LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AHE0_LEIIN
TriTrypDb:
LINF_270013000
Length:
917

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005929 cilium 4 7
GO:0042995 cell projection 2 7
GO:0043226 organelle 2 7
GO:0043227 membrane-bounded organelle 3 7
GO:0110165 cellular anatomical entity 1 7
GO:0120025 plasma membrane bounded cell projection 3 7

Expansion

Sequence features

E9AHE0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHE0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 629 633 PF00656 0.461
CLV_C14_Caspase3-7 863 867 PF00656 0.727
CLV_NRD_NRD_1 16 18 PF00675 0.657
CLV_NRD_NRD_1 186 188 PF00675 0.494
CLV_NRD_NRD_1 361 363 PF00675 0.668
CLV_NRD_NRD_1 517 519 PF00675 0.694
CLV_NRD_NRD_1 537 539 PF00675 0.481
CLV_PCSK_KEX2_1 16 18 PF00082 0.657
CLV_PCSK_KEX2_1 186 188 PF00082 0.463
CLV_PCSK_KEX2_1 361 363 PF00082 0.668
CLV_PCSK_KEX2_1 517 519 PF00082 0.694
CLV_PCSK_SKI1_1 231 235 PF00082 0.548
CLV_PCSK_SKI1_1 286 290 PF00082 0.539
CLV_PCSK_SKI1_1 450 454 PF00082 0.630
CLV_PCSK_SKI1_1 461 465 PF00082 0.633
CLV_PCSK_SKI1_1 651 655 PF00082 0.541
CLV_PCSK_SKI1_1 668 672 PF00082 0.325
CLV_PCSK_SKI1_1 734 738 PF00082 0.486
CLV_PCSK_SKI1_1 740 744 PF00082 0.448
CLV_PCSK_SKI1_1 839 843 PF00082 0.441
CLV_PCSK_SKI1_1 904 908 PF00082 0.480
CLV_Separin_Metazoa 287 291 PF03568 0.312
DEG_APCC_DBOX_1 230 238 PF00400 0.377
DEG_Nend_UBRbox_3 1 3 PF02207 0.430
DEG_SCF_FBW7_1 265 272 PF00400 0.369
DEG_SPOP_SBC_1 316 320 PF00917 0.475
DEG_SPOP_SBC_1 65 69 PF00917 0.370
DOC_ANK_TNKS_1 301 308 PF00023 0.412
DOC_CDC14_PxL_1 751 759 PF14671 0.667
DOC_CKS1_1 266 271 PF01111 0.362
DOC_CYCLIN_yCln2_LP_2 674 680 PF00134 0.347
DOC_MAPK_DCC_7 551 561 PF00069 0.390
DOC_MAPK_MEF2A_6 588 597 PF00069 0.327
DOC_PP1_RVXF_1 666 672 PF00149 0.325
DOC_PP2B_LxvP_1 485 488 PF13499 0.405
DOC_PP2B_LxvP_1 674 677 PF13499 0.347
DOC_PP2B_LxvP_1 752 755 PF13499 0.651
DOC_PP4_FxxP_1 214 217 PF00568 0.434
DOC_USP7_MATH_1 108 112 PF00917 0.510
DOC_USP7_MATH_1 12 16 PF00917 0.456
DOC_USP7_MATH_1 185 189 PF00917 0.600
DOC_USP7_MATH_1 220 224 PF00917 0.390
DOC_USP7_MATH_1 310 314 PF00917 0.491
DOC_USP7_MATH_1 380 384 PF00917 0.470
DOC_USP7_MATH_1 45 49 PF00917 0.503
DOC_USP7_MATH_1 452 456 PF00917 0.421
DOC_USP7_MATH_1 479 483 PF00917 0.455
DOC_USP7_MATH_1 569 573 PF00917 0.386
DOC_USP7_MATH_1 65 69 PF00917 0.324
DOC_USP7_MATH_1 736 740 PF00917 0.685
DOC_USP7_MATH_1 850 854 PF00917 0.654
DOC_WW_Pin1_4 120 125 PF00397 0.403
DOC_WW_Pin1_4 265 270 PF00397 0.378
DOC_WW_Pin1_4 318 323 PF00397 0.451
DOC_WW_Pin1_4 398 403 PF00397 0.476
DOC_WW_Pin1_4 554 559 PF00397 0.349
DOC_WW_Pin1_4 686 691 PF00397 0.697
LIG_14-3-3_CanoR_1 156 164 PF00244 0.651
