Autophagy-related protein 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Autophagy protein Apg9 - putative

Species:

Leishmania infantum

UniProt:

E9AHC0_LEIIN

TriTrypDb:

LINF_270009000

Length:

730

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0034045	phagophore assembly site membrane	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0000407	phagophore assembly site	2	1
GO:0005737	cytoplasm	2	1
GO:0005773	vacuole	5	1
GO:0005776	autophagosome	6	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0000502	proteasome complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1905368	peptidase complex	3	2
GO:1905369	endopeptidase complex	4	2

Expansion

Sequence features

E9AHC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHC0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006869	lipid transport	5	12
GO:0006914	autophagy	3	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009987	cellular process	1	12
GO:0044237	cellular metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0061919	process utilizing autophagic mechanism	2	12
GO:0071702	organic substance transport	4	12
GO:0000422	autophagy of mitochondrion	4	1
GO:0006996	organelle organization	4	1
GO:0007005	mitochondrion organization	5	1
GO:0008104	protein localization	4	1
GO:0016043	cellular component organization	3	1
GO:0022411	cellular component disassembly	4	1
GO:0033036	macromolecule localization	2	1
GO:0034497	protein localization to phagophore assembly site	5	1
GO:0044804	autophagy of nucleus	4	1
GO:0044805	late nucleophagy	5	1
GO:0051641	cellular localization	2	1
GO:0061726	mitochondrion disassembly	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1903008	organelle disassembly	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.500
CLV_C14_Caspase3-7	504	508	PF00656	0.500
CLV_C14_Caspase3-7	602	606	PF00656	0.648
CLV_C14_Caspase3-7	667	671	PF00656	0.713
CLV_NRD_NRD_1	371	373	PF00675	0.317
CLV_NRD_NRD_1	653	655	PF00675	0.591
CLV_NRD_NRD_1	716	718	PF00675	0.523
CLV_PCSK_KEX2_1	371	373	PF00082	0.318
CLV_PCSK_KEX2_1	567	569	PF00082	0.454
CLV_PCSK_KEX2_1	653	655	PF00082	0.591
CLV_PCSK_KEX2_1	716	718	PF00082	0.524
CLV_PCSK_PC1ET2_1	567	569	PF00082	0.454
CLV_PCSK_SKI1_1	29	33	PF00082	0.359
CLV_PCSK_SKI1_1	701	705	PF00082	0.496
DEG_SCF_FBW7_2	523	530	PF00400	0.700
DEG_SPOP_SBC_1	681	685	PF00917	0.667
DOC_CKS1_1	151	156	PF01111	0.479
DOC_CYCLIN_RxL_1	610	621	PF00134	0.472
DOC_CYCLIN_yCln2_LP_2	477	483	PF00134	0.341
DOC_CYCLIN_yCln2_LP_2	555	561	PF00134	0.676
DOC_CYCLIN_yCln2_LP_2	94	100	PF00134	0.316
DOC_MAPK_gen_1	11	19	PF00069	0.663
DOC_MAPK_gen_1	463	470	PF00069	0.296
DOC_MAPK_gen_1	567	576	PF00069	0.621
DOC_MAPK_MEF2A_6	463	470	PF00069	0.335
DOC_MAPK_MEF2A_6	567	576	PF00069	0.621
DOC_PP2B_LxvP_1	10	13	PF13499	0.680
DOC_PP2B_LxvP_1	477	480	PF13499	0.323
