LeishMANIAdb
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Putative paraflagellar rod protein 1D

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative paraflagellar rod protein 1D
Gene product:
paraflagellar rod protein 1D - putative
Species:
Leishmania infantum
UniProt:
E9AHJ2_LEIIN
TriTrypDb:
LINF_290025000
Length:
591

Annotations

Annotations by Jardim et al.

Flagella, paraflagellar rod 1D

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 8
Forrest at al. (procyclic) yes yes: 8
Silverman et al. no yes: 2
Pissara et al. yes yes: 28
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 8
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 24
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 46
NetGPI no yes: 0, no: 46
Cellular components
Term Name Level Count
GO:0005929 cilium 4 47
GO:0031514 motile cilium 5 47
GO:0042995 cell projection 2 47
GO:0043226 organelle 2 47
GO:0043227 membrane-bounded organelle 3 47
GO:0110165 cellular anatomical entity 1 47
GO:0120025 plasma membrane bounded cell projection 3 47
GO:0005737 cytoplasm 2 3
GO:0031974 membrane-enclosed lumen 2 3
GO:0031981 nuclear lumen 5 3
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 3
GO:0043233 organelle lumen 3 3
GO:0070013 intracellular organelle lumen 4 3
GO:0097014 ciliary plasm 5 3
GO:0099568 cytoplasmic region 3 3
GO:0005930 axoneme 2 1

Expansion

Sequence features

E9AHJ2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHJ2

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 47
GO:0005515 protein binding 2 47
GO:0005516 calmodulin binding 3 47

