Nodulin-like domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nodulin-like/Major Facilitator Superfamily - putative

Species:

Leishmania infantum

UniProt:

E9AHJ0_LEIIN

TriTrypDb:

LINF_290021500

Length:

648

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Annotations by Jardim et al.

Transporters, MFS transporter (oxalate:formate antiporter)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 110
NetGPI	no	yes: 0, no: 110

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	104
GO:0110165	cellular anatomical entity	1	104
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

E9AHJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHJ0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	52
GO:0022857	transmembrane transporter activity	2	52

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.566
CLV_NRD_NRD_1	216	218	PF00675	0.257
CLV_NRD_NRD_1	617	619	PF00675	0.345
CLV_PCSK_FUR_1	615	619	PF00082	0.432
CLV_PCSK_KEX2_1	215	217	PF00082	0.251
CLV_PCSK_KEX2_1	316	318	PF00082	0.578
CLV_PCSK_KEX2_1	399	401	PF00082	0.355
CLV_PCSK_KEX2_1	617	619	PF00082	0.341
CLV_PCSK_KEX2_1	634	636	PF00082	0.353
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.398
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.417
CLV_PCSK_PC1ET2_1	634	636	PF00082	0.415
CLV_PCSK_SKI1_1	149	153	PF00082	0.368
CLV_PCSK_SKI1_1	216	220	PF00082	0.321
CLV_PCSK_SKI1_1	316	320	PF00082	0.412
CLV_PCSK_SKI1_1	528	532	PF00082	0.273
CLV_PCSK_SKI1_1	564	568	PF00082	0.568
CLV_PCSK_SKI1_1	618	622	PF00082	0.351
DOC_CYCLIN_RxL_1	525	534	PF00134	0.377
DOC_MAPK_DCC_7	105	113	PF00069	0.181
DOC_MAPK_gen_1	205	214	PF00069	0.464
DOC_MAPK_gen_1	399	405	PF00069	0.464
DOC_MAPK_MEF2A_6	105	113	PF00069	0.312
DOC_MAPK_MEF2A_6	264	273	PF00069	0.293
DOC_PP2B_LxvP_1	496	499	PF13499	0.398
DOC_PP2B_PxIxI_1	474	480	PF00149	0.388
DOC_SPAK_OSR1_1	14	18	PF12202	0.518
DOC_USP7_MATH_1	257	261	PF00917	0.309
DOC_USP7_MATH_1	421	425	PF00917	0.514
DOC_USP7_MATH_1	482	486	PF00917	0.373
DOC_USP7_MATH_1	499	503	PF00917	0.360
DOC_USP7_UBL2_3	293	297	PF12436	0.702
DOC_USP7_UBL2_3	347	351	PF12436	0.599
DOC_USP7_UBL2_3	435	439	PF12436	0.272
DOC_USP7_UBL2_3	533	537	PF12436	0.482
DOC_WW_Pin1_4	576	581	PF00397	0.445
LIG_14-3-3_CanoR_1	168	176	PF00244	0.361
LIG_14-3-3_CanoR_1	215	224	PF00244	0.491
LIG_14-3-3_CanoR_1	264	270	PF00244	0.343
LIG_14-3-3_CanoR_1	380	390	PF00244	0.652
LIG_14-3-3_CanoR_1	456	460	PF00244	0.282
LIG_14-3-3_CanoR_1	635	640	PF00244	0.652
LIG_14-3-3_CanoR_1	8	16	PF00244	0.536
LIG_AP2alpha_1	510	514	PF02296	0.198
LIG_deltaCOP1_diTrp_1	402	408	PF00928	0.365
LIG_EH1_1	175	183	PF00400	0.440
LIG_FHA_1	108	114	PF00498	0.317
LIG_FHA_1	125	131	PF00498	0.314
LIG_FHA_1	185	191	PF00498	0.377
LIG_FHA_1	266	272	PF00498	0.393
LIG_FHA_1	471	477	PF00498	0.571
LIG_FHA_1	55	61	PF00498	0.334
LIG_FHA_1	602	608	PF00498	0.393
LIG_FHA_2	320	326	PF00498	0.745
LIG_FHA_2	46	52	PF00498	0.265
LIG_GBD_Chelix_1	272	280	PF00786	0.356
LIG_LIR_Gen_1	13	22	PF02991	0.482
LIG_LIR_Gen_1	171	182	PF02991	0.295
