Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AHG3_LEIIN

TriTrypDb:

LINF_270032000

Length:

129

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AHG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHG3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	49	53	PF00082	0.285
DEG_MDM2_SWIB_1	83	90	PF02201	0.316
DEG_Nend_Nbox_1	1	3	PF02207	0.300
DOC_MAPK_MEF2A_6	108	115	PF00069	0.537
DOC_USP7_MATH_1	96	100	PF00917	0.684
DOC_WW_Pin1_4	97	102	PF00397	0.576
LIG_14-3-3_CanoR_1	108	114	PF00244	0.525
LIG_BRCT_BRCA1_1	2	6	PF00533	0.293
LIG_deltaCOP1_diTrp_1	70	77	PF00928	0.375
LIG_FHA_1	110	116	PF00498	0.297
LIG_FHA_1	18	24	PF00498	0.409
LIG_FHA_1	29	35	PF00498	0.297
LIG_FHA_1	61	67	PF00498	0.316
LIG_LIR_Gen_1	104	114	PF02991	0.478
LIG_LIR_Gen_1	5	14	PF02991	0.278
LIG_LIR_Nem_3	104	109	PF02991	0.577
LIG_LIR_Nem_3	3	9	PF02991	0.288
LIG_Pex14_2	123	127	PF04695	0.331
LIG_Pex14_2	28	32	PF04695	0.316
LIG_Pex14_2	83	87	PF04695	0.324
LIG_SH2_SRC	114	117	PF00017	0.316
LIG_SH2_STAP1	19	23	PF00017	0.317
LIG_SH2_STAP1	4	8	PF00017	0.289
LIG_SH2_STAP1	55	59	PF00017	0.331
LIG_SH2_STAT3	122	125	PF00017	0.398
LIG_SH2_STAT5	106	109	PF00017	0.543
LIG_SH2_STAT5	114	117	PF00017	0.316
LIG_SH2_STAT5	122	125	PF00017	0.183
LIG_SH2_STAT5	19	22	PF00017	0.310
LIG_SH2_STAT5	8	11	PF00017	0.365
LIG_SH3_3	104	110	PF00018	0.568
LIG_SUMO_SIM_anti_2	22	27	PF11976	0.356
LIG_SUMO_SIM_anti_2	63	68	PF11976	0.316
LIG_SUMO_SIM_par_1	10	16	PF11976	0.316
LIG_SUMO_SIM_par_1	20	27	PF11976	0.336
LIG_WRC_WIRS_1	25	30	PF05994	0.351
MOD_CDC14_SPxK_1	100	103	PF00782	0.588
MOD_CDK_SPxK_1	97	103	PF00069	0.597
MOD_CK1_1	99	105	PF00069	0.671
MOD_GlcNHglycan	46	49	PF01048	0.391
MOD_GSK3_1	13	20	PF00069	0.308
MOD_GSK3_1	24	31	PF00069	0.290
MOD_NEK2_1	17	22	PF00069	0.410
MOD_NEK2_1	28	33	PF00069	0.310
MOD_NEK2_1	44	49	PF00069	0.585
MOD_NEK2_1	62	67	PF00069	0.343
MOD_Plk_4	109	115	PF00069	0.287
MOD_Plk_4	28	34	PF00069	0.420
MOD_Plk_4	53	59	PF00069	0.375
MOD_Plk_4	62	68	PF00069	0.287
MOD_Plk_4	7	13	PF00069	0.287
MOD_ProDKin_1	97	103	PF00069	0.570
TRG_ENDOCYTIC_2	106	109	PF00928	0.568
TRG_ENDOCYTIC_2	8	11	PF00928	0.280

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I817	Leptomonas seymouri	60%	100%
A0A3S7X132	Leishmania donovani	100%	100%
A4HG18	Leishmania braziliensis	84%	100%
E9ACV8	Leishmania major	93%	100%
E9AZE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%