LIG_14-3-3_CanoR_1 186 194 PF00244 0.612
LIG_14-3-3_CanoR_1 344 353 PF00244 0.475
LIG_14-3-3_CanoR_1 378 388 PF00244 0.564
LIG_14-3-3_CanoR_1 562 568 PF00244 0.403
LIG_14-3-3_CanoR_1 646 651 PF00244 0.368
LIG_14-3-3_CanoR_1 688 697 PF00244 0.625
LIG_14-3-3_CanoR_1 768 777 PF00244 0.702
LIG_14-3-3_CanoR_1 801 805 PF00244 0.620
LIG_14-3-3_CanoR_1 845 854 PF00244 0.611
LIG_14-3-3_CanoR_1 96 101 PF00244 0.438
LIG_APCC_ABBA_1 650 655 PF00400 0.335
LIG_BIR_III_4 219 223 PF00653 0.455
LIG_BRCT_BRCA1_1 68 72 PF00533 0.332
LIG_Clathr_ClatBox_1 339 343 PF01394 0.353
LIG_Clathr_ClatBox_1 793 797 PF01394 0.687
LIG_eIF4E_1 675 681 PF01652 0.369
LIG_FHA_1 136 142 PF00498 0.369
LIG_FHA_1 202 208 PF00498 0.304
LIG_FHA_1 266 272 PF00498 0.343
LIG_FHA_1 324 330 PF00498 0.415
LIG_FHA_1 355 361 PF00498 0.444
LIG_FHA_1 366 372 PF00498 0.479
LIG_FHA_1 387 393 PF00498 0.479
LIG_FHA_1 494 500 PF00498 0.405
LIG_FHA_1 647 653 PF00498 0.441
LIG_FHA_1 65 71 PF00498 0.391
LIG_FHA_1 655 661 PF00498 0.364
LIG_FHA_1 771 777 PF00498 0.792
LIG_FHA_1 788 794 PF00498 0.674
LIG_FHA_1 824 830 PF00498 0.663
LIG_FHA_1 906 912 PF00498 0.657
LIG_FHA_2 124 130 PF00498 0.370
LIG_FHA_2 213 219 PF00498 0.360
LIG_FHA_2 280 286 PF00498 0.363
LIG_FHA_2 309 315 PF00498 0.486
LIG_FHA_2 318 324 PF00498 0.450
LIG_FHA_2 526 532 PF00498 0.386
LIG_FHA_2 587 593 PF00498 0.392
LIG_FHA_2 861 867 PF00498 0.697
LIG_FHA_2 890 896 PF00498 0.640
LIG_LIR_Apic_2 131 137 PF02991 0.304
LIG_LIR_Apic_2 213 217 PF02991 0.430
LIG_LIR_Apic_2 575 581 PF02991 0.376
LIG_LIR_Gen_1 587 597 PF02991 0.446
LIG_LIR_Gen_1 69 79 PF02991 0.316
LIG_LIR_Gen_1 692 702 PF02991 0.747
LIG_LIR_Gen_1 894 903 PF02991 0.624
LIG_LIR_Nem_3 413 419 PF02991 0.586
LIG_LIR_Nem_3 531 537 PF02991 0.367
LIG_LIR_Nem_3 542 548 PF02991 0.361
LIG_LIR_Nem_3 587 593 PF02991 0.427
LIG_LIR_Nem_3 621 626 PF02991 0.504
LIG_LIR_Nem_3 69 75 PF02991 0.318
LIG_LIR_Nem_3 692 697 PF02991 0.748
LIG_LIR_Nem_3 894 899 PF02991 0.620
LIG_NRBOX 142 148 PF00104 0.325
LIG_OCRL_FandH_1 736 748 PF00620 0.687
LIG_PAM2_1 172 184 PF00658 0.636
LIG_PCNA_yPIPBox_3 224 234 PF02747 0.375
LIG_Pex14_1 663 667 PF04695 0.369
LIG_Pex14_2 667 671 PF04695 0.369
LIG_PTB_Apo_2 890 897 PF02174 0.624
LIG_SH2_CRK 678 682 PF00017 0.509
LIG_SH2_CRK 888 892 PF00017 0.651
LIG_SH2_NCK_1 888 892 PF00017 0.697
LIG_SH2_PTP2 134 137 PF00017 0.284
LIG_SH2_SRC 568 571 PF00017 0.416
LIG_SH2_SRC 673 676 PF00017 0.347
LIG_SH2_STAT3 547 550 PF00017 0.403
LIG_SH2_STAT5 134 137 PF00017 0.291
LIG_SH2_STAT5 416 419 PF00017 0.463
LIG_SH2_STAT5 421 424 PF00017 0.453
LIG_SH2_STAT5 547 550 PF00017 0.357
LIG_SH2_STAT5 578 581 PF00017 0.303
LIG_SH2_STAT5 673 676 PF00017 0.354
LIG_SH2_STAT5 74 77 PF00017 0.293
LIG_SH3_3 173 179 PF00018 0.639