DOC_PP2B_LxvP_1	94	97	PF13499	0.341
DOC_PP4_FxxP_1	151	154	PF00568	0.541
DOC_PP4_FxxP_1	209	212	PF00568	0.541
DOC_PP4_FxxP_1	386	389	PF00568	0.392
DOC_PP4_FxxP_1	655	658	PF00568	0.791
DOC_SPAK_OSR1_1	654	658	PF12202	0.727
DOC_USP7_MATH_1	277	281	PF00917	0.532
DOC_USP7_MATH_1	513	517	PF00917	0.555
DOC_USP7_MATH_1	539	543	PF00917	0.744
DOC_USP7_MATH_1	548	552	PF00917	0.737
DOC_USP7_MATH_1	561	565	PF00917	0.661
DOC_USP7_MATH_1	645	649	PF00917	0.711
DOC_USP7_MATH_1	680	684	PF00917	0.687
DOC_USP7_MATH_2	528	534	PF00917	0.688
DOC_USP7_UBL2_3	303	307	PF12436	0.390
DOC_USP7_UBL2_3	567	571	PF12436	0.652
DOC_WW_Pin1_4	150	155	PF00397	0.455
DOC_WW_Pin1_4	247	252	PF00397	0.559
DOC_WW_Pin1_4	523	528	PF00397	0.732
DOC_WW_Pin1_4	596	601	PF00397	0.750
LIG_14-3-3_CanoR_1	101	105	PF00244	0.330
LIG_14-3-3_CanoR_1	14	18	PF00244	0.652
LIG_14-3-3_CanoR_1	279	283	PF00244	0.541
LIG_14-3-3_CanoR_1	29	38	PF00244	0.541
LIG_14-3-3_CanoR_1	322	332	PF00244	0.287
LIG_14-3-3_CanoR_1	361	367	PF00244	0.319
LIG_14-3-3_CanoR_1	371	380	PF00244	0.293
LIG_14-3-3_CanoR_1	6	10	PF00244	0.700
LIG_14-3-3_CanoR_1	613	618	PF00244	0.547
LIG_14-3-3_CanoR_1	708	714	PF00244	0.709
LIG_Actin_WH2_2	228	244	PF00022	0.532
LIG_Actin_WH2_2	334	349	PF00022	0.332
LIG_Actin_WH2_2	575	591	PF00022	0.596
LIG_APCC_ABBA_1	332	337	PF00400	0.255
LIG_APCC_ABBAyCdc20_2	331	337	PF00400	0.341
LIG_BIR_II_1	1	5	PF00653	0.701
LIG_BRCT_BRCA1_1	205	209	PF00533	0.541
LIG_Clathr_ClatBox_1	225	229	PF01394	0.541
LIG_deltaCOP1_diTrp_1	327	332	PF00928	0.279
LIG_deltaCOP1_diTrp_1	445	453	PF00928	0.254
LIG_eIF4E_1	289	295	PF01652	0.410
LIG_FHA_1	129	135	PF00498	0.429
LIG_FHA_1	147	153	PF00498	0.397
LIG_FHA_1	282	288	PF00498	0.519
LIG_FHA_1	299	305	PF00498	0.203
LIG_FHA_1	30	36	PF00498	0.530
LIG_FHA_1	374	380	PF00498	0.326
LIG_FHA_1	405	411	PF00498	0.373
LIG_FHA_1	469	475	PF00498	0.366
LIG_FHA_1	56	62	PF00498	0.410
LIG_FHA_1	671	677	PF00498	0.684
LIG_FHA_1	707	713	PF00498	0.683
LIG_FHA_2	254	260	PF00498	0.553
LIG_FHA_2	428	434	PF00498	0.359
LIG_FHA_2	502	508	PF00498	0.521
LIG_FHA_2	593	599	PF00498	0.723
LIG_FHA_2	683	689	PF00498	0.640
LIG_GBD_Chelix_1	379	387	PF00786	0.344
LIG_GBD_Chelix_1	402	410	PF00786	0.405
LIG_GBD_Chelix_1	469	477	PF00786	0.371
LIG_LIR_Apic_2	148	154	PF02991	0.466
LIG_LIR_Apic_2	206	212	PF02991	0.541
LIG_LIR_Apic_2	385	389	PF02991	0.392
LIG_LIR_Apic_2	652	658	PF02991	0.780
LIG_LIR_Gen_1	259	268	PF02991	0.487
LIG_LIR_Gen_1	284	293	PF02991	0.500
LIG_LIR_Gen_1	423	432	PF02991	0.289
LIG_LIR_Gen_1	451	462	PF02991	0.257
LIG_LIR_Gen_1	578	583	PF02991	0.487
LIG_LIR_Gen_1	58	67	PF02991	0.451
LIG_LIR_Nem_3	102	108	PF02991	0.316
LIG_LIR_Nem_3	130	136	PF02991	0.490
LIG_LIR_Nem_3	173	177	PF02991	0.538
LIG_LIR_Nem_3	187	193	PF02991	0.394
LIG_LIR_Nem_3	259	265	PF02991	0.475
LIG_LIR_Nem_3	284	288	PF02991	0.516
LIG_LIR_Nem_3	423	429	PF02991	0.272
LIG_LIR_Nem_3	451	457	PF02991	0.257
LIG_LIR_Nem_3	578	582	PF02991	0.487
LIG_LIR_Nem_3	58	62	PF02991	0.442
LIG_Pex14_1	109	113	PF04695	0.415
LIG_Pex14_2	100	104	PF04695	0.359
LIG_Pex14_2	15	19	PF04695	0.622
LIG_Pex14_2	55	59	PF04695	0.382
LIG_Pex14_2	68	72	PF04695	0.250
LIG_Rb_pABgroove_1	256	264	PF01858	0.455
LIG_REV1ctd_RIR_1	459	469	PF16727	0.341
LIG_SH2_CRK	285	289	PF00017	0.380
LIG_SH2_CRK	426	430	PF00017	0.273
LIG_SH2_NCK_1	335	339	PF00017	0.266
LIG_SH2_NCK_1	413	417	PF00017	0.428
LIG_SH2_NCK_1	441	445	PF00017	0.363
LIG_SH2_NCK_1	454	458	PF00017	0.290
LIG_SH2_PTP2	248	251	PF00017	0.559
LIG_SH2_PTP2	299	302	PF00017	0.428
LIG_SH2_SRC	231	234	PF00017	0.521
LIG_SH2_SRC	426	429	PF00017	0.332
LIG_SH2_SRC	454	457	PF00017	0.359
LIG_SH2_STAP1	285	289	PF00017	0.388
LIG_SH2_STAT3	132	135	PF00017	0.541
LIG_SH2_STAT3	160	163	PF00017	0.500
LIG_SH2_STAT5	133	136	PF00017	0.507
LIG_SH2_STAT5	231	234	PF00017	0.455
LIG_SH2_STAT5	248	251	PF00017	0.496
LIG_SH2_STAT5	299	302	PF00017	0.380
LIG_SH2_STAT5	428	431	PF00017	0.279
LIG_SH2_STAT5	98	101	PF00017	0.341
LIG_SH3_2	215	220	PF14604	0.541
LIG_SH3_3	209	215	PF00018	0.541
LIG_SUMO_SIM_anti_2	407	412	PF11976	0.364
LIG_SUMO_SIM_par_1	231	237	PF11976	0.541
LIG_SUMO_SIM_par_1	465	471	PF11976	0.333
LIG_TYR_ITIM	283	288	PF00017	0.459
LIG_TYR_ITIM	314	319	PF00017	0.341
LIG_WRC_WIRS_1	383	388	PF05994	0.341
LIG_WRC_WIRS_1	56	61	PF05994	0.453
LIG_WRC_WIRS_1	576	581	PF05994	0.485
MOD_CDK_SPxxK_3	150	157	PF00069	0.466
MOD_CK1_1	516	522	PF00069	0.584
MOD_CK1_1	540	546	PF00069	0.777
MOD_CK1_1	575	581	PF00069	0.486
MOD_CK1_1	584	590	PF00069	0.538
MOD_CK1_1	599	605	PF00069	0.663
MOD_CK1_1	629	635	PF00069	0.678
MOD_CK1_1	639	645	PF00069	0.683
MOD_CK1_1	648	654	PF00069	0.597
MOD_CK1_1	695	701	PF00069	0.623
MOD_CK1_1	707	713	PF00069	0.636
MOD_CK2_1	427	433	PF00069	0.359
MOD_CK2_1	592	598	PF00069	0.731
MOD_CK2_1	629	635	PF00069	0.694
MOD_CK2_1	682	688	PF00069	0.645
MOD_CK2_1	76	82	PF00069	0.319
MOD_GlcNHglycan	203	206	PF01048	0.341
MOD_GlcNHglycan	21	24	PF01048	0.394
MOD_GlcNHglycan	448	451	PF01048	0.455
MOD_GlcNHglycan	50	53	PF01048	0.428
MOD_GlcNHglycan	532	535	PF01048	0.563
MOD_GlcNHglycan	539	542	PF01048	0.573
MOD_GlcNHglycan	549	553	PF01048	0.573
MOD_GlcNHglycan	563	566	PF01048	0.411
MOD_GlcNHglycan	631	634	PF01048	0.457
MOD_GlcNHglycan	672	676	PF01048	0.513
MOD_GSK3_1	113	120	PF00069	0.383
MOD_GSK3_1	146	153	PF00069	0.496
MOD_GSK3_1	249	256	PF00069	0.523
MOD_GSK3_1	277	284	PF00069	0.500
MOD_GSK3_1	360	367	PF00069	0.341
MOD_GSK3_1	378	385	PF00069	0.187
MOD_GSK3_1	513	520	PF00069	0.609
MOD_GSK3_1	592	599	PF00069	0.690
MOD_GSK3_1	622	629	PF00069	0.656
MOD_GSK3_1	639	646	PF00069	0.702
MOD_GSK3_1	692	699	PF00069	0.565
MOD_GSK3_1	76	83	PF00069	0.322
MOD_NEK2_1	100	105	PF00069	0.296
MOD_NEK2_1	113	118	PF00069	0.233
MOD_NEK2_1	128	133	PF00069	0.463
MOD_NEK2_1	193	198	PF00069	0.519
MOD_NEK2_1	241	246	PF00069	0.530
MOD_NEK2_1	257	262	PF00069	0.417
MOD_NEK2_1	31	36	PF00069	0.452
MOD_NEK2_1	360	365	PF00069	0.359
MOD_NEK2_1	392	397	PF00069	0.489
MOD_NEK2_1	435	440	PF00069	0.300
MOD_NEK2_1	473	478	PF00069	0.365
MOD_NEK2_1	5	10	PF00069	0.648
MOD_NEK2_1	500	505	PF00069	0.524
MOD_NEK2_1	55	60	PF00069	0.330
MOD_NEK2_1	692	697	PF00069	0.542
MOD_NEK2_1	704	709	PF00069	0.605
MOD_NEK2_2	13	18	PF00069	0.579
MOD_NEK2_2	645	650	PF00069	0.776
MOD_PIKK_1	29	35	PF00454	0.559
MOD_PIKK_1	317	323	PF00454	0.341
MOD_PIKK_1	581	587	PF00454	0.539
MOD_PIKK_1	692	698	PF00454	0.576
MOD_PIKK_1	707	713	PF00454	0.630
MOD_PK_1	203	209	PF00069	0.541
MOD_PKA_2	100	106	PF00069	0.338
MOD_PKA_2	13	19	PF00069	0.654
MOD_PKA_2	241	247	PF00069	0.500
MOD_PKA_2	278	284	PF00069	0.541
MOD_PKA_2	360	366	PF00069	0.325
MOD_PKA_2	5	11	PF00069	0.701
MOD_PKA_2	639	645	PF00069	0.717
MOD_PKA_2	707	713	PF00069	0.714
MOD_PKB_1	345	353	PF00069	0.300
MOD_Plk_4	100	106	PF00069	0.298
MOD_Plk_4	128	134	PF00069	0.509
MOD_Plk_4	249	255	PF00069	0.510
MOD_Plk_4	257	263	PF00069	0.483
MOD_Plk_4	278	284	PF00069	0.489
MOD_Plk_4	31	37	PF00069	0.533
MOD_Plk_4	382	388	PF00069	0.333
MOD_Plk_4	398	404	PF00069	0.341
MOD_Plk_4	457	463	PF00069	0.306
MOD_Plk_4	5	11	PF00069	0.699
MOD_Plk_4	55	61	PF00069	0.323
MOD_Plk_4	550	556	PF00069	0.748
MOD_ProDKin_1	150	156	PF00069	0.455
MOD_ProDKin_1	247	253	PF00069	0.559
MOD_ProDKin_1	523	529	PF00069	0.734
MOD_ProDKin_1	596	602	PF00069	0.745
TRG_DiLeu_BaEn_2	123	129	PF01217	0.466
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.351
TRG_ENDOCYTIC_2	285	288	PF00928	0.296
TRG_ENDOCYTIC_2	299	302	PF00928	0.329
TRG_ENDOCYTIC_2	316	319	PF00928	0.239
TRG_ENDOCYTIC_2	335	338	PF00928	0.147
TRG_ENDOCYTIC_2	426	429	PF00928	0.273
TRG_ENDOCYTIC_2	454	457	PF00928	0.266
TRG_ER_diArg_1	359	362	PF00400	0.289
TRG_ER_diArg_1	370	372	PF00400	0.275
TRG_ER_diArg_1	617	620	PF00400	0.620
TRG_ER_diArg_1	653	655	PF00400	0.791
TRG_NES_CRM1_1	217	229	PF08389	0.466
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.307

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5S4	Leptomonas seymouri	69%	100%
A0A0S4JRE4	Bodo saltans	29%	93%
A0A1X0P5B9	Trypanosomatidae	36%	100%
A0A3S5H7H3	Leishmania donovani	100%	100%
A0A422NTE4	Trypanosoma rangeli	36%	100%
D0A5N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AD16	Leishmania major	97%	100%
E9AIS5	Leishmania braziliensis	83%	100%
E9AYU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P0CM40	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	21%	83%
P0CM41	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	21%	83%
Q8RUS5	Arabidopsis thaliana	22%	84%
V5B7I2	Trypanosoma cruzi	34%	100%