LeishMANIAdb
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Putative GIPL galf transferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative GIPL galf transferase
Gene product:
GIPL galf transferase - putative
Species:
Leishmania infantum
UniProt:
E9AHM5_LEIIN
TriTrypDb:
LINF_320047050
Length:
596

Annotations

LeishMANIAdb annotations

A large family of glycosyltransferases expanded in parazitic kinetoplastids (and even more in T cruzi). Localization: ER (by homology)

Annotations by Jardim et al.

Glycolipid biosynthesis, GIPL galf transferase LPG1G

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 1
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

E9AHM5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHM5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 15
GO:0016740 transferase activity 2 15
GO:0016757 glycosyltransferase activity 3 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 231 237 PF00089 0.472
CLV_NRD_NRD_1 14 16 PF00675 0.502
CLV_NRD_NRD_1 233 235 PF00675 0.472
CLV_NRD_NRD_1 382 384 PF00675 0.539
CLV_NRD_NRD_1 483 485 PF00675 0.607
CLV_NRD_NRD_1 491 493 PF00675 0.552
CLV_NRD_NRD_1 542 544 PF00675 0.558
CLV_PCSK_KEX2_1 14 16 PF00082 0.501
CLV_PCSK_KEX2_1 170 172 PF00082 0.561
CLV_PCSK_KEX2_1 233 235 PF00082 0.472
CLV_PCSK_KEX2_1 384 386 PF00082 0.504
CLV_PCSK_KEX2_1 483 485 PF00082 0.608
CLV_PCSK_KEX2_1 491 493 PF00082 0.561
CLV_PCSK_KEX2_1 542 544 PF00082 0.556
CLV_PCSK_PC1ET2_1 170 172 PF00082 0.528
CLV_PCSK_PC1ET2_1 384 386 PF00082 0.489
CLV_PCSK_SKI1_1 148 152 PF00082 0.566
CLV_PCSK_SKI1_1 15 19 PF00082 0.466
CLV_PCSK_SKI1_1 176 180 PF00082 0.523
CLV_PCSK_SKI1_1 20 24 PF00082 0.305
CLV_PCSK_SKI1_1 337 341 PF00082 0.653
CLV_PCSK_SKI1_1 384 388 PF00082 0.507
CLV_PCSK_SKI1_1 408 412 PF00082 0.559
CLV_PCSK_SKI1_1 483 487 PF00082 0.660
CLV_PCSK_SKI1_1 52 56 PF00082 0.645
CLV_PCSK_SKI1_1 543 547 PF00082 0.518
DEG_APCC_DBOX_1 19 27 PF00400 0.545
DEG_APCC_DBOX_1 407 415 PF00400 0.305
DEG_SPOP_SBC_1 80 84 PF00917 0.505
DOC_CKS1_1 108 113 PF01111 0.491
DOC_CKS1_1 188 193 PF01111 0.315
DOC_CKS1_1 376 381 PF01111 0.328
DOC_MAPK_DCC_7 20 28 PF00069 0.472
DOC_MAPK_gen_1 11 19 PF00069 0.705
DOC_MAPK_HePTP_8 17 29 PF00069 0.488
DOC_MAPK_MEF2A_6 20 29 PF00069 0.525
DOC_MAPK_MEF2A_6 343 351 PF00069 0.404
DOC_PP4_FxxP_1 105 108 PF00568 0.492
DOC_PP4_FxxP_1 467 470 PF00568 0.438
DOC_SPAK_OSR1_1 240 244 PF12202 0.225
DOC_USP7_MATH_1 115 119 PF00917 0.490
DOC_USP7_MATH_1 122 126 PF00917 0.473
DOC_USP7_MATH_1 485 489 PF00917 0.374
DOC_USP7_MATH_1 71 75 PF00917 0.487
DOC_USP7_MATH_2 98 104 PF00917 0.507
DOC_WW_Pin1_4 107 112 PF00397 0.465
DOC_WW_Pin1_4 187 192 PF00397 0.311
DOC_WW_Pin1_4 375 380 PF00397 0.349
DOC_WW_Pin1_4 39 44 PF00397 0.548
DOC_WW_Pin1_4 392 397 PF00397 0.295
DOC_WW_Pin1_4 462 467 PF00397 0.436
DOC_WW_Pin1_4 73 78 PF00397 0.513
LIG_14-3-3_CanoR_1 14 20 PF00244 0.655
LIG_14-3-3_CanoR_1 176 185 PF00244 0.347
LIG_14-3-3_CanoR_1 408 417 PF00244 0.307
LIG_14-3-3_CanoR_1 484 490 PF00244 0.371
LIG_14-3-3_CanoR_1 72 76 PF00244 0.517
LIG_BIR_III_2 183 187 PF00653 0.311