LIG_SH3_3 430 436 PF00018 0.473
LIG_SH3_3 465 471 PF00018 0.450
LIG_SH3_3 507 513 PF00018 0.394
LIG_SUMO_SIM_anti_2 784 790 PF11976 0.736
LIG_SUMO_SIM_par_1 138 145 PF11976 0.355
LIG_SUMO_SIM_par_1 244 249 PF11976 0.327
LIG_SUMO_SIM_par_1 272 279 PF11976 0.347
LIG_SUMO_SIM_par_1 580 587 PF11976 0.323
LIG_SUMO_SIM_par_1 741 747 PF11976 0.647
LIG_SUMO_SIM_par_1 792 797 PF11976 0.651
LIG_TRAF2_1 529 532 PF00917 0.364
LIG_TRAF2_1 583 586 PF00917 0.375
LIG_TRAF2_1 892 895 PF00917 0.636
LIG_UBA3_1 616 625 PF00899 0.405
MOD_CK1_1 123 129 PF00069 0.404
MOD_CK1_1 270 276 PF00069 0.325
MOD_CK1_1 317 323 PF00069 0.456
MOD_CK1_1 366 372 PF00069 0.484
MOD_CK1_1 379 385 PF00069 0.476
MOD_CK1_1 386 392 PF00069 0.446
MOD_CK1_1 398 404 PF00069 0.514
MOD_CK1_1 423 429 PF00069 0.492
MOD_CK1_1 48 54 PF00069 0.507
MOD_CK1_1 628 634 PF00069 0.461
MOD_CK1_1 712 718 PF00069 0.674
MOD_CK1_1 784 790 PF00069 0.690
MOD_CK1_1 855 861 PF00069 0.680
MOD_CK1_1 889 895 PF00069 0.650
MOD_CK2_1 106 112 PF00069 0.484
MOD_CK2_1 186 192 PF00069 0.594
MOD_CK2_1 229 235 PF00069 0.296
MOD_CK2_1 279 285 PF00069 0.369
MOD_CK2_1 317 323 PF00069 0.458
MOD_CK2_1 32 38 PF00069 0.525
MOD_CK2_1 366 372 PF00069 0.502
MOD_CK2_1 525 531 PF00069 0.390
MOD_CK2_1 580 586 PF00069 0.385
MOD_CK2_1 889 895 PF00069 0.650
MOD_GlcNHglycan 247 251 PF01048 0.525
MOD_GlcNHglycan 346 349 PF01048 0.567
MOD_GlcNHglycan 372 376 PF01048 0.723
MOD_GlcNHglycan 378 381 PF01048 0.682
MOD_GlcNHglycan 403 406 PF01048 0.748
MOD_GlcNHglycan 424 428 PF01048 0.655
MOD_GlcNHglycan 441 444 PF01048 0.559
MOD_GlcNHglycan 488 491 PF01048 0.688
MOD_GlcNHglycan 50 53 PF01048 0.796
MOD_GlcNHglycan 519 522 PF01048 0.666
MOD_GlcNHglycan 58 61 PF01048 0.668
MOD_GlcNHglycan 628 631 PF01048 0.659
MOD_GlcNHglycan 632 636 PF01048 0.689
MOD_GlcNHglycan 691 694 PF01048 0.416
MOD_GlcNHglycan 718 721 PF01048 0.481
MOD_GlcNHglycan 725 728 PF01048 0.469
MOD_GlcNHglycan 783 786 PF01048 0.473
MOD_GlcNHglycan 848 851 PF01048 0.448
MOD_GlcNHglycan 854 857 PF01048 0.468
MOD_GlcNHglycan 888 891 PF01048 0.458
MOD_GSK3_1 12 19 PF00069 0.451
MOD_GSK3_1 265 272 PF00069 0.373
MOD_GSK3_1 310 317 PF00069 0.488
MOD_GSK3_1 362 369 PF00069 0.492
MOD_GSK3_1 376 383 PF00069 0.476
MOD_GSK3_1 386 393 PF00069 0.460
MOD_GSK3_1 394 401 PF00069 0.472
MOD_GSK3_1 415 422 PF00069 0.487
MOD_GSK3_1 439 446 PF00069 0.503
MOD_GSK3_1 46 53 PF00069 0.535
MOD_GSK3_1 522 529 PF00069 0.422
MOD_GSK3_1 550 557 PF00069 0.349
MOD_GSK3_1 569 576 PF00069 0.341
MOD_GSK3_1 580 587 PF00069 0.314
MOD_GSK3_1 712 719 PF00069 0.661
MOD_GSK3_1 73 80 PF00069 0.311
MOD_GSK3_1 766 773 PF00069 0.744
MOD_GSK3_1 846 853 PF00069 0.707
MOD_GSK3_1 860 867 PF00069 0.629
MOD_N-GLC_1 554 559 PF02516 0.549
MOD_NEK2_1 212 217 PF00069 0.396
MOD_NEK2_1 246 251 PF00069 0.323
MOD_NEK2_1 276 281 PF00069 0.362
MOD_NEK2_1 353 358 PF00069 0.404
MOD_NEK2_1 376 381 PF00069 0.527
MOD_NEK2_1 395 400 PF00069 0.487
MOD_NEK2_1 454 459 PF00069 0.410
MOD_NEK2_1 498 503 PF00069 0.378
MOD_NEK2_1 584 589 PF00069 0.399
MOD_NEK2_1 644 649 PF00069 0.404
MOD_NEK2_1 709 714 PF00069 0.652
MOD_NEK2_1 77 82 PF00069 0.317
MOD_NEK2_1 800 805 PF00069 0.631
MOD_PIKK_1 156 162 PF00454 0.711
MOD_PIKK_1 390 396 PF00454 0.503
MOD_PIKK_1 787 793 PF00454 0.704
MOD_PK_1 96 102 PF00069 0.445
MOD_PKA_1 16 22 PF00069 0.456
MOD_PKA_1 186 192 PF00069 0.625
MOD_PKA_1 517 523 PF00069 0.492
MOD_PKA_2 16 22 PF00069 0.487
MOD_PKA_2 185 191 PF00069 0.629
MOD_PKA_2 301 307 PF00069 0.375
MOD_PKA_2 380 386 PF00069 0.616
MOD_PKA_2 517 523 PF00069 0.492
MOD_PKA_2 645 651 PF00069 0.377
MOD_PKA_2 800 806 PF00069 0.644
MOD_PKA_2 886 892 PF00069 0.755
MOD_PKA_2 95 101 PF00069 0.423
MOD_Plk_1 128 134 PF00069 0.288
MOD_Plk_1 212 218 PF00069 0.412
MOD_Plk_1 276 282 PF00069 0.363
MOD_Plk_1 371 377 PF00069 0.522
MOD_Plk_1 522 528 PF00069 0.420
MOD_Plk_1 894 900 PF00069 0.633
MOD_Plk_2-3 32 38 PF00069 0.497
MOD_Plk_2-3 586 592 PF00069 0.364
MOD_Plk_4 135 141 PF00069 0.374
MOD_Plk_4 172 178 PF00069 0.631
MOD_Plk_4 194 200 PF00069 0.469
MOD_Plk_4 270 276 PF00069 0.323
MOD_Plk_4 522 528 PF00069 0.416
MOD_Plk_4 563 569 PF00069 0.401
MOD_Plk_4 573 579 PF00069 0.327
MOD_Plk_4 618 624 PF00069 0.393
MOD_Plk_4 639 645 PF00069 0.589
MOD_Plk_4 66 72 PF00069 0.361
MOD_Plk_4 784 790 PF00069 0.694
MOD_ProDKin_1 120 126 PF00069 0.403
MOD_ProDKin_1 265 271 PF00069 0.373
MOD_ProDKin_1 318 324 PF00069 0.444
MOD_ProDKin_1 398 404 PF00069 0.474
MOD_ProDKin_1 554 560 PF00069 0.351
MOD_ProDKin_1 686 692 PF00069 0.699
MOD_SUMO_for_1 841 844 PF00179 0.639
TRG_DiLeu_BaEn_1 747 752 PF01217 0.633
TRG_DiLeu_BaEn_1 778 783 PF01217 0.663
TRG_DiLeu_BaEn_2 745 751 PF01217 0.695
TRG_DiLeu_BaEn_4 894 900 PF01217 0.633
TRG_DiLeu_BaLyEn_6 789 794 PF01217 0.701
TRG_ENDOCYTIC_2 534 537 PF00928 0.360
TRG_ENDOCYTIC_2 590 593 PF00928 0.436
TRG_ENDOCYTIC_2 678 681 PF00928 0.511
TRG_ENDOCYTIC_2 735 738 PF00928 0.786
TRG_ENDOCYTIC_2 74 77 PF00928 0.312
TRG_ENDOCYTIC_2 888 891 PF00928 0.658
TRG_ER_diArg_1 360 362 PF00400 0.455
TRG_ER_diArg_1 516 518 PF00400 0.471
TRG_NES_CRM1_1 145 155 PF08389 0.428
TRG_Pf-PMV_PEXEL_1 456 460 PF00026 0.611
TRG_Pf-PMV_PEXEL_1 604 609 PF00026 0.559

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE25 Leptomonas seymouri 43% 97%
A0A3Q8IDB5 Leishmania donovani 99% 100%
A4HFJ3 Leishmania braziliensis 66% 100%
E9AD46 Leishmania major 89% 100%
E9AYX0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS