Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AHD6_LEIIN

TriTrypDb:

LINF_270012600

Length:

513

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AHD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHD6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	422	426	PF00656	0.611
CLV_C14_Caspase3-7	83	87	PF00656	0.378
CLV_NRD_NRD_1	368	370	PF00675	0.550
CLV_NRD_NRD_1	371	373	PF00675	0.599
CLV_NRD_NRD_1	406	408	PF00675	0.531
CLV_NRD_NRD_1	504	506	PF00675	0.467
CLV_PCSK_FUR_1	17	21	PF00082	0.407
CLV_PCSK_FUR_1	369	373	PF00082	0.463
CLV_PCSK_FUR_1	502	506	PF00082	0.515
CLV_PCSK_KEX2_1	19	21	PF00082	0.393
CLV_PCSK_KEX2_1	366	368	PF00082	0.531
CLV_PCSK_KEX2_1	371	373	PF00082	0.459
CLV_PCSK_KEX2_1	406	408	PF00082	0.531
CLV_PCSK_KEX2_1	504	506	PF00082	0.467
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.377
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.461
CLV_PCSK_PC7_1	15	21	PF00082	0.439
CLV_PCSK_PC7_1	367	373	PF00082	0.464
CLV_PCSK_PC7_1	500	506	PF00082	0.476
CLV_PCSK_SKI1_1	24	28	PF00082	0.271
CLV_PCSK_SKI1_1	407	411	PF00082	0.566
DEG_SPOP_SBC_1	232	236	PF00917	0.418
DEG_SPOP_SBC_1	281	285	PF00917	0.466
DEG_SPOP_SBC_1	288	292	PF00917	0.466
DEG_SPOP_SBC_1	348	352	PF00917	0.641
DOC_CKS1_1	496	501	PF01111	0.653
DOC_CYCLIN_RxL_1	19	28	PF00134	0.568
DOC_MAPK_DCC_7	440	449	PF00069	0.593
DOC_MAPK_gen_1	188	197	PF00069	0.324
DOC_MAPK_gen_1	502	511	PF00069	0.666
DOC_MAPK_MEF2A_6	306	315	PF00069	0.263
DOC_PP1_SILK_1	407	412	PF00149	0.729
DOC_PP2B_LxvP_1	356	359	PF13499	0.671
DOC_USP7_MATH_1	154	158	PF00917	0.281
DOC_USP7_MATH_1	289	293	PF00917	0.494
DOC_USP7_MATH_1	359	363	PF00917	0.668
DOC_USP7_MATH_1	377	381	PF00917	0.590
DOC_USP7_MATH_1	397	401	PF00917	0.574
DOC_USP7_MATH_1	8	12	PF00917	0.672
DOC_USP7_MATH_1	82	86	PF00917	0.303
DOC_WW_Pin1_4	277	282	PF00397	0.490
DOC_WW_Pin1_4	395	400	PF00397	0.713
DOC_WW_Pin1_4	495	500	PF00397	0.692
LIG_14-3-3_CanoR_1	24	30	PF00244	0.491
LIG_14-3-3_CanoR_1	369	377	PF00244	0.632
LIG_14-3-3_CanoR_1	453	460	PF00244	0.656
LIG_14-3-3_CanoR_1	502	512	PF00244	0.675
LIG_14-3-3_CanoR_1	66	72	PF00244	0.413
LIG_BRCT_BRCA1_1	437	441	PF00533	0.598
LIG_BRCT_BRCA1_1	507	511	PF00533	0.705
LIG_CtBP_PxDLS_1	446	450	PF00389	0.614
LIG_CtBP_PxDLS_1	464	468	PF00389	0.617
LIG_eIF4E_1	224	230	PF01652	0.394
LIG_FHA_1	282	288	PF00498	0.474
LIG_FHA_1	306	312	PF00498	0.317
LIG_FHA_1	460	466	PF00498	0.666
LIG_FHA_1	504	510	PF00498	0.708
LIG_FHA_2	291	297	PF00498	0.563
LIG_FHA_2	350	356	PF00498	0.635
LIG_GBD_Chelix_1	319	327	PF00786	0.370
LIG_LIR_Gen_1	314	324	PF02991	0.370
LIG_LIR_Nem_3	103	107	PF02991	0.271
LIG_LIR_Nem_3	141	147	PF02991	0.383
LIG_LIR_Nem_3	210	216	PF02991	0.249
LIG_LIR_Nem_3	308	313	PF02991	0.311
LIG_LIR_Nem_3	314	319	PF02991	0.321
LIG_LIR_Nem_3	438	444	PF02991	0.602
LIG_LIR_Nem_3	6	12	PF02991	0.574
LIG_SH2_CRK	18	22	PF00017	0.575
LIG_SH2_CRK	192	196	PF00017	0.317
LIG_SH2_CRK	9	13	PF00017	0.593
LIG_SH2_NCK_1	42	46	PF00017	0.355
LIG_SH2_STAP1	192	196	PF00017	0.281
LIG_SH2_STAP1	225	229	PF00017	0.383
LIG_SH2_STAP1	454	458	PF00017	0.614
LIG_SH2_STAT3	131	134	PF00017	0.365
LIG_SH2_STAT3	454	457	PF00017	0.615
LIG_SH2_STAT5	104	107	PF00017	0.279
LIG_SH2_STAT5	151	154	PF00017	0.289
LIG_SH3_1	440	446	PF00018	0.594
LIG_SH3_3	440	446	PF00018	0.633
LIG_SH3_3	76	82	PF00018	0.258
LIG_SUMO_SIM_par_1	193	198	PF11976	0.218
LIG_TRAF2_1	298	301	PF00917	0.518
LIG_WRC_WIRS_1	391	396	PF05994	0.721
LIG_WW_1	470	473	PF00397	0.650
MOD_CDC14_SPxK_1	398	401	PF00782	0.669
MOD_CDK_SPK_2	495	500	PF00069	0.673
MOD_CDK_SPxK_1	395	401	PF00069	0.712
MOD_CDK_SPxxK_3	495	502	PF00069	0.708
MOD_CK1_1	11	17	PF00069	0.606
MOD_CK1_1	117	123	PF00069	0.303
MOD_CK1_1	168	174	PF00069	0.317
MOD_CK1_1	198	204	PF00069	0.246
MOD_CK1_1	209	215	PF00069	0.302
MOD_CK1_1	292	298	PF00069	0.517
MOD_CK1_1	350	356	PF00069	0.780
MOD_CK1_1	370	376	PF00069	0.580
MOD_CK1_1	380	386	PF00069	0.787
MOD_CK1_1	387	393	PF00069	0.685
MOD_CK1_1	41	47	PF00069	0.331
MOD_CK1_1	426	432	PF00069	0.735
MOD_CK1_1	485	491	PF00069	0.667
MOD_CK1_1	507	513	PF00069	0.738
MOD_CK2_1	135	141	PF00069	0.281
MOD_CK2_1	212	218	PF00069	0.299
MOD_CK2_1	290	296	PF00069	0.561
MOD_CK2_1	349	355	PF00069	0.632
MOD_CK2_1	359	365	PF00069	0.652
MOD_Cter_Amidation	404	407	PF01082	0.523
MOD_GlcNHglycan	137	140	PF01048	0.481
MOD_GlcNHglycan	154	157	PF01048	0.479
MOD_GlcNHglycan	352	355	PF01048	0.486
MOD_GlcNHglycan	387	390	PF01048	0.486
MOD_GlcNHglycan	402	406	PF01048	0.418
MOD_GlcNHglycan	428	431	PF01048	0.488
MOD_GlcNHglycan	43	46	PF01048	0.576
MOD_GlcNHglycan	5	8	PF01048	0.453
MOD_GSK3_1	108	115	PF00069	0.270
MOD_GSK3_1	118	125	PF00069	0.270
MOD_GSK3_1	165	172	PF00069	0.290
MOD_GSK3_1	195	202	PF00069	0.268
MOD_GSK3_1	231	238	PF00069	0.418
MOD_GSK3_1	239	246	PF00069	0.423
MOD_GSK3_1	247	254	PF00069	0.451
MOD_GSK3_1	255	262	PF00069	0.416
MOD_GSK3_1	271	278	PF00069	0.434
MOD_GSK3_1	283	290	PF00069	0.472
MOD_GSK3_1	291	298	PF00069	0.417
MOD_GSK3_1	367	374	PF00069	0.760
MOD_GSK3_1	376	383	PF00069	0.670
MOD_GSK3_1	397	404	PF00069	0.683
MOD_GSK3_1	478	485	PF00069	0.729
MOD_GSK3_1	503	510	PF00069	0.718
MOD_GSK3_1	57	64	PF00069	0.400
MOD_N-GLC_1	383	388	PF02516	0.543
MOD_NEK2_1	10	15	PF00069	0.660
MOD_NEK2_1	108	113	PF00069	0.270
MOD_NEK2_1	114	119	PF00069	0.270
MOD_NEK2_1	195	200	PF00069	0.228
MOD_NEK2_1	272	277	PF00069	0.450
MOD_NEK2_1	458	463	PF00069	0.659
MOD_NEK2_1	482	487	PF00069	0.678
MOD_NEK2_1	503	508	PF00069	0.685
MOD_NEK2_1	61	66	PF00069	0.453
MOD_NEK2_2	377	382	PF00069	0.612
MOD_PIKK_1	114	120	PF00454	0.218
MOD_PIKK_1	195	201	PF00454	0.269
MOD_PIKK_1	296	302	PF00454	0.438
MOD_PIKK_1	61	67	PF00454	0.424
MOD_PK_1	505	511	PF00069	0.707
MOD_PKA_1	367	373	PF00069	0.747
MOD_PKA_1	504	510	PF00069	0.671
MOD_PKA_2	135	141	PF00069	0.253
MOD_PKA_2	367	373	PF00069	0.765
MOD_PKA_2	405	411	PF00069	0.728
MOD_PKA_2	452	458	PF00069	0.650
MOD_PKA_2	485	491	PF00069	0.665
MOD_PKA_2	503	509	PF00069	0.702
MOD_PKA_2	65	71	PF00069	0.424
MOD_PKB_1	369	377	PF00069	0.771
MOD_PKB_1	502	510	PF00069	0.673
MOD_Plk_1	57	63	PF00069	0.420
MOD_Plk_4	109	115	PF00069	0.411
MOD_Plk_4	209	215	PF00069	0.243
MOD_Plk_4	305	311	PF00069	0.450
MOD_Plk_4	478	484	PF00069	0.662
MOD_Plk_4	507	513	PF00069	0.654
MOD_ProDKin_1	277	283	PF00069	0.491
MOD_ProDKin_1	395	401	PF00069	0.712
MOD_ProDKin_1	495	501	PF00069	0.691
MOD_SUMO_rev_2	301	308	PF00179	0.427
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.452
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.641
TRG_ENDOCYTIC_2	137	140	PF00928	0.415
TRG_ENDOCYTIC_2	192	195	PF00928	0.331
TRG_ENDOCYTIC_2	224	227	PF00928	0.389
TRG_ENDOCYTIC_2	9	12	PF00928	0.580
TRG_ER_diArg_1	15	18	PF00400	0.610
TRG_ER_diArg_1	367	369	PF00400	0.740
TRG_ER_diArg_1	499	502	PF00400	0.672
TRG_ER_diArg_1	503	505	PF00400	0.659
TRG_NES_CRM1_1	442	456	PF08389	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6U3	Leptomonas seymouri	26%	100%
A0A3Q8ICK3	Leishmania donovani	100%	100%
A4HJ08	Leishmania braziliensis	58%	96%
E9AD43	Leishmania major	89%	98%
E9AYW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%