Dynein_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4470)/Domain of unknown function (DUF4471) - putative

Species:

Leishmania infantum

UniProt:

E9AHC9_LEIIN

TriTrypDb:

LINF_270011900

Length:

593

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

E9AHC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHC9

Function

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Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0043933	protein-containing complex organization	4	11
GO:0044458	motile cilium assembly	7	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.495
CLV_C14_Caspase3-7	299	303	PF00656	0.456
CLV_C14_Caspase3-7	567	571	PF00656	0.607
CLV_NRD_NRD_1	169	171	PF00675	0.264
CLV_NRD_NRD_1	238	240	PF00675	0.472
CLV_NRD_NRD_1	343	345	PF00675	0.256
CLV_NRD_NRD_1	40	42	PF00675	0.517
CLV_NRD_NRD_1	59	61	PF00675	0.727
CLV_NRD_NRD_1	95	97	PF00675	0.590
CLV_PCSK_FUR_1	38	42	PF00082	0.573

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILC1	Leptomonas seymouri	70%	100%
A0A1X0P5D9	Trypanosomatidae	50%	100%
A0A3R7RLZ6	Trypanosoma rangeli	52%	100%
A0A3S7X0G7	Leishmania donovani	99%	100%
A4HFI5	Leishmania braziliensis	84%	100%
D0A5R1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
D3ZCM9	Rattus norvegicus	27%	100%
E9AD36	Leishmania major	93%	100%
E9AYW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
F1MLB4	Bos taurus	31%	100%

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