RNA-binding protein, putative, UPB1

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein - putative - UPB1

Species:

Leishmania infantum

UniProt:

E9AH94_LEIIN

TriTrypDb:

LINF_250010200

Length:

233

Annotations

Annotations by Jardim et al.

Nucleic acid binding, RNA-binding , putative, UPB1

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 45

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0032991	protein-containing complex	1	11
GO:0110165	cellular anatomical entity	1	4
GO:1990904	ribonucleoprotein complex	2	11
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Phosphorylation

Promastigote: 63, 67

Expansion

Sequence features

E9AH94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH94

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003729	mRNA binding	5	2
GO:0003730	mRNA 3'-UTR binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	114	120	PF00089	0.328
CLV_PCSK_KEX2_1	164	166	PF00082	0.377
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.377
CLV_PCSK_SKI1_1	112	116	PF00082	0.377
CLV_PCSK_SKI1_1	164	168	PF00082	0.412
CLV_PCSK_SKI1_1	9	13	PF00082	0.347
DEG_APCC_DBOX_1	8	16	PF00400	0.343
DOC_CDC14_PxL_1	38	46	PF14671	0.388
DOC_CKS1_1	65	70	PF01111	0.603
DOC_CYCLIN_RxL_1	109	116	PF00134	0.577
DOC_CYCLIN_RxL_1	21	32	PF00134	0.332
DOC_CYCLIN_yCln2_LP_2	50	56	PF00134	0.391
DOC_MAPK_gen_1	164	170	PF00069	0.577
DOC_PP4_MxPP_1	66	69	PF00568	0.654
DOC_WW_Pin1_4	33	38	PF00397	0.385
DOC_WW_Pin1_4	49	54	PF00397	0.466
DOC_WW_Pin1_4	64	69	PF00397	0.606
LIG_BRCT_BRCA1_1	13	17	PF00533	0.333
LIG_FHA_1	41	47	PF00498	0.436
LIG_FHA_2	102	108	PF00498	0.577
LIG_IBAR_NPY_1	208	210	PF08397	0.648
LIG_LIR_Gen_1	14	25	PF02991	0.326
LIG_LIR_Nem_3	116	121	PF02991	0.603
LIG_LIR_Nem_3	135	141	PF02991	0.592
LIG_LIR_Nem_3	14	20	PF02991	0.330
LIG_LIR_Nem_3	36	41	PF02991	0.395
LIG_NRBOX	11	17	PF00104	0.409
LIG_OCRL_FandH_1	22	34	PF00620	0.337
LIG_Pex14_2	19	23	PF04695	0.326
LIG_SH2_CRK	138	142	PF00017	0.577
LIG_SH2_STAT3	181	184	PF00017	0.577
LIG_SH2_STAT3	210	213	PF00017	0.612
LIG_SH2_STAT3	222	225	PF00017	0.502
LIG_SH2_STAT3	7	10	PF00017	0.369
LIG_SH2_STAT5	101	104	PF00017	0.577
LIG_SH3_3	34	40	PF00018	0.391
LIG_SH3_3	75	81	PF00018	0.693
LIG_WRC_WIRS_1	16	21	PF05994	0.328
MOD_CK1_1	145	151	PF00069	0.577
MOD_CK1_1	36	42	PF00069	0.395
MOD_CK1_1	52	58	PF00069	0.467
MOD_CK2_1	102	108	PF00069	0.577
MOD_GlcNHglycan	144	147	PF01048	0.377
MOD_GlcNHglycan	172	175	PF01048	0.683
MOD_GlcNHglycan	31	34	PF01048	0.362
MOD_GSK3_1	11	18	PF00069	0.359
MOD_GSK3_1	29	36	PF00069	0.356
MOD_GSK3_1	48	55	PF00069	0.405
MOD_GSK3_1	56	63	PF00069	0.467
MOD_NEK2_1	15	20	PF00069	0.330
MOD_NEK2_1	170	175	PF00069	0.625
MOD_PIKK_1	60	66	PF00454	0.543
MOD_PKA_2	129	135	PF00069	0.577
MOD_Plk_4	11	17	PF00069	0.376
MOD_Plk_4	2	8	PF00069	0.433
MOD_Plk_4	40	46	PF00069	0.460
MOD_ProDKin_1	33	39	PF00069	0.386
MOD_ProDKin_1	49	55	PF00069	0.465
MOD_ProDKin_1	64	70	PF00069	0.612
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.320
TRG_ENDOCYTIC_2	138	141	PF00928	0.577
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID53	Leishmania donovani	99%	100%
A0A3S7WYY4	Leishmania donovani	100%	100%
A4HDZ1	Leishmania braziliensis	90%	100%
A4HDZ2	Leishmania braziliensis	90%	100%
A4I191	Leishmania infantum	99%	100%
A6NFN3	Homo sapiens	27%	75%
E9AXC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E9AXC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4QA45	Leishmania major	99%	100%
Q4QA46	Leishmania major	99%	100%