Putative short chain dehydrogenase/reductase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short chain dehydrogenase/reductase - putative

Species:

Leishmania infantum

UniProt:

E9AH89_LEIIN

TriTrypDb:

LINF_240024200

Length:

507

Annotations

Annotations by Jardim et al.

Oxidoreductase, short chain dehydrogenase/reductase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 31
NetGPI	no	yes: 0, no: 32

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	11
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	13

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Expansion

Sequence features

E9AH89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH89

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006633	fatty acid biosynthetic process	5	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004312	fatty acid synthase activity	5	3
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	5	3
GO:0008667	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity	5	1
GO:0016491	oxidoreductase activity	2	4
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	3
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	3
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	1
GO:0016740	transferase activity	2	3

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.217
CLV_NRD_NRD_1	169	171	PF00675	0.603
CLV_NRD_NRD_1	27	29	PF00675	0.430
CLV_NRD_NRD_1	324	326	PF00675	0.418
CLV_NRD_NRD_1	329	331	PF00675	0.414
CLV_NRD_NRD_1	388	390	PF00675	0.523
CLV_NRD_NRD_1	48	50	PF00675	0.557
CLV_PCSK_KEX2_1	127	129	PF00082	0.217
CLV_PCSK_KEX2_1	169	171	PF00082	0.632
CLV_PCSK_KEX2_1	27	29	PF00082	0.442

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S7	Leptomonas seymouri	80%	99%
A0A0N1HZ81	Leptomonas seymouri	32%	91%
A0A0S4IWT0	Bodo saltans	46%	100%
A0A0S4IZG2	Bodo saltans	30%	100%
A0A0S4J1I6	Bodo saltans	31%	100%
A0A1X0NVT8	Trypanosomatidae	65%	100%
A0A3Q8ID46	Leishmania donovani	99%	100%
A0A3Q8IM89	Leishmania donovani	28%	100%
A0A3R7K071	Trypanosoma rangeli	32%	100%
A0A3R7N7S2	Trypanosoma rangeli	26%	100%

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