DNA-directed RNA polymerase ii

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA polymerase subunit RPB10 - putative

Species:

Leishmania infantum

UniProt:

E9AH97_LEIIN

TriTrypDb:

LINF_250019300

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	9
GO:0030880	RNA polymerase complex	3	9
GO:0032991	protein-containing complex	1	9
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	9
GO:0140535	intracellular protein-containing complex	2	9
GO:1902494	catalytic complex	2	9
GO:1990234	transferase complex	3	9
GO:0000120	RNA polymerase I transcription regulator complex	3	1
GO:0005665	RNA polymerase II, core complex	4	1
GO:0005666	RNA polymerase III complex	4	1
GO:0005667	transcription regulator complex	2	1
GO:0005736	RNA polymerase I complex	4	1
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AH97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH97

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006351	DNA-templated transcription	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009059	macromolecule biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0018130	heterocycle biosynthetic process	4	10
GO:0019438	aromatic compound biosynthetic process	4	10
GO:0032774	RNA biosynthetic process	5	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034654	nucleobase-containing compound biosynthetic process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:0097659	nucleic acid-templated transcription	6	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901362	organic cyclic compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10
GO:0006360	transcription by RNA polymerase I	8	1
GO:0006366	transcription by RNA polymerase II	8	1
GO:0006383	transcription by RNA polymerase III	8	1
GO:0006399	tRNA metabolic process	7	1
GO:0009304	tRNA transcription	8	1
GO:0034660	ncRNA metabolic process	6	1
GO:0042797	tRNA transcription by RNA polymerase III	9	1
GO:0098781	ncRNA transcription	8	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0003824	catalytic activity	1	10
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	10
GO:0005488	binding	1	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016779	nucleotidyltransferase activity	4	10
GO:0034062	5'-3' RNA polymerase activity	5	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097747	RNA polymerase activity	4	10
GO:0140098	catalytic activity, acting on RNA	3	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.500
CLV_NRD_NRD_1	46	48	PF00675	0.218
CLV_PCSK_KEX2_1	46	48	PF00082	0.218
CLV_PCSK_PC7_1	42	48	PF00082	0.218
CLV_PCSK_SKI1_1	47	51	PF00082	0.218
DEG_APCC_DBOX_1	46	54	PF00400	0.418
DEG_Nend_Nbox_1	1	3	PF02207	0.280
DOC_CKS1_1	78	83	PF01111	0.518
DOC_PP2B_LxvP_1	76	79	PF13499	0.478
DOC_WW_Pin1_4	77	82	PF00397	0.536
LIG_14-3-3_CanoR_1	47	56	PF00244	0.437
LIG_14-3-3_CanoR_1	6	14	PF00244	0.418
LIG_FHA_2	28	34	PF00498	0.429
LIG_LIR_Gen_1	19	29	PF02991	0.435
LIG_LIR_Nem_3	19	24	PF02991	0.418
LIG_NRP_CendR_1	83	84	PF00754	0.582
LIG_SH2_CRK	21	25	PF00017	0.435
LIG_SH2_CRK	62	66	PF00017	0.416
LIG_SH2_NCK_1	29	33	PF00017	0.419
LIG_SH2_STAT5	29	32	PF00017	0.435
LIG_SH2_STAT5	43	46	PF00017	0.435
LIG_SUMO_SIM_anti_2	51	58	PF11976	0.435
MOD_CDK_SPxK_1	77	83	PF00069	0.500
MOD_CDK_SPxxK_3	77	84	PF00069	0.543
MOD_CK2_1	27	33	PF00069	0.424
MOD_GSK3_1	60	67	PF00069	0.458
MOD_NEK2_1	48	53	PF00069	0.428
MOD_ProDKin_1	77	83	PF00069	0.541
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.475
TRG_ENDOCYTIC_2	21	24	PF00928	0.418
TRG_ER_diArg_1	46	48	PF00400	0.418
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.275

