Ubiquitin carboxyl-terminal hydrolase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin carboxyl-terminal hydrolase - putative

Species:

Leishmania infantum

UniProt:

E9AHK7_LEIIN

TriTrypDb:

LINF_310006400

Length:

458

Annotations

Annotations by Jardim et al.

Protein modification, ubiquitin hydrolase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AHK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHK7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006511	ubiquitin-dependent protein catabolic process	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009987	cellular process	1	11
GO:0010498	proteasomal protein catabolic process	5	11
GO:0016579	protein deubiquitination	6	11
GO:0019538	protein metabolic process	3	11
GO:0019941	modification-dependent protein catabolic process	6	11
GO:0030163	protein catabolic process	4	11
GO:0036211	protein modification process	4	11
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0043632	modification-dependent macromolecule catabolic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044265	obsolete cellular macromolecule catabolic process	4	11
GO:0051603	proteolysis involved in protein catabolic process	5	11
GO:0070646	protein modification by small protein removal	5	11
GO:0070647	protein modification by small protein conjugation or removal	5	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901565	organonitrogen compound catabolic process	4	11
GO:1901575	organic substance catabolic process	3	11
GO:0009894	regulation of catabolic process	4	1
GO:0019222	regulation of metabolic process	3	1
GO:0030162	regulation of proteolysis	6	1
GO:0042176	regulation of protein catabolic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061136	regulation of proteasomal protein catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903050	regulation of proteolysis involved in protein catabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004843	cysteine-type deubiquitinase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0008234	cysteine-type peptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0019783	ubiquitin-like protein peptidase activity	4	11
GO:0101005	deubiquitinase activity	5	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0005488	binding	1	1
GO:0044877	protein-containing complex binding	2	1
GO:0070628	proteasome binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.405
CLV_NRD_NRD_1	343	345	PF00675	0.339
CLV_NRD_NRD_1	352	354	PF00675	0.355
CLV_PCSK_FUR_1	341	345	PF00082	0.416
CLV_PCSK_FUR_1	350	354	PF00082	0.404
CLV_PCSK_KEX2_1	343	345	PF00082	0.350
CLV_PCSK_KEX2_1	350	352	PF00082	0.357
CLV_PCSK_KEX2_1	428	430	PF00082	0.338
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.315
CLV_PCSK_SKI1_1	129	133	PF00082	0.411
CLV_PCSK_SKI1_1	27	31	PF00082	0.355
CLV_PCSK_SKI1_1	305	309	PF00082	0.328
CLV_PCSK_SKI1_1	311	315	PF00082	0.314
