LeishMANIAdb
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CRISPR-associated protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CRISPR-associated protein
Gene product:
Repeat of unknown function (DUF1126)/EF-hand domain pair - putative
Species:
Leishmania infantum
UniProt:
E9AHF6_LEIIN
TriTrypDb:
LINF_270014900
Length:
756

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005819 spindle 5 1
GO:0005930 axoneme 2 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0072686 mitotic spindle 6 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

E9AHF6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHF6

Function

Biological processes
Term Name Level Count
GO:0000226 microtubule cytoskeleton organization 3 1
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0001539 cilium or flagellum-dependent cell motility 3 1
GO:0006996 organelle organization 4 1
GO:0007010 cytoskeleton organization 5 1
GO:0007017 microtubule-based process 2 1
GO:0007051 spindle organization 3 1
GO:0007052 mitotic spindle organization 4 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022402 cell cycle process 2 1
GO:0048870 cell motility 2 1
GO:0060285 cilium-dependent cell motility 4 1
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:1902850 microtubule cytoskeleton organization involved in mitosis 4 1
GO:1903047 mitotic cell cycle process 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 7
GO:0005509 calcium ion binding 5 7
GO:0043167 ion binding 2 7
GO:0043169 cation binding 3 7
GO:0046872 metal ion binding 4 7
GO:0005515 protein binding 2 1
GO:0008092 cytoskeletal protein binding 3 1
GO:0015631 tubulin binding 4 1
GO:0043014 alpha-tubulin binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 723 729 PF00089 0.345
CLV_NRD_NRD_1 115 117 PF00675 0.169
CLV_NRD_NRD_1 251 253 PF00675 0.279
CLV_NRD_NRD_1 29 31 PF00675 0.421
CLV_NRD_NRD_1 34 36 PF00675 0.423
CLV_NRD_NRD_1 396 398 PF00675 0.488
CLV_NRD_NRD_1 416 418 PF00675 0.317
CLV_NRD_NRD_1 441 443 PF00675 0.181
CLV_NRD_NRD_1 478 480 PF00675 0.226
CLV_NRD_NRD_1 532 534 PF00675 0.304
CLV_NRD_NRD_1 646 648 PF00675 0.591
CLV_NRD_NRD_1 669 671 PF00675 0.312
CLV_NRD_NRD_1 699 701 PF00675 0.349
CLV_PCSK_KEX2_1 148 150 PF00082 0.191
CLV_PCSK_KEX2_1 29 31 PF00082 0.421
CLV_PCSK_KEX2_1 34 36 PF00082 0.423
CLV_PCSK_KEX2_1 396 398 PF00082 0.484
CLV_PCSK_KEX2_1 416 418 PF00082 0.328
CLV_PCSK_KEX2_1 441 443 PF00082 0.180
CLV_PCSK_KEX2_1 478 480 PF00082 0.169
CLV_PCSK_KEX2_1 669 671 PF00082 0.291
CLV_PCSK_KEX2_1 699 701 PF00082 0.458
CLV_PCSK_PC1ET2_1 148 150 PF00082 0.169
CLV_PCSK_PC7_1 30 36 PF00082 0.547
