Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AHA8_LEIIN

TriTrypDb:

LINF_260005900

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AHA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.471
CLV_NRD_NRD_1	249	251	PF00675	0.503
CLV_NRD_NRD_1	270	272	PF00675	0.632
CLV_NRD_NRD_1	273	275	PF00675	0.599
CLV_NRD_NRD_1	342	344	PF00675	0.608
CLV_NRD_NRD_1	62	64	PF00675	0.378
CLV_PCSK_FUR_1	246	250	PF00082	0.514
CLV_PCSK_KEX2_1	248	250	PF00082	0.515
CLV_PCSK_KEX2_1	342	344	PF00082	0.665
CLV_PCSK_KEX2_1	62	64	PF00082	0.372
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.515
CLV_PCSK_PC7_1	244	250	PF00082	0.498
CLV_PCSK_PC7_1	58	64	PF00082	0.404
CLV_PCSK_SKI1_1	249	253	PF00082	0.533
CLV_PCSK_SKI1_1	285	289	PF00082	0.509
CLV_PCSK_SKI1_1	342	346	PF00082	0.460
CLV_PCSK_SKI1_1	84	88	PF00082	0.485
DOC_MAPK_gen_1	79	88	PF00069	0.456
DOC_MAPK_MEF2A_6	82	90	PF00069	0.425
DOC_PP2B_LxvP_1	90	93	PF13499	0.530
DOC_SPAK_OSR1_1	71	75	PF12202	0.372
DOC_USP7_MATH_1	108	112	PF00917	0.441
DOC_USP7_MATH_1	313	317	PF00917	0.510
DOC_USP7_MATH_1	329	333	PF00917	0.458
DOC_USP7_MATH_1	77	81	PF00917	0.438
DOC_USP7_UBL2_3	285	289	PF12436	0.549
DOC_WW_Pin1_4	218	223	PF00397	0.540
DOC_WW_Pin1_4	349	354	PF00397	0.735
LIG_14-3-3_CanoR_1	16	20	PF00244	0.547
LIG_14-3-3_CanoR_1	186	195	PF00244	0.441
LIG_14-3-3_CanoR_1	294	300	PF00244	0.394
LIG_14-3-3_CanoR_1	312	318	PF00244	0.236
LIG_14-3-3_CanoR_1	342	351	PF00244	0.489
LIG_Actin_WH2_2	275	291	PF00022	0.500
LIG_Actin_WH2_2	298	314	PF00022	0.454
LIG_APCC_ABBAyCdc20_2	239	245	PF00400	0.421
LIG_BRCT_BRCA1_1	110	114	PF00533	0.407
LIG_BRCT_BRCA1_1	315	319	PF00533	0.473
LIG_Clathr_ClatBox_1	125	129	PF01394	0.394
LIG_FHA_1	121	127	PF00498	0.371
LIG_FHA_1	47	53	PF00498	0.455
LIG_FHA_2	150	156	PF00498	0.472
LIG_FHA_2	333	339	PF00498	0.490
LIG_LIR_Apic_2	127	133	PF02991	0.473
LIG_LIR_Apic_2	96	102	PF02991	0.436
LIG_LIR_Gen_1	189	199	PF02991	0.340
LIG_LIR_Gen_1	301	311	PF02991	0.444
LIG_LIR_Gen_1	316	327	PF02991	0.401
LIG_LIR_Nem_3	189	194	PF02991	0.343
LIG_LIR_Nem_3	277	282	PF02991	0.532
LIG_LIR_Nem_3	293	299	PF02991	0.329
LIG_LIR_Nem_3	301	307	PF02991	0.474
LIG_LIR_Nem_3	316	322	PF02991	0.311
LIG_NRBOX	336	342	PF00104	0.507
LIG_PTB_Apo_2	153	160	PF02174	0.450
LIG_RPA_C_Fungi	239	251	PF08784	0.504
LIG_SH2_NCK_1	237	241	PF00017	0.484
LIG_SH2_SRC	304	307	PF00017	0.549
LIG_SH2_STAP1	178	182	PF00017	0.426
LIG_SH2_STAP1	48	52	PF00017	0.485
LIG_SH2_STAT5	191	194	PF00017	0.450
LIG_SH2_STAT5	233	236	PF00017	0.367
LIG_SH2_STAT5	304	307	PF00017	0.441
LIG_SH2_STAT5	48	51	PF00017	0.475
LIG_SH2_STAT5	99	102	PF00017	0.360
LIG_SH3_3	133	139	PF00018	0.477
LIG_SH3_3	347	353	PF00018	0.688
LIG_SH3_3	47	53	PF00018	0.457
LIG_SH3_3	71	77	PF00018	0.413
LIG_Sin3_3	22	29	PF02671	0.445
LIG_SUMO_SIM_anti_2	120	127	PF11976	0.471
LIG_SUMO_SIM_anti_2	21	27	PF11976	0.424
LIG_SUMO_SIM_anti_2	332	341	PF11976	0.520
LIG_SUMO_SIM_par_1	120	127	PF11976	0.476
LIG_TRAF2_1	251	254	PF00917	0.488
LIG_TYR_ITIM	302	307	PF00017	0.419
LIG_WW_3	13	17	PF00397	0.618
LIG_WW_3	268	272	PF00397	0.582
MOD_CK1_1	120	126	PF00069	0.472
MOD_CK1_1	218	224	PF00069	0.550
MOD_CK1_1	295	301	PF00069	0.395
MOD_CK1_1	332	338	PF00069	0.441
MOD_CK2_1	149	155	PF00069	0.458
MOD_CK2_1	332	338	PF00069	0.467
MOD_Cter_Amidation	1	4	PF01082	0.678
MOD_GlcNHglycan	110	113	PF01048	0.364
MOD_GlcNHglycan	79	82	PF01048	0.499
MOD_GSK3_1	313	320	PF00069	0.460
MOD_GSK3_1	329	336	PF00069	0.353
MOD_N-GLC_1	186	191	PF02516	0.397
MOD_N-GLC_1	280	285	PF02516	0.547
MOD_NEK2_1	159	164	PF00069	0.361
MOD_NEK2_1	215	220	PF00069	0.427
MOD_NEK2_1	280	285	PF00069	0.500
MOD_NEK2_1	311	316	PF00069	0.552
MOD_NEK2_2	292	297	PF00069	0.504
MOD_NEK2_2	93	98	PF00069	0.481
MOD_PKA_1	3	9	PF00069	0.680
MOD_PKA_1	342	348	PF00069	0.474
MOD_PKA_2	15	21	PF00069	0.573
MOD_PKA_2	311	317	PF00069	0.503
MOD_PKA_2	342	348	PF00069	0.474
MOD_PKB_1	184	192	PF00069	0.473
MOD_Plk_1	264	270	PF00069	0.639
MOD_Plk_1	292	298	PF00069	0.502
MOD_Plk_1	333	339	PF00069	0.559
MOD_Plk_4	120	126	PF00069	0.420
MOD_Plk_4	313	319	PF00069	0.532
MOD_ProDKin_1	218	224	PF00069	0.539
MOD_ProDKin_1	349	355	PF00069	0.739
MOD_SUMO_rev_2	267	276	PF00179	0.627
TRG_DiLeu_BaEn_4	210	216	PF01217	0.466
TRG_ENDOCYTIC_2	191	194	PF00928	0.424
TRG_ENDOCYTIC_2	304	307	PF00928	0.429
TRG_ENDOCYTIC_2	64	67	PF00928	0.373
TRG_ER_diArg_1	341	343	PF00400	0.564
TRG_ER_diArg_1	62	64	PF00400	0.373
TRG_NLS_MonoExtN_4	246	252	PF00514	0.501
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIL9	Leptomonas seymouri	59%	89%
A0A0S4IRP2	Bodo saltans	28%	100%
A0A1X0NU99	Trypanosomatidae	40%	100%
A0A3Q8ICK6	Leishmania donovani	100%	100%
A0A422N352	Trypanosoma rangeli	38%	100%
A4HEL6	Leishmania braziliensis	89%	100%
A4I1U9	Leishmania infantum	100%	100%
E9AXZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q9I0	Leishmania major	97%	100%
V5DR77	Trypanosoma cruzi	40%	100%