LIG_BRCT_BRCA1_1 237 241 PF00533 0.225
LIG_BRCT_BRCA1_1 35 39 PF00533 0.235
LIG_CSL_BTD_1 56 59 PF09270 0.445
LIG_deltaCOP1_diTrp_1 270 276 PF00928 0.304
LIG_deltaCOP1_diTrp_1 430 440 PF00928 0.372
LIG_FHA_1 180 186 PF00498 0.337
LIG_FHA_1 191 197 PF00498 0.324
LIG_FHA_1 222 228 PF00498 0.341
LIG_FHA_1 35 41 PF00498 0.371
LIG_FHA_1 353 359 PF00498 0.388
LIG_FHA_1 401 407 PF00498 0.360
LIG_FHA_1 53 59 PF00498 0.437
LIG_FHA_1 532 538 PF00498 0.400
LIG_FHA_1 76 82 PF00498 0.510
LIG_FHA_2 118 124 PF00498 0.509
LIG_FHA_2 266 272 PF00498 0.324
LIG_FHA_2 298 304 PF00498 0.281
LIG_FHA_2 376 382 PF00498 0.357
LIG_FHA_2 393 399 PF00498 0.258
LIG_FHA_2 567 573 PF00498 0.414
LIG_FHA_2 88 94 PF00498 0.491
LIG_LIR_Apic_2 102 108 PF02991 0.505
LIG_LIR_Apic_2 465 470 PF02991 0.432
LIG_LIR_Gen_1 147 156 PF02991 0.386
LIG_LIR_Gen_1 238 248 PF02991 0.225
LIG_LIR_Gen_1 519 530 PF02991 0.390
LIG_LIR_Nem_3 195 201 PF02991 0.454
LIG_LIR_Nem_3 238 244 PF02991 0.225
LIG_LIR_Nem_3 323 329 PF02991 0.373
LIG_LIR_Nem_3 344 349 PF02991 0.412
LIG_LIR_Nem_3 419 425 PF02991 0.474
LIG_LIR_Nem_3 430 436 PF02991 0.332
LIG_LIR_Nem_3 452 457 PF02991 0.393
LIG_LIR_Nem_3 519 525 PF02991 0.473
LIG_LYPXL_yS_3 346 349 PF13949 0.414
LIG_OCRL_FandH_1 439 451 PF00620 0.312
LIG_Pex14_2 198 202 PF04695 0.316
LIG_Pex14_2 436 440 PF04695 0.350
LIG_SH2_CRK 212 216 PF00017 0.317
LIG_SH2_CRK 497 501 PF00017 0.363
LIG_SH2_NCK_1 457 461 PF00017 0.383
LIG_SH2_STAP1 329 333 PF00017 0.380
LIG_SH2_STAP1 481 485 PF00017 0.454
LIG_SH2_STAP1 552 556 PF00017 0.358
LIG_SH2_STAT3 214 217 PF00017 0.344
LIG_SH2_STAT3 552 555 PF00017 0.397
LIG_SH2_STAT5 201 204 PF00017 0.349
LIG_SH2_STAT5 214 217 PF00017 0.363
LIG_SH2_STAT5 390 393 PF00017 0.344
LIG_SH2_STAT5 416 419 PF00017 0.364
LIG_SH2_STAT5 421 424 PF00017 0.405
LIG_SH2_STAT5 489 492 PF00017 0.433
LIG_SH3_1 354 360 PF00018 0.342
LIG_SH3_2 357 362 PF14604 0.335
LIG_SH3_3 105 111 PF00018 0.476
LIG_SH3_3 344 350 PF00018 0.405
LIG_SH3_3 354 360 PF00018 0.298
LIG_SH3_3 65 71 PF00018 0.511
LIG_SH3_3 74 80 PF00018 0.476
LIG_SUMO_SIM_par_1 185 190 PF11976 0.353
LIG_SUMO_SIM_par_1 402 407 PF11976 0.316
LIG_TRAF2_1 268 271 PF00917 0.288
LIG_TRAF2_1 514 517 PF00917 0.405
LIG_TRAF2_1 569 572 PF00917 0.414
LIG_TYR_ITIM 210 215 PF00017 0.310
LIG_UBA3_1 188 197 PF00899 0.312
LIG_UBA3_1 288 294 PF00899 0.233
MOD_CK1_1 113 119 PF00069 0.493
MOD_CK1_1 558 564 PF00069 0.424
MOD_CK1_1 6 12 PF00069 0.674
MOD_CK1_1 79 85 PF00069 0.516
MOD_CK2_1 117 123 PF00069 0.486
MOD_CK2_1 265 271 PF00069 0.305
MOD_CK2_1 324 330 PF00069 0.377
MOD_CK2_1 375 381 PF00069 0.377
MOD_CK2_1 392 398 PF00069 0.244
MOD_CK2_1 566 572 PF00069 0.418
MOD_CK2_1 583 589 PF00069 0.357
MOD_CK2_1 87 93 PF00069 0.504
MOD_GlcNHglycan 112 115 PF01048 0.696
MOD_GlcNHglycan 117 120 PF01048 0.687
MOD_GlcNHglycan 123 127 PF01048 0.672
MOD_GlcNHglycan 237 240 PF01048 0.519
MOD_GlcNHglycan 252 255 PF01048 0.484
MOD_GlcNHglycan 343 346 PF01048 0.609
MOD_GlcNHglycan 373 376 PF01048 0.627
MOD_GlcNHglycan 571 575 PF01048 0.623
MOD_GlcNHglycan 59 62 PF01048 0.698
MOD_GlcNHglycan 83 86 PF01048 0.701
MOD_GSK3_1 109 116 PF00069 0.501
MOD_GSK3_1 130 137 PF00069 0.462
MOD_GSK3_1 2 9 PF00069 0.666
MOD_GSK3_1 34 41 PF00069 0.355
MOD_GSK3_1 371 378 PF00069 0.370
MOD_GSK3_1 400 407 PF00069 0.381
MOD_GSK3_1 44 51 PF00069 0.518
MOD_GSK3_1 53 60 PF00069 0.471
MOD_GSK3_1 566 573 PF00069 0.403
MOD_GSK3_1 71 78 PF00069 0.479
MOD_GSK3_1 88 95 PF00069 0.448
MOD_LATS_1 13 19 PF00433 0.606
MOD_N-GLC_1 324 329 PF02516 0.572
MOD_N-GLC_1 479 484 PF02516 0.638
MOD_N-GLC_1 525 530 PF02516 0.618
MOD_NEK2_1 1 6 PF00069 0.682
MOD_NEK2_1 235 240 PF00069 0.300
MOD_NEK2_1 409 414 PF00069 0.386
MOD_NEK2_1 525 530 PF00069 0.424
MOD_NEK2_1 546 551 PF00069 0.379
MOD_NEK2_1 570 575 PF00069 0.443
MOD_NEK2_1 63 68 PF00069 0.473
MOD_NEK2_2 34 39 PF00069 0.243
MOD_NEK2_2 439 444 PF00069 0.302
MOD_PK_1 3 9 PF00069 0.659
MOD_PKA_2 371 377 PF00069 0.435
MOD_PKA_2 490 496 PF00069 0.372
MOD_PKA_2 558 564 PF00069 0.414
MOD_PKA_2 71 77 PF00069 0.513
MOD_PKB_1 50 58 PF00069 0.470
MOD_Plk_1 222 228 PF00069 0.350
MOD_Plk_1 324 330 PF00069 0.387
MOD_Plk_1 52 58 PF00069 0.446
MOD_Plk_1 525 531 PF00069 0.364
MOD_Plk_1 561 567 PF00069 0.451
MOD_Plk_2-3 589 595 PF00069 0.381
MOD_Plk_4 124 130 PF00069 0.519
MOD_Plk_4 324 330 PF00069 0.377
MOD_Plk_4 34 40 PF00069 0.357
MOD_Plk_4 485 491 PF00069 0.374
MOD_Plk_4 53 59 PF00069 0.429
MOD_Plk_4 531 537 PF00069 0.338
MOD_ProDKin_1 107 113 PF00069 0.465
MOD_ProDKin_1 187 193 PF00069 0.314
MOD_ProDKin_1 375 381 PF00069 0.344
MOD_ProDKin_1 39 45 PF00069 0.551
MOD_ProDKin_1 392 398 PF00069 0.305
MOD_ProDKin_1 462 468 PF00069 0.442
MOD_ProDKin_1 73 79 PF00069 0.512
MOD_SUMO_rev_2 513 523 PF00179 0.380
MOD_SUMO_rev_2 586 593 PF00179 0.357
TRG_DiLeu_BaEn_1 124 129 PF01217 0.458
TRG_DiLeu_BaEn_4 571 577 PF01217 0.407
TRG_DiLeu_BaLyEn_6 183 188 PF01217 0.325
TRG_DiLeu_BaLyEn_6 354 359 PF01217 0.328
TRG_ENDOCYTIC_2 212 215 PF00928 0.385
TRG_ENDOCYTIC_2 346 349 PF00928 0.417
TRG_ENDOCYTIC_2 497 500 PF00928 0.399
TRG_ENDOCYTIC_2 520 523 PF00928 0.421
TRG_ER_diArg_1 14 16 PF00400 0.691
TRG_ER_diArg_1 171 174 PF00400 0.351
TRG_ER_diArg_1 233 235 PF00400 0.277
TRG_ER_diArg_1 244 247 PF00400 0.242
TRG_ER_diArg_1 334 337 PF00400 0.414
TRG_ER_diArg_1 362 365 PF00400 0.471
TRG_ER_diArg_1 382 385 PF00400 0.285
TRG_ER_diArg_1 490 492 PF00400 0.380
TRG_NES_CRM1_1 157 169 PF08389 0.327
TRG_Pf-PMV_PEXEL_1 568 572 PF00026 0.622

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IHI5 Leishmania donovani 99% 90%
A0A3S5H7D9 Leishmania donovani 28% 100%
A0A3S7X6F1 Leishmania donovani 30% 100%
A4HDU8 Leishmania braziliensis 27% 100%
A4HL36 Leishmania braziliensis 64% 96%
A4I143 Leishmania infantum 29% 100%
A4I8P7 Leishmania infantum 30% 100%
E9AXX9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B3H7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 99%
E9B3L0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
Q05889 Leishmania donovani 28% 100%
Q4QD44 Leishmania major 84% 100%
Q6XFB5 Leishmania major 27% 100%
Q9NC61 Leishmania major 27% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS