Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)
Plasma membrane, major surface protease gp63
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 2 |
| Forrest at al. (procyclic) | no | yes: 4 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | yes | yes: 72 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 5 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | yes | yes: 77, no: 31 |
| NetGPI | no | yes: 0, no: 108 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 109 |
| GO:0110165 | cellular anatomical entity | 1 | 109 |
| GO:0005737 | cytoplasm | 2 | 6 |
| GO:0018995 | host cellular component | 2 | 4 |
| GO:0033643 | host cell part | 3 | 4 |
| GO:0033646 | host intracellular part | 4 | 4 |
| GO:0033647 | host intracellular organelle | 5 | 4 |
| GO:0033648 | host intracellular membrane-bounded organelle | 6 | 4 |
| GO:0042025 | host cell nucleus | 7 | 4 |
Related structures:
AlphaFold database: E9AHH5
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006508 | proteolysis | 4 | 109 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 109 |
| GO:0007155 | cell adhesion | 2 | 109 |
| GO:0008152 | metabolic process | 1 | 109 |
| GO:0009987 | cellular process | 1 | 109 |
| GO:0019538 | protein metabolic process | 3 | 109 |
| GO:0043170 | macromolecule metabolic process | 3 | 109 |
| GO:0044238 | primary metabolic process | 2 | 109 |
| GO:0071704 | organic substance metabolic process | 2 | 109 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 109 |
| GO:0009966 | regulation of signal transduction | 4 | 4 |
| GO:0010646 | regulation of cell communication | 4 | 4 |
| GO:0010749 | regulation of nitric oxide mediated signal transduction | 6 | 4 |
| GO:0023051 | regulation of signaling | 3 | 4 |
| GO:0035821 | modulation of process of another organism | 2 | 4 |
| GO:0044003 | modulation by symbiont of host process | 3 | 4 |
| GO:0044068 | modulation by symbiont of host cellular process | 4 | 4 |
| GO:0044081 | modulation by symbiont of host nitric oxide-mediated signal transduction | 5 | 4 |
| GO:0044403 | biological process involved in symbiotic interaction | 2 | 4 |
| GO:0044419 | biological process involved in interspecies interaction between organisms | 1 | 4 |
| GO:0044501 | modulation of signal transduction in another organism | 3 | 4 |
| GO:0048583 | regulation of response to stimulus | 3 | 4 |
| GO:0050789 | regulation of biological process | 2 | 4 |
| GO:0050794 | regulation of cellular process | 3 | 4 |
| GO:0051701 | biological process involved in interaction with host | 3 | 4 |
| GO:0052027 | modulation by symbiont of host signal transduction pathway | 4 | 4 |
| GO:0065007 | biological regulation | 1 | 4 |
| GO:0075130 | modulation by symbiont of host protein kinase-mediated signal transduction | 5 | 4 |
| GO:1902531 | regulation of intracellular signal transduction | 5 | 4 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 109 |
| GO:0004175 | endopeptidase activity | 4 | 109 |
| GO:0004222 | metalloendopeptidase activity | 5 | 109 |
| GO:0005488 | binding | 1 | 109 |
| GO:0008233 | peptidase activity | 3 | 109 |
| GO:0008237 | metallopeptidase activity | 4 | 109 |
| GO:0016787 | hydrolase activity | 2 | 109 |
| GO:0043167 | ion binding | 2 | 109 |
| GO:0043169 | cation binding | 3 | 109 |
| GO:0046872 | metal ion binding | 4 | 109 |
| GO:0140096 | catalytic activity, acting on a protein | 2 | 109 |
| GO:0008047 | enzyme activator activity | 3 | 4 |
| GO:0008160 | protein tyrosine phosphatase activator activity | 6 | 4 |
| GO:0019208 | phosphatase regulator activity | 3 | 4 |
| GO:0019211 | phosphatase activator activity | 4 | 4 |
| GO:0019888 | protein phosphatase regulator activity | 4 | 4 |
| GO:0030234 | enzyme regulator activity | 2 | 4 |
| GO:0072542 | protein phosphatase activator activity | 5 | 4 |
| GO:0098772 | molecular function regulator activity | 1 | 4 |
| GO:0140677 | molecular function activator activity | 2 | 4 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 29 | 33 | PF00656 | 0.461 |
| CLV_C14_Caspase3-7 | 374 | 378 | PF00656 | 0.317 |
| CLV_MEL_PAP_1 | 48 | 54 | PF00089 | 0.393 |
| CLV_NRD_NRD_1 | 2 | 4 | PF00675 | 0.650 |
| CLV_NRD_NRD_1 | 304 | 306 | PF00675 | 0.428 |
| CLV_NRD_NRD_1 | 386 | 388 | PF00675 | 0.477 |
| CLV_PCSK_KEX2_1 | 122 | 124 | PF00082 | 0.553 |
| CLV_PCSK_KEX2_1 | 2 | 4 | PF00082 | 0.649 |
| CLV_PCSK_KEX2_1 | 303 | 305 | PF00082 | 0.422 |
| CLV_PCSK_KEX2_1 | 386 | 388 | PF00082 | 0.476 |
| CLV_PCSK_PC1ET2_1 | 122 | 124 | PF00082 | 0.554 |
| CLV_PCSK_PC1ET2_1 | 303 | 305 | PF00082 | 0.457 |
| CLV_PCSK_SKI1_1 | 122 | 126 | PF00082 | 0.510 |
| CLV_PCSK_SKI1_1 | 219 | 223 | PF00082 | 0.403 |
| CLV_PCSK_SKI1_1 | 243 | 247 | PF00082 | 0.493 |
| CLV_PCSK_SKI1_1 | 3 | 7 | PF00082 | 0.532 |
| CLV_PCSK_SKI1_1 | 305 | 309 | PF00082 | 0.475 |
| CLV_PCSK_SKI1_1 | 391 | 395 | PF00082 | 0.489 |
| CLV_PCSK_SKI1_1 | 538 | 542 | PF00082 | 0.468 |
| DEG_APCC_DBOX_1 | 1 | 9 | PF00400 | 0.521 |
| DEG_APCC_DBOX_1 | 122 | 130 | PF00400 | 0.193 |
| DEG_Nend_UBRbox_1 | 1 | 4 | PF02207 | 0.479 |
| DOC_ANK_TNKS_1 | 492 | 499 | PF00023 | 0.168 |
| DOC_CKS1_1 | 453 | 458 | PF01111 | 0.179 |
| DOC_CYCLIN_RxL_1 | 119 | 127 | PF00134 | 0.329 |
| DOC_MAPK_gen_1 | 119 | 128 | PF00069 | 0.331 |
| DOC_MAPK_gen_1 | 2 | 10 | PF00069 | 0.494 |
| DOC_MAPK_HePTP_8 | 116 | 128 | PF00069 | 0.175 |
| DOC_MAPK_MEF2A_6 | 119 | 128 | PF00069 | 0.365 |
| DOC_MAPK_MEF2A_6 | 2 | 10 | PF00069 | 0.418 |
| DOC_MAPK_NFAT4_5 | 123 | 131 | PF00069 | 0.178 |
| DOC_PP2B_LxvP_1 | 128 | 131 | PF13499 | 0.178 |
| DOC_PP4_FxxP_1 | 165 | 168 | PF00568 | 0.286 |
| DOC_PP4_FxxP_1 | 408 | 411 | PF00568 | 0.256 |
| DOC_USP7_MATH_1 | 548 | 552 | PF00917 | 0.530 |
| DOC_WW_Pin1_4 | 150 | 155 | PF00397 | 0.244 |
| DOC_WW_Pin1_4 | 214 | 219 | PF00397 | 0.330 |
| DOC_WW_Pin1_4 | 258 | 263 | PF00397 | 0.247 |
| DOC_WW_Pin1_4 | 452 | 457 | PF00397 | 0.394 |
| DOC_WW_Pin1_4 | 504 | 509 | PF00397 | 0.308 |
| LIG_14-3-3_CanoR_1 | 108 | 117 | PF00244 | 0.324 |
| LIG_14-3-3_CanoR_1 | 2 | 6 | PF00244 | 0.605 |
| LIG_14-3-3_CanoR_1 | 304 | 312 | PF00244 | 0.251 |
| LIG_14-3-3_CanoR_1 | 391 | 401 | PF00244 | 0.297 |
| LIG_14-3-3_CanoR_1 | 51 | 55 | PF00244 | 0.625 |
| LIG_14-3-3_CanoR_1 | 538 | 545 | PF00244 | 0.587 |
| LIG_14-3-3_CanoR_1 | 549 | 559 | PF00244 | 0.574 |
| LIG_APCC_ABBA_1 | 134 | 139 | PF00400 | 0.277 |
| LIG_APCC_ABBA_1 | 80 | 85 | PF00400 | 0.226 |
| LIG_APCC_ABBAyCdc20_2 | 79 | 85 | PF00400 | 0.226 |
| LIG_BRCT_BRCA1_1 | 506 | 510 | PF00533 | 0.358 |
| LIG_BRCT_BRCA1_2 | 506 | 512 | PF00533 | 0.195 |
| LIG_FHA_1 | 225 | 231 | PF00498 | 0.391 |
| LIG_FHA_1 | 240 | 246 | PF00498 | 0.317 |
| LIG_FHA_1 | 363 | 369 | PF00498 | 0.287 |
| LIG_FHA_1 | 436 | 442 | PF00498 | 0.268 |
| LIG_FHA_1 | 498 | 504 | PF00498 | 0.273 |
| LIG_FHA_1 | 551 | 557 | PF00498 | 0.567 |
| LIG_FHA_1 | 60 | 66 | PF00498 | 0.474 |
| LIG_FHA_1 | 82 | 88 | PF00498 | 0.304 |
| LIG_GBD_Chelix_1 | 555 | 563 | PF00786 | 0.644 |
| LIG_Integrin_isoDGR_2 | 206 | 208 | PF01839 | 0.476 |
| LIG_LIR_Gen_1 | 403 | 413 | PF02991 | 0.334 |
| LIG_LIR_Gen_1 | 519 | 528 | PF02991 | 0.345 |
| LIG_LIR_Gen_1 | 534 | 540 | PF02991 | 0.439 |
| LIG_LIR_Nem_3 | 178 | 184 | PF02991 | 0.327 |
| LIG_LIR_Nem_3 | 403 | 408 | PF02991 | 0.332 |
| LIG_LIR_Nem_3 | 421 | 425 | PF02991 | 0.234 |
| LIG_LIR_Nem_3 | 519 | 523 | PF02991 | 0.330 |
| LIG_LIR_Nem_3 | 531 | 536 | PF02991 | 0.420 |
| LIG_LIR_Nem_3 | 72 | 78 | PF02991 | 0.252 |
| LIG_MAD2 | 123 | 131 | PF02301 | 0.356 |
| LIG_NRBOX | 124 | 130 | PF00104 | 0.178 |
| LIG_SH2_CRK | 321 | 325 | PF00017 | 0.300 |
| LIG_SH2_CRK | 536 | 540 | PF00017 | 0.271 |
| LIG_SH2_NCK_1 | 339 | 343 | PF00017 | 0.225 |
| LIG_SH2_STAP1 | 536 | 540 | PF00017 | 0.260 |
| LIG_SH2_STAT5 | 220 | 223 | PF00017 | 0.285 |
| LIG_SH2_STAT5 | 404 | 407 | PF00017 | 0.308 |
| LIG_SH3_3 | 148 | 154 | PF00018 | 0.203 |
| LIG_SH3_3 | 373 | 379 | PF00018 | 0.185 |
| LIG_SH3_3 | 450 | 456 | PF00018 | 0.381 |
| LIG_SH3_3 | 55 | 61 | PF00018 | 0.667 |
| LIG_SUMO_SIM_anti_2 | 50 | 56 | PF11976 | 0.511 |
| LIG_WRC_WIRS_1 | 254 | 259 | PF05994 | 0.392 |
| MOD_CDK_SPK_2 | 214 | 219 | PF00069 | 0.361 |
| MOD_CDK_SPxxK_3 | 150 | 157 | PF00069 | 0.330 |
| MOD_CDK_SPxxK_3 | 260 | 267 | PF00069 | 0.229 |
| MOD_CK1_1 | 322 | 328 | PF00069 | 0.295 |
| MOD_CK1_1 | 381 | 387 | PF00069 | 0.318 |
| MOD_CK1_1 | 396 | 402 | PF00069 | 0.306 |
| MOD_CK1_1 | 504 | 510 | PF00069 | 0.320 |
| MOD_CK1_1 | 519 | 525 | PF00069 | 0.364 |
| MOD_CK1_1 | 53 | 59 | PF00069 | 0.651 |
| MOD_CK1_1 | 88 | 94 | PF00069 | 0.399 |
| MOD_CK1_1 | 97 | 103 | PF00069 | 0.174 |
| MOD_CK2_1 | 163 | 169 | PF00069 | 0.275 |
| MOD_CK2_1 | 528 | 534 | PF00069 | 0.345 |
| MOD_CK2_1 | 53 | 59 | PF00069 | 0.633 |
| MOD_GlcNHglycan | 111 | 114 | PF01048 | 0.555 |
| MOD_GlcNHglycan | 131 | 134 | PF01048 | 0.503 |
| MOD_GlcNHglycan | 185 | 188 | PF01048 | 0.404 |
| MOD_GlcNHglycan | 190 | 193 | PF01048 | 0.413 |
| MOD_GlcNHglycan | 267 | 270 | PF01048 | 0.508 |
| MOD_GlcNHglycan | 305 | 308 | PF01048 | 0.498 |
| MOD_GlcNHglycan | 315 | 318 | PF01048 | 0.481 |
| MOD_GlcNHglycan | 321 | 324 | PF01048 | 0.497 |
| MOD_GlcNHglycan | 462 | 466 | PF01048 | 0.479 |
| MOD_GlcNHglycan | 479 | 482 | PF01048 | 0.499 |
| MOD_GlcNHglycan | 489 | 492 | PF01048 | 0.563 |
| MOD_GlcNHglycan | 96 | 99 | PF01048 | 0.517 |
| MOD_GSK3_1 | 183 | 190 | PF00069 | 0.291 |
| MOD_GSK3_1 | 392 | 399 | PF00069 | 0.324 |
| MOD_GSK3_1 | 457 | 464 | PF00069 | 0.332 |
| MOD_GSK3_1 | 497 | 504 | PF00069 | 0.298 |
| MOD_GSK3_1 | 534 | 541 | PF00069 | 0.428 |
| MOD_GSK3_1 | 543 | 550 | PF00069 | 0.474 |
| MOD_GSK3_1 | 81 | 88 | PF00069 | 0.322 |
| MOD_LATS_1 | 301 | 307 | PF00433 | 0.255 |
| MOD_N-GLC_1 | 501 | 506 | PF02516 | 0.567 |
| MOD_N-GLC_1 | 528 | 533 | PF02516 | 0.497 |
| MOD_N-GLC_1 | 88 | 93 | PF02516 | 0.471 |
| MOD_NEK2_1 | 1 | 6 | PF00069 | 0.494 |
| MOD_NEK2_1 | 183 | 188 | PF00069 | 0.254 |
| MOD_NEK2_1 | 239 | 244 | PF00069 | 0.332 |
| MOD_NEK2_1 | 329 | 334 | PF00069 | 0.211 |
| MOD_NEK2_1 | 441 | 446 | PF00069 | 0.218 |
| MOD_NEK2_1 | 47 | 52 | PF00069 | 0.482 |
| MOD_PIKK_1 | 280 | 286 | PF00454 | 0.354 |
| MOD_PIKK_1 | 363 | 369 | PF00454 | 0.347 |
| MOD_PIKK_1 | 88 | 94 | PF00454 | 0.178 |
| MOD_PK_1 | 157 | 163 | PF00069 | 0.168 |
| MOD_PKA_1 | 157 | 163 | PF00069 | 0.168 |
| MOD_PKA_1 | 303 | 309 | PF00069 | 0.255 |
| MOD_PKA_2 | 1 | 7 | PF00069 | 0.569 |
| MOD_PKA_2 | 100 | 106 | PF00069 | 0.372 |
| MOD_PKA_2 | 107 | 113 | PF00069 | 0.378 |
| MOD_PKA_2 | 207 | 213 | PF00069 | 0.275 |
| MOD_PKA_2 | 303 | 309 | PF00069 | 0.254 |
| MOD_PKA_2 | 50 | 56 | PF00069 | 0.526 |
| MOD_PKA_2 | 548 | 554 | PF00069 | 0.672 |
| MOD_Plk_1 | 429 | 435 | PF00069 | 0.290 |
| MOD_Plk_1 | 461 | 467 | PF00069 | 0.325 |
| MOD_Plk_1 | 501 | 507 | PF00069 | 0.350 |
| MOD_Plk_1 | 528 | 534 | PF00069 | 0.337 |
| MOD_Plk_1 | 541 | 547 | PF00069 | 0.425 |
| MOD_Plk_4 | 190 | 196 | PF00069 | 0.315 |
| MOD_Plk_4 | 400 | 406 | PF00069 | 0.344 |
| MOD_Plk_4 | 441 | 447 | PF00069 | 0.237 |
| MOD_Plk_4 | 50 | 56 | PF00069 | 0.543 |
| MOD_Plk_4 | 528 | 534 | PF00069 | 0.299 |
| MOD_ProDKin_1 | 150 | 156 | PF00069 | 0.244 |
| MOD_ProDKin_1 | 214 | 220 | PF00069 | 0.330 |
| MOD_ProDKin_1 | 258 | 264 | PF00069 | 0.247 |
| MOD_ProDKin_1 | 452 | 458 | PF00069 | 0.394 |
| MOD_ProDKin_1 | 504 | 510 | PF00069 | 0.308 |
| MOD_SUMO_for_1 | 307 | 310 | PF00179 | 0.277 |
| MOD_SUMO_for_1 | 340 | 343 | PF00179 | 0.175 |
| MOD_SUMO_rev_2 | 115 | 124 | PF00179 | 0.273 |
| TRG_DiLeu_BaEn_1 | 535 | 540 | PF01217 | 0.258 |
| TRG_DiLeu_LyEn_5 | 535 | 540 | PF01217 | 0.258 |
| TRG_ENDOCYTIC_2 | 321 | 324 | PF00928 | 0.276 |
| TRG_ENDOCYTIC_2 | 446 | 449 | PF00928 | 0.394 |
| TRG_ENDOCYTIC_2 | 520 | 523 | PF00928 | 0.298 |
| TRG_ENDOCYTIC_2 | 536 | 539 | PF00928 | 0.438 |
| TRG_ER_diArg_1 | 1 | 3 | PF00400 | 0.666 |
| TRG_Pf-PMV_PEXEL_1 | 123 | 127 | PF00026 | 0.450 |
| TRG_Pf-PMV_PEXEL_1 | 538 | 542 | PF00026 | 0.300 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1IL11 | Leptomonas seymouri | 41% | 86% |
| A0A0S4IS53 | Bodo saltans | 39% | 100% |
| A0A0S4IUT6 | Bodo saltans | 31% | 69% |
| A0A0S4IUU1 | Bodo saltans | 30% | 86% |
| A0A0S4IYM3 | Bodo saltans | 31% | 78% |
| A0A1B0GTW7 | Homo sapiens | 25% | 72% |
| A0A1D5NSK0 | Danio rerio | 24% | 91% |
| A0A1L8HYT7 | Xenopus laevis | 24% | 79% |
| A0A1X0NDG7 | Trypanosomatidae | 31% | 87% |
| A0A1X0NDJ3 | Trypanosomatidae | 28% | 78% |
| A0A1X0NDK2 | Trypanosomatidae | 32% | 98% |
| A0A1X0NDK7 | Trypanosomatidae | 30% | 79% |
| A0A1X0NDK9 | Trypanosomatidae | 29% | 100% |
| A0A1X0NDM7 | Trypanosomatidae | 30% | 88% |
| A0A1X0NDU8 | Trypanosomatidae | 28% | 85% |
| A0A1X0NE71 | Trypanosomatidae | 29% | 100% |
| A0A1X0NER9 | Trypanosomatidae | 34% | 88% |
| A0A1X0NET7 | Trypanosomatidae | 32% | 100% |
| A0A1X0NEX7 | Trypanosomatidae | 34% | 86% |
| A0A1X0NEZ6 | Trypanosomatidae | 31% | 87% |
| A0A1X0NF32 | Trypanosomatidae | 29% | 100% |
| A0A1X0NF41 | Trypanosomatidae | 30% | 92% |
| A0A1X0NFJ0 | Trypanosomatidae | 31% | 100% |
| A0A1X0NFK3 | Trypanosomatidae | 29% | 84% |
| A0A1X0NFU4 | Trypanosomatidae | 29% | 69% |
| A0A1X0NFZ9 | Trypanosomatidae | 31% | 100% |
| A0A1X0NG20 | Trypanosomatidae | 31% | 91% |
| A0A1X0NGN3 | Trypanosomatidae | 37% | 100% |
| A0A1X0NGP3 | Trypanosomatidae | 30% | 66% |
| A0A1X0NGY3 | Trypanosomatidae | 28% | 74% |
| A0A1X0NGZ3 | Trypanosomatidae | 30% | 94% |
| A0A1X0NHP6 | Trypanosomatidae | 30% | 100% |
| A0A1X0NHQ6 | Trypanosomatidae | 32% | 100% |
| A0A1X0NI74 | Trypanosomatidae | 28% | 76% |
| A0A1X0NII4 | Trypanosomatidae | 28% | 67% |
| A0A1X0NIZ3 | Trypanosomatidae | 32% | 100% |
| A0A1X0NJS3 | Trypanosomatidae | 30% | 87% |
| A0A1X0NK66 | Trypanosomatidae | 31% | 86% |
| A0A1X0NKJ8 | Trypanosomatidae | 30% | 76% |
| A0A1X0NKW9 | Trypanosomatidae | 32% | 100% |
| A0A1X0NME2 | Trypanosomatidae | 32% | 90% |
| A0A1X0NMK3 | Trypanosomatidae | 28% | 100% |
| A0A1X0NMK7 | Trypanosomatidae | 37% | 100% |
| A0A1X0NMV0 | Trypanosomatidae | 29% | 77% |
| A0A1X0NN43 | Trypanosomatidae | 31% | 79% |
| A0A1X0NNK8 | Trypanosomatidae | 32% | 86% |
| A0A1X0NPW0 | Trypanosomatidae | 30% | 88% |
| A0A1X0NQJ5 | Trypanosomatidae | 34% | 100% |
| A0A1X0NQM4 | Trypanosomatidae | 32% | 100% |
| A0A1X0NQN3 | Trypanosomatidae | 36% | 100% |
| A0A1X0NQU4 | Trypanosomatidae | 35% | 88% |
| A0A1X0NQW6 | Trypanosomatidae | 30% | 99% |
| A0A1X0NRF3 | Trypanosomatidae | 29% | 84% |
| A0A1X0NRY8 | Trypanosomatidae | 35% | 100% |
| A0A1X0NTJ1 | Trypanosomatidae | 31% | 100% |
| A0A1X0NU16 | Trypanosomatidae | 38% | 94% |
| A0A1X0NUR2 | Trypanosomatidae | 31% | 77% |
| A0A1X0NV28 | Trypanosomatidae | 39% | 96% |
| A0A1X0NVC3 | Trypanosomatidae | 30% | 83% |
| A0A1X0NVE0 | Trypanosomatidae | 31% | 72% |
| A0A1X0NW07 | Trypanosomatidae | 29% | 90% |
| A0A1X0NX94 | Trypanosomatidae | 30% | 87% |
| A0A1X0NX98 | Trypanosomatidae | 30% | 71% |
| A0A1X0NXB6 | Trypanosomatidae | 31% | 80% |
| A0A1X0NXH6 | Trypanosomatidae | 32% | 77% |
| A0A1X0NXQ4 | Trypanosomatidae | 32% | 83% |
| A0A1X0NXR7 | Trypanosomatidae | 33% | 75% |
| A0A1X0NY94 | Trypanosomatidae | 39% | 100% |
| A0A1X0NYE3 | Trypanosomatidae | 31% | 91% |
| A0A1X0NYE7 | Trypanosomatidae | 32% | 100% |
| A0A1X0NYN2 | Trypanosomatidae | 36% | 100% |
| A0A1X0NYN4 | Trypanosomatidae | 30% | 79% |
| A0A1X0NYS5 | Trypanosomatidae | 37% | 94% |
| A0A1X0NYZ2 | Trypanosomatidae | 37% | 100% |
| A0A1X0NZ46 | Trypanosomatidae | 33% | 97% |
| A0A1X0NZ63 | Trypanosomatidae | 30% | 89% |
| A0A1X0NZN6 | Trypanosomatidae | 31% | 87% |
| A0A1X0NZS0 | Trypanosomatidae | 28% | 100% |
| A0A1X0P055 | Trypanosomatidae | 36% | 96% |
| A0A1X0P0C4 | Trypanosomatidae | 31% | 100% |
| A0A1X0P154 | Trypanosomatidae | 32% | 94% |
| A0A1X0P331 | Trypanosomatidae | 36% | 99% |
| A0A1X0P3K0 | Trypanosomatidae | 27% | 78% |
| A0A1X0P3S2 | Trypanosomatidae | 30% | 100% |
| A0A1X0P4L8 | Trypanosomatidae | 29% | 100% |
| A0A1X0P4Y5 | Trypanosomatidae | 28% | 88% |
| A0A1X0P544 | Trypanosomatidae | 29% | 88% |
| A0A1X0P5J0 | Trypanosomatidae | 31% | 83% |
| A0A1X0P7R3 | Trypanosomatidae | 39% | 100% |
| A0A1X0P8B4 | Trypanosomatidae | 30% | 100% |
| A0A1X0P9Z4 | Trypanosomatidae | 35% | 100% |
| A0A1X0PB04 | Trypanosomatidae | 32% | 100% |
| A0A3Q8I8N3 | Leishmania donovani | 37% | 95% |
| A0A3Q8I8P8 | Leishmania donovani | 37% | 94% |
| A0A3Q8I8S6 | Leishmania donovani | 36% | 88% |
| A0A3Q8I8S9 | Leishmania donovani | 37% | 94% |
| A0A3Q8IAZ8 | Leishmania donovani | 38% | 95% |
| A0A3Q8IC35 | Leishmania donovani | 38% | 95% |
| A0A3Q8IC44 | Leishmania donovani | 37% | 96% |
| A0A3Q8IH61 | Leishmania donovani | 37% | 96% |
| A0A3Q8IIN4 | Leishmania donovani | 42% | 89% |
| A0A3R7JT49 | Trypanosoma rangeli | 36% | 67% |
| A0A3R7JTB6 | Trypanosoma rangeli | 34% | 81% |
| A0A3R7JUS0 | Trypanosoma rangeli | 36% | 100% |
| A0A3R7JV87 | Trypanosoma rangeli | 35% | 100% |
| A0A3R7K7T9 | Trypanosoma rangeli | 36% | 94% |
| A0A3R7K9S1 | Trypanosoma rangeli | 35% | 100% |
| A0A3R7KLR6 | Trypanosoma rangeli | 32% | 88% |
| A0A3R7KMY2 | Trypanosoma rangeli | 36% | 85% |
| A0A3R7LFC4 | Trypanosoma rangeli | 37% | 84% |
| A0A3R7LFZ4 | Trypanosoma rangeli | 41% | 100% |
| A0A3R7LWG1 | Trypanosoma rangeli | 36% | 100% |
| A0A3R7LX11 | Trypanosoma rangeli | 36% | 100% |
| A0A3R7M1R8 | Trypanosoma rangeli | 34% | 98% |
| A0A3R7M574 | Trypanosoma rangeli | 35% | 88% |
| A0A3R7M5K4 | Trypanosoma rangeli | 38% | 100% |
| A0A3R7M7N6 | Trypanosoma rangeli | 35% | 82% |
| A0A3R7MTS2 | Trypanosoma rangeli | 42% | 100% |
| A0A3R7MW36 | Trypanosoma rangeli | 36% | 100% |
| A0A3R7MXF4 | Trypanosoma rangeli | 40% | 92% |
| A0A3R7N1W7 | Trypanosoma rangeli | 35% | 97% |
| A0A3R7N289 | Trypanosoma rangeli | 35% | 78% |
| A0A3R7N7I3 | Trypanosoma rangeli | 44% | 100% |
| A0A3R7NTI8 | Trypanosoma rangeli | 34% | 99% |
| A0A3R7R2J4 | Trypanosoma rangeli | 36% | 88% |
| A0A3R7R5R1 | Trypanosoma rangeli | 35% | 94% |
| A0A3R7R818 | Trypanosoma rangeli | 36% | 100% |
| A0A3S5H6G0 | Leishmania donovani | 37% | 94% |
| A0A3S5IQY2 | Trypanosoma rangeli | 40% | 100% |
| A0A3S7WR43 | Leishmania donovani | 38% | 95% |
| A0A3S7WR46 | Leishmania donovani | 37% | 94% |
| A0A3S7WR60 | Leishmania donovani | 37% | 94% |
| A0A3S7X192 | Leishmania donovani | 99% | 100% |
| A0A422MRQ6 | Trypanosoma rangeli | 36% | 76% |
| A0A422MTA9 | Trypanosoma rangeli | 34% | 78% |
| A0A422MU95 | Trypanosoma rangeli | 36% | 99% |
| A0A422MUY8 | Trypanosoma rangeli | 40% | 100% |
| A0A422MVF5 | Trypanosoma rangeli | 38% | 100% |
| A0A422MVS3 | Trypanosoma rangeli | 36% | 100% |
| A0A422MW99 | Trypanosoma rangeli | 36% | 76% |
| A0A422MZ47 | Trypanosoma rangeli | 38% | 100% |
| A0A422MZG4 | Trypanosoma rangeli | 37% | 96% |
| A0A422N361 | Trypanosoma rangeli | 36% | 100% |
| A0A422N7Q6 | Trypanosoma rangeli | 36% | 87% |
| A0A422NDS2 | Trypanosoma rangeli | 35% | 97% |
| A0A422NDT3 | Trypanosoma rangeli | 32% | 99% |
| A0A422NP82 | Trypanosoma rangeli | 40% | 99% |
| A4H626 | Leishmania braziliensis | 38% | 100% |
| A4H627 | Leishmania braziliensis | 38% | 100% |
| A4H629 | Leishmania braziliensis | 39% | 100% |
| A4H630 | Leishmania braziliensis | 39% | 100% |
| A4H631 | Leishmania braziliensis | 39% | 100% |
| A4H632 | Leishmania braziliensis | 38% | 100% |
| A4H633 | Leishmania braziliensis | 38% | 100% |
| A4H634 | Leishmania braziliensis | 39% | 100% |
| A4H635 | Leishmania braziliensis | 40% | 100% |
| A4H636 | Leishmania braziliensis | 38% | 100% |
| A4H637 | Leishmania braziliensis | 38% | 100% |
| A4H638 | Leishmania braziliensis | 38% | 100% |
| A4H639 | Leishmania braziliensis | 37% | 100% |
| A4H640 | Leishmania braziliensis | 39% | 100% |
| A4H6D3 | Leishmania braziliensis | 35% | 100% |
| A4H6D5 | Leishmania braziliensis | 37% | 80% |
| A4H6D7 | Leishmania braziliensis | 38% | 100% |
| A4H6D8 | Leishmania braziliensis | 37% | 100% |
| A4H6D9 | Leishmania braziliensis | 37% | 100% |
| A4H6E0 | Leishmania braziliensis | 37% | 80% |
| A4H6E1 | Leishmania braziliensis | 36% | 100% |
| A4H6E2 | Leishmania braziliensis | 35% | 100% |
| A4H6E3 | Leishmania braziliensis | 38% | 100% |
| A4H6E4 | Leishmania braziliensis | 38% | 100% |
| A4H6E5 | Leishmania braziliensis | 40% | 100% |
| A4HJI2 | Leishmania braziliensis | 40% | 100% |
| A4HUF6 | Leishmania infantum | 37% | 100% |
| A4HUF8 | Leishmania infantum | 36% | 100% |
| A4HUF9 | Leishmania infantum | 36% | 100% |
| A4HUG0 | Leishmania infantum | 36% | 100% |
| A4I6X5 | Leishmania infantum | 41% | 100% |
| C9ZUT5 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 39% | 97% |
| D0A1R8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 33% | 96% |
| D0A7S8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 31% | 84% |
| D0A855 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 39% | 92% |
| E9AN53 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 35% | 100% |
| E9AN54 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 35% | 100% |
| E9AN55 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 36% | 100% |
| E9AN56 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 35% | 100% |
| E9AN57 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 36% | 100% |
| E9AZL8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 82% | 100% |
| E9B1Z9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 40% | 100% |
| O62446 | Caenorhabditis elegans | 25% | 85% |
| P08148 | Leishmania major | 39% | 94% |
| P15706 | Leishmania chagasi | 36% | 94% |
| P23223 | Leishmania donovani | 38% | 96% |
| P43150 | Leishmania mexicana | 39% | 88% |
| Q00689 | Leishmania guyanensis | 38% | 91% |
| Q06031 | Crithidia fasciculata | 36% | 87% |
| Q27673 | Leishmania amazonensis | 38% | 95% |
| Q29AK2 | Drosophila pseudoobscura pseudoobscura | 25% | 83% |
| Q4Q662 | Leishmania major | 42% | 100% |
| Q4Q8L3 | Leishmania major | 85% | 100% |
| Q4QHG9 | Leishmania major | 37% | 100% |
| Q4QHH0 | Leishmania major | 36% | 100% |
| Q4QHH1 | Leishmania major | 37% | 100% |
| Q4QHH2 | Leishmania major | 37% | 100% |
| Q61YG1 | Caenorhabditis briggsae | 25% | 85% |
| Q6LA77 | Leishmania infantum | 36% | 94% |
| Q8BMN4 | Mus musculus | 28% | 83% |
| Q8MNZ1 | Leishmania tropica | 36% | 86% |
| Q96KR4 | Homo sapiens | 24% | 86% |
| Q9VH19 | Drosophila melanogaster | 24% | 83% |
| V5A303 | Trypanosoma cruzi | 42% | 100% |
| V5A359 | Trypanosoma cruzi | 41% | 100% |
| V5A488 | Trypanosoma cruzi | 34% | 70% |
| V5AII7 | Trypanosoma cruzi | 39% | 100% |
| V5AMH8 | Trypanosoma cruzi | 36% | 100% |
| V5AN34 | Trypanosoma cruzi | 42% | 100% |
| V5APQ4 | Trypanosoma cruzi | 34% | 71% |
| V5AX72 | Trypanosoma cruzi | 35% | 77% |
| V5B5M0 | Trypanosoma cruzi | 36% | 77% |
| V5B9W5 | Trypanosoma cruzi | 30% | 84% |
| V5BAL3 | Trypanosoma cruzi | 39% | 100% |
| V5BAN1 | Trypanosoma cruzi | 36% | 72% |
| V5BD39 | Trypanosoma cruzi | 43% | 100% |
| V5BLT3 | Trypanosoma cruzi | 34% | 90% |
| V5CI97 | Trypanosoma cruzi | 33% | 89% |
| V5CIA7 | Trypanosoma cruzi | 34% | 100% |
| V5D358 | Trypanosoma cruzi | 36% | 67% |