LeishMANIAdb
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Phosphatidate cytidylyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphatidate cytidylyltransferase
Gene product:
phosphatidate cytidylyltransferase-like protein
Species:
Leishmania infantum
UniProt:
E9AHM2_LEIIN
TriTrypDb:
LINF_320035800
Length:
493

Annotations

LeishMANIAdb annotations

Related to bacterial cytidyltransferase enzymes. Relatively conserved architecture, with the expection of an insertion of 2 helices.. Might have been acquired by horizontal gene transfer in the ancestors of Kinetoplastids.

Annotations by Jardim et al.

Phospholipid biosynthesis, Phosphatidate cytidylyltransferase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0005886 plasma membrane 3 1

Expansion

Sequence features

E9AHM2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHM2

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 7
GO:0006644 phospholipid metabolic process 4 7
GO:0006650 glycerophospholipid metabolic process 5 7
GO:0006793 phosphorus metabolic process 3 7
GO:0006796 phosphate-containing compound metabolic process 4 7
GO:0008152 metabolic process 1 7
GO:0008610 lipid biosynthetic process 4 7
GO:0008654 phospholipid biosynthetic process 5 7
GO:0009058 biosynthetic process 2 7
GO:0009987 cellular process 1 7
GO:0016024 CDP-diacylglycerol biosynthetic process 6 7
GO:0019637 organophosphate metabolic process 3 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0044249 cellular biosynthetic process 3 7
GO:0044255 cellular lipid metabolic process 3 7
GO:0045017 glycerolipid biosynthetic process 4 7
GO:0046341 CDP-diacylglycerol metabolic process 6 7
GO:0046474 glycerophospholipid biosynthetic process 5 7
GO:0046486 glycerolipid metabolic process 4 7
GO:0071704 organic substance metabolic process 2 7
GO:0090407 organophosphate biosynthetic process 4 7
GO:1901576 organic substance biosynthetic process 3 7
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0004605 phosphatidate cytidylyltransferase activity 6 8
GO:0016740 transferase activity 2 10
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 10
GO:0016779 nucleotidyltransferase activity 4 10
GO:0070567 cytidylyltransferase activity 5 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 463 467 PF00656 0.421
CLV_NRD_NRD_1 345 347 PF00675 0.381
CLV_PCSK_KEX2_1 347 349 PF00082 0.420
CLV_PCSK_KEX2_1 443 445 PF00082 0.221
CLV_PCSK_KEX2_1 70 72 PF00082 0.247
CLV_PCSK_PC1ET2_1 347 349 PF00082 0.420
CLV_PCSK_PC1ET2_1 443 445 PF00082 0.221
CLV_PCSK_PC1ET2_1 70 72 PF00082 0.262
CLV_PCSK_SKI1_1 238 242 PF00082 0.322
CLV_PCSK_SKI1_1 29 33 PF00082 0.377
CLV_PCSK_SKI1_1 316 320 PF00082 0.274
CLV_PCSK_SKI1_1 348 352 PF00082 0.422
CLV_PCSK_SKI1_1 358 362 PF00082 0.369
CLV_PCSK_SKI1_1 71 75 PF00082 0.248
DEG_APCC_DBOX_1 19 27 PF00400 0.601
DEG_MDM2_SWIB_1 272 280 PF02201 0.248
DEG_Nend_UBRbox_2 1 3 PF02207 0.623
DOC_CKS1_1 280 285 PF01111 0.281
DOC_CYCLIN_RxL_1 355 363 PF00134 0.529
DOC_CYCLIN_yCln2_LP_2 470 476 PF00134 0.503
DOC_MAPK_gen_1 70 77 PF00069 0.453
DOC_MAPK_MEF2A_6 464 472 PF00069 0.421
DOC_MAPK_MEF2A_6 70 79 PF00069 0.456
DOC_PP1_RVXF_1 135 142 PF00149 0.362
DOC_PP4_FxxP_1 453 456 PF00568 0.486
DOC_USP7_MATH_1 373 377 PF00917 0.426
DOC_USP7_UBL2_3 347 351 PF12436 0.537
DOC_USP7_UBL2_3 70 74 PF12436 0.473
DOC_WW_Pin1_4 107 112 PF00397 0.650
DOC_WW_Pin1_4 12 17 PF00397 0.613
DOC_WW_Pin1_4 279 284 PF00397 0.402
DOC_WW_Pin1_4 360 365 PF00397 0.531
DOC_WW_Pin1_4 369 374 PF00397 0.396
DOC_WW_Pin1_4 88 93 PF00397 0.654
LIG_14-3-3_CanoR_1 316 321 PF00244 0.454
LIG_14-3-3_CanoR_1 480 486 PF00244 0.489
LIG_Actin_WH2_2 430 445 PF00022 0.253
LIG_Clathr_ClatBox_1 156 160 PF01394 0.281
LIG_Clathr_ClatBox_1 78 82 PF01394 0.559
LIG_FHA_1 152 158 PF00498 0.382
LIG_FHA_1 28 34 PF00498 0.301
LIG_FHA_2 220 226 PF00498 0.621
LIG_FHA_2 330 336 PF00498 0.577
LIG_GSK3_LRP6_1 107 112 PF00069 0.523
LIG_LIR_Apic_2 121 126 PF02991 0.500
LIG_LIR_Apic_2 450 456 PF02991 0.444
LIG_LIR_Gen_1 131 139 PF02991 0.444
LIG_LIR_Gen_1 160 171 PF02991 0.274
LIG_LIR_Gen_1 245 255 PF02991 0.528
LIG_LIR_Gen_1 261 272 PF02991 0.378
LIG_LIR_Gen_1 412 423 PF02991 0.263
LIG_LIR_Nem_3 131 136 PF02991 0.497
LIG_LIR_Nem_3 158 164 PF02991 0.314
LIG_LIR_Nem_3 261 267 PF02991 0.468
LIG_LIR_Nem_3 270 275 PF02991 0.245
LIG_LIR_Nem_3 323 328 PF02991 0.580
LIG_LIR_Nem_3 390 394 PF02991 0.346
LIG_LIR_Nem_3 412 418 PF02991 0.234
LIG_LIR_Nem_3 65 69 PF02991 0.233
LIG_NRBOX 419 425 PF00104 0.422
LIG_NRBOX 437 443 PF00104 0.179
LIG_NRP_CendR_1 492 493 PF00754 0.352
LIG_Pex14_2 272 276 PF04695 0.248
LIG_Pex14_2 56 60 PF04695 0.252
LIG_SH2_CRK 123 127 PF00017 0.488
LIG_SH2_CRK 133 137 PF00017 0.423
LIG_SH2_CRK 325 329 PF00017 0.628
LIG_SH2_STAT5 162 165 PF00017 0.250
LIG_SH2_STAT5 246 249 PF00017 0.557
LIG_SH3_1 105 111 PF00018 0.576
LIG_SH3_1 123 129 PF00018 0.472
LIG_SH3_3 100 106 PF00018 0.497
LIG_SH3_3 114 120 PF00018 0.520
LIG_SH3_3 123 129 PF00018 0.487
LIG_SH3_3 289 295 PF00018 0.344
LIG_SH3_3 407 413 PF00018 0.303
LIG_SH3_3 86 92 PF00018 0.734
LIG_SUMO_SIM_par_1 154 160 PF11976 0.427
LIG_SUMO_SIM_par_1 167 172 PF11976 0.280
LIG_TRAF2_1 332 335 PF00917 0.572
LIG_UBA3_1 437 443 PF00899 0.248
LIG_WRC_WIRS_1 57 62 PF05994 0.348
MOD_CDC14_SPxK_1 15 18 PF00782 0.564
MOD_CDC14_SPxK_1 372 375 PF00782 0.421
MOD_CDK_SPxK_1 12 18 PF00069 0.576
MOD_CDK_SPxK_1 369 375 PF00069 0.421
MOD_CK1_1 193 199 PF00069 0.563
MOD_CK1_1 44 50 PF00069 0.386
MOD_CK1_1 484 490 PF00069 0.595
MOD_CK2_1 329 335 PF00069 0.542
MOD_DYRK1A_RPxSP_1 369 373 PF00069 0.486
MOD_GlcNHglycan 149 152 PF01048 0.591
MOD_GlcNHglycan 193 196 PF01048 0.457
MOD_GlcNHglycan 204 207 PF01048 0.469
MOD_GlcNHglycan 43 46 PF01048 0.406
MOD_GlcNHglycan 488 491 PF01048 0.337
MOD_GlcNHglycan 65 69 PF01048 0.237
MOD_GSK3_1 147 154 PF00069 0.428
MOD_GSK3_1 186 193 PF00069 0.597
MOD_GSK3_1 369 376 PF00069 0.421
MOD_GSK3_1 77 84 PF00069 0.611
MOD_N-GLC_1 373 378 PF02516 0.303
MOD_NEK2_1 297 302 PF00069 0.339
MOD_NEK2_1 41 46 PF00069 0.454
MOD_NEK2_1 423 428 PF00069 0.267
MOD_NEK2_1 437 442 PF00069 0.234
MOD_NEK2_1 483 488 PF00069 0.548
MOD_NEK2_1 56 61 PF00069 0.186
MOD_NEK2_1 81 86 PF00069 0.633
MOD_PIKK_1 186 192 PF00454 0.609
MOD_PIKK_1 193 199 PF00454 0.619
MOD_Plk_1 151 157 PF00069 0.228
MOD_Plk_1 229 235 PF00069 0.650
MOD_Plk_1 373 379 PF00069 0.503
MOD_Plk_1 81 87 PF00069 0.559
MOD_Plk_4 151 157 PF00069 0.247
MOD_Plk_4 297 303 PF00069 0.290
MOD_Plk_4 316 322 PF00069 0.504
MOD_Plk_4 423 429 PF00069 0.289
MOD_Plk_4 437 443 PF00069 0.213
MOD_Plk_4 56 62 PF00069 0.372
MOD_Plk_4 94 100 PF00069 0.532
MOD_ProDKin_1 107 113 PF00069 0.650
MOD_ProDKin_1 12 18 PF00069 0.611
MOD_ProDKin_1 279 285 PF00069 0.402
MOD_ProDKin_1 360 366 PF00069 0.533
MOD_ProDKin_1 369 375 PF00069 0.396
MOD_ProDKin_1 88 94 PF00069 0.650
MOD_SUMO_for_1 179 182 PF00179 0.531
MOD_SUMO_for_1 234 237 PF00179 0.660
TRG_DiLeu_BaEn_1 152 157 PF01217 0.303
TRG_DiLeu_BaEn_1 352 357 PF01217 0.515
TRG_ENDOCYTIC_2 133 136 PF00928 0.492
TRG_ENDOCYTIC_2 162 165 PF00928 0.339
TRG_ENDOCYTIC_2 325 328 PF00928 0.639
TRG_ENDOCYTIC_2 399 402 PF00928 0.274
TRG_ER_diArg_1 18 21 PF00400 0.636
TRG_ER_diArg_1 345 348 PF00400 0.571
TRG_NLS_MonoExtN_4 345 350 PF00514 0.555
TRG_Pf-PMV_PEXEL_1 348 352 PF00026 0.412

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEC8 Leptomonas seymouri 61% 100%
A0A1X0NT53 Trypanosomatidae 31% 100%
A0A3Q8IDC1 Leishmania donovani 100% 100%
A0A422NZP0 Trypanosoma rangeli 33% 100%
A4HKS8 Leishmania braziliensis 69% 96%
E9B366 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q4Y8 Leishmania major 89% 99%
V5AXY5 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS