Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Secreted protein

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AHL4_LEIIN

TriTrypDb:

LINF_310026000

Length:

152

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AHL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHL4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.635
CLV_NRD_NRD_1	29	31	PF00675	0.354
CLV_NRD_NRD_1	60	62	PF00675	0.542
CLV_PCSK_KEX2_1	29	31	PF00082	0.354
CLV_PCSK_KEX2_1	59	61	PF00082	0.533
CLV_PCSK_PC7_1	56	62	PF00082	0.482
CLV_PCSK_SKI1_1	30	34	PF00082	0.494
DOC_USP7_MATH_1	2	6	PF00917	0.398
DOC_USP7_MATH_1	35	39	PF00917	0.599
DOC_USP7_MATH_1	48	52	PF00917	0.645
DOC_USP7_MATH_1	62	66	PF00917	0.599
DOC_WW_Pin1_4	134	139	PF00397	0.799
DOC_WW_Pin1_4	54	59	PF00397	0.619
LIG_14-3-3_CanoR_1	29	33	PF00244	0.607
LIG_BIR_II_1	1	5	PF00653	0.415
LIG_FHA_1	5	11	PF00498	0.293
LIG_FHA_1	67	73	PF00498	0.684
LIG_FHA_2	1	7	PF00498	0.404
LIG_SH2_CRK	102	106	PF00017	0.605
LIG_SH2_GRB2like	117	120	PF00017	0.704
LIG_SH2_PTP2	17	20	PF00017	0.304
LIG_SH2_STAT5	17	20	PF00017	0.310
LIG_SH2_STAT5	26	29	PF00017	0.589
LIG_SH3_2	55	60	PF14604	0.623
LIG_SH3_3	101	107	PF00018	0.598
LIG_SH3_3	52	58	PF00018	0.613
LIG_SH3_3	65	71	PF00018	0.561
LIG_SUMO_SIM_anti_2	3	12	PF11976	0.360
LIG_TRAF2_1	132	135	PF00917	0.638
LIG_TYR_ITIM	15	20	PF00017	0.304
MOD_CDC14_SPxK_1	57	60	PF00782	0.625
MOD_CDK_SPK_2	54	59	PF00069	0.619
MOD_CDK_SPxK_1	54	60	PF00069	0.622
MOD_CDK_SPxxK_3	54	61	PF00069	0.624
MOD_CK1_1	137	143	PF00069	0.634
MOD_GlcNHglycan	122	127	PF01048	0.444
MOD_GlcNHglycan	50	53	PF01048	0.465
MOD_GlcNHglycan	64	67	PF01048	0.420
MOD_GSK3_1	50	57	PF00069	0.705
MOD_GSK3_1	62	69	PF00069	0.709
MOD_PIKK_1	50	56	PF00454	0.682
MOD_PKA_2	28	34	PF00069	0.670
MOD_Plk_1	113	119	PF00069	0.638
MOD_Plk_1	122	128	PF00069	0.630
MOD_Plk_4	113	119	PF00069	0.668
MOD_Plk_4	4	10	PF00069	0.316
MOD_ProDKin_1	134	140	PF00069	0.799
MOD_ProDKin_1	54	60	PF00069	0.622
TRG_DiLeu_BaEn_1	28	33	PF01217	0.588
TRG_ENDOCYTIC_2	102	105	PF00928	0.608
TRG_ENDOCYTIC_2	17	20	PF00928	0.310
TRG_ER_diArg_1	58	61	PF00400	0.728

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P382	Leptomonas seymouri	38%	100%
A0A3S5H7Q1	Leishmania donovani	99%	100%
E9AEF5	Leishmania major	90%	100%
E9AIU5	Leishmania braziliensis	70%	100%
E9B1Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%