Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UBA/TS-N domain containing protein - putative

Species:

Leishmania infantum

UniProt:

E9AHE3_LEIIN

TriTrypDb:

LINF_270013300

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AHE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHE3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0031593	polyubiquitin modification-dependent protein binding	4	1
GO:0140030	modification-dependent protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.572
CLV_C14_Caspase3-7	212	216	PF00656	0.651
CLV_NRD_NRD_1	176	178	PF00675	0.474
CLV_NRD_NRD_1	63	65	PF00675	0.615
CLV_NRD_NRD_1	75	77	PF00675	0.450
CLV_PCSK_KEX2_1	144	146	PF00082	0.471
CLV_PCSK_KEX2_1	175	177	PF00082	0.462
CLV_PCSK_KEX2_1	62	64	PF00082	0.590
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.515
CLV_PCSK_SKI1_1	12	16	PF00082	0.560
CLV_PCSK_SKI1_1	155	159	PF00082	0.562
CLV_PCSK_SKI1_1	164	168	PF00082	0.578
CLV_PCSK_SKI1_1	388	392	PF00082	0.384
CLV_PCSK_SKI1_1	49	53	PF00082	0.557
CLV_PCSK_SKI1_1	63	67	PF00082	0.627
CLV_PCSK_SKI1_1	76	80	PF00082	0.403
CLV_Separin_Metazoa	94	98	PF03568	0.677
DEG_Nend_UBRbox_2	1	3	PF02207	0.528
DEG_SCF_FBW7_1	250	257	PF00400	0.722
DEG_SPOP_SBC_1	311	315	PF00917	0.630
DOC_CKS1_1	251	256	PF01111	0.723
DOC_CKS1_1	333	338	PF01111	0.608
DOC_CYCLIN_RxL_1	158	170	PF00134	0.605
DOC_CYCLIN_RxL_1	60	68	PF00134	0.625
DOC_CYCLIN_RxL_1	72	83	PF00134	0.449
DOC_MAPK_FxFP_2	283	286	PF00069	0.694
DOC_MAPK_gen_1	9	17	PF00069	0.522
DOC_PP2B_LxvP_1	34	37	PF13499	0.563
DOC_PP4_FxxP_1	279	282	PF00568	0.651
DOC_PP4_FxxP_1	283	286	PF00568	0.623
DOC_PP4_MxPP_1	334	337	PF00568	0.514
DOC_USP7_MATH_1	118	122	PF00917	0.568
DOC_USP7_MATH_1	227	231	PF00917	0.661
DOC_USP7_MATH_1	256	260	PF00917	0.689
DOC_USP7_MATH_1	288	292	PF00917	0.682
DOC_USP7_MATH_1	300	304	PF00917	0.596
DOC_USP7_MATH_1	310	314	PF00917	0.606
DOC_USP7_MATH_1	359	363	PF00917	0.709
DOC_USP7_UBL2_3	102	106	PF12436	0.608
DOC_USP7_UBL2_3	111	115	PF12436	0.392
DOC_USP7_UBL2_3	144	148	PF12436	0.570
DOC_WW_Pin1_4	147	152	PF00397	0.581
DOC_WW_Pin1_4	250	255	PF00397	0.712
DOC_WW_Pin1_4	278	283	PF00397	0.704
DOC_WW_Pin1_4	289	294	PF00397	0.674
DOC_WW_Pin1_4	332	337	PF00397	0.641
DOC_WW_Pin1_4	346	351	PF00397	0.642
DOC_WW_Pin1_4	357	362	PF00397	0.666
LIG_14-3-3_CanoR_1	221	229	PF00244	0.713
LIG_14-3-3_CanoR_1	371	379	PF00244	0.415
LIG_14-3-3_CanoR_1	64	74	PF00244	0.661
LIG_BIR_III_4	273	277	PF00653	0.608
LIG_FHA_1	224	230	PF00498	0.737
LIG_FHA_1	296	302	PF00498	0.695
LIG_FHA_1	41	47	PF00498	0.499
LIG_FHA_2	123	129	PF00498	0.519
LIG_FHA_2	20	26	PF00498	0.414
LIG_FHA_2	206	212	PF00498	0.628
LIG_FHA_2	55	61	PF00498	0.571
LIG_LIR_Apic_2	281	286	PF02991	0.689
LIG_LIR_Nem_3	2	6	PF02991	0.491
LIG_LIR_Nem_3	275	280	PF02991	0.611
LIG_LIR_Nem_3	56	61	PF02991	0.440
LIG_NRBOX	162	168	PF00104	0.594
LIG_Pex14_2	279	283	PF04695	0.693
LIG_PTAP_UEV_1	336	341	PF05743	0.690
LIG_PTB_Apo_2	126	133	PF02174	0.516
LIG_SH2_CRK	3	7	PF00017	0.462
LIG_SH2_SRC	3	6	PF00017	0.499
LIG_SH2_STAT3	203	206	PF00017	0.626
LIG_SH2_STAT5	404	407	PF00017	0.514
LIG_SH3_3	334	340	PF00018	0.751
LIG_SH3_3	355	361	PF00018	0.695
LIG_TRAF2_1	101	104	PF00917	0.590
LIG_TRAF2_1	317	320	PF00917	0.718
LIG_UBA3_1	136	144	PF00899	0.552
LIG_UBA3_1	95	102	PF00899	0.581
MOD_CK1_1	332	338	PF00069	0.668
MOD_CK1_1	349	355	PF00069	0.676
MOD_CK1_1	362	368	PF00069	0.566
MOD_CK2_1	205	211	PF00069	0.634
MOD_CK2_1	222	228	PF00069	0.471
MOD_CK2_1	54	60	PF00069	0.564
MOD_CK2_1	98	104	PF00069	0.591
MOD_GlcNHglycan	258	261	PF01048	0.639
MOD_GlcNHglycan	308	311	PF01048	0.700
MOD_GlcNHglycan	314	317	PF01048	0.601
MOD_GlcNHglycan	337	340	PF01048	0.686
MOD_GlcNHglycan	373	376	PF01048	0.480
MOD_GlcNHglycan	91	94	PF01048	0.572
MOD_GSK3_1	118	125	PF00069	0.597
MOD_GSK3_1	223	230	PF00069	0.684
MOD_GSK3_1	250	257	PF00069	0.634
MOD_GSK3_1	306	313	PF00069	0.641
MOD_GSK3_1	335	342	PF00069	0.673
MOD_N-GLC_1	80	85	PF02516	0.590
MOD_NEK2_1	122	127	PF00069	0.503
MOD_NEK2_1	166	171	PF00069	0.483
MOD_NEK2_1	329	334	PF00069	0.690
MOD_NEK2_1	42	47	PF00069	0.536
MOD_NEK2_1	65	70	PF00069	0.659
MOD_PIKK_1	260	266	PF00454	0.671
MOD_PIKK_1	87	93	PF00454	0.656
MOD_PKA_2	223	229	PF00069	0.722
MOD_Plk_1	19	25	PF00069	0.439
MOD_Plk_1	365	371	PF00069	0.453
MOD_Plk_2-3	19	25	PF00069	0.464
MOD_Plk_2-3	205	211	PF00069	0.658
MOD_Plk_2-3	54	60	PF00069	0.538
MOD_Plk_4	118	124	PF00069	0.545
MOD_Plk_4	301	307	PF00069	0.709
MOD_Plk_4	321	327	PF00069	0.536
MOD_Plk_4	329	335	PF00069	0.584
MOD_Plk_4	359	365	PF00069	0.503
MOD_ProDKin_1	147	153	PF00069	0.576
MOD_ProDKin_1	250	256	PF00069	0.719
MOD_ProDKin_1	278	284	PF00069	0.706
MOD_ProDKin_1	289	295	PF00069	0.676
MOD_ProDKin_1	332	338	PF00069	0.648
MOD_ProDKin_1	346	352	PF00069	0.642
MOD_ProDKin_1	357	363	PF00069	0.662
MOD_SUMO_rev_2	101	107	PF00179	0.601
MOD_SUMO_rev_2	19	29	PF00179	0.565
TRG_ENDOCYTIC_2	3	6	PF00928	0.464
TRG_ER_diArg_1	175	177	PF00400	0.532
TRG_ER_diArg_1	61	64	PF00400	0.597
TRG_NES_CRM1_1	320	331	PF08389	0.466
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYN2	Leptomonas seymouri	52%	100%
A0A0S4JV76	Bodo saltans	27%	99%
A0A1X0P4A2	Trypanosomatidae	33%	100%
A0A3R7MIY7	Trypanosoma rangeli	31%	100%
A0A3S7X0H9	Leishmania donovani	100%	100%
A4HFJ5	Leishmania braziliensis	80%	100%
D0A5S0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AD49	Leishmania major	93%	100%
E9AYX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q9NIF3	Dictyostelium discoideum	24%	79%
V5B9I9	Trypanosoma cruzi	33%	100%