LeishMANIAdb
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Putative amino acid permease

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative amino acid permease
Gene product:
amino acid transporter aATP11 - putative
Species:
Leishmania infantum
UniProt:
E9AHD8_LEIIN
TriTrypDb:
LINF_310008700
Length:
264

Annotations

LeishMANIAdb annotations

An enormously expanded group of various amino acid transporters.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

E9AHD8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHD8

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016787 hydrolase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 19 21 PF00675 0.224
CLV_PCSK_KEX2_1 19 21 PF00082 0.224
CLV_PCSK_SKI1_1 20 24 PF00082 0.206
CLV_PCSK_SKI1_1 49 53 PF00082 0.415
DOC_MAPK_FxFP_2 215 218 PF00069 0.308
DOC_MAPK_gen_1 19 27 PF00069 0.206
DOC_MAPK_MEF2A_6 41 50 PF00069 0.203
DOC_PP2B_LxvP_1 193 196 PF13499 0.327
DOC_PP2B_PxIxI_1 195 201 PF00149 0.290
DOC_PP4_FxxP_1 215 218 PF00568 0.302
DOC_USP7_MATH_1 74 78 PF00917 0.239
DOC_WW_Pin1_4 82 87 PF00397 0.392
LIG_14-3-3_CanoR_1 49 58 PF00244 0.288
LIG_14-3-3_CanoR_1 88 92 PF00244 0.514
LIG_BRCT_BRCA1_1 208 212 PF00533 0.233
LIG_BRCT_BRCA1_1 239 243 PF00533 0.386
LIG_EH1_1 25 33 PF00400 0.341
LIG_eIF4E_1 104 110 PF01652 0.306
LIG_FHA_1 239 245 PF00498 0.231
LIG_FHA_1 92 98 PF00498 0.256
LIG_LIR_Gen_1 159 169 PF02991 0.425
LIG_LIR_Gen_1 219 224 PF02991 0.206
LIG_LIR_Gen_1 240 250 PF02991 0.284
LIG_LIR_Gen_1 63 74 PF02991 0.292
LIG_LIR_Gen_1 76 86 PF02991 0.433
LIG_LIR_Nem_3 159 165 PF02991 0.459
LIG_LIR_Nem_3 209 215 PF02991 0.347
LIG_LIR_Nem_3 21 26 PF02991 0.261
LIG_LIR_Nem_3 232 238 PF02991 0.429
LIG_LIR_Nem_3 240 246 PF02991 0.266
LIG_LIR_Nem_3 258 264 PF02991 0.359
LIG_LIR_Nem_3 63 69 PF02991 0.257
LIG_LYPXL_S_1 216 220 PF13949 0.284
LIG_MLH1_MIPbox_1 239 243 PF16413 0.206
LIG_NRBOX 11 17 PF00104 0.392
LIG_PALB2_WD40_1 231 239 PF16756 0.392
LIG_PAM2_1 185 197 PF00658 0.206
LIG_PCNA_yPIPBox_3 176 184 PF02747 0.419
LIG_Pex14_2 101 105 PF04695 0.296
LIG_Pex14_2 208 212 PF04695 0.318
LIG_Pex14_2 23 27 PF04695 0.377
LIG_Pex14_2 64 68 PF04695 0.343
LIG_SH2_CRK 127 131 PF00017 0.255
LIG_SH2_CRK 162 166 PF00017 0.447
LIG_SH2_PTP2 139 142 PF00017 0.259
LIG_SH2_STAT5 104 107 PF00017 0.316
LIG_SH2_STAT5 112 115 PF00017 0.228
LIG_SH2_STAT5 139 142 PF00017 0.330
LIG_SH2_STAT5 238 241 PF00017 0.235
LIG_SH2_STAT5 242 245 PF00017 0.243
LIG_SH2_STAT5 26 29 PF00017 0.412
LIG_TRAF2_1 77 80 PF00917 0.392
LIG_TYR_ITIM 137 142 PF00017 0.262
LIG_TYR_ITIM 24 29 PF00017 0.309
LIG_WRC_WIRS_1 169 174 PF05994 0.403
LIG_WRC_WIRS_1 217 222 PF05994 0.416
LIG_WRC_WIRS_1 61 66 PF05994 0.338
MOD_CDK_SPxK_1 82 88 PF00069 0.392
MOD_CK1_1 229 235 PF00069 0.447
MOD_CK1_1 59 65 PF00069 0.346
MOD_CK1_1 82 88 PF00069 0.460
MOD_CK2_1 74 80 PF00069 0.284
MOD_GlcNHglycan 121 124 PF01048 0.559
MOD_GlcNHglycan 208 211 PF01048 0.244
MOD_GlcNHglycan 224 227 PF01048 0.242
MOD_GlcNHglycan 34 37 PF01048 0.580
MOD_GlcNHglycan 58 61 PF01048 0.331
MOD_GSK3_1 222 229 PF00069 0.476
MOD_GSK3_1 49 56 PF00069 0.304
MOD_GSK3_1 87 94 PF00069 0.417
MOD_N-GLC_1 226 231 PF02516 0.247
MOD_N-GLC_2 177 179 PF02516 0.206
MOD_NEK2_1 119 124 PF00069 0.367
MOD_NEK2_1 50 55 PF00069 0.288
MOD_NEK2_1 87 92 PF00069 0.457
MOD_PIKK_1 67 73 PF00454 0.206
MOD_PKA_2 87 93 PF00069 0.487
MOD_Plk_1 226 232 PF00069 0.412
MOD_Plk_4 185 191 PF00069 0.274
MOD_Plk_4 216 222 PF00069 0.499
MOD_Plk_4 238 244 PF00069 0.374
MOD_Plk_4 256 262 PF00069 0.171
MOD_Plk_4 60 66 PF00069 0.343
MOD_ProDKin_1 82 88 PF00069 0.392
TRG_ENDOCYTIC_2 112 115 PF00928 0.295
TRG_ENDOCYTIC_2 127 130 PF00928 0.290
TRG_ENDOCYTIC_2 139 142 PF00928 0.300
TRG_ENDOCYTIC_2 162 165 PF00928 0.455
TRG_ENDOCYTIC_2 217 220 PF00928 0.343
TRG_ENDOCYTIC_2 242 245 PF00928 0.322
TRG_ENDOCYTIC_2 26 29 PF00928 0.347
TRG_ENDOCYTIC_2 261 264 PF00928 0.360
TRG_ENDOCYTIC_2 78 81 PF00928 0.397
TRG_ER_diArg_1 18 20 PF00400 0.224

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NDW9 Trypanosomatidae 41% 100%
A0A1X0NNV8 Trypanosomatidae 50% 100%
A0A3Q8IN54 Leishmania donovani 25% 82%
A0A451EJH9 Leishmania donovani 38% 89%
E9B1I3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 100%
V5DET2 Trypanosoma cruzi 57% 75%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS