Zeta_toxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AHG2_LEIIN

TriTrypDb:

LINF_270030900

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AHG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHG2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.700
CLV_NRD_NRD_1	101	103	PF00675	0.611
CLV_NRD_NRD_1	153	155	PF00675	0.644
CLV_NRD_NRD_1	204	206	PF00675	0.590
CLV_NRD_NRD_1	214	216	PF00675	0.519
CLV_NRD_NRD_1	252	254	PF00675	0.545
CLV_NRD_NRD_1	264	266	PF00675	0.466
CLV_NRD_NRD_1	69	71	PF00675	0.694
CLV_NRD_NRD_1	85	87	PF00675	0.406
CLV_PCSK_FUR_1	99	103	PF00082	0.683
CLV_PCSK_KEX2_1	101	103	PF00082	0.657
CLV_PCSK_KEX2_1	204	206	PF00082	0.589
CLV_PCSK_KEX2_1	214	216	PF00082	0.517
CLV_PCSK_KEX2_1	252	254	PF00082	0.551
CLV_PCSK_KEX2_1	264	266	PF00082	0.460
CLV_PCSK_KEX2_1	69	71	PF00082	0.694
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.589
CLV_PCSK_SKI1_1	101	105	PF00082	0.689
CLV_PCSK_SKI1_1	20	24	PF00082	0.504
CLV_PCSK_SKI1_1	245	249	PF00082	0.620
CLV_PCSK_SKI1_1	255	259	PF00082	0.481
CLV_PCSK_SKI1_1	341	345	PF00082	0.721
DEG_Nend_UBRbox_2	1	3	PF02207	0.703
DOC_CYCLIN_RxL_1	252	260	PF00134	0.539
DOC_CYCLIN_RxL_1	99	107	PF00134	0.698
DOC_MAPK_DCC_7	99	108	PF00069	0.632
DOC_MAPK_gen_1	252	259	PF00069	0.538
DOC_MAPK_gen_1	99	108	PF00069	0.702
DOC_MAPK_MEF2A_6	99	108	PF00069	0.702
DOC_MAPK_NFAT4_5	101	109	PF00069	0.717
DOC_PP1_RVXF_1	253	259	PF00149	0.518
DOC_PP1_RVXF_1	270	277	PF00149	0.526
DOC_PP1_RVXF_1	90	96	PF00149	0.664
DOC_PP4_FxxP_1	183	186	PF00568	0.580
DOC_SPAK_OSR1_1	112	116	PF12202	0.703
DOC_USP7_MATH_1	132	136	PF00917	0.620
DOC_USP7_MATH_1	291	295	PF00917	0.652
DOC_USP7_MATH_1	60	64	PF00917	0.594
DOC_USP7_UBL2_3	151	155	PF12436	0.692
LIG_14-3-3_CanoR_1	20	30	PF00244	0.655
LIG_14-3-3_CanoR_1	264	268	PF00244	0.658
LIG_14-3-3_CanoR_1	333	337	PF00244	0.746
LIG_14-3-3_CanoR_1	369	373	PF00244	0.597
LIG_14-3-3_CanoR_1	43	52	PF00244	0.614
LIG_Actin_WH2_2	232	250	PF00022	0.610
LIG_AP2alpha_1	282	286	PF02296	0.622
LIG_BRCT_BRCA1_1	26	30	PF00533	0.631
LIG_BRCT_BRCA1_1	282	286	PF00533	0.558
LIG_CtBP_PxDLS_1	105	109	PF00389	0.675
LIG_deltaCOP1_diTrp_1	284	288	PF00928	0.583
LIG_FHA_1	1	7	PF00498	0.609
LIG_FHA_1	176	182	PF00498	0.602
LIG_FHA_1	310	316	PF00498	0.569
LIG_FHA_1	326	332	PF00498	0.671
LIG_FHA_1	47	53	PF00498	0.667
LIG_FHA_2	27	33	PF00498	0.584
LIG_FHA_2	275	281	PF00498	0.657
LIG_FHA_2	357	363	PF00498	0.640
LIG_FHA_2	66	72	PF00498	0.688
LIG_LIR_Apic_2	180	186	PF02991	0.577
LIG_LIR_Gen_1	10	19	PF02991	0.544
LIG_LIR_Gen_1	273	282	PF02991	0.517
LIG_LIR_Nem_3	10	15	PF02991	0.525
LIG_LIR_Nem_3	273	279	PF02991	0.512
LIG_LIR_Nem_3	283	289	PF02991	0.492
LIG_LIR_Nem_3	334	339	PF02991	0.706
LIG_NRBOX	372	378	PF00104	0.581
LIG_NRBOX	78	84	PF00104	0.577
LIG_Pex14_2	282	286	PF04695	0.622