DEG_APCC_KENBOX_2	9	13	PF00400	0.533
DEG_COP1_1	73	83	PF00400	0.661
DOC_MAPK_DCC_7	156	164	PF00069	0.381
DOC_MAPK_DCC_7	305	315	PF00069	0.340
DOC_MAPK_gen_1	229	237	PF00069	0.450
DOC_MAPK_gen_1	305	315	PF00069	0.340
DOC_MAPK_gen_1	31	38	PF00069	0.520
DOC_MAPK_gen_1	7	17	PF00069	0.485
DOC_MAPK_MEF2A_6	10	19	PF00069	0.475
DOC_MAPK_MEF2A_6	156	164	PF00069	0.411
DOC_PP1_RVXF_1	3	9	PF00149	0.338
DOC_PP1_RVXF_1	309	316	PF00149	0.338
DOC_PP4_FxxP_1	263	266	PF00568	0.450
DOC_USP7_MATH_1	100	104	PF00917	0.575
DOC_USP7_MATH_1	199	203	PF00917	0.385
DOC_USP7_MATH_1	420	424	PF00917	0.450
DOC_USP7_UBL2_3	27	31	PF12436	0.565
DOC_USP7_UBL2_3	330	334	PF12436	0.392
DOC_USP7_UBL2_3	406	410	PF12436	0.427
DOC_WW_Pin1_4	358	363	PF00397	0.473
DOC_WW_Pin1_4	450	455	PF00397	0.569
LIG_14-3-3_CanoR_1	262	266	PF00244	0.346
LIG_14-3-3_CanoR_1	296	300	PF00244	0.381
LIG_14-3-3_CanoR_1	352	362	PF00244	0.359
LIG_Actin_WH2_2	316	332	PF00022	0.414
LIG_Actin_WH2_2	415	433	PF00022	0.450
LIG_APCC_ABBAyCdc20_2	410	416	PF00400	0.269
LIG_BIR_II_1	1	5	PF00653	0.444
LIG_FHA_1	110	116	PF00498	0.450
LIG_FHA_1	12	18	PF00498	0.512
LIG_FHA_1	164	170	PF00498	0.398
LIG_FHA_1	243	249	PF00498	0.439
LIG_FHA_1	319	325	PF00498	0.347
LIG_FHA_1	451	457	PF00498	0.522
LIG_FHA_1	65	71	PF00498	0.499
LIG_FHA_1	75	81	PF00498	0.589
LIG_FHA_2	172	178	PF00498	0.381
LIG_FHA_2	219	225	PF00498	0.401
LIG_Integrin_RGD_1	136	138	PF01839	0.450
LIG_Integrin_RGD_1	300	302	PF01839	0.405
LIG_LIR_Apic_2	260	266	PF02991	0.450
LIG_LIR_Gen_1	206	216	PF02991	0.479
LIG_LIR_Gen_1	234	244	PF02991	0.357
LIG_LIR_Gen_1	288	297	PF02991	0.338
LIG_LIR_Nem_3	206	211	PF02991	0.479
LIG_LIR_Nem_3	234	240	PF02991	0.338
LIG_LIR_Nem_3	288	292	PF02991	0.338
LIG_LIR_Nem_3	314	318	PF02991	0.346
LIG_LIR_Nem_3	379	385	PF02991	0.341
LIG_LIR_Nem_3	409	414	PF02991	0.359
LIG_MAD2	308	316	PF02301	0.338
LIG_NRBOX	192	198	PF00104	0.411
LIG_PDZ_Class_2	453	458	PF00595	0.491
LIG_Pex14_2	259	263	PF04695	0.450
LIG_PTB_Apo_2	108	115	PF02174	0.338
LIG_PTB_Apo_2	169	176	PF02174	0.381
LIG_PTB_Phospho_1	108	114	PF10480	0.338
LIG_SH2_GRB2like	114	117	PF00017	0.338
LIG_SH2_PTP2	289	292	PF00017	0.483
LIG_SH2_PTP2	440	443	PF00017	0.450
LIG_SH2_SRC	114	117	PF00017	0.450
LIG_SH2_STAP1	208	212	PF00017	0.435
LIG_SH2_STAP1	96	100	PF00017	0.686
LIG_SH2_STAT5	114	117	PF00017	0.375
LIG_SH2_STAT5	289	292	PF00017	0.349
LIG_SH2_STAT5	401	404	PF00017	0.338
LIG_SH2_STAT5	440	443	PF00017	0.338
LIG_SH2_STAT5	96	99	PF00017	0.783
LIG_SH3_3	220	226	PF00018	0.483
LIG_SH3_3	360	366	PF00018	0.424
LIG_SH3_3	451	457	PF00018	0.540
LIG_SUMO_SIM_anti_2	67	73	PF11976	0.499
LIG_TRAF2_1	366	369	PF00917	0.438
LIG_TYR_ITIM	438	443	PF00017	0.450
LIG_UBA3_1	43	47	PF00899	0.499
MOD_CDK_SPxxK_3	358	365	PF00069	0.403
MOD_CK1_1	281	287	PF00069	0.389
MOD_CK1_1	73	79	PF00069	0.663
MOD_CK2_1	121	127	PF00069	0.421
MOD_CK2_1	171	177	PF00069	0.315
MOD_Cter_Amidation	404	407	PF01082	0.432
MOD_GlcNHglycan	116	119	PF01048	0.411
MOD_GlcNHglycan	379	382	PF01048	0.330
MOD_GlcNHglycan	394	397	PF01048	0.322
MOD_GlcNHglycan	57	60	PF01048	0.373
MOD_GlcNHglycan	72	75	PF01048	0.399
MOD_GSK3_1	164	171	PF00069	0.456
MOD_GSK3_1	238	245	PF00069	0.420
MOD_GSK3_1	318	325	PF00069	0.469
MOD_GSK3_1	70	77	PF00069	0.639
MOD_GSK3_1	90	97	PF00069	0.655
MOD_N-GLC_1	11	16	PF02516	0.372
MOD_N-GLC_1	242	247	PF02516	0.441
MOD_N-GLC_1	377	382	PF02516	0.342
MOD_N-GLC_1	90	95	PF02516	0.683
MOD_N-GLC_2	111	113	PF02516	0.338
MOD_NEK2_1	121	126	PF00069	0.429
MOD_NEK2_1	151	156	PF00069	0.416
MOD_NEK2_1	164	169	PF00069	0.325
MOD_NEK2_1	19	24	PF00069	0.493
MOD_NEK2_1	216	221	PF00069	0.361
MOD_NEK2_1	319	324	PF00069	0.412
MOD_PIKK_1	186	192	PF00454	0.381
MOD_PKA_2	261	267	PF00069	0.346
MOD_PKA_2	278	284	PF00069	0.322
MOD_PKA_2	295	301	PF00069	0.335
MOD_PKB_1	351	359	PF00069	0.424
MOD_Plk_1	11	17	PF00069	0.510
MOD_Plk_1	319	325	PF00069	0.405
MOD_Plk_1	53	59	PF00069	0.499
MOD_Plk_2-3	11	17	PF00069	0.588
MOD_Plk_2-3	247	253	PF00069	0.380
MOD_Plk_4	164	170	PF00069	0.386
MOD_Plk_4	199	205	PF00069	0.374
MOD_Plk_4	319	325	PF00069	0.405
MOD_Plk_4	64	70	PF00069	0.499
MOD_ProDKin_1	358	364	PF00069	0.473
MOD_ProDKin_1	450	456	PF00069	0.572
MOD_SUMO_for_1	376	379	PF00179	0.493
MOD_SUMO_rev_2	364	373	PF00179	0.405
MOD_SUMO_rev_2	423	430	PF00179	0.334
TRG_DiLeu_BaEn_1	39	44	PF01217	0.565
TRG_DiLeu_BaEn_2	179	185	PF01217	0.450
TRG_DiLeu_BaEn_4	369	375	PF01217	0.385
TRG_ENDOCYTIC_2	208	211	PF00928	0.435
TRG_ENDOCYTIC_2	289	292	PF00928	0.339
TRG_ENDOCYTIC_2	382	385	PF00928	0.338
TRG_ENDOCYTIC_2	440	443	PF00928	0.338
TRG_ER_diArg_1	350	353	PF00400	0.412
TRG_ER_diArg_1	444	447	PF00400	0.391
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMH5	Leptomonas seymouri	81%	100%
A0A1X0NJ77	Trypanosomatidae	50%	97%
A0A3R7RDZ6	Trypanosoma rangeli	49%	98%
A0A3S7X418	Leishmania donovani	100%	100%
A4HIX8	Leishmania braziliensis	87%	100%
A5D9H7	Bos taurus	23%	100%
C9ZN32	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	98%
E9B1G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
F1M625	Rattus norvegicus	26%	100%
O57429	Gallus gallus	24%	100%
O75317	Homo sapiens	23%	100%
P40826	Oryctolagus cuniculus	32%	93%
P43593	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	92%
P54578	Homo sapiens	33%	93%
P60051	Pan troglodytes	33%	93%
P62068	Homo sapiens	26%	100%
P62069	Mus musculus	26%	100%
Q0IIF7	Bos taurus	33%	93%
Q17361	Caenorhabditis elegans	30%	94%
Q4Q6Q0	Leishmania major	95%	100%
Q4R6D3	Macaca fascicularis	22%	100%
Q5RBQ4	Pongo abelii	26%	100%
Q84WC6	Arabidopsis thaliana	30%	96%
Q92353	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	98%
Q949Y0	Arabidopsis thaliana	31%	95%
Q9JMA1	Mus musculus	32%	93%
Q9UMW8	Homo sapiens	25%	100%
Q9WTV6	Mus musculus	24%	100%
V5BIL0	Trypanosoma cruzi	52%	99%