SURF1-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

SURF1-like protein

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AHA2_LEIIN

TriTrypDb:

LINF_250031500

Length:

261

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AHA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AHA2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.364
CLV_NRD_NRD_1	112	114	PF00675	0.560
CLV_NRD_NRD_1	146	148	PF00675	0.530
CLV_NRD_NRD_1	35	37	PF00675	0.534
CLV_NRD_NRD_1	86	88	PF00675	0.564
CLV_PCSK_KEX2_1	112	114	PF00082	0.560
CLV_PCSK_KEX2_1	146	148	PF00082	0.542
CLV_PCSK_KEX2_1	245	247	PF00082	0.372
CLV_PCSK_KEX2_1	35	37	PF00082	0.593
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.361
CLV_PCSK_SKI1_1	112	116	PF00082	0.614
CLV_PCSK_SKI1_1	13	17	PF00082	0.616
CLV_PCSK_SKI1_1	238	242	PF00082	0.374
CLV_PCSK_SKI1_1	26	30	PF00082	0.593
CLV_PCSK_SKI1_1	83	87	PF00082	0.554
DEG_SCF_FBW7_1	121	128	PF00400	0.427
DOC_CKS1_1	122	127	PF01111	0.352
DOC_CKS1_1	42	47	PF01111	0.387
DOC_CYCLIN_RxL_1	235	243	PF00134	0.572
DOC_MAPK_gen_1	161	170	PF00069	0.389
DOC_MAPK_gen_1	251	261	PF00069	0.599
DOC_MAPK_gen_1	35	41	PF00069	0.325
DOC_MAPK_gen_1	7	17	PF00069	0.415
DOC_PP1_RVXF_1	11	18	PF00149	0.411
DOC_PP4_FxxP_1	122	125	PF00568	0.414
DOC_PP4_FxxP_1	169	172	PF00568	0.301
DOC_USP7_MATH_1	142	146	PF00917	0.423
DOC_USP7_UBL2_3	254	258	PF12436	0.640
DOC_WW_Pin1_4	121	126	PF00397	0.348
DOC_WW_Pin1_4	41	46	PF00397	0.388
LIG_14-3-3_CanoR_1	146	150	PF00244	0.403
LIG_Actin_WH2_2	74	89	PF00022	0.394
LIG_APCC_ABBAyCdc20_2	13	19	PF00400	0.402
LIG_BIR_II_1	1	5	PF00653	0.453
LIG_BRCT_BRCA1_1	165	169	PF00533	0.319
LIG_EH_1	74	78	PF12763	0.434
LIG_FHA_1	146	152	PF00498	0.429
LIG_FHA_1	19	25	PF00498	0.355
LIG_FHA_1	193	199	PF00498	0.319
LIG_FHA_1	52	58	PF00498	0.351
LIG_FHA_1	7	13	PF00498	0.376
LIG_LIR_Apic_2	119	125	PF02991	0.418
LIG_LIR_Apic_2	166	172	PF02991	0.309
LIG_LIR_Apic_2	93	99	PF02991	0.405
LIG_LIR_Gen_1	93	102	PF02991	0.380
LIG_LIR_Nem_3	55	61	PF02991	0.316
LIG_LIR_Nem_3	72	77	PF02991	0.384
LIG_LIR_Nem_3	93	97	PF02991	0.369
LIG_NRBOX	221	227	PF00104	0.475
LIG_PCNA_PIPBox_1	215	224	PF02747	0.413
LIG_PCNA_yPIPBox_3	213	222	PF02747	0.341
LIG_PTB_Apo_2	68	75	PF02174	0.316
LIG_PTB_Phospho_1	68	74	PF10480	0.350
LIG_SH2_PTP2	78	81	PF00017	0.406
LIG_SH2_STAP1	47	51	PF00017	0.358
LIG_SH2_STAT5	156	159	PF00017	0.404
LIG_SH2_STAT5	175	178	PF00017	0.294
LIG_SH2_STAT5	221	224	PF00017	0.328
LIG_SH2_STAT5	52	55	PF00017	0.356
LIG_SH2_STAT5	61	64	PF00017	0.197
LIG_SH2_STAT5	68	71	PF00017	0.277
LIG_SH2_STAT5	78	81	PF00017	0.267
LIG_SH2_STAT5	96	99	PF00017	0.298
LIG_SH3_3	154	160	PF00018	0.416
LIG_SH3_3	167	173	PF00018	0.306
LIG_SH3_3	39	45	PF00018	0.319
LIG_SH3_3	54	60	PF00018	0.319
LIG_TRFH_1	169	173	PF08558	0.307
LIG_WW_1	172	175	PF00397	0.296
MOD_CDK_SPK_2	41	46	PF00069	0.388
MOD_CK1_1	145	151	PF00069	0.378
MOD_CK1_1	6	12	PF00069	0.431
MOD_GSK3_1	121	128	PF00069	0.397
MOD_GSK3_1	190	197	PF00069	0.351
MOD_GSK3_1	37	44	PF00069	0.388
MOD_N-GLC_1	108	113	PF02516	0.562
MOD_N-GLC_2	212	214	PF02516	0.580
MOD_NEK2_1	130	135	PF00069	0.409
MOD_NEK2_1	136	141	PF00069	0.404
MOD_NEK2_1	81	86	PF00069	0.409
MOD_PKA_2	136	142	PF00069	0.448
MOD_PKA_2	145	151	PF00069	0.327
MOD_PKA_2	37	43	PF00069	0.373
MOD_Plk_4	125	131	PF00069	0.429
MOD_Plk_4	163	169	PF00069	0.322
MOD_ProDKin_1	121	127	PF00069	0.352
MOD_ProDKin_1	41	47	PF00069	0.387
MOD_SUMO_for_1	116	119	PF00179	0.433
TRG_ENDOCYTIC_2	221	224	PF00928	0.337
TRG_ENDOCYTIC_2	74	77	PF00928	0.402
TRG_ENDOCYTIC_2	78	81	PF00928	0.367
TRG_ENDOCYTIC_2	94	97	PF00928	0.174
TRG_ER_diArg_1	10	13	PF00400	0.448
TRG_ER_diArg_1	34	36	PF00400	0.414
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	26	31	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYG4	Leptomonas seymouri	83%	100%
A0A0S4JRT7	Bodo saltans	49%	100%
A0A1X0ND76	Trypanosomatidae	62%	100%
A0A3Q8ICJ6	Leishmania donovani	100%	100%
A0A3R7N4J0	Trypanosoma rangeli	62%	100%
A4HEE4	Leishmania braziliensis	88%	100%
C9ZKA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AXX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q9J6	Leishmania major	98%	100%
V5B2F8	Trypanosoma cruzi	62%	100%