SP-RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

lorien protein

Species:

Leishmania infantum

UniProt:

E9AHK2_LEIIN

TriTrypDb:

LINF_300040700

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AHK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHK2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0008270	zinc ion binding	6	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0046914	transition metal ion binding	5	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	249	253	PF00656	0.660
CLV_C14_Caspase3-7	254	258	PF00656	0.612
CLV_NRD_NRD_1	168	170	PF00675	0.693
CLV_NRD_NRD_1	174	176	PF00675	0.643
CLV_NRD_NRD_1	177	179	PF00675	0.617
CLV_NRD_NRD_1	234	236	PF00675	0.721
CLV_NRD_NRD_1	273	275	PF00675	0.499
CLV_NRD_NRD_1	335	337	PF00675	0.357
CLV_NRD_NRD_1	455	457	PF00675	0.555
CLV_PCSK_KEX2_1	168	170	PF00082	0.664
CLV_PCSK_KEX2_1	174	176	PF00082	0.666
CLV_PCSK_KEX2_1	179	181	PF00082	0.613
CLV_PCSK_KEX2_1	234	236	PF00082	0.747
CLV_PCSK_KEX2_1	238	240	PF00082	0.761
CLV_PCSK_KEX2_1	273	275	PF00082	0.565
CLV_PCSK_KEX2_1	335	337	PF00082	0.347
CLV_PCSK_KEX2_1	454	456	PF00082	0.531
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.693
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.657
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.626
CLV_PCSK_PC7_1	175	181	PF00082	0.689
CLV_PCSK_PC7_1	234	240	PF00082	0.654
CLV_PCSK_SKI1_1	123	127	PF00082	0.671
CLV_PCSK_SKI1_1	198	202	PF00082	0.765
CLV_PCSK_SKI1_1	235	239	PF00082	0.660
CLV_PCSK_SKI1_1	274	278	PF00082	0.464
CLV_PCSK_SKI1_1	290	294	PF00082	0.258
CLV_PCSK_SKI1_1	335	339	PF00082	0.362
CLV_PCSK_SKI1_1	408	412	PF00082	0.477
CLV_PCSK_SKI1_1	567	571	PF00082	0.452
CLV_Separin_Metazoa	278	282	PF03568	0.447
DEG_APCC_DBOX_1	273	281	PF00400	0.507
DEG_APCC_DBOX_1	289	297	PF00400	0.283
DEG_APCC_DBOX_1	335	343	PF00400	0.392
DEG_Nend_UBRbox_3	1	3	PF02207	0.463
DOC_CYCLIN_RxL_1	333	343	PF00134	0.465
DOC_CYCLIN_yClb5_NLxxxL_5	308	317	PF00134	0.570
DOC_MAPK_gen_1	273	279	PF00069	0.539
DOC_MAPK_gen_1	335	342	PF00069	0.346
DOC_MAPK_MEF2A_6	335	342	PF00069	0.346
DOC_MAPK_MEF2A_6	392	399	PF00069	0.424
DOC_MAPK_MEF2A_6	408	417	PF00069	0.250
DOC_PP2B_LxvP_1	317	320	PF13499	0.575
DOC_PP2B_LxvP_1	338	341	PF13499	0.405
DOC_PP2B_LxvP_1	402	405	PF13499	0.328
DOC_PP4_FxxP_1	285	288	PF00568	0.514
DOC_USP7_MATH_1	158	162	PF00917	0.641
DOC_USP7_MATH_1	202	206	PF00917	0.742
DOC_USP7_MATH_1	237	241	PF00917	0.728
DOC_USP7_MATH_1	464	468	PF00917	0.677
DOC_USP7_MATH_1	525	529	PF00917	0.478
DOC_USP7_MATH_1	547	551	PF00917	0.443
DOC_USP7_UBL2_3	570	574	PF12436	0.562
DOC_WW_Pin1_4	101	106	PF00397	0.677
DOC_WW_Pin1_4	186	191	PF00397	0.652
DOC_WW_Pin1_4	243	248	PF00397	0.741
DOC_WW_Pin1_4	291	296	PF00397	0.371
DOC_WW_Pin1_4	329	334	PF00397	0.549
DOC_WW_Pin1_4	369	374	PF00397	0.423
DOC_WW_Pin1_4	380	385	PF00397	0.467
DOC_WW_Pin1_4	397	402	PF00397	0.483
DOC_WW_Pin1_4	44	49	PF00397	0.507
DOC_WW_Pin1_4	460	465	PF00397	0.711
DOC_WW_Pin1_4	70	75	PF00397	0.630
LIG_14-3-3_CanoR_1	159	163	PF00244	0.609
LIG_14-3-3_CanoR_1	243	247	PF00244	0.735
LIG_14-3-3_CanoR_1	447	453	PF00244	0.503
LIG_Actin_WH2_2	554	572	PF00022	0.469
LIG_APCC_ABBA_1	365	370	PF00400	0.292
LIG_BIR_III_2	124	128	PF00653	0.721
LIG_BIR_III_2	264	268	PF00653	0.517
LIG_CSL_BTD_1	17	20	PF09270	0.430
LIG_eIF4E_1	96	102	PF01652	0.515
LIG_FHA_1	312	318	PF00498	0.495
LIG_FHA_1	394	400	PF00498	0.368
LIG_FHA_1	489	495	PF00498	0.442
LIG_FHA_1	581	587	PF00498	0.686
LIG_FHA_2	127	133	PF00498	0.599
LIG_FHA_2	20	26	PF00498	0.462
LIG_FHA_2	320	326	PF00498	0.503
LIG_FHA_2	354	360	PF00498	0.553
LIG_FHA_2	71	77	PF00498	0.541
LIG_FHA_2	82	88	PF00498	0.427
LIG_GSK3_LRP6_1	186	191	PF00069	0.652
LIG_LIR_Apic_2	283	288	PF02991	0.469
LIG_LIR_Apic_2	349	355	PF02991	0.438
LIG_LIR_Apic_2	43	48	PF02991	0.406
LIG_LIR_Gen_1	294	305	PF02991	0.455
LIG_LIR_Nem_3	294	300	PF02991	0.378
LIG_LIR_Nem_3	425	430	PF02991	0.419
LIG_LIR_Nem_3	50	55	PF02991	0.492
LIG_LYPXL_S_1	51	55	PF13949	0.458
LIG_MAD2	570	578	PF02301	0.636
LIG_PCNA_yPIPBox_3	532	546	PF02747	0.457
LIG_SH2_CRK	45	49	PF00017	0.507
LIG_SH2_STAT5	368	371	PF00017	0.502
LIG_SH2_STAT5	500	503	PF00017	0.512
LIG_SH2_STAT5	559	562	PF00017	0.473
LIG_SH3_1	180	186	PF00018	0.817
LIG_SH3_2	565	570	PF14604	0.402
LIG_SH3_3	103	109	PF00018	0.622
LIG_SH3_3	14	20	PF00018	0.462
LIG_SH3_3	180	186	PF00018	0.754
LIG_SH3_3	187	193	PF00018	0.657
LIG_SH3_3	209	215	PF00018	0.706
LIG_SH3_3	289	295	PF00018	0.423
LIG_SH3_3	371	377	PF00018	0.418
LIG_SH3_3	562	568	PF00018	0.403
LIG_SUMO_SIM_anti_2	582	591	PF11976	0.685
LIG_SUMO_SIM_par_1	395	400	PF11976	0.409
LIG_SUMO_SIM_par_1	582	591	PF11976	0.597
LIG_TRAF2_1	207	210	PF00917	0.729
LIG_TRAF2_1	258	261	PF00917	0.617
LIG_TRAF2_1	73	76	PF00917	0.571
LIG_TRFH_1	291	295	PF08558	0.407
MOD_CDC14_SPxK_1	332	335	PF00782	0.519
MOD_CDC14_SPxK_1	383	386	PF00782	0.578
MOD_CDK_SPxK_1	329	335	PF00069	0.531
MOD_CDK_SPxK_1	380	386	PF00069	0.565
MOD_CDK_SPxxK_3	329	336	PF00069	0.551
MOD_CK1_1	161	167	PF00069	0.716
MOD_CK1_1	205	211	PF00069	0.759
MOD_CK1_1	241	247	PF00069	0.710
MOD_CK1_1	311	317	PF00069	0.497
MOD_CK1_1	463	469	PF00069	0.651
MOD_CK2_1	114	120	PF00069	0.723
MOD_CK2_1	126	132	PF00069	0.465
MOD_CK2_1	19	25	PF00069	0.439
MOD_CK2_1	319	325	PF00069	0.487
MOD_CK2_1	353	359	PF00069	0.546
MOD_CK2_1	44	50	PF00069	0.535
MOD_CK2_1	464	470	PF00069	0.672
MOD_CK2_1	579	585	PF00069	0.722
MOD_CK2_1	70	76	PF00069	0.514
MOD_CK2_1	81	87	PF00069	0.492
MOD_DYRK1A_RPxSP_1	243	247	PF00069	0.714
MOD_GlcNHglycan	218	222	PF01048	0.716
MOD_GlcNHglycan	240	243	PF01048	0.743
MOD_GlcNHglycan	248	251	PF01048	0.781
MOD_GlcNHglycan	417	420	PF01048	0.480
MOD_GlcNHglycan	527	530	PF01048	0.278
MOD_GlcNHglycan	55	58	PF01048	0.556
MOD_GSK3_1	19	26	PF00069	0.562
MOD_GSK3_1	237	244	PF00069	0.679
MOD_GSK3_1	308	315	PF00069	0.442
MOD_GSK3_1	342	349	PF00069	0.372
MOD_GSK3_1	393	400	PF00069	0.461
MOD_GSK3_1	460	467	PF00069	0.695
MOD_N-GLC_1	144	149	PF02516	0.571
MOD_N-GLC_1	311	316	PF02516	0.451
MOD_N-GLC_1	81	86	PF02516	0.597
MOD_NEK2_1	313	318	PF00069	0.450
MOD_NEK2_1	363	368	PF00069	0.469
MOD_PIKK_1	4	10	PF00454	0.486
MOD_PIKK_1	547	553	PF00454	0.433
MOD_PKA_1	238	244	PF00069	0.660
MOD_PKA_2	158	164	PF00069	0.633
MOD_PKA_2	205	211	PF00069	0.650
MOD_PKA_2	23	29	PF00069	0.555
MOD_PKA_2	238	244	PF00069	0.702
MOD_Plk_1	477	483	PF00069	0.537
MOD_Plk_1	81	87	PF00069	0.609
MOD_Plk_4	135	141	PF00069	0.639
MOD_Plk_4	363	369	PF00069	0.443
MOD_ProDKin_1	101	107	PF00069	0.685
MOD_ProDKin_1	186	192	PF00069	0.652
MOD_ProDKin_1	243	249	PF00069	0.740
MOD_ProDKin_1	291	297	PF00069	0.372
MOD_ProDKin_1	329	335	PF00069	0.540
MOD_ProDKin_1	369	375	PF00069	0.430
MOD_ProDKin_1	380	386	PF00069	0.465
MOD_ProDKin_1	397	403	PF00069	0.478
MOD_ProDKin_1	44	50	PF00069	0.507
MOD_ProDKin_1	460	466	PF00069	0.710
MOD_ProDKin_1	70	76	PF00069	0.621
MOD_SUMO_for_1	531	534	PF00179	0.482
TRG_DiLeu_BaEn_2	28	34	PF01217	0.572
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.526
TRG_ENDOCYTIC_2	297	300	PF00928	0.427
TRG_ENDOCYTIC_2	52	55	PF00928	0.460
TRG_ER_diArg_1	167	169	PF00400	0.647
TRG_ER_diArg_1	173	175	PF00400	0.695
TRG_ER_diArg_1	180	183	PF00400	0.692
TRG_ER_diArg_1	234	236	PF00400	0.586
TRG_ER_diArg_1	335	337	PF00400	0.362
TRG_NES_CRM1_1	425	438	PF08389	0.464
TRG_NLS_Bipartite_1	168	183	PF00514	0.752
TRG_NLS_MonoExtC_3	177	182	PF00514	0.727
TRG_NLS_MonoExtN_4	175	182	PF00514	0.700
TRG_Pf-PMV_PEXEL_1	165	170	PF00026	0.627
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I181	Leptomonas seymouri	59%	100%
A0A0S4JLR1	Bodo saltans	31%	100%
A0A1X0P185	Trypanosomatidae	38%	100%
A0A3R7KHL3	Trypanosoma rangeli	37%	100%
A4HIT7	Leishmania braziliensis	78%	100%
V5BSC2	Trypanosoma cruzi	38%	100%