Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AHG6_LEIIN

TriTrypDb:

LINF_280023300

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AHG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHG6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.561
CLV_PCSK_KEX2_1	157	159	PF00082	0.562
CLV_PCSK_SKI1_1	117	121	PF00082	0.568
CLV_PCSK_SKI1_1	126	130	PF00082	0.442
CLV_PCSK_SKI1_1	174	178	PF00082	0.648
CLV_PCSK_SKI1_1	21	25	PF00082	0.773
CLV_PCSK_SKI1_1	343	347	PF00082	0.592
CLV_PCSK_SKI1_1	374	378	PF00082	0.475
CLV_PCSK_SKI1_1	459	463	PF00082	0.619
CLV_PCSK_SKI1_1	93	97	PF00082	0.479
DEG_APCC_DBOX_1	6	14	PF00400	0.734
DEG_ODPH_VHL_1	208	219	PF01847	0.598
DEG_SCF_FBW7_1	79	85	PF00400	0.529
DEG_SPOP_SBC_1	192	196	PF00917	0.733
DOC_CKS1_1	79	84	PF01111	0.656
DOC_CYCLIN_yCln2_LP_2	288	294	PF00134	0.623
DOC_CYCLIN_yCln2_LP_2	347	353	PF00134	0.517
DOC_MAPK_DCC_7	158	168	PF00069	0.631
DOC_MAPK_DCC_7	93	103	PF00069	0.577
DOC_MAPK_gen_1	88	96	PF00069	0.446
DOC_MAPK_MEF2A_6	343	351	PF00069	0.470
DOC_PP1_RVXF_1	91	97	PF00149	0.466
DOC_PP2B_LxvP_1	109	112	PF13499	0.593
DOC_PP2B_LxvP_1	24	27	PF13499	0.771
DOC_PP2B_LxvP_1	347	350	PF13499	0.539
DOC_PP2B_LxvP_1	415	418	PF13499	0.629
DOC_USP7_MATH_1	192	196	PF00917	0.711
DOC_USP7_MATH_1	203	207	PF00917	0.644
DOC_USP7_MATH_1	331	335	PF00917	0.772
DOC_USP7_MATH_1	336	340	PF00917	0.654
DOC_USP7_MATH_1	39	43	PF00917	0.766
DOC_USP7_MATH_1	61	65	PF00917	0.626
DOC_USP7_MATH_1	66	70	PF00917	0.504
DOC_USP7_UBL2_3	384	388	PF12436	0.497
DOC_WW_Pin1_4	194	199	PF00397	0.716
DOC_WW_Pin1_4	52	57	PF00397	0.721
DOC_WW_Pin1_4	78	83	PF00397	0.608
DOC_WW_Pin1_4	94	99	PF00397	0.414
LIG_14-3-3_CanoR_1	323	331	PF00244	0.740
LIG_14-3-3_CanoR_1	33	43	PF00244	0.760
LIG_14-3-3_CanoR_1	378	385	PF00244	0.504
LIG_14-3-3_CanoR_1	431	435	PF00244	0.590
LIG_BRCT_BRCA1_1	298	302	PF00533	0.346
LIG_eIF4E_1	283	289	PF01652	0.499
LIG_FHA_1	116	122	PF00498	0.462
LIG_FHA_1	15	21	PF00498	0.735
LIG_FHA_1	259	265	PF00498	0.407
LIG_FHA_1	295	301	PF00498	0.432
LIG_FHA_1	365	371	PF00498	0.394
LIG_FHA_1	456	462	PF00498	0.591
LIG_FHA_2	118	124	PF00498	0.572
LIG_FHA_2	263	269	PF00498	0.539
LIG_FHA_2	35	41	PF00498	0.738
LIG_LIR_Apic_2	69	74	PF02991	0.628
LIG_LIR_Gen_1	212	219	PF02991	0.449
LIG_LIR_Gen_1	293	303	PF02991	0.512
LIG_LIR_Nem_3	212	216	PF02991	0.479
LIG_LIR_Nem_3	248	254	PF02991	0.560
LIG_LIR_Nem_3	293	298	PF02991	0.414
LIG_LYPXL_yS_3	251	254	PF13949	0.597
LIG_MYND_1	405	409	PF01753	0.664
LIG_PAM2_1	61	73	PF00658	0.643
LIG_Pex14_2	430	434	PF04695	0.588
LIG_SH2_CRK	136	140	PF00017	0.517
LIG_SH2_CRK	213	217	PF00017	0.602
LIG_SH2_CRK	227	231	PF00017	0.401
LIG_SH2_CRK	71	75	PF00017	0.571
LIG_SH2_GRB2like	213	216	PF00017	0.666
LIG_SH2_GRB2like	283	286	PF00017	0.433
LIG_SH2_NCK_1	227	231	PF00017	0.521
LIG_SH2_NCK_1	71	75	PF00017	0.559
LIG_SH2_SRC	134	137	PF00017	0.526
LIG_SH2_STAP1	213	217	PF00017	0.629
LIG_SH2_STAP1	390	394	PF00017	0.493
LIG_SH2_STAT3	152	155	PF00017	0.575
LIG_SH2_STAT3	283	286	PF00017	0.545
LIG_SH2_STAT3	426	429	PF00017	0.540
LIG_SH2_STAT5	134	137	PF00017	0.414
LIG_SH2_STAT5	152	155	PF00017	0.574
LIG_SH2_STAT5	283	286	PF00017	0.433
LIG_SH2_STAT5	365	368	PF00017	0.450
LIG_SH3_1	57	63	PF00018	0.691
LIG_SH3_2	338	343	PF14604	0.720
LIG_SH3_3	195	201	PF00018	0.705
LIG_SH3_3	306	312	PF00018	0.578
LIG_SH3_3	313	319	PF00018	0.705
LIG_SH3_3	335	341	PF00018	0.706
LIG_SH3_3	53	59	PF00018	0.648
LIG_SH3_3	60	66	PF00018	0.469
LIG_SH3_3	73	79	PF00018	0.545
LIG_SH3_4	384	391	PF00018	0.531
LIG_SUMO_SIM_par_1	117	123	PF11976	0.574
LIG_SUMO_SIM_par_1	138	143	PF11976	0.540
LIG_SUMO_SIM_par_1	296	301	PF11976	0.450
LIG_TRAF2_1	102	105	PF00917	0.620
LIG_TRAF2_1	112	115	PF00917	0.484
LIG_TRAF2_1	319	322	PF00917	0.650
LIG_TRAF2_1	389	392	PF00917	0.469
LIG_TYR_ITIM	211	216	PF00017	0.477
LIG_UBA3_1	235	239	PF00899	0.469
LIG_UBA3_1	43	51	PF00899	0.582
LIG_WRC_WIRS_1	83	88	PF05994	0.483
LIG_WW_2	60	63	PF00397	0.679
LIG_WW_3	416	420	PF00397	0.593
MOD_CDK_SPK_2	52	57	PF00069	0.648
MOD_CDK_SPK_2	94	99	PF00069	0.563
MOD_CK1_1	194	200	PF00069	0.697
MOD_CK1_1	339	345	PF00069	0.682
MOD_CK1_1	383	389	PF00069	0.540
MOD_CK2_1	117	123	PF00069	0.555
MOD_CK2_1	262	268	PF00069	0.532
MOD_CK2_1	298	304	PF00069	0.425
MOD_CK2_1	34	40	PF00069	0.786
MOD_CK2_1	386	392	PF00069	0.445
MOD_DYRK1A_RPxSP_1	78	82	PF00069	0.687
MOD_GlcNHglycan	205	208	PF01048	0.694
MOD_GlcNHglycan	333	336	PF01048	0.743
MOD_GlcNHglycan	447	450	PF01048	0.613
MOD_GlcNHglycan	47	50	PF01048	0.731
MOD_GSK3_1	187	194	PF00069	0.723
MOD_GSK3_1	258	265	PF00069	0.445
MOD_GSK3_1	290	297	PF00069	0.512
MOD_GSK3_1	325	332	PF00069	0.763
MOD_GSK3_1	35	42	PF00069	0.752
MOD_GSK3_1	364	371	PF00069	0.417
MOD_GSK3_1	43	50	PF00069	0.637
MOD_GSK3_1	78	85	PF00069	0.576
MOD_NEK2_1	187	192	PF00069	0.580
MOD_NEK2_1	19	24	PF00069	0.747
MOD_NEK2_1	193	198	PF00069	0.611
MOD_NEK2_1	294	299	PF00069	0.427
MOD_NEK2_1	43	48	PF00069	0.716
MOD_NEK2_1	430	435	PF00069	0.469
MOD_NEK2_2	82	87	PF00069	0.490
MOD_PIKK_1	1	7	PF00454	0.763
MOD_PIKK_1	336	342	PF00454	0.682
MOD_PKA_2	329	335	PF00069	0.653
MOD_PKA_2	377	383	PF00069	0.481
MOD_PKA_2	430	436	PF00069	0.498
MOD_PKA_2	8	14	PF00069	0.770
MOD_Plk_1	39	45	PF00069	0.587
MOD_Plk_4	298	304	PF00069	0.448
MOD_Plk_4	39	45	PF00069	0.682
MOD_Plk_4	66	72	PF00069	0.529
MOD_ProDKin_1	194	200	PF00069	0.718
MOD_ProDKin_1	52	58	PF00069	0.719
MOD_ProDKin_1	78	84	PF00069	0.596
MOD_ProDKin_1	94	100	PF00069	0.419
MOD_SUMO_rev_2	386	394	PF00179	0.505
TRG_DiLeu_BaEn_1	104	109	PF01217	0.638
TRG_DiLeu_BaEn_4	104	110	PF01217	0.642
TRG_ENDOCYTIC_2	213	216	PF00928	0.469
TRG_ENDOCYTIC_2	251	254	PF00928	0.597
TRG_ER_diArg_1	146	149	PF00400	0.420
TRG_ER_diArg_1	156	158	PF00400	0.425
TRG_ER_diArg_1	6	9	PF00400	0.663
TRG_NES_CRM1_1	290	304	PF08389	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8F3	Leptomonas seymouri	57%	90%
A0A1X0NSE8	Trypanosomatidae	35%	100%
A0A3Q8IB15	Leishmania donovani	100%	100%
A0A422NZ46	Trypanosoma rangeli	35%	100%
D0A8B6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AZY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q896	Leishmania major	92%	100%
V5DBC1	Trypanosoma cruzi	35%	100%