Putative ADP-ribosylation factor

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylation factor - putative

Species:

Leishmania infantum

UniProt:

E9AHL7_LEIIN

TriTrypDb:

LINF_310031000

Length:

182

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, ADP-ribosylation factor

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 12
Forrest at al. (procyclic)	yes	yes: 12
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 27

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 30

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

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Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	14
GO:0043226	organelle	2	14
GO:0043227	membrane-bounded organelle	3	14
GO:0043229	intracellular organelle	3	14
GO:0043231	intracellular membrane-bounded organelle	4	14
GO:0110165	cellular anatomical entity	1	14

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Expansion

Sequence features

E9AHL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHL7

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	15
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	15
GO:0009987	cellular process	1	15
GO:0015031	protein transport	4	15
GO:0016192	vesicle-mediated transport	4	15
GO:0033036	macromolecule localization	2	15
GO:0045184	establishment of protein localization	3	15
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	15

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	20
GO:0003824	catalytic activity	1	20
GO:0003924	GTPase activity	7	20
GO:0005488	binding	1	20
GO:0005525	GTP binding	5	20
GO:0016462	pyrophosphatase activity	5	20
GO:0016787	hydrolase activity	2	20
GO:0016817	hydrolase activity, acting on acid anhydrides	3	20
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	20
GO:0017076	purine nucleotide binding	4	20

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	151	153	PF00675	0.470
CLV_PCSK_FUR_1	149	153	PF00082	0.470
CLV_PCSK_KEX2_1	151	153	PF00082	0.470
CLV_PCSK_SKI1_1	59	63	PF00082	0.348
CLV_PCSK_SKI1_1	99	103	PF00082	0.400
DEG_SPOP_SBC_1	133	137	PF00917	0.358
DEG_SPOP_SBC_1	42	46	PF00917	0.470
DOC_MAPK_gen_1	15	25	PF00069	0.507
DOC_MAPK_MEF2A_6	117	124	PF00069	0.303
DOC_MAPK_MEF2A_6	15	22	PF00069	0.358

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q3	Leptomonas seymouri	52%	96%
A0A0N0P4P7	Leptomonas seymouri	35%	100%
A0A0N0P633	Leptomonas seymouri	96%	99%
A0A0N0P8D4	Leptomonas seymouri	42%	100%
A0A0N0P8G7	Leptomonas seymouri	23%	84%
A0A0N0P8Z3	Leptomonas seymouri	40%	100%
A0A0N1HS40	Leptomonas seymouri	41%	100%
A0A0N1HTN6	Leptomonas seymouri	51%	96%
A0A0N1I3A9	Leptomonas seymouri	43%	100%
A0A0N1I556	Leptomonas seymouri	78%	100%

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