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P890	Leptomonas seymouri	45%	94%
A0A0N1IKV3	Leptomonas seymouri	93%	100%
A0A0S4JEQ2	Bodo saltans	52%	100%
A0A0S4KJV1	Bodo saltans	77%	87%
A0A3Q8I9P7	Leishmania donovani	46%	94%
A0A3Q8IGL4	Leishmania donovani	100%	100%
A0A3R7RS40	Trypanosoma rangeli	80%	66%
A0B6E7	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	43%	100%
A1RSD9	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	41%	100%
A2BK83	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	32%	100%
A2SSV3	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	52%	100%
A3CWI3	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	46%	100%
A3DMR0	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	39%	100%
A3MXZ9	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	44%	100%
A4FWK8	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	41%	100%
A4H798	Leishmania braziliensis	48%	100%
A4HE74	Leishmania braziliensis	93%	100%
A4HVP0	Leishmania infantum	46%	100%
A4WNA8	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	44%	100%
A4YIM8	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	35%	100%
A6UPX1	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	40%	100%
A6VGR3	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	41%	100%
A7IAH1	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	45%	100%
A8M9S4	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	41%	100%
A8Y1E9	Caenorhabditis briggsae	58%	100%
A9A9Y7	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	41%	100%
B0R4Y6	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	48%	100%
B1YC34	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	48%	100%
B6YSQ7	Thermococcus onnurineus (strain NA1)	45%	100%
B8GEG1	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	46%	100%
B8YB63	Saccharolobus shibatae	39%	100%
B9LPW4	Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)	49%	100%
C3MJQ1	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	39%	100%
C3MZ09	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	39%	100%
C3N058	Sulfolobus islandicus (strain M.16.27)	39%	100%
C3N8S2	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	39%	100%
C3NMP6	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	39%	100%
C4KJ97	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	39%	100%
C9ZJZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9ACT0	Leishmania major	99%	100%
E9APD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9AXL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O13877	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	62%	100%
O29135	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	44%	100%
O59298	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	53%	100%
P22139	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	58%	100%
P29199	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	43%	100%
P39472	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	41%	100%
P60291	Pyrococcus abyssi (strain GE5 / Orsay)	52%	100%
P60292	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	52%	100%
P62875	Homo sapiens	63%	100%
P62876	Mus musculus	63%	100%
Q0W8C7	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	44%	100%
Q12TI4	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	48%	100%
Q18G60	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	47%	100%
Q2FTN7	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	51%	100%
Q32P78	Bos taurus	63%	100%
Q39290	Brassica napus	61%	100%
Q3IQT2	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	48%	100%
Q46CK8	Methanosarcina barkeri (strain Fusaro / DSM 804)	52%	100%
Q4QG42	Leishmania major	48%	100%
Q55AB6	Dictyostelium discoideum	63%	100%
Q57649	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	33%	100%
Q5JJC9	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	44%	100%
Q6L292	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	47%	100%
Q6LXM4	Methanococcus maripaludis (strain S2 / LL)	41%	100%
Q6QN04	Chinchilla lanigera	63%	100%
Q75BV8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	55%	100%
Q8LFJ6	Arabidopsis thaliana	62%	100%
Q8PW43	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	54%	100%
Q8SRS6	Encephalitozoon cuniculi (strain GB-M1)	50%	100%
Q8TT41	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	52%	100%
Q8TVB4	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	51%	100%
Q8ZYP9	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	43%	100%
Q96YW4	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	42%	100%
Q979K0	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	44%	100%
Q980Z8	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	38%	100%
Q9GR61	Caenorhabditis elegans	58%	100%
Q9HL09	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	43%	100%
Q9HQJ1	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	48%	100%
Q9SYA6	Arabidopsis thaliana	58%	100%
Q9VC49	Drosophila melanogaster	62%	100%
Q9YB47	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	39%	100%