Putative aminopeptidase P1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aminopeptidase P1 - putative

Species:

Leishmania infantum

UniProt:

E9AHA3_LEIIN

TriTrypDb:

LINF_020005300

Length:

505

Annotations

Annotations by Jardim et al.

Proteases, aminopeptidase P1

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AHA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHA3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004177	aminopeptidase activity	5	13
GO:0005488	binding	1	13
GO:0008233	peptidase activity	3	13
GO:0008235	metalloexopeptidase activity	5	13
GO:0008237	metallopeptidase activity	4	13
GO:0008238	exopeptidase activity	4	13
GO:0016787	hydrolase activity	2	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0070006	metalloaminopeptidase activity	6	13
GO:0140096	catalytic activity, acting on a protein	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	148	150	PF00675	0.427
CLV_NRD_NRD_1	275	277	PF00675	0.403
CLV_NRD_NRD_1	55	57	PF00675	0.409
CLV_PCSK_KEX2_1	16	18	PF00082	0.411
CLV_PCSK_KEX2_1	55	57	PF00082	0.405
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.333
CLV_PCSK_SKI1_1	149	153	PF00082	0.405
CLV_PCSK_SKI1_1	164	168	PF00082	0.316
CLV_PCSK_SKI1_1	185	189	PF00082	0.282
CLV_PCSK_SKI1_1	221	225	PF00082	0.405
CLV_PCSK_SKI1_1	342	346	PF00082	0.291
DEG_APCC_DBOX_1	16	24	PF00400	0.357
DEG_APCC_DBOX_1	341	349	PF00400	0.351
DEG_Nend_UBRbox_3	1	3	PF02207	0.240
DOC_MAPK_DCC_7	39	47	PF00069	0.226
DOC_MAPK_gen_1	185	193	PF00069	0.273
DOC_MAPK_gen_1	276	282	PF00069	0.405
DOC_MAPK_gen_1	65	73	PF00069	0.252
DOC_MAPK_HePTP_8	101	113	PF00069	0.405
DOC_MAPK_MEF2A_6	104	113	PF00069	0.301
DOC_MAPK_MEF2A_6	437	444	PF00069	0.384
DOC_PP1_RVXF_1	207	214	PF00149	0.273
DOC_PP1_RVXF_1	296	303	PF00149	0.273
DOC_PP1_RVXF_1	41	48	PF00149	0.226
DOC_PP4_FxxP_1	302	305	PF00568	0.273
DOC_PP4_MxPP_1	30	33	PF00568	0.560
DOC_USP7_MATH_1	322	326	PF00917	0.351
DOC_USP7_MATH_2	267	273	PF00917	0.405
DOC_WW_Pin1_4	263	268	PF00397	0.337
DOC_WW_Pin1_4	495	500	PF00397	0.538
LIG_14-3-3_CanoR_1	156	165	PF00244	0.363
LIG_14-3-3_CanoR_1	416	425	PF00244	0.485
LIG_Actin_WH2_2	170	187	PF00022	0.318
LIG_Actin_WH2_2	72	88	PF00022	0.291
LIG_BRCT_BRCA1_1	324	328	PF00533	0.405
LIG_BRCT_BRCA1_2	324	330	PF00533	0.405
LIG_FHA_1	117	123	PF00498	0.378
LIG_FHA_1	169	175	PF00498	0.359
LIG_FHA_1	206	212	PF00498	0.289
LIG_FHA_1	291	297	PF00498	0.272
LIG_FHA_1	312	318	PF00498	0.269
LIG_FHA_1	482	488	PF00498	0.474
LIG_FHA_2	231	237	PF00498	0.436
LIG_FHA_2	444	450	PF00498	0.265
LIG_FHA_2	49	55	PF00498	0.345
LIG_FHA_2	5	11	PF00498	0.324
LIG_IBAR_NPY_1	2	4	PF08397	0.283
LIG_LIR_Apic_2	299	305	PF02991	0.273
LIG_LIR_Gen_1	10	18	PF02991	0.486
LIG_LIR_Gen_1	103	113	PF02991	0.373
LIG_LIR_Gen_1	243	253	PF02991	0.279
LIG_LIR_Gen_1	311	321	PF02991	0.291
LIG_LIR_Gen_1	362	370	PF02991	0.273
LIG_LIR_Gen_1	492	499	PF02991	0.552
LIG_LIR_Nem_3	10	14	PF02991	0.408
LIG_LIR_Nem_3	103	109	PF02991	0.260
LIG_LIR_Nem_3	131	135	PF02991	0.334
LIG_LIR_Nem_3	160	166	PF02991	0.405
LIG_LIR_Nem_3	243	248	PF02991	0.284
LIG_LIR_Nem_3	249	253	PF02991	0.274
LIG_LIR_Nem_3	311	316	PF02991	0.291
LIG_LIR_Nem_3	362	366	PF02991	0.273
LIG_LIR_Nem_3	478	482	PF02991	0.398
LIG_LIR_Nem_3	492	497	PF02991	0.656
LIG_LIR_Nem_3	89	95	PF02991	0.260
LIG_Pex14_1	452	456	PF04695	0.394
LIG_PTB_Apo_2	90	97	PF02174	0.405
LIG_SH2_CRK	313	317	PF00017	0.273
LIG_SH2_CRK	494	498	PF00017	0.555
LIG_SH2_CRK	92	96	PF00017	0.279
LIG_SH2_GRB2like	106	109	PF00017	0.425
LIG_SH2_GRB2like	112	115	PF00017	0.384
LIG_SH2_NCK_1	229	233	PF00017	0.351
LIG_SH2_NCK_1	265	269	PF00017	0.337
LIG_SH2_NCK_1	92	96	PF00017	0.322
LIG_SH2_NCK_1	99	103	PF00017	0.309
LIG_SH2_PTP2	112	115	PF00017	0.405
LIG_SH2_PTP2	41	44	PF00017	0.394
LIG_SH2_SRC	106	109	PF00017	0.284
LIG_SH2_SRC	112	115	PF00017	0.148
LIG_SH2_SRC	352	355	PF00017	0.273
LIG_SH2_SRC	97	100	PF00017	0.293
LIG_SH2_STAP1	313	317	PF00017	0.273
LIG_SH2_STAP1	97	101	PF00017	0.316
LIG_SH2_STAT3	482	485	PF00017	0.351
LIG_SH2_STAT5	112	115	PF00017	0.405
LIG_SH2_STAT5	210	213	PF00017	0.273
LIG_SH2_STAT5	281	284	PF00017	0.329
LIG_SH2_STAT5	313	316	PF00017	0.273
LIG_SH2_STAT5	4	7	PF00017	0.475
LIG_SH2_STAT5	41	44	PF00017	0.409
LIG_SH2_STAT5	425	428	PF00017	0.398
LIG_SH2_STAT5	479	482	PF00017	0.265
LIG_SH2_STAT5	494	497	PF00017	0.527
LIG_SH3_3	174	180	PF00018	0.416
LIG_SUMO_SIM_anti_2	441	449	PF11976	0.448
LIG_SUMO_SIM_anti_2	69	74	PF11976	0.359
LIG_SUMO_SIM_par_1	438	443	PF11976	0.326
LIG_SUMO_SIM_par_1	69	74	PF11976	0.342
LIG_TYR_ITIM	90	95	PF00017	0.337
LIG_UBA3_1	464	470	PF00899	0.245
LIG_UBA3_1	59	66	PF00899	0.337
LIG_WRC_WIRS_1	360	365	PF05994	0.273
MOD_CDK_SPxxK_3	495	502	PF00069	0.538
MOD_CK1_1	249	255	PF00069	0.273
MOD_CK1_1	388	394	PF00069	0.342
MOD_CK1_1	428	434	PF00069	0.440
MOD_CK1_1	443	449	PF00069	0.230
MOD_CK2_1	230	236	PF00069	0.360
MOD_CK2_1	263	269	PF00069	0.394
MOD_CK2_1	4	10	PF00069	0.332
MOD_CK2_1	443	449	PF00069	0.265
MOD_CK2_1	48	54	PF00069	0.346
MOD_Cter_Amidation	147	150	PF01082	0.342
MOD_GlcNHglycan	271	274	PF01048	0.275
MOD_GlcNHglycan	284	287	PF01048	0.280
MOD_GlcNHglycan	332	335	PF01048	0.310
MOD_GlcNHglycan	419	422	PF01048	0.487
MOD_GlcNHglycan	73	76	PF01048	0.273
MOD_GSK3_1	263	270	PF00069	0.390
MOD_GSK3_1	290	297	PF00069	0.272
MOD_GSK3_1	419	426	PF00069	0.409
MOD_NEK2_1	282	287	PF00069	0.273
MOD_NEK2_2	170	175	PF00069	0.405
MOD_NEK2_2	271	276	PF00069	0.226
MOD_NEK2_2	48	53	PF00069	0.214
MOD_PIKK_1	481	487	PF00454	0.320
MOD_PKA_2	12	18	PF00069	0.476
MOD_PKA_2	155	161	PF00069	0.405
MOD_Plk_1	440	446	PF00069	0.342
MOD_Plk_4	311	317	PF00069	0.274
MOD_Plk_4	322	328	PF00069	0.271
MOD_Plk_4	359	365	PF00069	0.273
MOD_Plk_4	385	391	PF00069	0.323
MOD_Plk_4	440	446	PF00069	0.373
MOD_Plk_4	460	466	PF00069	0.148
MOD_Plk_4	492	498	PF00069	0.552
MOD_ProDKin_1	263	269	PF00069	0.337
MOD_ProDKin_1	495	501	PF00069	0.536
MOD_SUMO_for_1	187	190	PF00179	0.313
MOD_SUMO_rev_2	136	145	PF00179	0.342
MOD_SUMO_rev_2	498	504	PF00179	0.554
TRG_DiLeu_BaEn_1	311	316	PF01217	0.316
TRG_DiLeu_BaEn_1	492	497	PF01217	0.552
TRG_ENDOCYTIC_2	106	109	PF00928	0.211
TRG_ENDOCYTIC_2	135	138	PF00928	0.278
TRG_ENDOCYTIC_2	313	316	PF00928	0.273
TRG_ENDOCYTIC_2	494	497	PF00928	0.556
TRG_ENDOCYTIC_2	92	95	PF00928	0.296
TRG_ENDOCYTIC_2	99	102	PF00928	0.257
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	437	441	PF00026	0.265

