Aminopeptidase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Aminopeptidase

Gene product:

aminopeptidase-like protein

Species:

Leishmania infantum

UniProt:

E9AHB1_LEIIN

TriTrypDb:

LINF_260008000

Length:

883

Annotations

Annotations by Jardim et al.

Proteases, Aminopeptidase-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9AHB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHB1

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043171	peptide catabolic process	4	1
GO:0043603	amide metabolic process	3	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004177	aminopeptidase activity	5	11
GO:0005488	binding	1	11
GO:0008233	peptidase activity	3	11
GO:0008235	metalloexopeptidase activity	5	1
GO:0008237	metallopeptidase activity	4	11
GO:0008238	exopeptidase activity	4	11
GO:0008270	zinc ion binding	6	11
GO:0016787	hydrolase activity	2	11
GO:0033218	amide binding	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.314
CLV_NRD_NRD_1	175	177	PF00675	0.323
CLV_NRD_NRD_1	492	494	PF00675	0.391
CLV_NRD_NRD_1	664	666	PF00675	0.405
CLV_NRD_NRD_1	803	805	PF00675	0.252
CLV_PCSK_KEX2_1	142	144	PF00082	0.293
CLV_PCSK_KEX2_1	492	494	PF00082	0.459
CLV_PCSK_KEX2_1	664	666	PF00082	0.302
CLV_PCSK_KEX2_1	700	702	PF00082	0.296
CLV_PCSK_KEX2_1	803	805	PF00082	0.252

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R5	Leptomonas seymouri	29%	100%
A0A0S4JBK9	Bodo saltans	38%	100%
A0A1X0NMW3	Trypanosomatidae	41%	100%
A0A3Q8ICL6	Leishmania donovani	100%	100%
A0A3R7K1R9	Trypanosoma rangeli	40%	100%
A0A6J2ATK2	Acinonyx jubatus	27%	89%
A2RI32	Lactococcus lactis subsp. cremoris (strain MG1363)	29%	100%
A5HUI5	Gloydius brevicaudus	27%	92%
A6QPT7	Bos taurus	27%	93%
D0A6I7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%

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