LIG_Pex14_2	37	41	PF04695	0.567
LIG_REV1ctd_RIR_1	284	292	PF16727	0.691
LIG_SH2_CRK	336	340	PF00017	0.711
LIG_SH2_NCK_1	61	65	PF00017	0.567
LIG_SH2_SRC	398	401	PF00017	0.466
LIG_SH2_STAP1	398	402	PF00017	0.580
LIG_SH3_3	336	342	PF00018	0.700
LIG_SUMO_SIM_par_1	2	11	PF11976	0.644
LIG_TYR_ITIM	59	64	PF00017	0.585
LIG_UBA3_1	52	57	PF00899	0.615
LIG_UBA3_1	78	87	PF00899	0.581
LIG_WRC_WIRS_1	34	39	PF05994	0.638
LIG_WRC_WIRS_1	9	14	PF05994	0.524
MOD_CK1_1	127	133	PF00069	0.601
MOD_CK1_1	144	150	PF00069	0.672
MOD_CK1_1	176	182	PF00069	0.511
MOD_CK1_1	24	30	PF00069	0.665
MOD_CK1_1	270	276	PF00069	0.650
MOD_CK1_1	294	300	PF00069	0.630
MOD_CK1_1	327	333	PF00069	0.789
MOD_CK1_1	46	52	PF00069	0.578
MOD_CK2_1	274	280	PF00069	0.648
MOD_CK2_1	41	47	PF00069	0.690
MOD_CK2_1	65	71	PF00069	0.598
MOD_CMANNOS	298	301	PF00535	0.678
MOD_Cter_Amidation	262	265	PF01082	0.603
MOD_GlcNHglycan	231	234	PF01048	0.518
MOD_GSK3_1	118	125	PF00069	0.635
MOD_GSK3_1	140	147	PF00069	0.693
MOD_GSK3_1	22	29	PF00069	0.675
MOD_GSK3_1	263	270	PF00069	0.652
MOD_GSK3_1	321	328	PF00069	0.751
MOD_N-GLC_1	166	171	PF02516	0.652
MOD_N-GLC_1	280	285	PF02516	0.576
MOD_NEK2_1	229	234	PF00069	0.589
MOD_NEK2_1	274	279	PF00069	0.644
MOD_NEK2_1	367	372	PF00069	0.608
MOD_NEK2_1	5	10	PF00069	0.635
MOD_NEK2_1	73	78	PF00069	0.583
MOD_NEK2_2	309	314	PF00069	0.487
MOD_NEK2_2	398	403	PF00069	0.583
MOD_PIKK_1	173	179	PF00454	0.533
MOD_PIKK_1	291	297	PF00454	0.648
MOD_PIKK_1	302	308	PF00454	0.563
MOD_PK_1	118	124	PF00069	0.651
MOD_PKA_2	117	123	PF00069	0.696
MOD_PKA_2	173	179	PF00069	0.533
MOD_PKA_2	263	269	PF00069	0.564
MOD_PKA_2	274	280	PF00069	0.541
MOD_PKA_2	324	330	PF00069	0.804
MOD_PKA_2	332	338	PF00069	0.659
MOD_PKA_2	368	374	PF00069	0.658
MOD_Plk_1	118	124	PF00069	0.651
MOD_Plk_1	166	172	PF00069	0.724
MOD_Plk_1	270	276	PF00069	0.650
MOD_Plk_1	398	404	PF00069	0.580
MOD_Plk_2-3	26	32	PF00069	0.605
MOD_Plk_4	118	124	PF00069	0.581
MOD_Plk_4	33	39	PF00069	0.518
MOD_Plk_4	368	374	PF00069	0.587
MOD_Plk_4	48	54	PF00069	0.562
MOD_Plk_4	73	79	PF00069	0.577
MOD_SUMO_rev_2	187	194	PF00179	0.637
MOD_SUMO_rev_2	81	88	PF00179	0.544
TRG_DiLeu_BaEn_1	390	395	PF01217	0.552
TRG_DiLeu_BaEn_2	25	31	PF01217	0.562
TRG_ENDOCYTIC_2	336	339	PF00928	0.711
TRG_ENDOCYTIC_2	61	64	PF00928	0.604
TRG_ER_diArg_1	14	17	PF00400	0.518
TRG_ER_diArg_1	213	215	PF00400	0.617
TRG_ER_diArg_1	251	253	PF00400	0.553
TRG_ER_diArg_1	315	318	PF00400	0.574
TRG_ER_diArg_1	99	102	PF00400	0.630
TRG_NES_CRM1_1	72	85	PF08389	0.647
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.637
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T5	Leptomonas seymouri	29%	99%
A0A3Q8IEE0	Leishmania donovani	99%	100%
A4HG13	Leishmania braziliensis	66%	100%
E9ACV3	Leishmania major	88%	100%
E9AZE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%