LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AHI6_LEIIN
TriTrypDb:
LINF_290017000
Length:
625

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

E9AHI6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHI6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 254 258 PF00656 0.574
CLV_C14_Caspase3-7 31 35 PF00656 0.674
CLV_C14_Caspase3-7 314 318 PF00656 0.434
CLV_C14_Caspase3-7 96 100 PF00656 0.566
CLV_NRD_NRD_1 129 131 PF00675 0.516
CLV_NRD_NRD_1 301 303 PF00675 0.461
CLV_NRD_NRD_1 370 372 PF00675 0.400
CLV_NRD_NRD_1 593 595 PF00675 0.596
CLV_PCSK_KEX2_1 129 131 PF00082 0.538
CLV_PCSK_KEX2_1 136 138 PF00082 0.483
CLV_PCSK_KEX2_1 298 300 PF00082 0.488
CLV_PCSK_KEX2_1 370 372 PF00082 0.440
CLV_PCSK_KEX2_1 593 595 PF00082 0.609
CLV_PCSK_KEX2_1 599 601 PF00082 0.606
CLV_PCSK_KEX2_1 82 84 PF00082 0.585
CLV_PCSK_PC1ET2_1 136 138 PF00082 0.570
CLV_PCSK_PC1ET2_1 298 300 PF00082 0.537
CLV_PCSK_PC1ET2_1 599 601 PF00082 0.617
CLV_PCSK_PC1ET2_1 82 84 PF00082 0.585
CLV_PCSK_PC7_1 125 131 PF00082 0.602
CLV_PCSK_SKI1_1 125 129 PF00082 0.565
CLV_PCSK_SKI1_1 130 134 PF00082 0.522
CLV_PCSK_SKI1_1 346 350 PF00082 0.491
CLV_PCSK_SKI1_1 53 57 PF00082 0.639
DEG_Nend_UBRbox_2 1 3 PF02207 0.682
DEG_SPOP_SBC_1 147 151 PF00917 0.672
DOC_CDC14_PxL_1 188 196 PF14671 0.652
DOC_MAPK_DCC_7 406 416 PF00069 0.492
DOC_MAPK_gen_1 240 250 PF00069 0.512
DOC_MAPK_gen_1 283 293 PF00069 0.470
DOC_MAPK_gen_1 370 376 PF00069 0.382
DOC_MAPK_MEF2A_6 240 248 PF00069 0.574
DOC_PP2B_LxvP_1 336 339 PF13499 0.355
DOC_USP7_MATH_1 147 151 PF00917 0.667
DOC_USP7_MATH_1 156 160 PF00917 0.718
DOC_USP7_MATH_1 23 27 PF00917 0.658
DOC_USP7_MATH_1 466 470 PF00917 0.637
DOC_USP7_MATH_1 531 535 PF00917 0.571
DOC_USP7_MATH_1 580 584 PF00917 0.690
DOC_USP7_MATH_1 587 591 PF00917 0.707
DOC_USP7_MATH_1 611 615 PF00917 0.698
LIG_14-3-3_CanoR_1 199 209 PF00244 0.538
LIG_14-3-3_CanoR_1 217 223 PF00244 0.648
LIG_14-3-3_CanoR_1 276 284 PF00244 0.520
LIG_14-3-3_CanoR_1 354 363 PF00244 0.458
LIG_14-3-3_CanoR_1 401 407 PF00244 0.634
LIG_14-3-3_CanoR_1 498 507 PF00244 0.539
LIG_Actin_WH2_2 392 410 PF00022 0.637
LIG_Actin_WH2_2 484 500 PF00022 0.589
LIG_APCC_ABBA_1 570 575 PF00400 0.586
LIG_BIR_III_4 34 38 PF00653 0.685
LIG_BRCT_BRCA1_1 311 315 PF00533 0.446
LIG_CaM_IQ_9 290 305 PF13499 0.402
LIG_eIF4E_1 202 208 PF01652 0.556
LIG_FHA_1 101 107 PF00498 0.619
LIG_FHA_1 233 239 PF00498 0.624
LIG_FHA_1 259 265 PF00498 0.306
LIG_FHA_1 283 289 PF00498 0.385
LIG_FHA_1 331 337 PF00498 0.503
LIG_FHA_1 351 357 PF00498 0.141
LIG_FHA_1 384 390 PF00498 0.540
LIG_FHA_1 561 567 PF00498 0.646
LIG_FHA_1 86 92 PF00498 0.636
LIG_FHA_2 232 238 PF00498 0.638
LIG_FHA_2 312 318 PF00498 0.481
LIG_FHA_2 389 395 PF00498 0.510
LIG_FHA_2 400 406 PF00498 0.655
LIG_Integrin_RGD_1 32 34 PF01839 0.697
LIG_LIR_Apic_2 60 65 PF02991 0.568
LIG_LIR_Gen_1 257 268 PF02991 0.392
LIG_LIR_Gen_1 485 495 PF02991 0.628
LIG_LIR_Gen_1 504 515 PF02991 0.599
LIG_LIR_Gen_1 567 577 PF02991 0.522
LIG_LIR_Gen_1 616 622 PF02991 0.716
LIG_LIR_Nem_3 2 6 PF02991 0.643
LIG_LIR_Nem_3 257 263 PF02991 0.418
LIG_LIR_Nem_3 342 348 PF02991 0.385
LIG_LIR_Nem_3 44 48 PF02991 0.537
LIG_LIR_Nem_3 485 491 PF02991 0.596
LIG_LIR_Nem_3 504 510 PF02991 0.521
LIG_LIR_Nem_3 540 546 PF02991 0.602
LIG_LIR_Nem_3 616 621 PF02991 0.720
LIG_LIR_Nem_3 63 69 PF02991 0.461
LIG_LYPXL_yS_3 66 69 PF13949 0.651
LIG_NRBOX 287 293 PF00104 0.417
LIG_Pex14_1 289 293 PF04695 0.363
LIG_Pex14_1 62 66 PF04695 0.568
LIG_Pex14_2 311 315 PF04695 0.446
LIG_PTB_Apo_2 406 413 PF02174 0.639
LIG_PTB_Phospho_1 406 412 PF10480 0.649
LIG_SH2_CRK 507 511 PF00017 0.640
LIG_SH2_CRK 546 550 PF00017 0.532
LIG_SH2_GRB2like 390 393 PF00017 0.499
LIG_SH2_NCK_1 202 206 PF00017 0.633
LIG_SH2_NCK_1 390 394 PF00017 0.505
LIG_SH2_NCK_1 546 550 PF00017 0.617
LIG_SH2_STAP1 341 345 PF00017 0.445
LIG_SH2_STAP1 352 356 PF00017 0.338
LIG_SH2_STAP1 359 363 PF00017 0.298
LIG_SH2_STAP1 499 503 PF00017 0.499
LIG_SH2_STAT5 202 205 PF00017 0.546
LIG_SH2_STAT5 352 355 PF00017 0.312
LIG_SH2_STAT5 385 388 PF00017 0.517
LIG_SH2_STAT5 390 393 PF00017 0.465
LIG_SH2_STAT5 520 523 PF00017 0.486
LIG_SH2_STAT5 543 546 PF00017 0.592
LIG_SH2_STAT5 569 572 PF00017 0.514
LIG_SH3_3 112 118 PF00018 0.575
LIG_SH3_3 194 200 PF00018 0.659
LIG_SH3_3 415 421 PF00018 0.465
LIG_SH3_3 453 459 PF00018 0.519
LIG_SH3_3 61 67 PF00018 0.536
LIG_SUMO_SIM_par_1 346 351 PF11976 0.463
LIG_SUMO_SIM_par_1 4 11 PF11976 0.683
LIG_TRAF2_1 209 212 PF00917 0.621
LIG_TRAF2_1 234 237 PF00917 0.656
LIG_TRAF2_1 7 10 PF00917 0.687
LIG_TRFH_1 114 118 PF08558 0.560
LIG_TYR_ITIM 111 116 PF00017 0.563
LIG_TYR_ITIM 544 549 PF00017 0.601
LIG_TYR_ITIM 64 69 PF00017 0.630
MOD_CK1_1 11 17 PF00069 0.683
MOD_CK1_1 149 155 PF00069 0.641
MOD_CK1_1 258 264 PF00069 0.321
MOD_CK1_1 277 283 PF00069 0.468
MOD_CK1_1 313 319 PF00069 0.528
MOD_CK2_1 231 237 PF00069 0.644
MOD_CK2_1 388 394 PF00069 0.508
MOD_CK2_1 4 10 PF00069 0.682
MOD_GlcNHglycan 153 156 PF01048 0.691
MOD_GlcNHglycan 25 28 PF01048 0.642
MOD_GlcNHglycan 277 280 PF01048 0.462
MOD_GlcNHglycan 402 405 PF01048 0.683
MOD_GlcNHglycan 421 424 PF01048 0.556
MOD_GlcNHglycan 501 504 PF01048 0.630
MOD_GlcNHglycan 9 13 PF01048 0.690
MOD_GSK3_1 146 153 PF00069 0.591
MOD_GSK3_1 251 258 PF00069 0.530
MOD_GSK3_1 275 282 PF00069 0.390
MOD_GSK3_1 309 316 PF00069 0.382
MOD_GSK3_1 350 357 PF00069 0.417
MOD_GSK3_1 37 44 PF00069 0.607
MOD_GSK3_1 4 11 PF00069 0.686
MOD_GSK3_1 493 500 PF00069 0.522
MOD_GSK3_1 560 567 PF00069 0.661
MOD_N-GLC_1 156 161 PF02516 0.746
MOD_N-GLC_1 558 563 PF02516 0.706
MOD_NEK2_1 105 110 PF00069 0.556
MOD_NEK2_1 274 279 PF00069 0.407
MOD_NEK2_1 293 298 PF00069 0.435
MOD_NEK2_1 311 316 PF00069 0.332
MOD_NEK2_1 399 404 PF00069 0.593
MOD_NEK2_1 407 412 PF00069 0.574
MOD_NEK2_1 493 498 PF00069 0.513
MOD_NEK2_1 84 89 PF00069 0.654
MOD_PIKK_1 11 17 PF00454 0.693
MOD_PIKK_1 218 224 PF00454 0.618
MOD_PIKK_1 251 257 PF00454 0.562
MOD_PIKK_1 37 43 PF00454 0.653
MOD_PKA_2 275 281 PF00069 0.517
MOD_PKA_2 282 288 PF00069 0.451
MOD_PKA_2 330 336 PF00069 0.489
MOD_PKA_2 400 406 PF00069 0.611
MOD_PKA_2 497 503 PF00069 0.578
MOD_Plk_1 258 264 PF00069 0.469
MOD_Plk_1 449 455 PF00069 0.536
MOD_Plk_1 503 509 PF00069 0.526
MOD_Plk_1 85 91 PF00069 0.662
MOD_Plk_4 407 413 PF00069 0.625
MOD_Plk_4 516 522 PF00069 0.505
MOD_SUMO_for_1 598 601 PF00179 0.732
MOD_SUMO_rev_2 394 400 PF00179 0.582
MOD_SUMO_rev_2 79 84 PF00179 0.649
TRG_DiLeu_BaEn_2 440 446 PF01217 0.544
TRG_DiLeu_BaEn_4 441 447 PF01217 0.544
TRG_DiLeu_BaLyEn_6 344 349 PF01217 0.455
TRG_ENDOCYTIC_2 113 116 PF00928 0.560
TRG_ENDOCYTIC_2 202 205 PF00928 0.546
TRG_ENDOCYTIC_2 390 393 PF00928 0.499
TRG_ENDOCYTIC_2 507 510 PF00928 0.640
TRG_ENDOCYTIC_2 546 549 PF00928 0.531
TRG_ENDOCYTIC_2 569 572 PF00928 0.519
TRG_ENDOCYTIC_2 66 69 PF00928 0.571
TRG_ENDOCYTIC_2 81 84 PF00928 0.533
TRG_ER_diArg_1 128 130 PF00400 0.592
TRG_ER_diArg_1 161 164 PF00400 0.718
TRG_ER_diArg_1 593 595 PF00400 0.723
TRG_Pf-PMV_PEXEL_1 199 204 PF00026 0.551
TRG_Pf-PMV_PEXEL_1 262 266 PF00026 0.469
TRG_Pf-PMV_PEXEL_1 346 351 PF00026 0.455
TRG_Pf-PMV_PEXEL_1 379 383 PF00026 0.493

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHI1 Leptomonas seymouri 67% 100%
A0A0S4JMH1 Bodo saltans 29% 100%
A0A1X0P058 Trypanosomatidae 34% 96%
A0A3R7M9T5 Trypanosoma rangeli 33% 98%
A0A3S7X2F4 Leishmania donovani 100% 100%
A4HHC1 Leishmania braziliensis 88% 100%
C9ZLL7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 97%
E9ADW9 Leishmania major 95% 100%
E9ALW2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
V5DI43 Trypanosoma cruzi 34% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS