Glutaredoxin-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glutaredoxin-like protein

Species:

Leishmania infantum

UniProt:

E9AHF3_LEIIN

TriTrypDb:

LINF_270014300

Length:

108

Annotations

Annotations by Jardim et al.

Redox homeostasis, Glutaredoxin-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AHF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHF3

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0006979	response to oxidative stress	3	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034599	cellular response to oxidative stress	4	1
GO:0042221	response to chemical	2	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0062197	cellular response to chemical stress	4	1
GO:0070887	cellular response to chemical stimulus	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0015035	protein-disulfide reductase activity	3	9
GO:0015036	disulfide oxidoreductase activity	4	9
GO:0016491	oxidoreductase activity	2	9
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	9
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	4	9
GO:0019153	protein-disulfide reductase (glutathione) activity	4	9
GO:0097573	obsolete glutathione oxidoreductase activity	4	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:0015038	glutathione disulfide oxidoreductase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	57	61	PF00656	0.278
CLV_PCSK_SKI1_1	41	45	PF00082	0.283
DEG_Nend_Nbox_1	1	3	PF02207	0.520
DOC_PP1_RVXF_1	23	30	PF00149	0.271
DOC_PP2B_PxIxI_1	78	84	PF00149	0.305
DOC_USP7_MATH_1	35	39	PF00917	0.304
DOC_USP7_UBL2_3	41	45	PF12436	0.342
LIG_14-3-3_CanoR_1	9	14	PF00244	0.496
LIG_BRCT_BRCA1_1	2	6	PF00533	0.512
LIG_FHA_2	14	20	PF00498	0.436
LIG_PTB_Apo_2	81	88	PF02174	0.305
LIG_SH2_STAT5	36	39	PF00017	0.249
LIG_SH3_3	29	35	PF00018	0.271
LIG_UBA3_1	43	49	PF00899	0.282
MOD_CK2_1	13	19	PF00069	0.460
MOD_GlcNHglycan	99	102	PF01048	0.460
MOD_GSK3_1	9	16	PF00069	0.469
MOD_NEK2_1	1	6	PF00069	0.598
MOD_PKA_2	8	14	PF00069	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIF5	Leptomonas seymouri	74%	100%
A0A0N1PD78	Leptomonas seymouri	29%	100%
A0A0S4JTJ5	Bodo saltans	25%	87%
A0A0S4JUD4	Bodo saltans	47%	100%
A0A0S4JWT8	Bodo saltans	32%	100%
A0A0S4KNN2	Bodo saltans	32%	100%
A0A1X0NXP8	Trypanosomatidae	29%	100%
A0A3Q8IG95	Leishmania donovani	100%	100%
A0A3S7WVZ7	Leishmania donovani	29%	100%
A0A422NLI8	Trypanosoma rangeli	32%	100%
A4HYU2	Leishmania infantum	29%	100%
B7ZFT1	Rhizophagus irregularis (strain DAOM 181602 / DAOM 197198 / MUCL 43194)	36%	100%
C9ZIB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
D0A5S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AD58	Leishmania major	94%	100%
E9AIF1	Leishmania braziliensis	29%	100%
E9AIS6	Leishmania braziliensis	72%	100%
E9AUN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AYY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O23417	Arabidopsis thaliana	26%	100%
O36032	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
O81187	Vernicia fordii	33%	100%
P0AC62	Escherichia coli (strain K12)	36%	100%
P0AC63	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	36%	100%
P0AC64	Escherichia coli O157:H7	36%	100%
P10575	Bos taurus	35%	100%
P12309	Sus scrofa	34%	100%
P12864	Oryctolagus cuniculus	38%	100%
P17695	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	76%
P25373	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	98%
P35754	Homo sapiens	40%	100%
P55142	Oryza sativa subsp. japonica	36%	96%
P55143	Ricinus communis	38%	100%
P73492	Synechocystis sp. (strain PCC 6803 / Kazusa)	37%	100%
P74593	Synechocystis sp. (strain PCC 6803 / Kazusa)	34%	99%
Q0DAE4	Oryza sativa subsp. japonica	38%	79%
Q0IRB0	Oryza sativa subsp. japonica	31%	99%
Q19297	Caenorhabditis elegans	40%	74%
Q1RHJ0	Rickettsia bellii (strain RML369-C)	35%	100%
Q2R073	Oryza sativa subsp. japonica	31%	99%
Q2R075	Oryza sativa subsp. japonica	32%	99%
Q32L67	Bos taurus	33%	69%
Q4QCU5	Leishmania major	29%	100%
Q4UKL7	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	35%	100%
Q54GP8	Dictyostelium discoideum	39%	100%
Q5RC53	Pongo abelii	34%	67%
Q68XG4	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	35%	100%
Q6AXW1	Rattus norvegicus	35%	69%
Q6H628	Oryza sativa subsp. japonica	33%	82%
Q6K953	Oryza sativa subsp. japonica	40%	81%
Q8L8T2	Arabidopsis thaliana	37%	86%
Q8L8Z8	Arabidopsis thaliana	26%	100%
Q8LFQ6	Arabidopsis thaliana	37%	80%
Q923X4	Mus musculus	34%	69%
Q92J02	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	36%	100%
Q9ESH6	Rattus norvegicus	38%	100%
Q9FNE2	Arabidopsis thaliana	36%	97%
Q9FVX1	Arabidopsis thaliana	39%	83%
Q9HU55	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	40%	100%
Q9LYC8	Arabidopsis thaliana	33%	100%
Q9QUH0	Mus musculus	37%	100%
Q9SA68	Arabidopsis thaliana	32%	100%
Q9UTI2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	98%
Q9ZDW1	Rickettsia prowazekii (strain Madrid E)	35%	100%
Q9ZR41	Solanum lycopersicum	33%	100%