LeishMANIAdb
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RRM domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
RRM domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AHE1_LEIIN
TriTrypDb:
LINF_270013100
Length:
453

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

E9AHE1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHE1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 326 330 PF00656 0.405
CLV_NRD_NRD_1 160 162 PF00675 0.612
CLV_NRD_NRD_1 368 370 PF00675 0.616
CLV_NRD_NRD_1 385 387 PF00675 0.590
CLV_NRD_NRD_1 422 424 PF00675 0.653
CLV_PCSK_KEX2_1 160 162 PF00082 0.612
CLV_PCSK_KEX2_1 310 312 PF00082 0.392
CLV_PCSK_KEX2_1 368 370 PF00082 0.616
CLV_PCSK_KEX2_1 373 375 PF00082 0.605
CLV_PCSK_KEX2_1 385 387 PF00082 0.628
CLV_PCSK_KEX2_1 421 423 PF00082 0.649
CLV_PCSK_PC1ET2_1 310 312 PF00082 0.392
CLV_PCSK_PC1ET2_1 373 375 PF00082 0.583
CLV_PCSK_PC7_1 306 312 PF00082 0.398
CLV_PCSK_PC7_1 369 375 PF00082 0.534
CLV_PCSK_SKI1_1 17 21 PF00082 0.698
CLV_PCSK_SKI1_1 201 205 PF00082 0.438
CLV_PCSK_SKI1_1 310 314 PF00082 0.332
DEG_Nend_UBRbox_3 1 3 PF02207 0.741
DEG_SCF_FBW7_1 105 112 PF00400 0.547
DEG_SCF_FBW7_1 140 146 PF00400 0.725
DEG_SCF_FBW7_1 25 31 PF00400 0.607
DOC_CKS1_1 106 111 PF01111 0.534
DOC_CKS1_1 140 145 PF01111 0.625
DOC_CKS1_1 25 30 PF01111 0.615
DOC_CYCLIN_RxL_1 306 315 PF00134 0.386
DOC_MAPK_gen_1 204 212 PF00069 0.415
DOC_MAPK_gen_1 347 355 PF00069 0.424
DOC_PP1_RVXF_1 206 213 PF00149 0.350
DOC_PP1_RVXF_1 308 315 PF00149 0.376
DOC_PP2B_LxvP_1 337 340 PF13499 0.491
DOC_PP4_FxxP_1 192 195 PF00568 0.464
DOC_PP4_FxxP_1 44 47 PF00568 0.628
DOC_USP7_MATH_1 109 113 PF00917 0.652
DOC_USP7_MATH_1 118 122 PF00917 0.584
DOC_USP7_MATH_1 147 151 PF00917 0.645
DOC_USP7_MATH_1 156 160 PF00917 0.525
DOC_USP7_MATH_1 279 283 PF00917 0.403
DOC_USP7_MATH_1 349 353 PF00917 0.425
DOC_USP7_MATH_1 362 366 PF00917 0.552
DOC_USP7_MATH_1 394 398 PF00917 0.720
DOC_WW_Pin1_4 101 106 PF00397 0.625
DOC_WW_Pin1_4 133 138 PF00397 0.612
DOC_WW_Pin1_4 139 144 PF00397 0.625
DOC_WW_Pin1_4 24 29 PF00397 0.621
DOC_WW_Pin1_4 37 42 PF00397 0.470
DOC_WW_Pin1_4 48 53 PF00397 0.516
DOC_WW_Pin1_4 87 92 PF00397 0.615
LIG_14-3-3_CanoR_1 17 25 PF00244 0.608
LIG_14-3-3_CanoR_1 374 381 PF00244 0.618
LIG_14-3-3_CanoR_1 390 399 PF00244 0.456
LIG_Clathr_ClatBox_1 84 88 PF01394 0.732
LIG_EVH1_2 442 446 PF00568 0.611
LIG_FHA_1 189 195 PF00498 0.554
LIG_FHA_1 37 43 PF00498 0.588
LIG_FHA_2 263 269 PF00498 0.389
LIG_FHA_2 322 328 PF00498 0.406
LIG_FHA_2 428 434 PF00498 0.657
LIG_FHA_2 81 87 PF00498 0.637
LIG_GSK3_LRP6_1 37 42 PF00069 0.639
LIG_IBAR_NPY_1 125 127 PF08397 0.596
LIG_LIR_Apic_2 104 109 PF02991 0.613
LIG_LIR_Apic_2 189 195 PF02991 0.501
LIG_LIR_Apic_2 62 67 PF02991 0.590
LIG_LIR_Gen_1 333 342 PF02991 0.532
LIG_LIR_Nem_3 333 337 PF02991 0.523
LIG_SH2_CRK 106 110 PF00017 0.727
LIG_SH2_CRK 72 76 PF00017 0.607
LIG_SH2_PTP2 334 337 PF00017 0.519
LIG_SH2_SRC 431 434 PF00017 0.734
LIG_SH2_STAP1 127 131 PF00017 0.610
LIG_SH2_STAP1 431 435 PF00017 0.732
LIG_SH2_STAT3 32 35 PF00017 0.616
LIG_SH2_STAT3 441 444 PF00017 0.615
LIG_SH2_STAT3 8 11 PF00017 0.641
LIG_SH2_STAT5 127 130 PF00017 0.631
LIG_SH2_STAT5 209 212 PF00017 0.339
LIG_SH2_STAT5 292 295 PF00017 0.364
LIG_SH2_STAT5 334 337 PF00017 0.417
LIG_SH3_3 137 143 PF00018 0.547
LIG_SH3_3 214 220 PF00018 0.478
LIG_SH3_3 35 41 PF00018 0.603
LIG_SH3_3 433 439 PF00018 0.612
LIG_SUMO_SIM_anti_2 301 307 PF11976 0.397
LIG_SUMO_SIM_par_1 83 90 PF11976 0.630
LIG_TRAF2_1 430 433 PF00917 0.732
LIG_TRAF2_2 52 57 PF00917 0.632
LIG_TRFH_1 192 196 PF08558 0.447
MOD_CDC14_SPxK_1 90 93 PF00782 0.719
MOD_CDK_SPxK_1 87 93 PF00069 0.719
MOD_CK1_1 132 138 PF00069 0.612
MOD_CK1_1 141 147 PF00069 0.623
MOD_CK1_1 237 243 PF00069 0.729
MOD_CK1_1 24 30 PF00069 0.667
MOD_CK1_1 246 252 PF00069 0.461
MOD_CK1_1 377 383 PF00069 0.643
MOD_CK1_1 4 10 PF00069 0.678
MOD_CK1_1 62 68 PF00069 0.612
MOD_CK2_1 262 268 PF00069 0.397
MOD_CK2_1 279 285 PF00069 0.401
MOD_CK2_1 321 327 PF00069 0.404
MOD_CK2_1 427 433 PF00069 0.736
MOD_CK2_1 442 448 PF00069 0.442
MOD_CK2_1 80 86 PF00069 0.640
MOD_Cter_Amidation 366 369 PF01082 0.704
MOD_GlcNHglycan 119 123 PF01048 0.643
MOD_GlcNHglycan 131 134 PF01048 0.389
MOD_GlcNHglycan 149 152 PF01048 0.644
MOD_GlcNHglycan 153 157 PF01048 0.597
MOD_GlcNHglycan 164 167 PF01048 0.493
MOD_GlcNHglycan 242 245 PF01048 0.624
MOD_GlcNHglycan 364 367 PF01048 0.645
MOD_GlcNHglycan 381 384 PF01048 0.616
MOD_GlcNHglycan 392 395 PF01048 0.579
MOD_GlcNHglycan 396 399 PF01048 0.467
MOD_GlcNHglycan 406 409 PF01048 0.575
MOD_GlcNHglycan 432 436 PF01048 0.628
MOD_GlcNHglycan 48 51 PF01048 0.661
MOD_GlcNHglycan 59 62 PF01048 0.504
MOD_GSK3_1 105 112 PF00069 0.553
MOD_GSK3_1 125 132 PF00069 0.693
MOD_GSK3_1 139 146 PF00069 0.633
MOD_GSK3_1 147 154 PF00069 0.611
MOD_GSK3_1 17 24 PF00069 0.529
MOD_GSK3_1 233 240 PF00069 0.672
MOD_GSK3_1 243 250 PF00069 0.502
MOD_GSK3_1 279 286 PF00069 0.382
MOD_GSK3_1 300 307 PF00069 0.358
MOD_GSK3_1 390 397 PF00069 0.726
MOD_GSK3_1 400 407 PF00069 0.404
MOD_GSK3_1 427 434 PF00069 0.736
MOD_GSK3_1 95 102 PF00069 0.591
MOD_N-GLC_1 232 237 PF02516 0.725
MOD_N-GLC_1 4 9 PF02516 0.694
MOD_NEK2_1 1 6 PF00069 0.638
MOD_NEK2_1 129 134 PF00069 0.581
MOD_NEK2_1 152 157 PF00069 0.553
MOD_NEK2_1 162 167 PF00069 0.593
MOD_NEK2_1 188 193 PF00069 0.615
MOD_NEK2_1 262 267 PF00069 0.424
MOD_NEK2_1 304 309 PF00069 0.345
MOD_NEK2_1 402 407 PF00069 0.659
MOD_NEK2_1 59 64 PF00069 0.692
MOD_PIKK_1 30 36 PF00454 0.621
MOD_PIKK_1 400 406 PF00454 0.701
MOD_PKA_2 349 355 PF00069 0.419
MOD_PKB_1 15 23 PF00069 0.611
MOD_Plk_1 188 194 PF00069 0.536
MOD_Plk_1 247 253 PF00069 0.543
MOD_Plk_1 300 306 PF00069 0.397
MOD_Plk_1 377 383 PF00069 0.643
MOD_Plk_1 4 10 PF00069 0.640
MOD_Plk_4 300 306 PF00069 0.363
MOD_Plk_4 349 355 PF00069 0.419
MOD_Plk_4 59 65 PF00069 0.638
MOD_ProDKin_1 101 107 PF00069 0.626
MOD_ProDKin_1 133 139 PF00069 0.615
MOD_ProDKin_1 143 149 PF00069 0.624
MOD_ProDKin_1 24 30 PF00069 0.624
MOD_ProDKin_1 37 43 PF00069 0.471
MOD_ProDKin_1 48 54 PF00069 0.517
MOD_ProDKin_1 87 93 PF00069 0.617
MOD_SUMO_rev_2 351 360 PF00179 0.447
TRG_DiLeu_BaEn_1 268 273 PF01217 0.371
TRG_DiLeu_BaLyEn_6 337 342 PF01217 0.543
TRG_ENDOCYTIC_2 209 212 PF00928 0.339
TRG_ENDOCYTIC_2 334 337 PF00928 0.519
TRG_ER_diArg_1 14 17 PF00400 0.619
TRG_ER_diArg_1 160 162 PF00400 0.608
TRG_ER_diArg_1 206 209 PF00400 0.404
TRG_ER_diArg_1 421 423 PF00400 0.553
TRG_Pf-PMV_PEXEL_1 17 21 PF00026 0.611
TRG_Pf-PMV_PEXEL_1 201 205 PF00026 0.438
TRG_Pf-PMV_PEXEL_1 311 315 PF00026 0.364
TRG_Pf-PMV_PEXEL_1 82 86 PF00026 0.668

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5L6 Leptomonas seymouri 57% 100%
A0A3S7X0I2 Leishmania donovani 99% 100%
A4HFJ4 Leishmania braziliensis 72% 100%
E9AD47 Leishmania major 93% 100%
E9AYX1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS