 156 158 PF00675 0.566
CLV_NRD_NRD_1 197 199 PF00675 0.582
CLV_NRD_NRD_1 282 284 PF00675 0.525
CLV_PCSK_KEX2_1 120 122 PF00082 0.299
CLV_PCSK_KEX2_1 155 157 PF00082 0.602
CLV_PCSK_KEX2_1 196 198 PF00082 0.535
CLV_PCSK_KEX2_1 282 284 PF00082 0.488
CLV_PCSK_PC1ET2_1 155 157 PF00082 0.604
CLV_PCSK_PC7_1 193 199 PF00082 0.620
CLV_PCSK_SKI1_1 161 165 PF00082 0.497
CLV_PCSK_SKI1_1 2 6 PF00082 0.404
CLV_PCSK_SKI1_1 235 239 PF00082 0.643
CLV_PCSK_SKI1_1 294 298 PF00082 0.554
DEG_Nend_UBRbox_1 1 4 PF02207 0.613
DEG_SPOP_SBC_1 103 107 PF00917 0.648
DEG_SPOP_SBC_1 22 26 PF00917 0.552
DOC_AGCK_PIF_1 125 130 PF00069 0.393
DOC_CYCLIN_yCln2_LP_2 147 153 PF00134 0.359
DOC_CYCLIN_yCln2_LP_2 171 177 PF00134 0.329
DOC_MAPK_gen_1 193 202 PF00069 0.380
DOC_MAPK_MEF2A_6 196 204 PF00069 0.442
DOC_PP4_FxxP_1 132 135 PF00568 0.393
DOC_USP7_MATH_1 103 107 PF00917 0.732
DOC_USP7_MATH_1 318 322 PF00917 0.340
DOC_USP7_MATH_1 55 59 PF00917 0.626
DOC_WW_Pin1_4 170 175 PF00397 0.308
DOC_WW_Pin1_4 236 241 PF00397 0.401
DOC_WW_Pin1_4 58 63 PF00397 0.585
DOC_WW_Pin1_4 66 71 PF00397 0.532
DOC_WW_Pin1_4 88 93 PF00397 0.634
DOC_WW_Pin1_4 98 103 PF00397 0.725
LIG_14-3-3_CanoR_1 120 124 PF00244 0.464
LIG_14-3-3_CanoR_1 316 326 PF00244 0.300
LIG_APCC_ABBA_1 186 191 PF00400 0.380
LIG_BRCT_BRCA1_1 121 125 PF00533 0.454
LIG_BRCT_BRCA1_1 126 130 PF00533 0.294
LIG_FHA_1 111 117 PF00498 0.592
LIG_FHA_1 170 176 PF00498 0.284
LIG_FHA_2 179 185 PF00498 0.310
LIG_FHA_2 242 248 PF00498 0.464
LIG_FHA_2 35 41 PF00498 0.583
LIG_FXI_DFP_1 286 290 PF00024 0.597
LIG_LIR_Apic_2 129 135 PF02991 0.393
LIG_LIR_Gen_1 122 132 PF02991 0.276
LIG_LIR_Gen_1 272 281 PF02991 0.363
LIG_LIR_Nem_3 122 128 PF02991 0.294
LIG_LIR_Nem_3 173 179 PF02991 0.319
LIG_LIR_Nem_3 184 189 PF02991 0.296
LIG_LIR_Nem_3 231 237 PF02991 0.454
LIG_LIR_Nem_3 272 277 PF02991 0.333
LIG_LIR_Nem_3 288 292 PF02991 0.226
LIG_Pex14_1 304 308 PF04695 0.242
LIG_Pex14_2 128 132 PF04695 0.300
LIG_Pex14_2 234 238 PF04695 0.447
LIG_Pex14_2 270 274 PF04695 0.365
LIG_PTB_Apo_2 262 269 PF02174 0.401
LIG_REV1ctd_RIR_1 184 194 PF16727 0.378
LIG_SH2_NCK_1 295 299 PF00017 0.318
LIG_SH2_SRC 310 313 PF00017 0.284
LIG_SH2_STAP1 295 299 PF00017 0.284
LIG_SH2_STAT5 11 14 PF00017 0.546
LIG_SH2_STAT5 136 139 PF00017 0.404
LIG_SH2_STAT5 166 169 PF00017 0.318
LIG_SH2_STAT5 176 179 PF00017 0.251
LIG_SH2_STAT5 273 276 PF00017 0.426
LIG_SH2_STAT5 310 313 PF00017 0.242
LIG_SH2_STAT5 333 336 PF00017 0.420
LIG_SH3_3 234 240 PF00018 0.456
LIG_SH3_3 64 70 PF00018 0.552
LIG_SH3_3 86 92 PF00018 0.623
LIG_SUMO_SIM_par_1 113 118 PF11976 0.545
LIG_SUMO_SIM_par_1 63 69 PF11976 0.648
LIG_UBA3_1 330 339 PF00899 0.491
LIG_UBA3_1 4 13 PF00899 0.546
LIG_WRC_WIRS_1 125 130 PF05994 0.276
MOD_CDC14_SPxK_1 239 242 PF00782 0.364
MOD_CDK_SPxK_1 236 242 PF00069 0.366
MOD_CK1_1 58 64 PF00069 0.609
MOD_CK2_1 241 247 PF00069 0.466
MOD_CK2_1 34 40 PF00069 0.580
MOD_Cter_Amidation 194 197 PF01082 0.554
MOD_GlcNHglycan 106 109 PF01048 0.480
MOD_GlcNHglycan 320 323 PF01048 0.352
MOD_GlcNHglycan 327 330 PF01048 0.314
MOD_GSK3_1 325 332 PF00069 0.335
MOD_GSK3_1 84 91 PF00069 0.688
MOD_GSK3_1 94 101 PF00069 0.684
MOD_N-GLC_1 111 116 PF02516 0.330
MOD_N-GLC_1 55 60 PF02516 0.393
MOD_N-GLC_1 98 103 PF02516 0.570
MOD_NEK2_1 119 124 PF00069 0.474
MOD_NEK2_1 21 26 PF00069 0.558
MOD_NEK2_1 241 246 PF00069 0.488
MOD_NEK2_1 248 253 PF00069 0.464
MOD_NEK2_1 317 322 PF00069 0.497
MOD_NEK2_1 335 340 PF00069 0.504
MOD_NEK2_1 63 68 PF00069 0.595
MOD_PIKK_1 55 61 PF00454 0.574
MOD_PKA_2 119 125 PF00069 0.475
MOD_PKA_2 241 247 PF00069 0.442
MOD_PKA_2 84 90 PF00069 0.635
MOD_Plk_1 111 117 PF00069 0.564
MOD_Plk_1 248 254 PF00069 0.433
MOD_Plk_1 344 350 PF00069 0.626
MOD_Plk_4 111 117 PF00069 0.548
MOD_Plk_4 162 168 PF00069 0.290
MOD_Plk_4 175 181 PF00069 0.276
MOD_Plk_4 329 335 PF00069 0.380
MOD_Plk_4 34 40 PF00069 0.539
MOD_Plk_4 6 12 PF00069 0.575
MOD_ProDKin_1 170 176 PF00069 0.309
MOD_ProDKin_1 236 242 PF00069 0.405
MOD_ProDKin_1 58 64 PF00069 0.578
MOD_ProDKin_1 66 72 PF00069 0.530
MOD_ProDKin_1 88 94 PF00069 0.638
MOD_ProDKin_1 98 104 PF00069 0.725
TRG_DiLeu_BaLyEn_6 143 148 PF01217 0.373
TRG_ENDOCYTIC_2 141 144 PF00928 0.278
TRG_ENDOCYTIC_2 259 262 PF00928 0.417
TRG_ER_diArg_1 119 121 PF00400 0.500
TRG_ER_diArg_1 196 198 PF00400 0.361
TRG_ER_diArg_1 281 283 PF00400 0.288
TRG_ER_diArg_1 75 78 PF00400 0.608
TRG_Pf-PMV_PEXEL_1 283 288 PF00026 0.459

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PA32 Leptomonas seymouri 69% 100%
A0A0S4JM85 Bodo saltans 29% 100%
A0A3Q8IGN8 Leishmania donovani 100% 100%
A0A3S5IR52 Trypanosoma rangeli 30% 100%
A4HL63 Leishmania braziliensis 84% 100%
E9B3K6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q4J3 Leishmania major 95% 100%
V5BB92 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS