LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
NOL1/NOP2/sun family/FtsJ-like methyltransferase - putative
Species:
Leishmania infantum
UniProt:
E9AHJ5_LEIIN
TriTrypDb:
LINF_290033200
Length:
634

Annotations

Annotations by Jardim et al.

Ribosomal Protein, NOL1/NOP2/sun family, putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

E9AHJ5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHJ5

Function

Biological processes
Term Name Level Count
GO:0001510 RNA methylation 4 12
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009451 RNA modification 5 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0032259 methylation 2 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0043414 macromolecule methylation 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044260 obsolete cellular macromolecule metabolic process 3 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0008168 methyltransferase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016741 transferase activity, transferring one-carbon groups 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 212 216 PF00656 0.475
CLV_C14_Caspase3-7 415 419 PF00656 0.620
CLV_C14_Caspase3-7 73 77 PF00656 0.453
CLV_NRD_NRD_1 111 113 PF00675 0.549
CLV_NRD_NRD_1 243 245 PF00675 0.215
CLV_NRD_NRD_1 382 384 PF00675 0.275
CLV_NRD_NRD_1 6 8 PF00675 0.594
CLV_PCSK_FUR_1 380 384 PF00082 0.320
CLV_PCSK_KEX2_1 111 113 PF00082 0.429
CLV_PCSK_KEX2_1 12 14 PF00082 0.600
CLV_PCSK_KEX2_1 120 122 PF00082 0.363
CLV_PCSK_KEX2_1 382 384 PF00082 0.239
CLV_PCSK_KEX2_1 420 422 PF00082 0.399
CLV_PCSK_KEX2_1 90 92 PF00082 0.403
CLV_PCSK_PC1ET2_1 111 113 PF00082 0.429
CLV_PCSK_PC1ET2_1 12 14 PF00082 0.597
CLV_PCSK_PC1ET2_1 120 122 PF00082 0.363
CLV_PCSK_PC1ET2_1 420 422 PF00082 0.399
CLV_PCSK_PC1ET2_1 90 92 PF00082 0.446
CLV_PCSK_PC7_1 107 113 PF00082 0.414
CLV_PCSK_SKI1_1 117 121 PF00082 0.379
CLV_PCSK_SKI1_1 267 271 PF00082 0.197
CLV_PCSK_SKI1_1 335 339 PF00082 0.249
CLV_PCSK_SKI1_1 382 386 PF00082 0.254
CLV_PCSK_SKI1_1 595 599 PF00082 0.460
DEG_APCC_DBOX_1 266 274 PF00400 0.440
DEG_SPOP_SBC_1 558 562 PF00917 0.434
DOC_CYCLIN_RxL_1 434 446 PF00134 0.435
DOC_CYCLIN_yCln2_LP_2 221 224 PF00134 0.482
DOC_MAPK_MEF2A_6 164 173 PF00069 0.464
DOC_MAPK_MEF2A_6 595 602 PF00069 0.407
DOC_MAPK_NFAT4_5 595 603 PF00069 0.468
DOC_PP1_RVXF_1 498 504 PF00149 0.320
DOC_PP1_RVXF_1 97 104 PF00149 0.446
DOC_PP2B_LxvP_1 221 224 PF13499 0.482
DOC_PP2B_LxvP_1 441 444 PF13499 0.317
DOC_PP2B_LxvP_1 598 601 PF13499 0.458
DOC_PP4_MxPP_1 140 143 PF00568 0.320
DOC_USP7_MATH_1 187 191 PF00917 0.517
DOC_USP7_MATH_1 296 300 PF00917 0.431
DOC_USP7_MATH_1 573 577 PF00917 0.454
DOC_USP7_UBL2_3 8 12 PF12436 0.640
DOC_WW_Pin1_4 312 317 PF00397 0.466
DOC_WW_Pin1_4 321 326 PF00397 0.436
DOC_WW_Pin1_4 521 526 PF00397 0.410
DOC_WW_Pin1_4 532 537 PF00397 0.433
LIG_14-3-3_CanoR_1 271 281 PF00244 0.484
LIG_14-3-3_CanoR_1 357 361 PF00244 0.478
LIG_14-3-3_CanoR_1 434 438 PF00244 0.475
LIG_14-3-3_CanoR_1 502 511 PF00244 0.324
LIG_Actin_WH2_2 228 246 PF00022 0.415
LIG_Actin_WH2_2 482 497 PF00022 0.406
LIG_BIR_II_1 1 5 PF00653 0.651
LIG_BRCT_BRCA1_1 486 490 PF00533 0.329
LIG_BRCT_BRCA1_1 61 65 PF00533 0.448
LIG_BRCT_BRCA1_1 83 87 PF00533 0.421
LIG_deltaCOP1_diTrp_1 248 253 PF00928 0.415
LIG_deltaCOP1_diTrp_1 47 51 PF00928 0.355
LIG_FHA_1 163 169 PF00498 0.413
LIG_FHA_1 284 290 PF00498 0.426
LIG_FHA_1 306 312 PF00498 0.450
LIG_FHA_1 313 319 PF00498 0.425
LIG_FHA_1 332 338 PF00498 0.416
LIG_FHA_1 368 374 PF00498 0.468
LIG_FHA_1 379 385 PF00498 0.399
LIG_FHA_1 503 509 PF00498 0.469
LIG_FHA_1 522 528 PF00498 0.428
LIG_FHA_1 544 550 PF00498 0.494
LIG_FHA_1 78 84 PF00498 0.484
LIG_FHA_2 131 137 PF00498 0.320
LIG_FHA_2 210 216 PF00498 0.415
LIG_FHA_2 30 36 PF00498 0.488
LIG_FHA_2 331 337 PF00498 0.447
LIG_Integrin_RGD_1 107 109 PF01839 0.473
LIG_LIR_Gen_1 226 236 PF02991 0.419
LIG_LIR_Gen_1 308 317 PF02991 0.522
LIG_LIR_Gen_1 446 454 PF02991 0.418
LIG_LIR_Gen_1 46 55 PF02991 0.347
LIG_LIR_Gen_1 487 496 PF02991 0.448
LIG_LIR_Nem_3 217 222 PF02991 0.414
LIG_LIR_Nem_3 226 231 PF02991 0.405
LIG_LIR_Nem_3 308 312 PF02991 0.430
LIG_LIR_Nem_3 32 37 PF02991 0.388
LIG_LIR_Nem_3 446 452 PF02991 0.424
LIG_LIR_Nem_3 46 51 PF02991 0.299
LIG_LIR_Nem_3 487 493 PF02991 0.329
LIG_MAD2 153 161 PF02301 0.426
LIG_MYND_1 220 224 PF01753 0.482
LIG_NRBOX 167 173 PF00104 0.476
LIG_PTB_Apo_2 28 35 PF02174 0.375
LIG_SH2_GRB2like 496 499 PF00017 0.374
LIG_SH2_SRC 344 347 PF00017 0.493
LIG_SH2_SRC 362 365 PF00017 0.522
LIG_SH2_STAT5 131 134 PF00017 0.348
LIG_SH2_STAT5 465 468 PF00017 0.316
LIG_SH2_STAT5 570 573 PF00017 0.319
LIG_SH3_1 90 96 PF00018 0.387
LIG_SH3_2 513 518 PF14604 0.238
LIG_SH3_3 217 223 PF00018 0.414
LIG_SH3_3 422 428 PF00018 0.467
LIG_SH3_3 510 516 PF00018 0.337
LIG_SH3_3 562 568 PF00018 0.490
LIG_SH3_3 90 96 PF00018 0.401
LIG_SUMO_SIM_anti_2 190 196 PF11976 0.428
LIG_SUMO_SIM_par_1 519 524 PF11976 0.384
LIG_TRAF2_1 133 136 PF00917 0.342
LIG_TRAF2_1 605 608 PF00917 0.632
LIG_TRAF2_1 613 616 PF00917 0.666
LIG_TRFH_1 219 223 PF08558 0.415
LIG_UBA3_1 269 277 PF00899 0.455
MOD_CK1_1 11 17 PF00069 0.685
MOD_CK1_1 163 169 PF00069 0.415
MOD_CK1_1 275 281 PF00069 0.520
MOD_CK1_1 285 291 PF00069 0.415
MOD_CK1_1 543 549 PF00069 0.536
MOD_CK2_1 130 136 PF00069 0.333
MOD_CK2_1 29 35 PF00069 0.457
MOD_CK2_1 43 49 PF00069 0.315
MOD_CK2_1 602 608 PF00069 0.575
MOD_CMANNOS 250 253 PF00535 0.215
MOD_GlcNHglycan 123 126 PF01048 0.399
MOD_GlcNHglycan 237 240 PF01048 0.215
MOD_GlcNHglycan 277 280 PF01048 0.320
MOD_GlcNHglycan 298 301 PF01048 0.307
MOD_GlcNHglycan 414 417 PF01048 0.550
MOD_GlcNHglycan 429 432 PF01048 0.401
MOD_GlcNHglycan 541 545 PF01048 0.485
MOD_GlcNHglycan 624 627 PF01048 0.551
MOD_GSK3_1 130 137 PF00069 0.348
MOD_GSK3_1 235 242 PF00069 0.415
MOD_GSK3_1 321 328 PF00069 0.448
MOD_GSK3_1 331 338 PF00069 0.415
MOD_GSK3_1 352 359 PF00069 0.466
MOD_GSK3_1 466 473 PF00069 0.432
MOD_GSK3_1 519 526 PF00069 0.404
MOD_GSK3_1 553 560 PF00069 0.428
MOD_GSK3_1 77 84 PF00069 0.441
MOD_N-GLC_1 115 120 PF02516 0.490
MOD_N-GLC_1 3 8 PF02516 0.520
MOD_N-GLC_1 622 627 PF02516 0.648
MOD_NEK2_1 103 108 PF00069 0.415
MOD_NEK2_1 209 214 PF00069 0.435
MOD_NEK2_1 261 266 PF00069 0.426
MOD_NEK2_1 29 34 PF00069 0.422
MOD_NEK2_1 302 307 PF00069 0.439
MOD_NEK2_1 433 438 PF00069 0.429
MOD_NEK2_1 519 524 PF00069 0.369
MOD_NEK2_1 557 562 PF00069 0.359
MOD_NEK2_2 115 120 PF00069 0.412
MOD_NEK2_2 239 244 PF00069 0.415
MOD_NEK2_2 272 277 PF00069 0.501
MOD_PIKK_1 163 169 PF00454 0.415
MOD_PIKK_1 261 267 PF00454 0.426
MOD_PIKK_1 385 391 PF00454 0.464
MOD_PIKK_1 472 478 PF00454 0.419
MOD_PIKK_1 77 83 PF00454 0.485
MOD_PKA_2 243 249 PF00069 0.415
MOD_PKA_2 356 362 PF00069 0.471
MOD_PKA_2 433 439 PF00069 0.449
MOD_PKB_1 410 418 PF00069 0.589
MOD_Plk_1 115 121 PF00069 0.489
MOD_Plk_1 214 220 PF00069 0.439
MOD_Plk_1 573 579 PF00069 0.332
MOD_Plk_1 622 628 PF00069 0.554
MOD_Plk_4 136 142 PF00069 0.302
MOD_Plk_4 362 368 PF00069 0.413
MOD_Plk_4 489 495 PF00069 0.380
MOD_Plk_4 523 529 PF00069 0.363
MOD_Plk_4 553 559 PF00069 0.372
MOD_Plk_4 574 580 PF00069 0.424
MOD_ProDKin_1 312 318 PF00069 0.466
MOD_ProDKin_1 321 327 PF00069 0.436
MOD_ProDKin_1 521 527 PF00069 0.406
MOD_ProDKin_1 532 538 PF00069 0.431
MOD_SUMO_rev_2 345 350 PF00179 0.502
MOD_SUMO_rev_2 414 422 PF00179 0.609
MOD_SUMO_rev_2 457 464 PF00179 0.285
MOD_SUMO_rev_2 84 92 PF00179 0.464
TRG_DiLeu_BaEn_2 46 52 PF01217 0.392
TRG_DiLeu_BaLyEn_6 140 145 PF01217 0.427
TRG_DiLeu_BaLyEn_6 217 222 PF01217 0.426
TRG_DiLeu_BaLyEn_6 313 318 PF01217 0.436
TRG_ENDOCYTIC_2 539 542 PF00928 0.470
TRG_ER_diArg_1 380 383 PF00400 0.461
TRG_NLS_MonoCore_2 110 115 PF00514 0.568
TRG_NLS_MonoExtC_3 11 17 PF00514 0.639
TRG_NLS_MonoExtN_4 111 116 PF00514 0.565
TRG_Pf-PMV_PEXEL_1 230 234 PF00026 0.215

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6Y2 Leptomonas seymouri 72% 99%
A0A0S4IKI3 Bodo saltans 50% 94%
A0A1X0P924 Trypanosomatidae 54% 92%
A0A3Q8IJ07 Leishmania donovani 99% 100%
A0A3Q8INR5 Leishmania donovani 32% 83%
A0A3S5IQZ3 Trypanosoma rangeli 57% 100%
A4HIZ4 Leishmania braziliensis 27% 100%
A4IDJ1 Leishmania infantum 32% 83%
A8GDM6 Serratia proteamaculans (strain 568) 28% 100%
C9ZKZ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 97%
D0A386 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 86%
E9AEB6 Leishmania major 95% 100%
E9AIT8 Leishmania braziliensis 85% 100%
E9ALH0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9ASZ4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 83%
O13935 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 30% 93%
P38205 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 34% 93%
Q08J23 Homo sapiens 35% 83%
Q1HFZ0 Mus musculus 38% 84%
Q4Q1K4 Leishmania major 32% 83%
Q4Q6P5 Leishmania major 27% 100%
Q4V7N2 Xenopus laevis 36% 91%
Q9HGQ2 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 92%
Q9W4M9 Drosophila melanogaster 35% 85%
V5BSK4 Trypanosoma cruzi 54% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS