IMD domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AHL0_LEIIN

TriTrypDb:

LINF_310013450

Length:

311

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AHL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHL0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.509
CLV_NRD_NRD_1	123	125	PF00675	0.465
CLV_PCSK_KEX2_1	191	193	PF00082	0.436
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.424
CLV_PCSK_SKI1_1	104	108	PF00082	0.632
CLV_PCSK_SKI1_1	111	115	PF00082	0.507
CLV_PCSK_SKI1_1	117	121	PF00082	0.451
CLV_PCSK_SKI1_1	124	128	PF00082	0.416
CLV_PCSK_SKI1_1	183	187	PF00082	0.538
DOC_MAPK_gen_1	157	164	PF00069	0.485
DOC_PP4_FxxP_1	7	10	PF00568	0.538
DOC_USP7_MATH_1	115	119	PF00917	0.531
DOC_USP7_MATH_1	138	142	PF00917	0.554
DOC_USP7_MATH_1	160	164	PF00917	0.455
DOC_USP7_MATH_1	22	26	PF00917	0.466
DOC_USP7_MATH_1	53	57	PF00917	0.504
DOC_USP7_UBL2_3	103	107	PF12436	0.442
DOC_WW_Pin1_4	297	302	PF00397	0.734
LIG_14-3-3_CanoR_1	230	234	PF00244	0.596
LIG_14-3-3_CanoR_1	283	289	PF00244	0.585
LIG_Actin_WH2_2	88	105	PF00022	0.481
LIG_AP2alpha_1	171	175	PF02296	0.458
LIG_BIR_II_1	1	5	PF00653	0.658
LIG_BRCT_BRCA1_1	47	51	PF00533	0.483
LIG_BRCT_BRCA1_1	55	59	PF00533	0.516
LIG_CaM_IQ_9	161	176	PF13499	0.331
LIG_FHA_1	200	206	PF00498	0.467
LIG_FHA_2	207	213	PF00498	0.485
LIG_FHA_2	58	64	PF00498	0.457
LIG_LIR_Apic_2	6	10	PF02991	0.549
LIG_LIR_Gen_1	172	182	PF02991	0.452
LIG_LIR_Gen_1	48	59	PF02991	0.472
LIG_LIR_Nem_3	118	123	PF02991	0.480
LIG_LIR_Nem_3	172	178	PF02991	0.449
LIG_LIR_Nem_3	25	29	PF02991	0.556
LIG_LIR_Nem_3	48	54	PF02991	0.467
LIG_Pex14_2	171	175	PF04695	0.431
LIG_Rb_LxCxE_1	216	235	PF01857	0.396
LIG_SH2_CRK	87	91	PF00017	0.449
LIG_SH2_SRC	67	70	PF00017	0.474
LIG_SH2_STAT5	193	196	PF00017	0.437
LIG_SH2_STAT5	67	70	PF00017	0.472
LIG_SH3_3	92	98	PF00018	0.434
LIG_SUMO_SIM_anti_2	243	249	PF11976	0.396
LIG_TRAF2_1	214	217	PF00917	0.483
LIG_TRAF2_2	10	15	PF00917	0.498
LIG_TRFH_1	254	258	PF08558	0.538
LIG_UBA3_1	33	38	PF00899	0.516
LIG_WRC_WIRS_1	23	28	PF05994	0.485
LIG_WW_3	292	296	PF00397	0.576
MOD_CK1_1	149	155	PF00069	0.539
MOD_CK1_1	243	249	PF00069	0.549
MOD_CK1_1	273	279	PF00069	0.635
MOD_CK1_1	286	292	PF00069	0.659
MOD_CK2_1	102	108	PF00069	0.546
MOD_CK2_1	115	121	PF00069	0.436
MOD_CK2_1	211	217	PF00069	0.474
MOD_CK2_1	229	235	PF00069	0.633
MOD_CK2_1	57	63	PF00069	0.587
MOD_CK2_1	74	80	PF00069	0.412
MOD_GlcNHglycan	116	120	PF01048	0.401
MOD_GlcNHglycan	26	29	PF01048	0.525
MOD_GSK3_1	24	31	PF00069	0.471
MOD_GSK3_1	282	289	PF00069	0.694
MOD_GSK3_1	297	304	PF00069	0.600
MOD_GSK3_1	53	60	PF00069	0.538
MOD_N-GLC_1	183	188	PF02516	0.562
MOD_NEK2_1	102	107	PF00069	0.471
MOD_NEK2_1	144	149	PF00069	0.518
MOD_NEK2_1	40	45	PF00069	0.490
MOD_PIKK_1	248	254	PF00454	0.516
MOD_PKA_2	229	235	PF00069	0.487
MOD_PKA_2	282	288	PF00069	0.708
MOD_Plk_1	115	121	PF00069	0.628
MOD_Plk_1	243	249	PF00069	0.682
MOD_Plk_2-3	74	80	PF00069	0.361
MOD_Plk_4	200	206	PF00069	0.470
MOD_Plk_4	229	235	PF00069	0.558
MOD_Plk_4	243	249	PF00069	0.593
MOD_ProDKin_1	297	303	PF00069	0.736
MOD_SUMO_for_1	113	116	PF00179	0.502
TRG_DiLeu_BaEn_4	216	222	PF01217	0.515
TRG_ENDOCYTIC_2	193	196	PF00928	0.443
TRG_ENDOCYTIC_2	87	90	PF00928	0.479
TRG_ER_diArg_1	294	297	PF00400	0.584
TRG_NLS_MonoExtN_4	122	128	PF00514	0.491
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P348	Leptomonas seymouri	24%	71%
A0A0N0P3S1	Leptomonas seymouri	60%	68%
A0A0N0P4S1	Leptomonas seymouri	23%	100%
A0A1X0NK28	Trypanosomatidae	38%	76%
A0A3Q8IG21	Leishmania donovani	94%	74%
A0A3Q8IIE7	Leishmania donovani	98%	100%
A0A3S5H792	Leishmania donovani	24%	100%
A0A3S7WQB3	Leishmania donovani	25%	74%
A4H6C6	Leishmania braziliensis	23%	100%
A4HJ56	Leishmania braziliensis	68%	100%
A4HTM7	Leishmania infantum	25%	74%
A4HZL5	Leishmania infantum	24%	100%
A4I6H9	Leishmania infantum	93%	100%
E9AMG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	74%
E9B1M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
E9B1N5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
E9B1N6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q6H8	Leishmania major	82%	100%
Q4Q6I6	Leishmania major	79%	99%
Q4QCL3	Leishmania major	25%	100%
Q4QI82	Leishmania major	24%	100%