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I539	Leptomonas seymouri	78%	84%
A0A1X0NZN4	Trypanosomatidae	58%	84%
A0A3Q8IFI4	Leishmania donovani	99%	100%
A0A3R7KZD6	Trypanosoma rangeli	58%	85%
A0A451EJE2	Leishmania donovani	100%	82%
A1CAQ1	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	44%	77%
A1DF27	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	46%	77%
A2QGR5	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	45%	82%
A4HEE5	Leishmania braziliensis	88%	100%
A4HRK6	Leishmania infantum	100%	100%
A4RF35	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	42%	82%
A6R035	Ajellomyces capsulatus (strain NAm1 / WU24)	42%	82%
A6RK67	Botryotinia fuckeliana (strain B05.10)	41%	84%
A7E4T8	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	44%	84%
A8P5H7	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	45%	81%
B0DZL3	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	43%	79%
B0Y3V7	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	46%	77%
B1AVD1	Mus musculus	36%	75%
B2AWV6	Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)	42%	74%
B2VUU7	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	42%	85%
B6HQC9	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	42%	82%
B6QG01	Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)	43%	77%
B8M9W2	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	42%	77%
B8NEI6	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	44%	77%
C0NDZ7	Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)	42%	82%
C0SCV1	Paracoccidioides brasiliensis (strain Pb03)	45%	82%
C1GEY4	Paracoccidioides brasiliensis (strain Pb18)	44%	82%
C1H978	Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01)	44%	82%
C5FHR9	Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)	37%	81%
C5GXZ9	Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)	41%	82%
C5K105	Blastomyces gilchristii (strain SLH14081)	41%	82%
C5P7J2	Coccidioides posadasii (strain C735)	43%	78%
C6HSY3	Ajellomyces capsulatus (strain H143)	40%	79%
C7Z9Z7	Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)	45%	82%
C9SR45	Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136)	43%	83%
C9ZKA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	82%
D1ZKF3	Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)	45%	82%
D4ARJ9	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	42%	72%
D4D891	Trichophyton verrucosum (strain HKI 0517)	41%	72%
D5GAC6	Tuber melanosporum (strain Mel28)	44%	82%
E3QCU0	Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212)	40%	82%
E3S7K9	Pyrenophora teres f. teres (strain 0-1)	43%	77%
E4USI8	Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893)	42%	80%
E5ABQ8	Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)	43%	83%
E9AC78	Leishmania major	95%	100%
E9CTR7	Coccidioides posadasii (strain RMSCC 757 / Silveira)	42%	83%
E9E9B2	Metarhizium acridum (strain CQMa 102)	44%	82%
E9EUE6	Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075)	44%	82%
F4JQH3	Arabidopsis thaliana	38%	78%
O43895	Homo sapiens	35%	75%
O44750	Caenorhabditis elegans	36%	82%
O54975	Rattus norvegicus	40%	81%
Q07825	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	67%
Q09795	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	84%
Q0CDB3	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	44%	77%
Q0UFY4	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	42%	78%
Q1JPJ2	Bos taurus	39%	81%
Q2H8T2	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	43%	81%
Q2U7S5	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	44%	77%
Q4Q9J5	Leishmania major	94%	100%
Q4WUD3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	46%	77%
Q54G06	Dictyostelium discoideum	42%	81%
Q5AVF0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	43%	77%
Q6P1B1	Mus musculus	40%	81%
Q7RYL6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	44%	74%
Q8RY11	Arabidopsis thaliana	37%	71%
Q95333	Sus scrofa	37%	75%
Q99MA2	Rattus norvegicus	36%	75%
Q9NQW7	Homo sapiens	40%	81%
Q9VJG0	Drosophila melanogaster	40%	82%
V5DIX7	Trypanosoma cruzi	58%	85%