CLV_PCSK_PC7_1 474 480 PF00082 0.169
CLV_PCSK_SKI1_1 117 121 PF00082 0.154
CLV_PCSK_SKI1_1 188 192 PF00082 0.335
CLV_PCSK_SKI1_1 245 249 PF00082 0.302
CLV_PCSK_SKI1_1 252 256 PF00082 0.204
CLV_PCSK_SKI1_1 271 275 PF00082 0.092
CLV_PCSK_SKI1_1 308 312 PF00082 0.154
CLV_PCSK_SKI1_1 354 358 PF00082 0.169
CLV_PCSK_SKI1_1 442 446 PF00082 0.169
CLV_PCSK_SKI1_1 495 499 PF00082 0.243
CLV_PCSK_SKI1_1 55 59 PF00082 0.500
CLV_PCSK_SKI1_1 657 661 PF00082 0.416
CLV_PCSK_SKI1_1 670 674 PF00082 0.322
CLV_PCSK_SKI1_1 717 721 PF00082 0.383
CLV_Separin_Metazoa 26 30 PF03568 0.427
DEG_SIAH_1 198 206 PF03145 0.429
DOC_ANK_TNKS_1 604 611 PF00023 0.381
DOC_CDC14_PxL_1 15 23 PF14671 0.474
DOC_CYCLIN_RxL_1 185 193 PF00134 0.506
DOC_CYCLIN_RxL_1 568 579 PF00134 0.286
DOC_CYCLIN_RxL_1 664 676 PF00134 0.310
DOC_CYCLIN_RxL_1 695 708 PF00134 0.434
DOC_MAPK_FxFP_2 141 144 PF00069 0.367
DOC_MAPK_gen_1 114 122 PF00069 0.372
DOC_MAPK_gen_1 242 250 PF00069 0.288
DOC_MAPK_gen_1 34 42 PF00069 0.555
DOC_MAPK_gen_1 439 449 PF00069 0.391
DOC_MAPK_MEF2A_6 114 122 PF00069 0.426
DOC_MAPK_MEF2A_6 441 449 PF00069 0.391
DOC_PP4_FxxP_1 13 16 PF00568 0.411
DOC_PP4_FxxP_1 141 144 PF00568 0.367
DOC_PP4_FxxP_1 389 392 PF00568 0.554
DOC_USP7_MATH_1 450 454 PF00917 0.450
DOC_USP7_MATH_1 608 612 PF00917 0.482
DOC_USP7_MATH_1 631 635 PF00917 0.620
DOC_USP7_MATH_1 653 657 PF00917 0.335
DOC_USP7_MATH_1 684 688 PF00917 0.454
DOC_USP7_MATH_1 725 729 PF00917 0.365
DOC_USP7_MATH_1 748 752 PF00917 0.452
DOC_USP7_UBL2_3 435 439 PF12436 0.427
DOC_USP7_UBL2_3 530 534 PF12436 0.376
DOC_WW_Pin1_4 155 160 PF00397 0.382
DOC_WW_Pin1_4 227 232 PF00397 0.468
DOC_WW_Pin1_4 234 239 PF00397 0.410
DOC_WW_Pin1_4 382 387 PF00397 0.427
LIG_14-3-3_CanoR_1 419 425 PF00244 0.341
LIG_14-3-3_CanoR_1 657 666 PF00244 0.230
LIG_14-3-3_CanoR_1 726 730 PF00244 0.332
LIG_AP2alpha_2 184 186 PF02296 0.427
LIG_AP2alpha_2 298 300 PF02296 0.369
LIG_BIR_II_1 1 5 PF00653 0.419
LIG_BIR_III_2 182 186 PF00653 0.427
LIG_BRCT_BRCA1_1 169 173 PF00533 0.373
LIG_BRCT_BRCA1_1 283 287 PF00533 0.391
LIG_BRCT_BRCA1_1 315 319 PF00533 0.412
LIG_BRCT_BRCA1_1 325 329 PF00533 0.351
LIG_BRCT_BRCA1_1 499 503 PF00533 0.463
LIG_BRCT_BRCA1_1 690 694 PF00533 0.392
LIG_eIF4E_1 683 689 PF01652 0.448
LIG_FHA_1 110 116 PF00498 0.411
LIG_FHA_1 126 132 PF00498 0.330
LIG_FHA_1 175 181 PF00498 0.369
LIG_FHA_1 185 191 PF00498 0.445
LIG_FHA_1 262 268 PF00498 0.383
LIG_FHA_1 541 547 PF00498 0.369
LIG_FHA_1 658 664 PF00498 0.232
LIG_FHA_1 89 95 PF00498 0.257
LIG_FHA_2 258 264 PF00498 0.463
LIG_FHA_2 326 332 PF00498 0.376
LIG_FHA_2 337 343 PF00498 0.357
LIG_FHA_2 393 399 PF00498 0.661
LIG_FHA_2 401 407 PF00498 0.417
LIG_FHA_2 576 582 PF00498 0.338
LIG_LIR_Apic_2 12 16 PF02991 0.416
LIG_LIR_Apic_2 139 144 PF02991 0.367
LIG_LIR_Gen_1 206 217 PF02991 0.405
LIG_LIR_Gen_1 244 255 PF02991 0.227
LIG_LIR_Gen_1 270 280 PF02991 0.447
LIG_LIR_Gen_1 500 510 PF02991 0.429
LIG_LIR_Gen_1 564 573 PF02991 0.186
LIG_LIR_Gen_1 598 607 PF02991 0.364
LIG_LIR_Gen_1 619 628 PF02991 0.320
LIG_LIR_Gen_1 660 666 PF02991 0.356
LIG_LIR_Gen_1 676 684 PF02991 0.274
LIG_LIR_Gen_1 728 736 PF02991 0.408
LIG_LIR_Nem_3 177 181 PF02991 0.432
LIG_LIR_Nem_3 244 250 PF02991 0.227
LIG_LIR_Nem_3 270 276 PF02991 0.380
LIG_LIR_Nem_3 298 303 PF02991 0.369
LIG_LIR_Nem_3 360 364 PF02991 0.406
LIG_LIR_Nem_3 376 381 PF02991 0.340
LIG_LIR_Nem_3 455 460 PF02991 0.401
LIG_LIR_Nem_3 500 506 PF02991 0.429
LIG_LIR_Nem_3 564 569 PF02991 0.186
LIG_LIR_Nem_3 594 599 PF02991 0.208
LIG_LIR_Nem_3 619 623 PF02991 0.311
LIG_LIR_Nem_3 660 665 PF02991 0.349
LIG_LIR_Nem_3 676 680 PF02991 0.202
LIG_LIR_Nem_3 728 732 PF02991 0.413
LIG_Pex14_1 620 624 PF04695 0.455
LIG_Pex14_2 673 677 PF04695 0.351
LIG_SH2_CRK 378 382 PF00017 0.440
LIG_SH2_NCK_1 378 382 PF00017 0.304
LIG_SH2_NCK_1 599 603 PF00017 0.338
LIG_SH2_SRC 378 381 PF00017 0.279
LIG_SH2_SRC 599 602 PF00017 0.338
LIG_SH2_SRC 624 627 PF00017 0.426
LIG_SH2_STAP1 599 603 PF00017 0.207
LIG_SH2_STAP1 729 733 PF00017 0.397
LIG_SH2_STAP1 742 746 PF00017 0.455
LIG_SH2_STAT3 352 355 PF00017 0.427
LIG_SH2_STAT5 100 103 PF00017 0.383
LIG_SH2_STAT5 123 126 PF00017 0.463
LIG_SH2_STAT5 209 212 PF00017 0.443
LIG_SH2_STAT5 278 281 PF00017 0.383
LIG_SH2_STAT5 338 341 PF00017 0.369
LIG_SH2_STAT5 364 367 PF00017 0.479
LIG_SH2_STAT5 448 451 PF00017 0.411
LIG_SH2_STAT5 484 487 PF00017 0.404
LIG_SH2_STAT5 491 494 PF00017 0.410
LIG_SH2_STAT5 588 591 PF00017 0.207
LIG_SH2_STAT5 596 599 PF00017 0.207
LIG_SH3_3 128 134 PF00018 0.470
LIG_SH3_3 13 19 PF00018 0.405
LIG_SH3_3 149 155 PF00018 0.426
LIG_SH3_3 385 391 PF00018 0.393
LIG_SH3_3 719 725 PF00018 0.343
LIG_SUMO_SIM_anti_2 581 587 PF11976 0.226
LIG_TRAF2_1 578 581 PF00917 0.207
LIG_TRAF2_1 598 601 PF00917 0.075
LIG_TRAF2_1 708 711 PF00917 0.418
LIG_TRAF2_1 728 731 PF00917 0.213
LIG_TYR_ITIM 597 602 PF00017 0.320
LIG_TYR_ITSM 374 381 PF00017 0.355
LIG_UBA3_1 582 591 PF00899 0.219
MOD_CK1_1 281 287 PF00069 0.443
MOD_CK1_1 323 329 PF00069 0.456
MOD_CK1_1 400 406 PF00069 0.453
MOD_CK1_1 541 547 PF00069 0.357
MOD_CK1_1 595 601 PF00069 0.207
MOD_CK1_1 705 711 PF00069 0.426
MOD_CK2_1 105 111 PF00069 0.372
MOD_CK2_1 127 133 PF00069 0.374
MOD_CK2_1 19 25 PF00069 0.402
MOD_CK2_1 325 331 PF00069 0.404
MOD_CK2_1 392 398 PF00069 0.562
MOD_CK2_1 400 406 PF00069 0.395
MOD_CK2_1 452 458 PF00069 0.401
MOD_CK2_1 575 581 PF00069 0.207
MOD_CK2_1 595 601 PF00069 0.075
MOD_CK2_1 705 711 PF00069 0.330
MOD_CK2_1 725 731 PF00069 0.248
MOD_GlcNHglycan 107 110 PF01048 0.245
MOD_GlcNHglycan 137 141 PF01048 0.192
MOD_GlcNHglycan 294 297 PF01048 0.169
MOD_GlcNHglycan 313 316 PF01048 0.169
MOD_GlcNHglycan 463 466 PF01048 0.183
MOD_GlcNHglycan 557 560 PF01048 0.307
MOD_GlcNHglycan 609 613 PF01048 0.512
MOD_GSK3_1 105 112 PF00069 0.469
MOD_GSK3_1 125 132 PF00069 0.341
MOD_GSK3_1 203 210 PF00069 0.450
MOD_GSK3_1 222 229 PF00069 0.401
MOD_GSK3_1 257 264 PF00069 0.463
MOD_GSK3_1 319 326 PF00069 0.418
MOD_GSK3_1 332 339 PF00069 0.343
MOD_GSK3_1 505 512 PF00069 0.381
MOD_GSK3_1 55 62 PF00069 0.561
MOD_GSK3_1 608 615 PF00069 0.491
MOD_GSK3_1 653 660 PF00069 0.365
MOD_GSK3_1 684 691 PF00069 0.414
MOD_GSK3_1 738 745 PF00069 0.448
MOD_GSK3_1 748 755 PF00069 0.476
MOD_N-GLC_1 555 560 PF02516 0.311
MOD_N-GLC_1 592 597 PF02516 0.216
MOD_N-GLC_1 616 621 PF02516 0.366
MOD_N-GLC_1 736 741 PF02516 0.307
MOD_NEK2_1 1 6 PF00069 0.426
MOD_NEK2_1 267 272 PF00069 0.450
MOD_NEK2_1 319 324 PF00069 0.445
MOD_NEK2_1 373 378 PF00069 0.375
MOD_NEK2_1 420 425 PF00069 0.439
MOD_NEK2_1 538 543 PF00069 0.348
MOD_NEK2_1 702 707 PF00069 0.386
MOD_NEK2_1 736 741 PF00069 0.325
MOD_NEK2_2 169 174 PF00069 0.329
MOD_NEK2_2 325 330 PF00069 0.401
MOD_NEK2_2 65 70 PF00069 0.563
MOD_PIKK_1 1 7 PF00454 0.430
MOD_PKA_2 241 247 PF00069 0.344
MOD_PKA_2 461 467 PF00069 0.397
MOD_PKA_2 646 652 PF00069 0.462
MOD_PKA_2 725 731 PF00069 0.332
MOD_Plk_1 257 263 PF00069 0.463
MOD_Plk_1 319 325 PF00069 0.465
MOD_Plk_1 400 406 PF00069 0.453
MOD_Plk_1 450 456 PF00069 0.369
MOD_Plk_1 509 515 PF00069 0.470
MOD_Plk_1 53 59 PF00069 0.534
MOD_Plk_1 592 598 PF00069 0.197
MOD_Plk_1 616 622 PF00069 0.397
MOD_Plk_1 702 708 PF00069 0.410
MOD_Plk_2-3 616 622 PF00069 0.380
MOD_Plk_2-3 703 709 PF00069 0.345
MOD_Plk_4 169 175 PF00069 0.470
MOD_Plk_4 231 237 PF00069 0.553
MOD_Plk_4 263 269 PF00069 0.452
MOD_Plk_4 272 278 PF00069 0.375
MOD_Plk_4 332 338 PF00069 0.383
MOD_Plk_4 420 426 PF00069 0.463
MOD_Plk_4 452 458 PF00069 0.473
MOD_Plk_4 565 571 PF00069 0.264
MOD_Plk_4 581 587 PF00069 0.128
MOD_Plk_4 592 598 PF00069 0.207
MOD_Plk_4 631 637 PF00069 0.551
MOD_Plk_4 684 690 PF00069 0.321
MOD_ProDKin_1 155 161 PF00069 0.382
MOD_ProDKin_1 227 233 PF00069 0.467
MOD_ProDKin_1 234 240 PF00069 0.404
MOD_ProDKin_1 382 388 PF00069 0.437
MOD_SUMO_rev_2 249 255 PF00179 0.463
MOD_SUMO_rev_2 432 440 PF00179 0.427
MOD_SUMO_rev_2 634 642 PF00179 0.454
MOD_SUMO_rev_2 643 649 PF00179 0.403
MOD_SUMO_rev_2 687 696 PF00179 0.333
TRG_DiLeu_BaEn_1 731 736 PF01217 0.399
TRG_DiLeu_BaEn_4 710 716 PF01217 0.402
TRG_DiLeu_LyEn_5 731 736 PF01217 0.348
TRG_ENDOCYTIC_2 209 212 PF00928 0.408
TRG_ENDOCYTIC_2 277 280 PF00928 0.374
TRG_ENDOCYTIC_2 378 381 PF00928 0.416
TRG_ENDOCYTIC_2 599 602 PF00928 0.207
TRG_ENDOCYTIC_2 729 732 PF00928 0.356
TRG_ER_diArg_1 212 215 PF00400 0.446
TRG_ER_diArg_1 28 30 PF00400 0.427
TRG_ER_diArg_1 306 309 PF00400 0.374
TRG_ER_diArg_1 415 417 PF00400 0.524
TRG_ER_diArg_1 440 442 PF00400 0.382
TRG_ER_diArg_1 477 479 PF00400 0.427
TRG_Pf-PMV_PEXEL_1 188 193 PF00026 0.456
TRG_Pf-PMV_PEXEL_1 397 401 PF00026 0.560

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5H4 Leptomonas seymouri 23% 90%
A0A0N1HZ98 Leptomonas seymouri 25% 98%
A0A0N1I3M2 Leptomonas seymouri 76% 99%
A0A0N1PBW1 Leptomonas seymouri 27% 100%
A0A0S4IJW8 Bodo saltans 26% 92%
A0A0S4IQM0 Bodo saltans 24% 100%
A0A0S4J8J7 Bodo saltans 29% 82%
A0A1X0NEV8 Trypanosomatidae 24% 95%
A0A1X0NLI2 Trypanosomatidae 27% 100%
A0A1X0NMQ3 Trypanosomatidae 26% 97%
A0A1X0P419 Trypanosomatidae 62% 99%
A0A3Q1N1R0 Bos taurus 30% 100%
A0A3Q8IDH4 Leishmania donovani 26% 98%
A0A3Q8IPU3 Leishmania donovani 100% 100%
A0A3R7KM50 Trypanosoma rangeli 27% 95%
A0A3R7L048 Trypanosoma rangeli 59% 100%
A0A3S7XC76 Leishmania donovani 27% 100%
A0A422N0Z6 Trypanosoma rangeli 24% 97%
A0A422NK00 Trypanosoma rangeli 29% 100%
A4HE78 Leishmania braziliensis 26% 99%
A4HFK9 Leishmania braziliensis 88% 100%
A4HQF8 Leishmania braziliensis 26% 96%
A4I1J2 Leishmania infantum 26% 100%
A4IC94 Leishmania infantum 27% 97%
C9ZJX4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 94%
C9ZPE7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 97%
D0A3K7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
D0A5T5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
E1BKH1 Bos taurus 29% 100%
E9AD64 Leishmania major 98% 100%
E9AI34 Leishmania braziliensis 23% 100%
E9AMI2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9AU74 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 96%
E9AXM7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 99%
E9AYY9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q32TF8 Danio rerio 30% 100%
Q32TG3 Gallus gallus 28% 100%
Q4Q0C0 Leishmania major 27% 97%
Q4Q9U5 Leishmania major 25% 100%
Q4QI57 Leishmania major 23% 87%
Q5JST6 Homo sapiens 28% 100%
Q5JVL4 Homo sapiens 30% 100%
Q9D485 Mus musculus 29% 100%
Q9D9T8 Mus musculus 30% 100%
V5ASV2 Trypanosoma cruzi 26% 100%
V5D3X9 Trypanosoma cruzi 24% 97%
V5DA42 Trypanosoma cruzi 59% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS