Leucine-rich repeat protein (LRRP)

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeat - putative

Species:

Leishmania infantum

UniProt:

E9AHF2_LEIIN

TriTrypDb:

LINF_270014200

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

E9AHF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHF2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.566
CLV_NRD_NRD_1	245	247	PF00675	0.563
CLV_NRD_NRD_1	293	295	PF00675	0.543
CLV_NRD_NRD_1	321	323	PF00675	0.476
CLV_NRD_NRD_1	390	392	PF00675	0.485
CLV_NRD_NRD_1	93	95	PF00675	0.583
CLV_PCSK_KEX2_1	245	247	PF00082	0.563
CLV_PCSK_KEX2_1	293	295	PF00082	0.543
CLV_PCSK_KEX2_1	321	323	PF00082	0.476
CLV_PCSK_KEX2_1	390	392	PF00082	0.485
CLV_PCSK_KEX2_1	95	97	PF00082	0.579
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.579
CLV_PCSK_SKI1_1	181	185	PF00082	0.678
CLV_PCSK_SKI1_1	214	218	PF00082	0.497
CLV_PCSK_SKI1_1	245	249	PF00082	0.454
CLV_PCSK_SKI1_1	49	53	PF00082	0.490
DEG_Nend_UBRbox_4	1	3	PF02207	0.422
DOC_CYCLIN_RxL_1	240	251	PF00134	0.465
DOC_CYCLIN_RxL_1	307	318	PF00134	0.449
DOC_MAPK_gen_1	365	374	PF00069	0.427
DOC_MAPK_MEF2A_6	13	21	PF00069	0.414
DOC_USP7_MATH_1	118	122	PF00917	0.558
DOC_USP7_MATH_1	146	150	PF00917	0.703
DOC_USP7_MATH_1	183	187	PF00917	0.559
DOC_WW_Pin1_4	101	106	PF00397	0.662
DOC_WW_Pin1_4	192	197	PF00397	0.470
DOC_WW_Pin1_4	206	211	PF00397	0.602
LIG_14-3-3_CanoR_1	181	189	PF00244	0.588
LIG_14-3-3_CanoR_1	198	208	PF00244	0.408
LIG_14-3-3_CanoR_1	214	219	PF00244	0.569
LIG_14-3-3_CanoR_1	293	297	PF00244	0.544
LIG_14-3-3_CanoR_1	315	321	PF00244	0.432
LIG_14-3-3_CterR_2	390	395	PF00244	0.584
LIG_Actin_WH2_2	10	25	PF00022	0.420
LIG_Actin_WH2_2	305	323	PF00022	0.473
LIG_Actin_WH2_2	33	51	PF00022	0.331
LIG_AP2alpha_1	305	309	PF02296	0.437
LIG_APCC_ABBA_1	274	279	PF00400	0.436
LIG_APCC_ABBA_1	3	8	PF00400	0.388
LIG_Clathr_ClatBox_1	215	219	PF01394	0.471
LIG_Clathr_ClatBox_1	260	264	PF01394	0.457
LIG_FHA_1	118	124	PF00498	0.426
LIG_FHA_1	182	188	PF00498	0.623
LIG_FHA_1	215	221	PF00498	0.419
LIG_FHA_1	278	284	PF00498	0.598
LIG_FHA_1	309	315	PF00498	0.538
LIG_FHA_1	330	336	PF00498	0.411
LIG_GBD_Chelix_1	312	320	PF00786	0.488
LIG_LIR_Apic_2	12	18	PF02991	0.413
LIG_LIR_Gen_1	117	127	PF02991	0.491
LIG_LIR_Gen_1	209	220	PF02991	0.533
LIG_LIR_Nem_3	117	122	PF02991	0.511
LIG_LIR_Nem_3	209	215	PF02991	0.581
LIG_LIR_Nem_3	307	312	PF02991	0.425
LIG_MYND_1	30	34	PF01753	0.386
LIG_NRBOX	243	249	PF00104	0.451
LIG_PCNA_yPIPBox_3	246	260	PF02747	0.318
LIG_Pex14_2	305	309	PF04695	0.437
LIG_Rb_LxCxE_1	217	235	PF01857	0.556
LIG_SH2_CRK	15	19	PF00017	0.402
LIG_SH2_PTP2	212	215	PF00017	0.525
LIG_SH2_STAT5	212	215	PF00017	0.612
LIG_SH2_STAT5	35	38	PF00017	0.425
LIG_SH2_STAT5	359	362	PF00017	0.495
LIG_SH3_3	68	74	PF00018	0.479
LIG_SUMO_SIM_anti_2	153	160	PF11976	0.497
LIG_SUMO_SIM_par_1	214	219	PF11976	0.477
LIG_TYR_ITIM	33	38	PF00017	0.382
LIG_WRC_WIRS_1	385	390	PF05994	0.583
MOD_CDC14_SPxK_1	195	198	PF00782	0.485
MOD_CDK_SPxK_1	192	198	PF00069	0.467
MOD_CK1_1	109	115	PF00069	0.623
MOD_CK1_1	153	159	PF00069	0.567
MOD_CK1_1	265	271	PF00069	0.543
MOD_CK1_1	329	335	PF00069	0.377
MOD_CK2_1	111	117	PF00069	0.680
MOD_CK2_1	142	148	PF00069	0.524
MOD_CK2_1	265	271	PF00069	0.545
MOD_CK2_1	328	334	PF00069	0.475
MOD_CK2_1	374	380	PF00069	0.562
MOD_GlcNHglycan	144	147	PF01048	0.634
MOD_GlcNHglycan	148	151	PF01048	0.663
MOD_GlcNHglycan	152	155	PF01048	0.546
MOD_GlcNHglycan	201	204	PF01048	0.539
MOD_GlcNHglycan	234	237	PF01048	0.484
MOD_GlcNHglycan	264	267	PF01048	0.578
MOD_GlcNHglycan	349	352	PF01048	0.443
MOD_GSK3_1	142	149	PF00069	0.663
MOD_GSK3_1	153	160	PF00069	0.468
MOD_GSK3_1	181	188	PF00069	0.523
MOD_GSK3_1	199	206	PF00069	0.465
MOD_GSK3_1	248	255	PF00069	0.439
MOD_GSK3_1	277	284	PF00069	0.597
MOD_GSK3_1	329	336	PF00069	0.493
MOD_N-GLC_1	142	147	PF02516	0.528
MOD_N-GLC_1	252	257	PF02516	0.542
MOD_NEK2_1	199	204	PF00069	0.590
MOD_NEK2_1	22	27	PF00069	0.415
MOD_NEK2_1	232	237	PF00069	0.499
MOD_NEK2_1	248	253	PF00069	0.284
MOD_NEK2_1	262	267	PF00069	0.493
MOD_NEK2_1	314	319	PF00069	0.543
MOD_NEK2_1	374	379	PF00069	0.586
MOD_NEK2_1	38	43	PF00069	0.545
MOD_NEK2_1	52	57	PF00069	0.472
MOD_NEK2_1	85	90	PF00069	0.519
MOD_NEK2_2	292	297	PF00069	0.603
MOD_PKA_2	22	28	PF00069	0.421
MOD_PKA_2	292	298	PF00069	0.529
MOD_PKA_2	314	320	PF00069	0.490
MOD_Plk_1	109	115	PF00069	0.606
MOD_Plk_1	252	258	PF00069	0.314
MOD_Plk_1	333	339	PF00069	0.544
MOD_Plk_2-3	185	191	PF00069	0.538
MOD_Plk_4	118	124	PF00069	0.466
MOD_Plk_4	126	132	PF00069	0.453
MOD_Plk_4	153	159	PF00069	0.501
MOD_Plk_4	28	34	PF00069	0.408
MOD_Plk_4	334	340	PF00069	0.523
MOD_Plk_4	38	44	PF00069	0.332
MOD_Plk_4	384	390	PF00069	0.588
MOD_ProDKin_1	101	107	PF00069	0.658
MOD_ProDKin_1	192	198	PF00069	0.467
MOD_ProDKin_1	206	212	PF00069	0.594
TRG_DiLeu_BaEn_1	370	375	PF01217	0.592
TRG_DiLeu_BaLyEn_6	228	233	PF01217	0.538
TRG_DiLeu_BaLyEn_6	243	248	PF01217	0.339
TRG_DiLeu_LyEn_5	370	375	PF01217	0.592
TRG_ENDOCYTIC_2	212	215	PF00928	0.628
TRG_ENDOCYTIC_2	35	38	PF00928	0.425
TRG_ER_diArg_1	244	246	PF00400	0.565
TRG_ER_diArg_1	320	322	PF00400	0.478
TRG_ER_diArg_1	389	391	PF00400	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0A7	Leptomonas seymouri	39%	100%
A0A3S7X0J8	Leishmania donovani	100%	100%
A4HFK3	Leishmania braziliensis	69%	100%
E9AD57	Leishmania major	89%	100%
E9AYY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%