LIG_LIR_Gen_1	245	254	PF02991	0.349
LIG_LIR_Gen_1	392	403	PF02991	0.506
LIG_LIR_Gen_1	442	451	PF02991	0.316
LIG_LIR_Gen_1	609	619	PF02991	0.347
LIG_LIR_Nem_3	13	18	PF02991	0.505
LIG_LIR_Nem_3	150	154	PF02991	0.344
LIG_LIR_Nem_3	171	177	PF02991	0.263
LIG_LIR_Nem_3	231	237	PF02991	0.507
LIG_LIR_Nem_3	245	249	PF02991	0.307
LIG_LIR_Nem_3	29	34	PF02991	0.338
LIG_LIR_Nem_3	392	398	PF02991	0.515
LIG_LIR_Nem_3	442	447	PF02991	0.342
LIG_LIR_Nem_3	609	614	PF02991	0.322
LIG_LIR_Nem_3	66	72	PF02991	0.314
LIG_LYPXL_yS_3	227	230	PF13949	0.388
LIG_NRBOX	491	497	PF00104	0.395
LIG_NRBOX	90	96	PF00104	0.295
LIG_Pex14_2	233	237	PF04695	0.328
LIG_Pex14_2	510	514	PF04695	0.349
LIG_PTB_Apo_2	160	167	PF02174	0.310
LIG_PTB_Apo_2	430	437	PF02174	0.336
LIG_PTB_Phospho_1	430	436	PF10480	0.388
LIG_REV1ctd_RIR_1	164	173	PF16727	0.281
LIG_SH2_CRK	256	260	PF00017	0.330
LIG_SH2_CRK	428	432	PF00017	0.298
LIG_SH2_CRK	444	448	PF00017	0.359
LIG_SH2_GRB2like	256	259	PF00017	0.351
LIG_SH2_NCK_1	256	260	PF00017	0.329
LIG_SH2_NCK_1	96	100	PF00017	0.447
LIG_SH2_SRC	256	259	PF00017	0.360
LIG_SH2_STAP1	444	448	PF00017	0.373
LIG_SH2_STAP1	562	566	PF00017	0.305
LIG_SH2_STAP1	96	100	PF00017	0.392
LIG_SH2_STAT3	223	226	PF00017	0.446
LIG_SH2_STAT3	562	565	PF00017	0.359
LIG_SH2_STAT5	223	226	PF00017	0.459
LIG_SH2_STAT5	234	237	PF00017	0.320
LIG_SH2_STAT5	246	249	PF00017	0.310
LIG_SH2_STAT5	337	340	PF00017	0.554
LIG_SH2_STAT5	543	546	PF00017	0.375
LIG_SH3_1	297	303	PF00018	0.631
LIG_SH3_3	297	303	PF00018	0.626
LIG_SH3_3	315	321	PF00018	0.750
LIG_SH3_3	577	583	PF00018	0.364
LIG_SUMO_SIM_anti_2	157	163	PF11976	0.434
LIG_SUMO_SIM_anti_2	187	192	PF11976	0.375
LIG_SUMO_SIM_anti_2	268	274	PF11976	0.317
LIG_SUMO_SIM_par_1	239	245	PF11976	0.289
LIG_SUMO_SIM_par_1	445	452	PF11976	0.325
LIG_TRAF2_1	322	325	PF00917	0.774
LIG_TYR_ITIM	244	249	PF00017	0.352
LIG_TYR_ITSM	440	447	PF00017	0.352
LIG_UBA3_1	495	503	PF00899	0.379
LIG_WRC_WIRS_1	148	153	PF05994	0.377
LIG_WRC_WIRS_1	249	254	PF05994	0.376
LIG_WRC_WIRS_1	28	33	PF05994	0.443
LIG_WRC_WIRS_1	307	312	PF05994	0.462
LIG_WRC_WIRS_1	511	516	PF05994	0.389
MOD_CK1_1	10	16	PF00069	0.453
MOD_CK1_1	124	130	PF00069	0.346
MOD_CK1_1	353	359	PF00069	0.647
MOD_CK1_1	449	455	PF00069	0.346
MOD_CK2_1	319	325	PF00069	0.720
MOD_CK2_1	352	358	PF00069	0.702
MOD_CMANNOS	404	407	PF00535	0.356
MOD_Cter_Amidation	348	351	PF01082	0.513
MOD_Cter_Amidation	586	589	PF01082	0.465
MOD_GlcNHglycan	261	264	PF01048	0.375
MOD_GlcNHglycan	423	426	PF01048	0.386
MOD_GlcNHglycan	444	447	PF01048	0.323
MOD_GlcNHglycan	451	454	PF01048	0.313
MOD_GSK3_1	120	127	PF00069	0.342
MOD_GSK3_1	133	140	PF00069	0.318
MOD_GSK3_1	22	29	PF00069	0.341
MOD_GSK3_1	349	356	PF00069	0.610
MOD_GSK3_1	390	397	PF00069	0.438
MOD_GSK3_1	442	449	PF00069	0.365
MOD_GSK3_1	50	57	PF00069	0.318
MOD_GSK3_1	516	523	PF00069	0.349
MOD_N-GLC_1	162	167	PF02516	0.343
MOD_N-GLC_1	45	50	PF02516	0.373
MOD_N-GLC_1	601	606	PF02516	0.286
MOD_NEK2_1	120	125	PF00069	0.333
MOD_NEK2_1	154	159	PF00069	0.378
MOD_NEK2_1	265	270	PF00069	0.316
MOD_NEK2_1	394	399	PF00069	0.379
MOD_NEK2_1	45	50	PF00069	0.330
MOD_NEK2_1	510	515	PF00069	0.349
MOD_NEK2_2	27	32	PF00069	0.331
MOD_PIKK_1	222	228	PF00454	0.354
MOD_PIKK_1	633	639	PF00454	0.503
MOD_PK_1	635	641	PF00069	0.512
MOD_PKA_1	216	222	PF00069	0.417
MOD_PKA_1	350	356	PF00069	0.469
MOD_PKA_2	167	173	PF00069	0.430
MOD_PKA_2	216	222	PF00069	0.330
MOD_PKA_2	455	461	PF00069	0.317
MOD_PKA_2	7	13	PF00069	0.401
MOD_Plk_1	10	16	PF00069	0.529
MOD_Plk_1	162	168	PF00069	0.377
MOD_Plk_1	203	209	PF00069	0.440
MOD_Plk_1	50	56	PF00069	0.312
MOD_Plk_1	601	607	PF00069	0.303
MOD_Plk_2-3	306	312	PF00069	0.720
MOD_Plk_4	126	132	PF00069	0.322
MOD_Plk_4	154	160	PF00069	0.364
MOD_Plk_4	162	168	PF00069	0.379
MOD_Plk_4	242	248	PF00069	0.319
MOD_Plk_4	265	271	PF00069	0.347
MOD_Plk_4	27	33	PF00069	0.315
MOD_Plk_4	390	396	PF00069	0.407
MOD_Plk_4	439	445	PF00069	0.282
MOD_Plk_4	607	613	PF00069	0.276
MOD_ProDKin_1	576	582	PF00069	0.563
MOD_SUMO_rev_2	309	318	PF00179	0.653
MOD_SUMO_rev_2	374	379	PF00179	0.588
MOD_SUMO_rev_2	432	440	PF00179	0.475
TRG_DiLeu_BaEn_2	10	16	PF01217	0.437
TRG_ENDOCYTIC_2	164	167	PF00928	0.352
TRG_ENDOCYTIC_2	174	177	PF00928	0.277
TRG_ENDOCYTIC_2	198	201	PF00928	0.350
TRG_ENDOCYTIC_2	227	230	PF00928	0.398
TRG_ENDOCYTIC_2	234	237	PF00928	0.361
TRG_ENDOCYTIC_2	246	249	PF00928	0.289
TRG_ENDOCYTIC_2	428	431	PF00928	0.361
TRG_ENDOCYTIC_2	444	447	PF00928	0.312
TRG_ENDOCYTIC_2	539	542	PF00928	0.323
TRG_ENDOCYTIC_2	558	561	PF00928	0.445
TRG_ENDOCYTIC_2	616	619	PF00928	0.392
TRG_ER_diArg_1	214	217	PF00400	0.337
TRG_ER_diArg_1	616	618	PF00400	0.431
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	28%	100%
A0A0N1HZC2	Leptomonas seymouri	30%	100%
A0A0N1IKC5	Leptomonas seymouri	32%	100%
A0A0N1PB63	Leptomonas seymouri	27%	98%
A0A0N1PD04	Leptomonas seymouri	24%	100%
A0A0N1PFR4	Leptomonas seymouri	32%	98%
A0A1X0NKK0	Trypanosomatidae	30%	100%
A0A1X0NM09	Trypanosomatidae	29%	100%
A0A1X0NRW5	Trypanosomatidae	26%	93%
A0A1X0NV13	Trypanosomatidae	32%	100%
A0A1X0NV19	Trypanosomatidae	33%	100%
A0A1X0NV27	Trypanosomatidae	32%	100%
A0A1X0NVF9	Trypanosomatidae	22%	97%
A0A1X0NVH8	Trypanosomatidae	30%	98%
A0A1X0NVM7	Trypanosomatidae	30%	100%
A0A1X0NWQ1	Trypanosomatidae	33%	100%
A0A1X0NZE6	Trypanosomatidae	29%	100%
A0A1X0NZU2	Trypanosomatidae	33%	100%
A0A1X0NZU5	Trypanosomatidae	54%	100%
A0A1X0NZW1	Trypanosomatidae	31%	100%
A0A1X0P0M7	Trypanosomatidae	28%	100%
A0A381MMW5	Leishmania infantum	100%	100%
A0A3Q8IEC4	Leishmania donovani	100%	100%
A0A3Q8IF95	Leishmania donovani	28%	100%
A0A3Q8IIT5	Leishmania donovani	32%	96%
A0A3Q8ISY9	Leishmania donovani	27%	100%
A0A3R7KKN8	Trypanosoma rangeli	31%	100%
A0A3R7MAQ7	Trypanosoma rangeli	27%	92%
A0A3R7N3S6	Trypanosoma rangeli	25%	100%
A0A3R7N415	Trypanosoma rangeli	31%	100%
A0A3R7N921	Trypanosoma rangeli	28%	100%
A0A3R7R443	Trypanosoma rangeli	30%	100%
A0A3S7WRJ4	Leishmania donovani	30%	100%
A0A3S7WRJ5	Leishmania donovani	32%	93%
A0A3S7WRS3	Leishmania donovani	24%	100%
A0A3S7WSR4	Leishmania donovani	32%	100%
A0A3S7WWU1	Leishmania donovani	26%	98%
A0A3S7X2G0	Leishmania donovani	100%	99%
A0A3S7X2K5	Leishmania donovani	97%	100%
A0A3S7XB11	Leishmania donovani	30%	100%
A0A422MSE4	Trypanosoma rangeli	34%	100%
A0A422MSP6	Trypanosoma rangeli	48%	100%
A0A422MST9	Trypanosoma rangeli	30%	100%
A0A422MU68	Trypanosoma rangeli	29%	100%
A4H6J0	Leishmania braziliensis	30%	100%
A4H6J1	Leishmania braziliensis	32%	100%
A4H6Q5	Leishmania braziliensis	26%	100%
A4HC19	Leishmania braziliensis	28%	100%
A4HHG2	Leishmania braziliensis	30%	100%
A4HHG3	Leishmania braziliensis	82%	100%
A4HHG4	Leishmania braziliensis	74%	100%
A4HJW3	Leishmania braziliensis	28%	100%
A4HPE2	Leishmania braziliensis	29%	99%
A4HUX5	Leishmania infantum	31%	100%
A4HUX6	Leishmania infantum	32%	100%
A4HV40	Leishmania infantum	25%	100%
A4HZF5	Leishmania infantum	28%	100%
A4HZJ4	Leishmania infantum	26%	100%
A4I4L2	Leishmania infantum	31%	100%
A4I7C5	Leishmania infantum	28%	100%
A4ICI3	Leishmania infantum	29%	99%
C9ZL97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZL98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZL99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZLA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZLA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZTR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZTR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZTR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZTR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZTR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZTS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZUT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0A7B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A7H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0AAQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	95%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AE01	Leishmania major	95%	100%
E9AE09	Leishmania major	31%	100%
E9AE10	Leishmania major	31%	100%
E9AE11	Leishmania major	88%	100%
E9AGK5	Leishmania infantum	32%	98%
E9AHJ1	Leishmania infantum	97%	100%
E9ALS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9ALS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9ANS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	98%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	96%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	99%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q4Q1E4	Leishmania major	29%	99%
Q4Q5T8	Leishmania major	27%	100%
Q4QC27	Leishmania major	26%	100%
Q4QC28	Leishmania major	27%	96%
Q4QFY5	Leishmania major	32%	99%
Q4QGU8	Leishmania major	26%	100%
Q4QH14	Leishmania major	31%	100%
Q4QH15	Leishmania major	31%	100%
V5B647	Trypanosoma cruzi	31%	100%
V5B983	Trypanosoma cruzi	46%	100%
V5BBB1	Trypanosoma cruzi	31%	100%
V5BFV8	Trypanosoma cruzi	32%	97%
V5BQY6	Trypanosoma cruzi	29%	92%
V5BVP0	Trypanosoma cruzi	30%	100%
V5BWJ7	Trypanosoma cruzi	22%	100%
V5DT25	Trypanosoma cruzi	31%	100%