LeishMANIAdb
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Hypothetical predicted multi-pass transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical predicted multi-pass transmembrane protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E9AH92_LEIIN
TriTrypDb:
LINF_240024500
Length:
413

Annotations

Annotations by Jardim et al.

Membrane associated proteins, Hypothetical predicted multi-pass transmembrane

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 3, no: 3
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

E9AH92
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH92

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 202 206 PF00656 0.534
CLV_C14_Caspase3-7 301 305 PF00656 0.575
CLV_NRD_NRD_1 144 146 PF00675 0.723
CLV_NRD_NRD_1 220 222 PF00675 0.774
CLV_NRD_NRD_1 223 225 PF00675 0.762
CLV_NRD_NRD_1 306 308 PF00675 0.695
CLV_NRD_NRD_1 320 322 PF00675 0.572
CLV_NRD_NRD_1 392 394 PF00675 0.460
CLV_NRD_NRD_1 7 9 PF00675 0.515
CLV_PCSK_FUR_1 221 225 PF00082 0.748
CLV_PCSK_KEX2_1 144 146 PF00082 0.723
CLV_PCSK_KEX2_1 219 221 PF00082 0.783
CLV_PCSK_KEX2_1 223 225 PF00082 0.759
CLV_PCSK_KEX2_1 306 308 PF00082 0.695
CLV_PCSK_KEX2_1 7 9 PF00082 0.529
CLV_PCSK_PC7_1 219 225 PF00082 0.744
CLV_PCSK_PC7_1 3 9 PF00082 0.539
CLV_PCSK_SKI1_1 177 181 PF00082 0.722
CLV_PCSK_SKI1_1 213 217 PF00082 0.697
DEG_Nend_UBRbox_3 1 3 PF02207 0.770
DOC_CKS1_1 67 72 PF01111 0.496
DOC_MAPK_gen_1 306 315 PF00069 0.517
DOC_MAPK_MEF2A_6 20 27 PF00069 0.397
DOC_MAPK_MEF2A_6 306 315 PF00069 0.517
DOC_MAPK_MEF2A_6 368 376 PF00069 0.402
DOC_PP1_RVXF_1 386 393 PF00149 0.650
DOC_PP2B_LxvP_1 102 105 PF13499 0.496
DOC_PP4_FxxP_1 100 103 PF00568 0.437
DOC_PP4_MxPP_1 101 104 PF00568 0.419
DOC_USP7_MATH_1 19 23 PF00917 0.436
DOC_USP7_MATH_1 237 241 PF00917 0.615
DOC_USP7_MATH_1 243 247 PF00917 0.569
DOC_USP7_MATH_1 256 260 PF00917 0.389
DOC_USP7_MATH_1 305 309 PF00917 0.537
DOC_USP7_MATH_1 323 327 PF00917 0.380
DOC_USP7_MATH_1 361 365 PF00917 0.493
DOC_USP7_MATH_1 73 77 PF00917 0.567
DOC_USP7_MATH_1 91 95 PF00917 0.527
DOC_WW_Pin1_4 231 236 PF00397 0.586
DOC_WW_Pin1_4 66 71 PF00397 0.466
LIG_14-3-3_CanoR_1 20 24 PF00244 0.411
LIG_14-3-3_CanoR_1 224 232 PF00244 0.572
LIG_14-3-3_CanoR_1 251 261 PF00244 0.544
LIG_14-3-3_CanoR_1 362 366 PF00244 0.481
LIG_14-3-3_CanoR_1 393 400 PF00244 0.648
LIG_BRCT_BRCA1_1 96 100 PF00533 0.458
LIG_FHA_1 261 267 PF00498 0.502
LIG_FHA_1 353 359 PF00498 0.493
LIG_FHA_1 384 390 PF00498 0.635
LIG_FHA_1 62 68 PF00498 0.406
LIG_FHA_2 292 298 PF00498 0.518
LIG_GBD_Chelix_1 23 31 PF00786 0.513
LIG_LIR_Apic_2 97 103 PF02991 0.475
LIG_LIR_Gen_1 344 351 PF02991 0.491
LIG_LIR_Gen_1 377 387 PF02991 0.513
LIG_LIR_Gen_1 76 87 PF02991 0.458
LIG_LIR_Nem_3 154 158 PF02991 0.444
LIG_LIR_Nem_3 186 192 PF02991 0.460
LIG_LIR_Nem_3 364 370 PF02991 0.433
LIG_LIR_Nem_3 377 383 PF02991 0.437
LIG_NRBOX 26 32 PF00104 0.513
LIG_NRBOX 51 57 PF00104 0.492
LIG_Pex14_1 371 375 PF04695 0.436
LIG_Pex14_2 365 369 PF04695 0.449
LIG_REV1ctd_RIR_1 177 186 PF16727 0.488
LIG_REV1ctd_RIR_1 363 371 PF16727 0.442
LIG_RPA_C_Fungi 15 27 PF08784 0.299
LIG_RPA_C_Fungi 383 395 PF08784 0.571
LIG_SH2_CRK 380 384 PF00017 0.389
LIG_SH2_STAP1 347 351 PF00017 0.691
LIG_SH2_STAP1 380 384 PF00017 0.436
LIG_SH2_STAT3 192 195 PF00017 0.601
LIG_SH2_STAT5 298 301 PF00017 0.713
LIG_SH3_3 229 235 PF00018 0.749
LIG_SUMO_SIM_anti_2 22 28 PF11976 0.436
LIG_SUMO_SIM_anti_2 51 57 PF11976 0.605
LIG_SUMO_SIM_par_1 63 69 PF11976 0.515
LIG_TRAF2_1 115 118 PF00917 0.817
LIG_TRAF2_1 159 162 PF00917 0.564
LIG_TRAF2_1 283 286 PF00917 0.799
LIG_TRFH_1 100 104 PF08558 0.609
MOD_CDK_SPK_2 231 236 PF00069 0.747
MOD_CK1_1 396 402 PF00069 0.678
MOD_CK1_1 66 72 PF00069 0.608
MOD_CK1_1 94 100 PF00069 0.597
MOD_CK2_1 156 162 PF00069 0.554
MOD_CK2_1 201 207 PF00069 0.739
MOD_CK2_1 238 244 PF00069 0.819
MOD_CK2_1 291 297 PF00069 0.710
MOD_GlcNHglycan 130 133 PF01048 0.697
MOD_GlcNHglycan 227 230 PF01048 0.641
MOD_GlcNHglycan 241 244 PF01048 0.718
MOD_GlcNHglycan 245 248 PF01048 0.696
MOD_GlcNHglycan 254 257 PF01048 0.587
MOD_GlcNHglycan 258 261 PF01048 0.498
MOD_GlcNHglycan 270 273 PF01048 0.531
MOD_GlcNHglycan 278 282 PF01048 0.536
MOD_GlcNHglycan 325 328 PF01048 0.684
MOD_GlcNHglycan 401 404 PF01048 0.642
MOD_GlcNHglycan 93 96 PF01048 0.705
MOD_GSK3_1 124 131 PF00069 0.702
MOD_GSK3_1 15 22 PF00069 0.438
MOD_GSK3_1 199 206 PF00069 0.692
MOD_GSK3_1 231 238 PF00069 0.833
MOD_GSK3_1 239 246 PF00069 0.741
MOD_GSK3_1 252 259 PF00069 0.604
MOD_GSK3_1 401 408 PF00069 0.578
MOD_GSK3_1 73 80 PF00069 0.654
MOD_NEK2_1 139 144 PF00069 0.720
MOD_NEK2_1 151 156 PF00069 0.461
MOD_NEK2_1 268 273 PF00069 0.713
MOD_NEK2_1 374 379 PF00069 0.513
MOD_NEK2_1 383 388 PF00069 0.364
MOD_NEK2_1 48 53 PF00069 0.633
MOD_NEK2_2 361 366 PF00069 0.613
MOD_PIKK_1 139 145 PF00454 0.638
MOD_PIKK_1 393 399 PF00454 0.607
MOD_PIKK_1 86 92 PF00454 0.724
MOD_PKA_1 219 225 PF00069 0.619
MOD_PKA_1 393 399 PF00069 0.583
MOD_PKA_2 19 25 PF00069 0.411
MOD_PKA_2 219 225 PF00069 0.689
MOD_PKA_2 305 311 PF00069 0.612
MOD_PKA_2 352 358 PF00069 0.690
MOD_PKA_2 361 367 PF00069 0.549
MOD_Plk_1 291 297 PF00069 0.710
MOD_Plk_2-3 201 207 PF00069 0.662
MOD_Plk_4 19 25 PF00069 0.436
MOD_Plk_4 361 367 PF00069 0.587
MOD_Plk_4 48 54 PF00069 0.545
MOD_Plk_4 73 79 PF00069 0.516
MOD_Plk_4 94 100 PF00069 0.576
MOD_ProDKin_1 231 237 PF00069 0.747
MOD_ProDKin_1 66 72 PF00069 0.593
TRG_ENDOCYTIC_2 347 350 PF00928 0.696
TRG_ENDOCYTIC_2 367 370 PF00928 0.183
TRG_ENDOCYTIC_2 380 383 PF00928 0.390
TRG_ER_diArg_1 108 111 PF00400 0.785
TRG_ER_diArg_1 218 221 PF00400 0.739
TRG_ER_diArg_1 223 226 PF00400 0.716
TRG_ER_diArg_1 7 9 PF00400 0.655
TRG_ER_diLys_1 409 413 PF00400 0.688
TRG_NLS_Bipartite_1 393 413 PF00514 0.520

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P420 Leptomonas seymouri 38% 98%
A0A3S7WYI6 Leishmania donovani 100% 100%
A4HDP6 Leishmania braziliensis 64% 98%
E9AX30 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4QAE6 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS