Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AHE2_LEIIN

TriTrypDb:

LINF_270013200

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AHE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHE2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	359	363	PF00656	0.460
CLV_NRD_NRD_1	107	109	PF00675	0.561
CLV_NRD_NRD_1	127	129	PF00675	0.651
CLV_NRD_NRD_1	235	237	PF00675	0.555
CLV_NRD_NRD_1	300	302	PF00675	0.466
CLV_NRD_NRD_1	331	333	PF00675	0.384
CLV_NRD_NRD_1	37	39	PF00675	0.459
CLV_NRD_NRD_1	8	10	PF00675	0.421
CLV_PCSK_KEX2_1	107	109	PF00082	0.558
CLV_PCSK_KEX2_1	127	129	PF00082	0.718
CLV_PCSK_KEX2_1	235	237	PF00082	0.557
CLV_PCSK_KEX2_1	247	249	PF00082	0.456
CLV_PCSK_KEX2_1	300	302	PF00082	0.466
CLV_PCSK_KEX2_1	331	333	PF00082	0.384
CLV_PCSK_KEX2_1	36	38	PF00082	0.676
CLV_PCSK_KEX2_1	8	10	PF00082	0.516
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.412
CLV_PCSK_PC7_1	123	129	PF00082	0.600
CLV_PCSK_PC7_1	296	302	PF00082	0.430
CLV_PCSK_SKI1_1	193	197	PF00082	0.423
CLV_PCSK_SKI1_1	316	320	PF00082	0.498
CLV_PCSK_SKI1_1	389	393	PF00082	0.529
CLV_PCSK_SKI1_1	414	418	PF00082	0.457
CLV_PCSK_SKI1_1	8	12	PF00082	0.512
DEG_COP1_1	258	267	PF00400	0.354
DEG_Nend_Nbox_1	1	3	PF02207	0.429
DOC_ANK_TNKS_1	404	411	PF00023	0.417
DOC_CKS1_1	116	121	PF01111	0.533
DOC_CYCLIN_RxL_1	411	422	PF00134	0.395
DOC_MAPK_gen_1	107	116	PF00069	0.663
DOC_MAPK_gen_1	275	282	PF00069	0.394
DOC_MAPK_gen_1	36	47	PF00069	0.468
DOC_MAPK_MEF2A_6	252	261	PF00069	0.459
DOC_MAPK_MEF2A_6	275	282	PF00069	0.423
DOC_MAPK_RevD_3	114	128	PF00069	0.576
DOC_PP1_RVXF_1	234	241	PF00149	0.570
DOC_PP1_RVXF_1	412	419	PF00149	0.356
DOC_PP2B_LxvP_1	261	264	PF13499	0.449
DOC_PP4_FxxP_1	310	313	PF00568	0.564
DOC_USP7_MATH_1	132	136	PF00917	0.642
DOC_USP7_MATH_1	138	142	PF00917	0.630
DOC_USP7_MATH_1	164	168	PF00917	0.647
DOC_USP7_MATH_1	262	266	PF00917	0.474
DOC_USP7_MATH_1	342	346	PF00917	0.463
DOC_USP7_MATH_1	86	90	PF00917	0.679
DOC_WW_Pin1_4	115	120	PF00397	0.689
DOC_WW_Pin1_4	152	157	PF00397	0.594
DOC_WW_Pin1_4	362	367	PF00397	0.537
DOC_WW_Pin1_4	428	433	PF00397	0.445
LIG_14-3-3_CanoR_1	111	117	PF00244	0.438
LIG_14-3-3_CanoR_1	214	218	PF00244	0.643
LIG_14-3-3_CanoR_1	235	239	PF00244	0.425
LIG_14-3-3_CanoR_1	305	309	PF00244	0.576
LIG_14-3-3_CanoR_1	40	46	PF00244	0.648
LIG_14-3-3_CanoR_1	92	98	PF00244	0.630
LIG_BRCT_BRCA1_1	306	310	PF00533	0.463
LIG_BRCT_BRCA1_1	93	97	PF00533	0.484
LIG_CaM_NSCaTE_8	143	150	PF13499	0.405
LIG_deltaCOP1_diTrp_1	239	244	PF00928	0.453
LIG_deltaCOP1_diTrp_1	434	442	PF00928	0.452
LIG_FHA_1	194	200	PF00498	0.560
LIG_FHA_1	23	29	PF00498	0.429
LIG_FHA_1	411	417	PF00498	0.374
LIG_FHA_1	419	425	PF00498	0.279
LIG_FHA_1	428	434	PF00498	0.328
LIG_FHA_1	468	474	PF00498	0.586
LIG_FHA_2	132	138	PF00498	0.605
LIG_FHA_2	206	212	PF00498	0.574
LIG_FHA_2	286	292	PF00498	0.574
LIG_FHA_2	373	379	PF00498	0.555
LIG_FHA_2	450	456	PF00498	0.521
LIG_LIR_Apic_2	307	313	PF02991	0.574
LIG_LIR_Gen_1	118	126	PF02991	0.584
LIG_LIR_Gen_1	141	152	PF02991	0.502
LIG_LIR_Gen_1	73	84	PF02991	0.499
LIG_LIR_Nem_3	118	124	PF02991	0.578
LIG_LIR_Nem_3	141	147	PF02991	0.394
LIG_LIR_Nem_3	237	243	PF02991	0.467
LIG_LIR_Nem_3	434	439	PF02991	0.403
LIG_LIR_Nem_3	470	474	PF02991	0.421
LIG_LIR_Nem_3	5	10	PF02991	0.407
LIG_LIR_Nem_3	73	79	PF02991	0.453
LIG_NRBOX	415	421	PF00104	0.425
LIG_Pex14_1	144	148	PF04695	0.428
LIG_SH2_STAP1	148	152	PF00017	0.622
LIG_SH2_STAT5	186	189	PF00017	0.436
LIG_SH2_STAT5	233	236	PF00017	0.557
LIG_SH2_STAT5	441	444	PF00017	0.573
LIG_SH3_2	161	166	PF14604	0.637
LIG_SH3_3	113	119	PF00018	0.645
LIG_SH3_3	155	161	PF00018	0.645
LIG_SH3_3	195	201	PF00018	0.431
LIG_SH3_3	207	213	PF00018	0.522
LIG_SH3_3	235	241	PF00018	0.481
LIG_SH3_3	403	409	PF00018	0.537
LIG_SUMO_SIM_anti_2	24	30	PF11976	0.437
LIG_SUMO_SIM_par_1	255	260	PF11976	0.391
LIG_TRAF2_1	375	378	PF00917	0.523
LIG_WRC_WIRS_1	32	37	PF05994	0.446
LIG_WRC_WIRS_1	415	420	PF05994	0.372
MOD_CK1_1	14	20	PF00069	0.435
MOD_CK1_1	365	371	PF00069	0.432
MOD_CK1_1	399	405	PF00069	0.612
MOD_CK1_1	78	84	PF00069	0.623
MOD_CK2_1	131	137	PF00069	0.463
MOD_CK2_1	205	211	PF00069	0.573
MOD_CK2_1	372	378	PF00069	0.558
MOD_CK2_1	428	434	PF00069	0.454
MOD_CK2_1	449	455	PF00069	0.522
MOD_CK2_1	478	484	PF00069	0.599
MOD_GlcNHglycan	13	16	PF01048	0.432
MOD_GlcNHglycan	134	137	PF01048	0.675
MOD_GlcNHglycan	220	223	PF01048	0.642
MOD_GlcNHglycan	264	267	PF01048	0.470
MOD_GlcNHglycan	344	347	PF01048	0.400
MOD_GlcNHglycan	70	73	PF01048	0.433
MOD_GlcNHglycan	81	84	PF01048	0.538
MOD_GSK3_1	164	171	PF00069	0.625
MOD_GSK3_1	304	311	PF00069	0.525
MOD_GSK3_1	410	417	PF00069	0.406
MOD_GSK3_1	487	494	PF00069	0.595
MOD_GSK3_1	70	77	PF00069	0.426
MOD_GSK3_1	78	85	PF00069	0.510
MOD_N-GLC_1	41	46	PF02516	0.741
MOD_NEK2_1	11	16	PF00069	0.546
MOD_NEK2_1	2	7	PF00069	0.478
MOD_NEK2_1	257	262	PF00069	0.395
MOD_NEK2_1	278	283	PF00069	0.412
MOD_NEK2_1	304	309	PF00069	0.496
MOD_NEK2_1	347	352	PF00069	0.377
MOD_NEK2_1	355	360	PF00069	0.479
MOD_NEK2_1	383	388	PF00069	0.544
MOD_NEK2_1	418	423	PF00069	0.330
MOD_NEK2_1	427	432	PF00069	0.396
MOD_NEK2_1	457	462	PF00069	0.460
MOD_NEK2_1	489	494	PF00069	0.674
MOD_NEK2_1	75	80	PF00069	0.504
MOD_PIKK_1	193	199	PF00454	0.443
MOD_PIKK_1	365	371	PF00454	0.432
MOD_PIKK_1	383	389	PF00454	0.414
MOD_PIKK_1	487	493	PF00454	0.687
MOD_PKA_2	213	219	PF00069	0.579
MOD_PKA_2	234	240	PF00069	0.422
MOD_PKA_2	304	310	PF00069	0.525
MOD_PKA_2	91	97	PF00069	0.566
MOD_PKB_1	36	44	PF00069	0.462
MOD_Plk_1	193	199	PF00069	0.497
MOD_Plk_1	2	8	PF00069	0.405
MOD_Plk_1	257	263	PF00069	0.365
MOD_Plk_1	285	291	PF00069	0.546
MOD_Plk_1	356	362	PF00069	0.519
MOD_Plk_1	41	47	PF00069	0.681
MOD_Plk_2-3	449	455	PF00069	0.522
MOD_Plk_4	139	145	PF00069	0.623
MOD_Plk_4	22	28	PF00069	0.430
MOD_Plk_4	239	245	PF00069	0.455
MOD_Plk_4	414	420	PF00069	0.368
MOD_Plk_4	473	479	PF00069	0.432
MOD_Plk_4	70	76	PF00069	0.433
MOD_ProDKin_1	115	121	PF00069	0.684
MOD_ProDKin_1	152	158	PF00069	0.605
MOD_ProDKin_1	362	368	PF00069	0.531
MOD_ProDKin_1	428	434	PF00069	0.454
TRG_DiLeu_BaEn_1	411	416	PF01217	0.314
TRG_DiLeu_BaEn_4	484	490	PF01217	0.508
TRG_ER_diArg_1	330	332	PF00400	0.522
TRG_ER_diArg_1	35	38	PF00400	0.516
TRG_ER_diArg_1	45	48	PF00400	0.649
TRG_ER_diArg_1	7	9	PF00400	0.428
TRG_NES_CRM1_1	182	194	PF08389	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU3	Leptomonas seymouri	38%	100%
A0A0S4JRJ3	Bodo saltans	25%	100%
A0A3Q8IPT0	Leishmania donovani	99%	100%
A0A3R7KFH1	Trypanosoma rangeli	28%	100%
E9AD48	Leishmania major	89%	100%
E9AYX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BIJ6	Trypanosoma cruzi	27%	100%