6-phosphogluconolactonase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

6-phosphogluconolactonase

Species:

Leishmania infantum

UniProt:

E9AHB9_LEIIN

TriTrypDb:

LINF_260032900

Length:

267

Annotations

Annotations by Jardim et al.

Pentose Phosphate Pathway, 6-phosphogluconolactonase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

E9AHB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHB9

PDB structure(s): 3ch7_A , 3css_A

Function

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Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0006091	generation of precursor metabolites and energy	3	12
GO:0006098	pentose-phosphate shunt	5	11
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006739	NADP metabolic process	7	12
GO:0006740	NADPH regeneration	4	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016853	isomerase activity	2	1
GO:0017057	6-phosphogluconolactonase activity	5	12
GO:0052689	carboxylic ester hydrolase activity	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	50	52	PF00082	0.403
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.403
CLV_PCSK_SKI1_1	93	97	PF00082	0.273
DOC_CYCLIN_RxL_1	90	98	PF00134	0.400
DOC_MAPK_gen_1	247	257	PF00069	0.377
DOC_MAPK_gen_1	32	41	PF00069	0.356
DOC_MAPK_MEF2A_6	35	43	PF00069	0.352
DOC_PP4_FxxP_1	190	193	PF00568	0.279
DOC_WW_Pin1_4	189	194	PF00397	0.322
DOC_WW_Pin1_4	45	50	PF00397	0.250

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9Y4	Leptomonas seymouri	68%	98%
A0A0S4J8H1	Bodo saltans	35%	100%
A0A1X0NX24	Trypanosomatidae	48%	100%
A0A3Q8IG46	Leishmania donovani	100%	100%
A0A3R7NAW7	Trypanosoma rangeli	45%	100%
A2XI04	Oryza sativa subsp. indica	25%	90%
A2YNH4	Oryza sativa subsp. indica	25%	95%
A2YXS5	Oryza sativa subsp. indica	28%	82%
A2Z3C4	Oryza sativa subsp. indica	31%	82%
A4HFB4	Leishmania braziliensis	83%	100%

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