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 149 153 PF00656 0.507
CLV_C14_Caspase3-7 512 516 PF00656 0.415
CLV_NRD_NRD_1 13 15 PF00675 0.578
CLV_NRD_NRD_1 147 149 PF00675 0.496
CLV_NRD_NRD_1 270 272 PF00675 0.410
CLV_NRD_NRD_1 346 348 PF00675 0.417
CLV_NRD_NRD_1 357 359 PF00675 0.395
CLV_NRD_NRD_1 535 537 PF00675 0.401
CLV_PCSK_KEX2_1 147 149 PF00082 0.496
CLV_PCSK_KEX2_1 269 271 PF00082 0.379
CLV_PCSK_KEX2_1 299 301 PF00082 0.409
CLV_PCSK_KEX2_1 345 347 PF00082 0.410
CLV_PCSK_KEX2_1 356 358 PF00082 0.419
CLV_PCSK_KEX2_1 445 447 PF00082 0.415
CLV_PCSK_KEX2_1 535 537 PF00082 0.414
CLV_PCSK_KEX2_1 562 564 PF00082 0.596
CLV_PCSK_PC1ET2_1 269 271 PF00082 0.384
CLV_PCSK_PC1ET2_1 299 301 PF00082 0.415
CLV_PCSK_PC1ET2_1 345 347 PF00082 0.412
CLV_PCSK_PC1ET2_1 356 358 PF00082 0.419
CLV_PCSK_PC1ET2_1 445 447 PF00082 0.414
CLV_PCSK_PC1ET2_1 562 564 PF00082 0.593
CLV_PCSK_PC7_1 353 359 PF00082 0.435
CLV_PCSK_PC7_1 558 564 PF00082 0.593
CLV_PCSK_SKI1_1 110 114 PF00082 0.502
CLV_PCSK_SKI1_1 162 166 PF00082 0.503
CLV_PCSK_SKI1_1 266 270 PF00082 0.400
CLV_PCSK_SKI1_1 310 314 PF00082 0.516
CLV_PCSK_SKI1_1 372 376 PF00082 0.423
DEG_APCC_KENBOX_2 312 316 PF00400 0.538
DOC_CYCLIN_RxL_1 369 378 PF00134 0.420
DOC_CYCLIN_RxL_1 425 438 PF00134 0.393
DOC_MAPK_gen_1 120 128 PF00069 0.532
DOC_MAPK_gen_1 14 23 PF00069 0.565
DOC_MAPK_gen_1 372 379 PF00069 0.416
DOC_MAPK_gen_1 452 461 PF00069 0.410
DOC_MAPK_MEF2A_6 372 379 PF00069 0.420
DOC_MAPK_MEF2A_6 455 463 PF00069 0.420
DOC_MAPK_NFAT4_5 372 380 PF00069 0.420
DOC_PP1_RVXF_1 122 129 PF00149 0.500
DOC_PP4_FxxP_1 521 524 PF00568 0.410
DOC_USP7_MATH_1 179 183 PF00917 0.525
LIG_14-3-3_CanoR_1 124 129 PF00244 0.517
LIG_Actin_WH2_2 132 149 PF00022 0.507
LIG_APCC_ABBA_1 419 424 PF00400 0.420
LIG_APCC_ABBAyCdc20_2 418 424 PF00400 0.420
LIG_BIR_III_4 515 519 PF00653 0.415
LIG_BIR_III_4 6 10 PF00653 0.726
LIG_CtBP_PxDLS_1 86 92 PF00389 0.558
LIG_DLG_GKlike_1 124 131 PF00625 0.647
LIG_eIF4E_1 76 82 PF01652 0.515
LIG_FHA_1 121 127 PF00498 0.546
LIG_FHA_1 159 165 PF00498 0.497
LIG_FHA_1 195 201 PF00498 0.524
LIG_FHA_1 23 29 PF00498 0.520
LIG_FHA_1 387 393 PF00498 0.405
LIG_FHA_2 408 414 PF00498 0.400
LIG_FHA_2 545 551 PF00498 0.602
LIG_FHA_2 6 12 PF00498 0.630
LIG_IRF3_LxIS_1 33 40 PF10401 0.672
LIG_LIR_Apic_2 520 524 PF02991 0.403
LIG_LIR_Gen_1 127 136 PF02991 0.500
LIG_LIR_Gen_1 215 223 PF02991 0.484
LIG_LIR_Gen_1 320 329 PF02991 0.389
LIG_LIR_Gen_1 338 348 PF02991 0.419
LIG_LIR_Gen_1 68 78 PF02991 0.665
LIG_LIR_Nem_3 127 131 PF02991 0.619
LIG_LIR_Nem_3 215 221 PF02991 0.483
LIG_LIR_Nem_3 233 238 PF02991 0.457
LIG_LIR_Nem_3 320 326 PF02991 0.404
LIG_LIR_Nem_3 338 344 PF02991 0.421
LIG_LIR_Nem_3 427 432 PF02991 0.399
LIG_NRBOX 226 232 PF00104 0.597
LIG_PCNA_yPIPBox_3 220 231 PF02747 0.462
LIG_PTB_Apo_2 358 365 PF02174 0.538
LIG_SH2_STAP1 587 591 PF00017 0.588
LIG_SH2_STAT3 252 255 PF00017 0.574
LIG_SH2_STAT5 428 431 PF00017 0.393
LIG_SH2_STAT5 433 436 PF00017 0.381
LIG_SUMO_SIM_par_1 373 378 PF11976 0.420
LIG_TRAF2_1 258 261 PF00917 0.542
LIG_TRAF2_1 547 550 PF00917 0.584
LIG_UBA3_1 227 234 PF00899 0.474
LIG_WRC_WIRS_1 125 130 PF05994 0.521
LIG_WRC_WIRS_1 465 470 PF05994 0.395
MOD_CK1_1 40 46 PF00069 0.595
MOD_CK1_1 544 550 PF00069 0.593
MOD_CK2_1 5 11 PF00069 0.665
MOD_CK2_1 544 550 PF00069 0.537
MOD_CK2_1 566 572 PF00069 0.720
MOD_CK2_1 87 93 PF00069 0.546
MOD_GlcNHglycan 568 571 PF01048 0.654
MOD_GlcNHglycan 572 575 PF01048 0.667
MOD_GlcNHglycan 579 582 PF01048 0.673
MOD_GSK3_1 120 127 PF00069 0.546
MOD_GSK3_1 566 573 PF00069 0.697
MOD_N-GLC_1 120 125 PF02516 0.553
MOD_N-GLC_1 171 176 PF02516 0.525
MOD_NEK2_1 146 151 PF00069 0.515
MOD_NEK2_1 171 176 PF00069 0.525
MOD_NEK2_1 375 380 PF00069 0.409
MOD_NEK2_1 386 391 PF00069 0.492
MOD_NEK2_1 432 437 PF00069 0.401
MOD_NEK2_1 566 571 PF00069 0.652
MOD_NEK2_1 87 92 PF00069 0.543
MOD_NEK2_2 160 165 PF00069 0.530
MOD_PIKK_1 126 132 PF00454 0.516
MOD_PIKK_1 146 152 PF00454 0.536
MOD_PIKK_1 171 177 PF00454 0.558
MOD_PIKK_1 186 192 PF00454 0.585
MOD_PIKK_1 260 266 PF00454 0.424
MOD_PIKK_1 42 48 PF00454 0.605
MOD_PIKK_1 87 93 PF00454 0.536
MOD_PKA_2 146 152 PF00069 0.525
MOD_PKA_2 386 392 PF00069 0.443
MOD_PKA_2 534 540 PF00069 0.404
MOD_PKB_1 273 281 PF00069 0.532
MOD_Plk_1 120 126 PF00069 0.532
MOD_Plk_1 132 138 PF00069 0.435
MOD_Plk_1 151 157 PF00069 0.343
MOD_Plk_1 171 177 PF00069 0.568
MOD_Plk_1 260 266 PF00069 0.367
MOD_Plk_1 375 381 PF00069 0.451
MOD_Plk_4 375 381 PF00069 0.418
MOD_Plk_4 435 441 PF00069 0.415
MOD_SUMO_for_1 137 140 PF00179 0.533
MOD_SUMO_for_1 478 481 PF00179 0.424
MOD_SUMO_rev_2 277 283 PF00179 0.388
MOD_SUMO_rev_2 505 510 PF00179 0.401
MOD_SUMO_rev_2 537 544 PF00179 0.439
MOD_SUMO_rev_2 557 564 PF00179 0.627
MOD_SUMO_rev_2 93 101 PF00179 0.558
TRG_DiLeu_BaEn_1 29 34 PF01217 0.535
TRG_DiLeu_BaEn_2 359 365 PF01217 0.420
TRG_DiLeu_BaEn_3 490 496 PF01217 0.421
TRG_DiLeu_BaEn_4 491 497 PF01217 0.407
TRG_DiLeu_BaLyEn_6 223 228 PF01217 0.486
TRG_DiLeu_BaLyEn_6 562 567 PF01217 0.623
TRG_ENDOCYTIC_2 428 431 PF00928 0.404
TRG_ENDOCYTIC_2 433 436 PF00928 0.398
TRG_ER_diArg_1 146 148 PF00400 0.494
TRG_ER_diArg_1 270 273 PF00400 0.408
TRG_ER_diArg_1 346 348 PF00400 0.408
TRG_ER_diArg_1 357 359 PF00400 0.414
TRG_ER_diArg_1 483 486 PF00400 0.473
TRG_ER_diArg_1 563 566 PF00400 0.581
TRG_NLS_MonoExtC_3 268 273 PF00514 0.420
TRG_NLS_MonoExtN_4 266 273 PF00514 0.420
TRG_Pf-PMV_PEXEL_1 270 274 PF00026 0.384
TRG_Pf-PMV_PEXEL_1 310 314 PF00026 0.402
TRG_Pf-PMV_PEXEL_1 346 350 PF00026 0.402
TRG_Pf-PMV_PEXEL_1 372 376 PF00026 0.420
TRG_Pf-PMV_PEXEL_1 445 449 PF00026 0.411

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2I5 Leptomonas seymouri 96% 100%
A0A0N0P5J5 Leptomonas seymouri 23% 74%
A0A0N1IFZ5 Leptomonas seymouri 66% 99%
A0A0S4IW44 Bodo saltans 29% 89%
A0A0S4IZY8 Bodo saltans 67% 100%
A0A0S4J013 Bodo saltans 29% 90%
A0A0S4J193 Bodo saltans 26% 96%
A0A0S4J561 Bodo saltans 28% 84%
A0A0S4JS20 Bodo saltans 87% 100%
A0A1X0NR57 Trypanosomatidae 23% 75%
A0A1X0NYU4 Trypanosomatidae 65% 98%
A0A1X0P0B7 Trypanosomatidae 88% 100%
A0A381MH18 Leishmania infantum 67% 100%
A0A381MN58 Leishmania infantum 100% 100%
A0A3Q8IAP5 Leishmania donovani 67% 99%
A0A3Q8IEH2 Leishmania donovani 100% 99%
A0A3R7KDB9 Trypanosoma rangeli 65% 98%
A0A3S5IRI8 Trypanosoma rangeli 87% 100%
A0A3S7WQV4 Leishmania donovani 21% 98%
A0A3S7X0V5 Leishmania donovani 24% 76%
A0A3S7X2K1 Leishmania donovani 100% 100%
A0A422NJR9 Trypanosoma rangeli 22% 80%
A4H8S1 Leishmania braziliensis 66% 100%
A4HFV9 Leishmania braziliensis 24% 100%
A4HIY0 Leishmania braziliensis 97% 100%
A4HU55 Leishmania infantum 23% 100%
A4HX40 Leishmania infantum 65% 100%
A4I2Z1 Leishmania infantum 24% 76%
C9ZJD8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 78%
C9ZLC1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 86% 100%
C9ZLC2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 86% 100%
C9ZU76 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 86%
C9ZVV0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 98%
E9ADG3 Leishmania major 25% 76%
E9AE36 Leishmania major 99% 100%
E9AE37 Leishmania major 99% 100%
E9ALP7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
E9ALP8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
E9AMY4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9AQV6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 65% 100%
E9AZ87 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 76%
P22225 Trypanosoma brucei brucei 66% 98%
Q26789 Trypanosoma brucei brucei 85% 99%
Q4QEM2 Leishmania major 66% 100%
Q4QHP3 Leishmania major 23% 100%
V5BDW8 Trypanosoma cruzi 87% 100%
V5BIN9 Trypanosoma cruzi 23% 80%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS