Putative heat-shock protein hsp70

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock protein 70 - putative

Species:

Leishmania infantum

UniProt:

E9AHH0_LEIIN

TriTrypDb:

LINF_280036400

Length:

621

Annotations

LeishMANIAdb annotations

ER-associated chaperone protein

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 14

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	13
GO:0110165	cellular anatomical entity	1	13

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Phosphorylation

Promastigote/Amastigote: 163, 433

Expansion

Sequence features

E9AHH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHH0

Function

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Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0006458	'de novo' protein folding	3	1
GO:0006950	response to stress	2	1
GO:0006986	response to unfolded protein	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1
GO:0033554	cellular response to stress	3	1
GO:0034620	cellular response to unfolded protein	5	1
GO:0035966	response to topologically incorrect protein	3	1
GO:0035967	cellular response to topologically incorrect protein	4	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	13
GO:0005515	protein binding	2	1
GO:0005524	ATP binding	5	13
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	515	519	PF00656	0.323
CLV_NRD_NRD_1	157	159	PF00675	0.320
CLV_NRD_NRD_1	330	332	PF00675	0.323
CLV_NRD_NRD_1	346	348	PF00675	0.323
CLV_PCSK_FUR_1	354	358	PF00082	0.323
CLV_PCSK_KEX2_1	153	155	PF00082	0.305
CLV_PCSK_KEX2_1	330	332	PF00082	0.323
CLV_PCSK_KEX2_1	346	348	PF00082	0.323
CLV_PCSK_KEX2_1	356	358	PF00082	0.323
CLV_PCSK_KEX2_1	413	415	PF00082	0.323

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0D1CD96	Ustilago maydis (strain 521 / FGSC 9021)	61%	94%
A0A0N0P290	Leptomonas seymouri	96%	94%
A0A0N1I1E4	Leptomonas seymouri	64%	94%
A0A0N1I1R3	Leptomonas seymouri	66%	93%
A0A0N1I3L9	Leptomonas seymouri	48%	94%
A0A0N1PDD3	Leptomonas seymouri	27%	74%
A0A0N1PEK8	Leptomonas seymouri	30%	67%
A0A0S4IPK6	Bodo saltans	64%	94%
A0A0S4IR51	Bodo saltans	25%	100%
A0A0S4IRP7	Bodo saltans	60%	100%

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