LeishMANIAdb
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6-phosphogluconolactonase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
6-phosphogluconolactonase
Gene product:
6-phosphogluconolactonase
Species:
Leishmania infantum
UniProt:
E9AHB9_LEIIN
TriTrypDb:
LINF_260032900
Length:
267

Annotations

Annotations by Jardim et al.

Pentose Phosphate Pathway, 6-phosphogluconolactonase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

E9AHB9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHB9

PDB structure(s): 3ch7_A , 3css_A

Function

Biological processes
Term Name Level Count
GO:0005975 carbohydrate metabolic process 3 12
GO:0006091 generation of precursor metabolites and energy 3 12
GO:0006098 pentose-phosphate shunt 5 11
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006739 NADP metabolic process 7 12
GO:0006740 NADPH regeneration 4 12
GO:0006753 nucleoside phosphate metabolic process 4 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009117 nucleotide metabolic process 5 12
GO:0009987 cellular process 1 12
GO:0019362 pyridine nucleotide metabolic process 5 12
GO:0019637 organophosphate metabolic process 3 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044281 small molecule metabolic process 2 12
GO:0046483 heterocycle metabolic process 3 12
GO:0046496 nicotinamide nucleotide metabolic process 6 12
GO:0051156 glucose 6-phosphate metabolic process 4 12
GO:0055086 nucleobase-containing small molecule metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0072524 pyridine-containing compound metabolic process 4 12
GO:1901135 carbohydrate derivative metabolic process 3 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:0009051 pentose-phosphate shunt, oxidative branch 5 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0016787 hydrolase activity 2 12
GO:0016788 hydrolase activity, acting on ester bonds 3 12
GO:0017057 6-phosphogluconolactonase activity 5 12
GO:0052689 carboxylic ester hydrolase activity 4 12
GO:0016853 isomerase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 50 52 PF00082 0.403
CLV_PCSK_PC1ET2_1 50 52 PF00082 0.403
CLV_PCSK_SKI1_1 93 97 PF00082 0.273
DOC_CYCLIN_RxL_1 90 98 PF00134 0.400
DOC_MAPK_gen_1 247 257 PF00069 0.377
DOC_MAPK_gen_1 32 41 PF00069 0.356
DOC_MAPK_MEF2A_6 35 43 PF00069 0.352
DOC_PP4_FxxP_1 190 193 PF00568 0.279
DOC_WW_Pin1_4 189 194 PF00397 0.322
DOC_WW_Pin1_4 45 50 PF00397 0.250
LIG_14-3-3_CanoR_1 201 205 PF00244 0.321
LIG_14-3-3_CanoR_1 250 256 PF00244 0.462
LIG_BIR_II_1 1 5 PF00653 0.430
LIG_BRCT_BRCA1_1 186 190 PF00533 0.294
LIG_FHA_1 167 173 PF00498 0.263
LIG_FHA_1 252 258 PF00498 0.329
LIG_FHA_1 90 96 PF00498 0.365
LIG_FHA_2 113 119 PF00498 0.346
LIG_FHA_2 178 184 PF00498 0.297
LIG_FHA_2 79 85 PF00498 0.275
LIG_LIR_Apic_2 187 193 PF02991 0.280
LIG_PCNA_yPIPBox_3 222 232 PF02747 0.400
LIG_PDZ_Class_2 262 267 PF00595 0.483
LIG_SH2_STAP1 133 137 PF00017 0.294
LIG_SH3_3 185 191 PF00018 0.285
LIG_SH3_3 233 239 PF00018 0.345
LIG_SUMO_SIM_anti_2 157 162 PF11976 0.260
LIG_SUMO_SIM_anti_2 60 65 PF11976 0.393
LIG_SUMO_SIM_par_1 101 108 PF11976 0.336
LIG_SUMO_SIM_par_1 180 189 PF11976 0.409
LIG_SUMO_SIM_par_1 39 44 PF11976 0.400
LIG_WRC_WIRS_1 1 6 PF05994 0.481
MOD_CDK_SPK_2 45 50 PF00069 0.259
MOD_CDK_SPxK_1 45 51 PF00069 0.400
MOD_CK1_1 15 21 PF00069 0.396
MOD_CK1_1 189 195 PF00069 0.369
MOD_CK1_1 44 50 PF00069 0.302
MOD_CK1_1 86 92 PF00069 0.365
MOD_CK2_1 113 119 PF00069 0.346
MOD_CK2_1 78 84 PF00069 0.275
MOD_GlcNHglycan 108 112 PF01048 0.275
MOD_GlcNHglycan 18 21 PF01048 0.330
MOD_GlcNHglycan 236 239 PF01048 0.193
MOD_GlcNHglycan 260 263 PF01048 0.438
MOD_GlcNHglycan 34 38 PF01048 0.286
MOD_GlcNHglycan 43 46 PF01048 0.220
MOD_GSK3_1 12 19 PF00069 0.348
MOD_GSK3_1 173 180 PF00069 0.327
MOD_GSK3_1 200 207 PF00069 0.305
MOD_GSK3_1 41 48 PF00069 0.285
MOD_N-GLC_1 146 151 PF02516 0.409
MOD_N-GLC_1 86 91 PF02516 0.345
MOD_NEK2_1 204 209 PF00069 0.419
MOD_NEK2_1 41 46 PF00069 0.305
MOD_PIKK_1 141 147 PF00454 0.307
MOD_PKA_2 200 206 PF00069 0.259
MOD_PKA_2 249 255 PF00069 0.463
MOD_Plk_1 12 18 PF00069 0.365
MOD_Plk_1 86 92 PF00069 0.345
MOD_Plk_4 168 174 PF00069 0.286
MOD_Plk_4 204 210 PF00069 0.298
MOD_Plk_4 251 257 PF00069 0.321
MOD_ProDKin_1 189 195 PF00069 0.322
MOD_ProDKin_1 45 51 PF00069 0.250
MOD_SUMO_rev_2 132 137 PF00179 0.456
TRG_ENDOCYTIC_2 53 56 PF00928 0.259
TRG_Pf-PMV_PEXEL_1 244 248 PF00026 0.318
TRG_Pf-PMV_PEXEL_1 50 54 PF00026 0.400

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1P9Y4 Leptomonas seymouri 68% 98%
A0A0S4J8H1 Bodo saltans 35% 100%
A0A1X0NX24 Trypanosomatidae 48% 100%
A0A3Q8IG46 Leishmania donovani 100% 100%
A0A3R7NAW7 Trypanosoma rangeli 45% 100%
A2XI04 Oryza sativa subsp. indica 25% 90%
A2YNH4 Oryza sativa subsp. indica 25% 95%
A2YXS5 Oryza sativa subsp. indica 28% 82%
A2Z3C4 Oryza sativa subsp. indica 31% 82%
A4HFB4 Leishmania braziliensis 83% 100%
A6VVU9 Marinomonas sp. (strain MWYL1) 27% 100%
A6ZT71 Saccharomyces cerevisiae (strain YJM789) 27% 100%
B3LSS7 Saccharomyces cerevisiae (strain RM11-1a) 27% 100%
B5VK90 Saccharomyces cerevisiae (strain AWRI1631) 27% 100%
D0A7E6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
E9AYQ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
O18229 Caenorhabditis elegans 29% 99%
O51240 Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) 24% 100%
O74455 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 100%
O83490 Treponema pallidum (strain Nichols) 32% 100%
O84189 Chlamydia trachomatis (strain D/UW-3/Cx) 25% 100%
O95336 Homo sapiens 31% 100%
P37262 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 85%
P38858 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 100%
P46016 Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) 31% 100%
P50278 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 83%
P53315 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 100%
P63339 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 33% 100%
P74618 Synechocystis sp. (strain PCC 6803 / Kazusa) 33% 100%
P85971 Rattus norvegicus 31% 100%
P9WQP4 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 33% 100%
P9WQP5 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 33% 100%
Q2TBQ8 Bos taurus 29% 100%
Q49700 Mycobacterium leprae (strain TN) 28% 100%
Q4Q8S1 Leishmania major 94% 100%
Q57039 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 30% 100%
Q69NG5 Oryza sativa subsp. japonica 31% 82%
Q6Z4H0 Oryza sativa subsp. japonica 25% 95%
Q6Z9C3 Oryza sativa subsp. japonica 28% 82%
Q75IV7 Oryza sativa subsp. japonica 25% 90%
Q84WW2 Arabidopsis thaliana 28% 82%
Q8LG70 Arabidopsis thaliana 27% 100%
Q989A3 Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) 28% 100%
Q9CQ60 Mus musculus 31% 100%
Q9FIN1 Arabidopsis thaliana 29% 100%
Q9LMX8 Arabidopsis thaliana 26% 100%
Q9PKK7 Chlamydia muridarum (strain MoPn / Nigg) 28% 100%
Q9VZ64 Drosophila melanogaster 28% 100%
Q9X0N8 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 29% 100%
Q9Z8U5 Chlamydia pneumoniae 28% 100%
V5D050 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS