LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AHM4_LEIIN
TriTrypDb:
LINF_320043500 *
Length:
372

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AHM4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHM4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 50 54 PF00656 0.554
CLV_NRD_NRD_1 2 4 PF00675 0.506
CLV_NRD_NRD_1 69 71 PF00675 0.580
CLV_PCSK_KEX2_1 2 4 PF00082 0.528
CLV_PCSK_KEX2_1 69 71 PF00082 0.580
CLV_PCSK_SKI1_1 185 189 PF00082 0.557
DEG_Nend_UBRbox_1 1 4 PF02207 0.475
DOC_CYCLIN_yCln2_LP_2 357 363 PF00134 0.584
DOC_MAPK_gen_1 271 279 PF00069 0.404
DOC_PP2B_LxvP_1 160 163 PF13499 0.686
DOC_PP2B_LxvP_1 357 360 PF13499 0.569
DOC_USP7_MATH_1 110 114 PF00917 0.571
DOC_USP7_MATH_1 118 122 PF00917 0.553
DOC_USP7_MATH_1 132 136 PF00917 0.587
DOC_USP7_MATH_1 155 159 PF00917 0.630
DOC_USP7_MATH_1 174 178 PF00917 0.607
DOC_USP7_MATH_1 187 191 PF00917 0.586
DOC_USP7_MATH_1 224 228 PF00917 0.682
DOC_USP7_MATH_1 311 315 PF00917 0.527
DOC_USP7_MATH_1 32 36 PF00917 0.476
DOC_USP7_MATH_1 343 347 PF00917 0.566
DOC_USP7_MATH_1 361 365 PF00917 0.613
DOC_USP7_MATH_1 51 55 PF00917 0.561
DOC_USP7_MATH_1 57 61 PF00917 0.661
DOC_USP7_MATH_1 65 69 PF00917 0.677
DOC_USP7_MATH_2 146 152 PF00917 0.733
DOC_WW_Pin1_4 178 183 PF00397 0.822
DOC_WW_Pin1_4 21 26 PF00397 0.514
DOC_WW_Pin1_4 70 75 PF00397 0.612
LIG_14-3-3_CanoR_1 271 279 PF00244 0.438
LIG_14-3-3_CanoR_1 285 294 PF00244 0.478
LIG_14-3-3_CanoR_1 33 39 PF00244 0.571
LIG_14-3-3_CanoR_1 333 337 PF00244 0.591
LIG_14-3-3_CanoR_1 69 75 PF00244 0.559
LIG_14-3-3_CanoR_1 84 94 PF00244 0.588
LIG_Actin_WH2_2 308 324 PF00022 0.457
LIG_CaM_IQ_9 292 307 PF13499 0.439
LIG_CSL_BTD_1 264 267 PF09270 0.440
LIG_EH1_1 194 202 PF00400 0.489
LIG_FHA_1 22 28 PF00498 0.587
LIG_FHA_1 53 59 PF00498 0.601
LIG_FHA_2 342 348 PF00498 0.552
LIG_GBD_Chelix_1 349 357 PF00786 0.537
LIG_LIR_Nem_3 262 268 PF02991 0.437
LIG_LIR_Nem_3 95 100 PF02991 0.495
LIG_LYPXL_yS_3 44 47 PF13949 0.469
LIG_NRBOX 7 13 PF00104 0.447
LIG_PCNA_yPIPBox_3 2 12 PF02747 0.438
LIG_Pex14_1 265 269 PF04695 0.428
LIG_SH2_CRK 269 273 PF00017 0.396
LIG_SH2_GRB2like 278 281 PF00017 0.445
LIG_SH2_PTP2 93 96 PF00017 0.512
LIG_SH2_SRC 93 96 PF00017 0.539
LIG_SH2_STAP1 100 104 PF00017 0.567
LIG_SH2_STAT3 293 296 PF00017 0.421
LIG_SH2_STAT5 104 107 PF00017 0.459
LIG_SH2_STAT5 278 281 PF00017 0.485
LIG_SH2_STAT5 293 296 PF00017 0.344
LIG_SH2_STAT5 93 96 PF00017 0.524
LIG_SH3_3 261 267 PF00018 0.537
LIG_TRAF2_1 146 149 PF00917 0.708
LIG_TRAF2_1 219 222 PF00917 0.560
MOD_CDK_SPxxK_3 178 185 PF00069 0.567
MOD_CK1_1 151 157 PF00069 0.638
MOD_CK1_1 158 164 PF00069 0.627
MOD_CK1_1 288 294 PF00069 0.406
MOD_CK1_1 334 340 PF00069 0.572
MOD_CK1_1 68 74 PF00069 0.771
MOD_CK2_1 128 134 PF00069 0.698
MOD_CK2_1 216 222 PF00069 0.697
MOD_CK2_1 95 101 PF00069 0.474
MOD_DYRK1A_RPxSP_1 70 74 PF00069 0.653
MOD_GlcNHglycan 112 115 PF01048 0.548
MOD_GlcNHglycan 120 123 PF01048 0.655
MOD_GlcNHglycan 130 133 PF01048 0.648
MOD_GlcNHglycan 134 138 PF01048 0.685
MOD_GlcNHglycan 153 156 PF01048 0.640
MOD_GlcNHglycan 157 160 PF01048 0.640
MOD_GlcNHglycan 174 177 PF01048 0.704
MOD_GlcNHglycan 189 192 PF01048 0.500
MOD_GlcNHglycan 218 221 PF01048 0.659
MOD_GlcNHglycan 287 290 PF01048 0.398
MOD_GlcNHglycan 353 356 PF01048 0.543
MOD_GlcNHglycan 59 62 PF01048 0.660
MOD_GlcNHglycan 65 68 PF01048 0.602
MOD_GlcNHglycan 70 73 PF01048 0.527
MOD_GlcNHglycan 97 100 PF01048 0.466
MOD_GSK3_1 128 135 PF00069 0.676
MOD_GSK3_1 151 158 PF00069 0.635
MOD_GSK3_1 174 181 PF00069 0.727
MOD_GSK3_1 212 219 PF00069 0.614
MOD_GSK3_1 267 274 PF00069 0.476
MOD_GSK3_1 281 288 PF00069 0.490
MOD_N-GLC_1 128 133 PF02516 0.692
MOD_NEK2_1 11 16 PF00069 0.447
MOD_NEK2_1 272 277 PF00069 0.401
MOD_PIKK_1 246 252 PF00454 0.474
MOD_PIKK_1 361 367 PF00454 0.623
MOD_PKA_2 140 146 PF00069 0.682
MOD_PKA_2 216 222 PF00069 0.688
MOD_PKA_2 299 305 PF00069 0.468
MOD_PKA_2 32 38 PF00069 0.421
MOD_PKA_2 332 338 PF00069 0.548
MOD_PKA_2 68 74 PF00069 0.655
MOD_PKA_2 85 91 PF00069 0.630
MOD_Plk_1 148 154 PF00069 0.700
MOD_Plk_1 155 161 PF00069 0.641
MOD_Plk_4 288 294 PF00069 0.534
MOD_ProDKin_1 178 184 PF00069 0.822
MOD_ProDKin_1 21 27 PF00069 0.509
MOD_ProDKin_1 70 76 PF00069 0.611
MOD_SUMO_rev_2 228 237 PF00179 0.532
MOD_SUMO_rev_2 275 284 PF00179 0.480
TRG_ENDOCYTIC_2 269 272 PF00928 0.395
TRG_ENDOCYTIC_2 44 47 PF00928 0.595
TRG_ER_diArg_1 1 3 PF00400 0.552
TRG_ER_diArg_1 324 327 PF00400 0.514
TRG_ER_diArg_1 83 86 PF00400 0.574

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IK58 Leptomonas seymouri 43% 83%
A0A3Q8IJP5 Leishmania donovani 99% 85%
A4HL02 Leishmania braziliensis 70% 100%
E9B3E3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4Q4Q9 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS