Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AHD5_LEIIN

TriTrypDb:

LINF_270012500

Length:

167

Annotations

LeishMANIAdb annotations

Belongs to a unique family or proteins highly conserved in Kinetoplastida, but not seen outside that group.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	8
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AHD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHD5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.327
CLV_NRD_NRD_1	138	140	PF00675	0.340
CLV_NRD_NRD_1	17	19	PF00675	0.348
CLV_NRD_NRD_1	61	63	PF00675	0.637
CLV_PCSK_KEX2_1	120	122	PF00082	0.337
CLV_PCSK_KEX2_1	138	140	PF00082	0.340
CLV_PCSK_KEX2_1	61	63	PF00082	0.583
CLV_PCSK_SKI1_1	99	103	PF00082	0.417
DEG_APCC_DBOX_1	98	106	PF00400	0.440
DEG_Nend_UBRbox_1	1	4	PF02207	0.607
DOC_MAPK_MEF2A_6	145	154	PF00069	0.569
DOC_PP4_FxxP_1	64	67	PF00568	0.429
DOC_WW_Pin1_4	90	95	PF00397	0.368
LIG_14-3-3_CanoR_1	128	133	PF00244	0.562
LIG_14-3-3_CanoR_1	18	28	PF00244	0.541
LIG_deltaCOP1_diTrp_1	11	20	PF00928	0.535
LIG_eIF4E_1	97	103	PF01652	0.353
LIG_FHA_1	105	111	PF00498	0.378
LIG_FHA_2	20	26	PF00498	0.536
LIG_GBD_Chelix_1	150	158	PF00786	0.420
LIG_LIR_Gen_1	147	156	PF02991	0.617
LIG_LIR_Nem_3	107	111	PF02991	0.335
LIG_LIR_Nem_3	147	152	PF02991	0.570
LIG_PCNA_yPIPBox_3	138	150	PF02747	0.631
LIG_PDZ_Class_2	162	167	PF00595	0.680
LIG_SH2_CRK	97	101	PF00017	0.313
LIG_SH2_STAT3	126	129	PF00017	0.545
LIG_SH2_STAT3	92	95	PF00017	0.362
LIG_SH2_STAT5	126	129	PF00017	0.545
LIG_SH2_STAT5	149	152	PF00017	0.603
LIG_SH2_STAT5	53	56	PF00017	0.354
LIG_SH2_STAT5	9	12	PF00017	0.539
LIG_SH2_STAT5	92	95	PF00017	0.362
LIG_SH3_3	100	106	PF00018	0.407
LIG_WRC_WIRS_1	105	110	PF05994	0.411
MOD_N-GLC_1	160	165	PF02516	0.456
MOD_NEK2_2	56	61	PF00069	0.365
MOD_PIKK_1	160	166	PF00454	0.636
MOD_Plk_1	160	166	PF00069	0.657
MOD_Plk_1	3	9	PF00069	0.577
MOD_Plk_4	104	110	PF00069	0.319
MOD_Plk_4	128	134	PF00069	0.554
MOD_ProDKin_1	90	96	PF00069	0.369
MOD_SUMO_for_1	1	4	PF00179	0.607
MOD_SUMO_rev_2	147	157	PF00179	0.691
MOD_SUMO_rev_2	71	78	PF00179	0.491
TRG_ENDOCYTIC_2	149	152	PF00928	0.602
TRG_ENDOCYTIC_2	97	100	PF00928	0.295
TRG_ER_diArg_1	120	122	PF00400	0.539
TRG_ER_diArg_1	138	140	PF00400	0.542
TRG_ER_diArg_1	60	62	PF00400	0.416
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P780	Leptomonas seymouri	82%	100%
A0A0S4JRI7	Bodo saltans	61%	99%
A0A1X0P491	Trypanosomatidae	62%	99%
A0A3Q8IE57	Leishmania donovani	99%	100%
A0A422NMQ9	Trypanosoma rangeli	65%	99%
A4HFJ1	Leishmania braziliensis	92%	100%
D0A5R7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	99%
E9AD42	Leishmania major	98%	100%
E9AYW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%