LeishMANIAdb
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Putative amino acid transporter aATP11

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative amino acid transporter aATP11
Gene product:
amino acid transporter aATP11 - putative
Species:
Leishmania infantum
UniProt:
E9AHK8_LEIIN
TriTrypDb:
LINF_310008700
Length:
321

Annotations

LeishMANIAdb annotations

An enormously expanded group of various amino acid transporters.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 6
Forrest at al. (procyclic) yes yes: 8
Silverman et al. no yes: 0
Pissara et al. yes yes: 33
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 86
NetGPI no yes: 0, no: 86
Cellular components
Term Name Level Count
GO:0016020 membrane 2 81
GO:0110165 cellular anatomical entity 1 81

Phosphorylation

Promastigote: 19, 20

Expansion

Sequence features

E9AHK8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHK8

Function

Biological processes
Term Name Level Count
GO:0003333 amino acid transmembrane transport 5 5
GO:0006810 transport 3 5
GO:0006865 amino acid transport 5 5
GO:0009987 cellular process 1 5
GO:0015849 organic acid transport 5 5
GO:0051179 localization 1 5
GO:0051234 establishment of localization 2 5
GO:0055085 transmembrane transport 2 5
GO:0071702 organic substance transport 4 5
GO:0071705 nitrogen compound transport 4 5
GO:1903825 organic acid transmembrane transport 3 5
GO:1905039 carboxylic acid transmembrane transport 4 5
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 5
GO:0005342 organic acid transmembrane transporter activity 3 5
GO:0015171 amino acid transmembrane transporter activity 5 5
GO:0015179 L-amino acid transmembrane transporter activity 6 5
GO:0022857 transmembrane transporter activity 2 5
GO:0046943 carboxylic acid transmembrane transporter activity 4 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 177 181 PF00656 0.393
CLV_NRD_NRD_1 35 37 PF00675 0.447
CLV_NRD_NRD_1 51 53 PF00675 0.369
CLV_PCSK_KEX2_1 35 37 PF00082 0.481
CLV_PCSK_KEX2_1 51 53 PF00082 0.356
CLV_PCSK_PC7_1 31 37 PF00082 0.502
CLV_PCSK_SKI1_1 138 142 PF00082 0.313
CLV_PCSK_SKI1_1 169 173 PF00082 0.510
CLV_PCSK_SKI1_1 193 197 PF00082 0.353
CLV_PCSK_SKI1_1 252 256 PF00082 0.480
DEG_Nend_UBRbox_2 1 3 PF02207 0.575
DOC_MAPK_MEF2A_6 217 226 PF00069 0.493
DOC_MAPK_MEF2A_6 244 253 PF00069 0.407
DOC_PP1_RVXF_1 191 198 PF00149 0.481
DOC_PP2B_LxvP_1 207 210 PF13499 0.327
DOC_USP7_MATH_1 277 281 PF00917 0.476
DOC_USP7_MATH_1 80 84 PF00917 0.383
DOC_USP7_MATH_2 210 216 PF00917 0.502
DOC_WW_Pin1_4 179 184 PF00397 0.344
DOC_WW_Pin1_4 285 290 PF00397 0.506
LIG_14-3-3_CanoR_1 193 198 PF00244 0.315
LIG_14-3-3_CanoR_1 217 226 PF00244 0.476
LIG_14-3-3_CanoR_1 252 261 PF00244 0.340
LIG_14-3-3_CanoR_1 291 295 PF00244 0.507
LIG_EH1_1 228 236 PF00400 0.290
LIG_FHA_1 171 177 PF00498 0.390
LIG_FHA_1 194 200 PF00498 0.344
LIG_FHA_1 295 301 PF00498 0.382
LIG_LIR_Apic_2 64 68 PF02991 0.674
LIG_LIR_Gen_1 146 156 PF02991 0.550
LIG_LIR_Gen_1 266 277 PF02991 0.373
LIG_LIR_Gen_1 279 289 PF02991 0.289
LIG_LIR_Nem_3 114 119 PF02991 0.365
LIG_LIR_Nem_3 146 151 PF02991 0.515
LIG_LIR_Nem_3 266 272 PF02991 0.381
LIG_LIR_Nem_3 28 32 PF02991 0.706
LIG_NRBOX 308 314 PF00104 0.396
LIG_Pex14_1 154 158 PF04695 0.369
LIG_Pex14_2 151 155 PF04695 0.373
LIG_Pex14_2 226 230 PF04695 0.325
LIG_Pex14_2 267 271 PF04695 0.353
LIG_Pex14_2 304 308 PF04695 0.397
LIG_SH2_CRK 69 73 PF00017 0.589
LIG_SH2_SRC 164 167 PF00017 0.302
LIG_SH2_STAP1 116 120 PF00017 0.386
LIG_SH2_STAP1 133 137 PF00017 0.429
LIG_SH2_STAP1 93 97 PF00017 0.230
LIG_SH2_STAT5 112 115 PF00017 0.345
LIG_SH2_STAT5 119 122 PF00017 0.355
LIG_SH2_STAT5 147 150 PF00017 0.364
LIG_SH2_STAT5 164 167 PF00017 0.295
LIG_SH2_STAT5 218 221 PF00017 0.379
LIG_SH2_STAT5 229 232 PF00017 0.324
LIG_SH2_STAT5 62 65 PF00017 0.630
LIG_SH3_5 143 147 PF00018 0.596
LIG_SUMO_SIM_anti_2 220 226 PF11976 0.444
LIG_SUMO_SIM_par_1 163 170 PF11976 0.306
LIG_TRAF2_1 280 283 PF00917 0.416
LIG_TYR_ITIM 110 115 PF00017 0.410
LIG_TYR_ITIM 227 232 PF00017 0.388
LIG_TYR_ITIM 67 72 PF00017 0.575
LIG_UBA3_1 204 211 PF00899 0.320
LIG_UBA3_1 312 321 PF00899 0.348
LIG_WRC_WIRS_1 155 160 PF05994 0.343
LIG_WRC_WIRS_1 194 199 PF05994 0.448
LIG_WRC_WIRS_1 264 269 PF05994 0.376
MOD_CDK_SPxK_1 285 291 PF00069 0.497
MOD_CK1_1 262 268 PF00069 0.382
MOD_CK1_1 285 291 PF00069 0.521
MOD_CK2_1 16 22 PF00069 0.734
MOD_CK2_1 277 283 PF00069 0.387
MOD_GlcNHglycan 19 22 PF01048 0.541
MOD_GlcNHglycan 237 240 PF01048 0.439
MOD_GlcNHglycan 261 264 PF01048 0.323
MOD_GlcNHglycan 317 320 PF01048 0.585
MOD_GlcNHglycan 97 100 PF01048 0.495
MOD_GSK3_1 160 167 PF00069 0.401
MOD_GSK3_1 252 259 PF00069 0.387
MOD_GSK3_1 290 297 PF00069 0.516
MOD_N-GLC_1 95 100 PF02516 0.434
MOD_NEK2_1 253 258 PF00069 0.295
MOD_NEK2_1 290 295 PF00069 0.501
MOD_NEK2_1 312 317 PF00069 0.355
MOD_NEK2_1 72 77 PF00069 0.503
MOD_NEK2_1 79 84 PF00069 0.339
MOD_NEK2_1 95 100 PF00069 0.282
MOD_NEK2_2 111 116 PF00069 0.351
MOD_NEK2_2 164 169 PF00069 0.477
MOD_PIKK_1 270 276 PF00454 0.395
MOD_PKA_2 290 296 PF00069 0.496
MOD_Plk_1 160 166 PF00069 0.442
MOD_Plk_1 27 33 PF00069 0.730
MOD_Plk_4 111 117 PF00069 0.322
MOD_Plk_4 160 166 PF00069 0.419
MOD_Plk_4 193 199 PF00069 0.357
MOD_Plk_4 263 269 PF00069 0.379
MOD_Plk_4 312 318 PF00069 0.255
MOD_ProDKin_1 179 185 PF00069 0.344
MOD_ProDKin_1 285 291 PF00069 0.506
MOD_SUMO_rev_2 2 12 PF00179 0.769
TRG_DiLeu_BaLyEn_6 190 195 PF01217 0.330
TRG_ENDOCYTIC_2 106 109 PF00928 0.364
TRG_ENDOCYTIC_2 112 115 PF00928 0.370
TRG_ENDOCYTIC_2 118 121 PF00928 0.372
TRG_ENDOCYTIC_2 133 136 PF00928 0.424
TRG_ENDOCYTIC_2 229 232 PF00928 0.364
TRG_ENDOCYTIC_2 281 284 PF00928 0.442
TRG_ENDOCYTIC_2 69 72 PF00928 0.574
TRG_ER_diArg_1 34 36 PF00400 0.701
TRG_ER_diArg_1 51 53 PF00400 0.642

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5D2 Leptomonas seymouri 45% 67%
A0A0N0P613 Leptomonas seymouri 25% 79%
A0A0N0P6F5 Leptomonas seymouri 28% 78%
A0A0N0P6F6 Leptomonas seymouri 38% 66%
A0A0N0P955 Leptomonas seymouri 42% 68%
A0A0N1I2L5 Leptomonas seymouri 38% 67%
A0A0N1I9T3 Leptomonas seymouri 44% 67%
A0A0N1IAJ0 Leptomonas seymouri 23% 67%
A0A0S4JHM8 Bodo saltans 26% 68%
A0A0S4JQ87 Bodo saltans 32% 71%
A0A0S4JU02 Bodo saltans 38% 66%
A0A1X0NKS5 Trypanosomatidae 51% 68%
A0A1X0NKW7 Trypanosomatidae 52% 68%
A0A1X0NNX9 Trypanosomatidae 41% 71%
A0A1X0NPV3 Trypanosomatidae 44% 71%
A0A1X0NQH3 Trypanosomatidae 41% 72%
A0A1X0NR26 Trypanosomatidae 40% 70%
A0A1X0NRL3 Trypanosomatidae 49% 69%
A0A1X0NRL7 Trypanosomatidae 43% 68%
A0A1X0P1N2 Trypanosomatidae 25% 70%
A0A1X0P4S1 Trypanosomatidae 24% 78%
A0A1X0P9N8 Trypanosomatidae 30% 71%
A0A3Q8IDG8 Leishmania donovani 42% 67%
A0A3Q8IG00 Leishmania donovani 41% 68%
A0A3Q8IJH2 Leishmania donovani 48% 66%
A0A3Q8IJX8 Leishmania donovani 39% 67%
A0A3Q8ILE0 Leishmania donovani 43% 66%
A0A3R7JSA0 Trypanosoma rangeli 42% 67%
A0A3R7KDS3 Trypanosoma rangeli 42% 78%
A0A3R7MWF1 Trypanosoma rangeli 27% 74%
A0A3R7N2A2 Trypanosoma rangeli 42% 73%
A0A3R7R2W8 Trypanosoma rangeli 42% 69%
A0A3R7RQX3 Trypanosoma rangeli 46% 67%
A0A3S7X443 Leishmania donovani 98% 69%
A0A3S7X4A1 Leishmania donovani 39% 67%
A0A3S7XA86 Leishmania donovani 24% 78%
A0A3S7XCE3 Leishmania donovani 21% 67%
A0A422N5W8 Trypanosoma rangeli 24% 78%
A0A422NBM3 Trypanosoma rangeli 41% 68%
A0A422NBQ2 Trypanosoma rangeli 35% 73%
A0A422NZS1 Trypanosoma rangeli 40% 68%
A2VCW5 Rattus norvegicus 25% 67%
A4HC75 Leishmania braziliensis 36% 66%
A4HFT5 Leishmania braziliensis 43% 67%
A4HJ35 Leishmania braziliensis 42% 68%
A4HJ63 Leishmania braziliensis 36% 67%
A4HKQ7 Leishmania braziliensis 42% 68%
A4HNJ6 Leishmania braziliensis 26% 78%
A4HNJ7 Leishmania braziliensis 23% 79%
A4HNQ0 Leishmania braziliensis 28% 66%
A4HZQ0 Leishmania infantum 43% 66%
A4I6I1 Leishmania infantum 39% 67%
A4I6J9 Leishmania infantum 99% 100%
A4I6L3 Leishmania infantum 41% 68%
A4I6L4 Leishmania infantum 39% 67%
A4I887 Leishmania infantum 48% 66%
A4IC53 Leishmania infantum 24% 78%
A4IC66 Leishmania infantum 23% 79%
A4ICC3 Leishmania infantum 22% 67%
A8KBL5 Danio rerio 27% 72%
C9ZMB9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 68%
C9ZMD2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 68%
C9ZMD4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 68%
C9ZN51 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 71%
C9ZN59 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 66%
C9ZN60 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 68%
C9ZWQ7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 69%
C9ZWQ8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 69%
C9ZWQ9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 69%
C9ZWR0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 69%
C9ZWR7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 69%
C9ZWX2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 70%
C9ZWX3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 70%
C9ZWX4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 70%
C9ZWX5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 70%
C9ZWX6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 70%
C9ZWX7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 70%
C9ZWY0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 68%
C9ZWY1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 68%
D0A362 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 78%
D0AAF6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 69%
D0AAF8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 69%
D3Z813 Rattus norvegicus 26% 71%
E8NHF9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 78%
E9ADD7 Leishmania major 44% 67%
E9AG08 Leishmania major 25% 78%
E9AG09 Leishmania major 23% 79%
E9AHL2 Leishmania infantum 36% 69%
E9AUB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 21% 67%
E9AVK6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 66%
E9AZ62 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 67%
E9B1I4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9B1K7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 68%
E9B1N8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 67%
E9B1N9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 67%
E9B345 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 66%
E9B761 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 78%
E9B762 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 79%
F4KBM7 Arabidopsis thaliana 25% 70%
G3UVW3 Mus musculus 22% 70%
O74327 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 76%
P38176 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 70%
P40074 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 72%
Q28HE5 Xenopus tropicalis 24% 72%
Q3U1J0 Mus musculus 27% 67%
Q3USY0 Mus musculus 25% 71%
Q4Q072 Leishmania major 22% 67%
Q4Q6H5 Leishmania major 38% 67%
Q4Q6K6 Leishmania major 43% 68%
Q4Q6M9 Leishmania major 96% 100%
Q4QBX3 Leishmania major 42% 66%
Q503G8 Danio rerio 25% 71%
Q5E9S9 Bos taurus 26% 67%
Q5EA97 Bos taurus 29% 69%
Q6DEL1 Danio rerio 23% 69%
Q6WWW3 Rattus norvegicus 23% 70%
Q8K2P7 Mus musculus 23% 66%
Q8WUX1 Homo sapiens 25% 68%
Q9JM15 Rattus norvegicus 23% 66%
Q9LI61 Arabidopsis thaliana 25% 70%
Q9LYM2 Arabidopsis thaliana 24% 74%
V5AXD0 Trypanosoma cruzi 26% 74%
V5B9A6 Trypanosoma cruzi 46% 70%
V5BA72 Trypanosoma cruzi 42% 69%
V5BH70 Trypanosoma cruzi 36% 72%
V5BMG4 Trypanosoma cruzi 46% 68%
V5D7K9 Trypanosoma cruzi 35% 71%
V5DCG4 Trypanosoma cruzi 42% 70%
V5DKR4 Trypanosoma cruzi 36% 72%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS