LeishMANIAdb
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Putative short chain dehydrogenase/reductase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative short chain dehydrogenase/reductase
Gene product:
short chain dehydrogenase/reductase - putative
Species:
Leishmania infantum
UniProt:
E9AH89_LEIIN
TriTrypDb:
LINF_240024200
Length:
507

Annotations

Annotations by Jardim et al.

Oxidoreductase, short chain dehydrogenase/reductase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 31
NetGPI no yes: 0, no: 32
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 13
GO:0005737 cytoplasm 2 2
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

E9AH89
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH89

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 1
GO:0006629 lipid metabolic process 3 1
GO:0006631 fatty acid metabolic process 4 1
GO:0006633 fatty acid biosynthetic process 5 1
GO:0008152 metabolic process 1 1
GO:0008610 lipid biosynthetic process 4 1
GO:0009058 biosynthetic process 2 1
GO:0009987 cellular process 1 1
GO:0016053 organic acid biosynthetic process 4 1
GO:0019752 carboxylic acid metabolic process 5 1
GO:0030497 fatty acid elongation 6 1
GO:0032787 monocarboxylic acid metabolic process 6 1
GO:0043436 oxoacid metabolic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044255 cellular lipid metabolic process 3 1
GO:0044281 small molecule metabolic process 2 1
GO:0044283 small molecule biosynthetic process 3 1
GO:0046394 carboxylic acid biosynthetic process 5 1
GO:0071704 organic substance metabolic process 2 1
GO:0072330 monocarboxylic acid biosynthetic process 6 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 4
GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity 5 1
GO:0016491 oxidoreductase activity 2 4
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3 1
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 4 1
GO:0004312 fatty acid synthase activity 5 3
GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity 5 3
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 3
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 3
GO:0016740 transferase activity 2 3
GO:0016746 acyltransferase activity 3 3
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 127 129 PF00675 0.217
CLV_NRD_NRD_1 169 171 PF00675 0.603
CLV_NRD_NRD_1 27 29 PF00675 0.430
CLV_NRD_NRD_1 324 326 PF00675 0.418
CLV_NRD_NRD_1 329 331 PF00675 0.414
CLV_NRD_NRD_1 388 390 PF00675 0.523
CLV_NRD_NRD_1 48 50 PF00675 0.557
CLV_PCSK_KEX2_1 127 129 PF00082 0.217
CLV_PCSK_KEX2_1 169 171 PF00082 0.632
CLV_PCSK_KEX2_1 27 29 PF00082 0.442
CLV_PCSK_KEX2_1 329 331 PF00082 0.360
CLV_PCSK_KEX2_1 388 390 PF00082 0.523
CLV_PCSK_KEX2_1 478 480 PF00082 0.514
CLV_PCSK_KEX2_1 48 50 PF00082 0.566
CLV_PCSK_PC1ET2_1 478 480 PF00082 0.595
CLV_PCSK_PC7_1 325 331 PF00082 0.341
CLV_PCSK_SKI1_1 175 179 PF00082 0.564
CLV_PCSK_SKI1_1 27 31 PF00082 0.455
CLV_PCSK_SKI1_1 274 278 PF00082 0.438
CLV_PCSK_SKI1_1 354 358 PF00082 0.566
CLV_PCSK_SKI1_1 478 482 PF00082 0.549
CLV_PCSK_SKI1_1 73 77 PF00082 0.542
DEG_APCC_DBOX_1 127 135 PF00400 0.469
DEG_APCC_DBOX_1 6 14 PF00400 0.559
DEG_Nend_Nbox_1 1 3 PF02207 0.694
DEG_SPOP_SBC_1 237 241 PF00917 0.384
DEG_SPOP_SBC_1 36 40 PF00917 0.558
DEG_SPOP_SBC_1 58 62 PF00917 0.634
DOC_CYCLIN_RxL_1 24 33 PF00134 0.565
DOC_CYCLIN_yCln2_LP_2 129 135 PF00134 0.345
DOC_MAPK_DCC_7 397 406 PF00069 0.381
DOC_MAPK_gen_1 127 135 PF00069 0.483
DOC_MAPK_gen_1 214 221 PF00069 0.291
DOC_MAPK_gen_1 299 308 PF00069 0.267
DOC_MAPK_gen_1 329 337 PF00069 0.167
DOC_MAPK_gen_1 388 395 PF00069 0.309
DOC_MAPK_MEF2A_6 127 135 PF00069 0.479
DOC_MAPK_MEF2A_6 301 310 PF00069 0.365
DOC_MAPK_NFAT4_5 128 136 PF00069 0.343
DOC_PP1_RVXF_1 25 32 PF00149 0.651
DOC_PP1_RVXF_1 250 256 PF00149 0.265
DOC_PP2B_LxvP_1 129 132 PF13499 0.345
DOC_PP4_FxxP_1 310 313 PF00568 0.268
DOC_PP4_MxPP_1 78 81 PF00568 0.531
DOC_USP7_MATH_1 155 159 PF00917 0.431
DOC_USP7_MATH_1 209 213 PF00917 0.349
DOC_USP7_MATH_1 238 242 PF00917 0.508
DOC_USP7_MATH_1 36 40 PF00917 0.764
DOC_USP7_MATH_1 58 62 PF00917 0.665
DOC_USP7_MATH_1 74 78 PF00917 0.664
DOC_USP7_MATH_1 81 85 PF00917 0.674
DOC_USP7_MATH_1 86 90 PF00917 0.636
DOC_USP7_MATH_1 98 102 PF00917 0.534
DOC_USP7_UBL2_3 496 500 PF12436 0.406
DOC_WW_Pin1_4 240 245 PF00397 0.534
LIG_14-3-3_CanoR_1 163 167 PF00244 0.328
LIG_14-3-3_CanoR_1 252 256 PF00244 0.238
LIG_14-3-3_CanoR_1 369 376 PF00244 0.264
LIG_14-3-3_CanoR_1 397 404 PF00244 0.382
LIG_14-3-3_CanoR_1 434 440 PF00244 0.336
LIG_APCC_ABBAyCdc20_2 170 176 PF00400 0.277
LIG_BRCT_BRCA1_1 59 63 PF00533 0.563
LIG_CSL_BTD_1 129 132 PF09270 0.264
LIG_EH_1 423 427 PF12763 0.410
LIG_eIF4E_1 194 200 PF01652 0.258
LIG_eIF4E_1 466 472 PF01652 0.308
LIG_FHA_1 154 160 PF00498 0.411
LIG_FHA_1 179 185 PF00498 0.258
LIG_FHA_1 186 192 PF00498 0.268
LIG_FHA_1 232 238 PF00498 0.546
LIG_FHA_1 315 321 PF00498 0.260
LIG_LIR_Apic_2 143 148 PF02991 0.361
LIG_LIR_Gen_1 120 129 PF02991 0.541
LIG_LIR_Gen_1 178 184 PF02991 0.304
LIG_LIR_Gen_1 254 261 PF02991 0.248
LIG_LIR_Nem_3 120 124 PF02991 0.495
LIG_LIR_Nem_3 178 183 PF02991 0.309
LIG_Pex14_2 310 314 PF04695 0.235
LIG_PTB_Apo_2 384 391 PF02174 0.379
LIG_PTB_Apo_2 459 466 PF02174 0.288
LIG_PTB_Phospho_1 384 390 PF10480 0.375
LIG_PTB_Phospho_1 459 465 PF10480 0.290
LIG_SH2_CRK 180 184 PF00017 0.311
LIG_SH2_GRB2like 145 148 PF00017 0.214
LIG_SH2_NCK_1 113 117 PF00017 0.621
LIG_SH2_NCK_1 154 158 PF00017 0.483
LIG_SH2_SRC 145 148 PF00017 0.214
LIG_SH2_STAP1 136 140 PF00017 0.356
LIG_SH2_STAP1 180 184 PF00017 0.311
LIG_SH2_STAP1 466 470 PF00017 0.287
LIG_SH2_STAT3 260 263 PF00017 0.321
LIG_SH2_STAT3 380 383 PF00017 0.224
LIG_SH2_STAT3 502 505 PF00017 0.295
LIG_SH2_STAT5 103 106 PF00017 0.621
LIG_SH2_STAT5 121 124 PF00017 0.545
LIG_SH2_STAT5 145 148 PF00017 0.321
LIG_SH2_STAT5 180 183 PF00017 0.264
LIG_SH2_STAT5 194 197 PF00017 0.209
LIG_SH2_STAT5 336 339 PF00017 0.261
LIG_SH2_STAT5 502 505 PF00017 0.421
LIG_SH3_3 15 21 PF00018 0.537
LIG_SH3_3 225 231 PF00018 0.431
LIG_SUMO_SIM_anti_2 262 268 PF11976 0.228
LIG_SUMO_SIM_anti_2 279 285 PF11976 0.261
LIG_TYR_ITSM 176 183 PF00017 0.313
LIG_UBA3_1 320 326 PF00899 0.220
MOD_CK1_1 112 118 PF00069 0.578
MOD_CK1_1 14 20 PF00069 0.712
MOD_CK1_1 240 246 PF00069 0.524
MOD_CK1_1 37 43 PF00069 0.727
MOD_CK1_1 474 480 PF00069 0.318
MOD_CK1_1 61 67 PF00069 0.601
MOD_CK2_1 209 215 PF00069 0.351
MOD_Cter_Amidation 167 170 PF01082 0.642
MOD_GlcNHglycan 114 117 PF01048 0.413
MOD_GlcNHglycan 13 16 PF01048 0.365
MOD_GlcNHglycan 142 145 PF01048 0.339
MOD_GlcNHglycan 188 191 PF01048 0.487
MOD_GlcNHglycan 211 214 PF01048 0.599
MOD_GlcNHglycan 240 243 PF01048 0.727
MOD_GlcNHglycan 32 35 PF01048 0.369
MOD_GlcNHglycan 371 374 PF01048 0.455
MOD_GlcNHglycan 39 42 PF01048 0.515
MOD_GlcNHglycan 473 476 PF01048 0.511
MOD_GlcNHglycan 50 53 PF01048 0.415
MOD_GlcNHglycan 64 67 PF01048 0.453
MOD_GlcNHglycan 83 86 PF01048 0.433
MOD_GlcNHglycan 99 103 PF01048 0.328
MOD_GSK3_1 178 185 PF00069 0.285
MOD_GSK3_1 233 240 PF00069 0.501
MOD_GSK3_1 30 37 PF00069 0.639
MOD_GSK3_1 320 327 PF00069 0.232
MOD_GSK3_1 40 47 PF00069 0.629
MOD_GSK3_1 57 64 PF00069 0.591
MOD_N-GLC_1 22 27 PF02516 0.362
MOD_N-GLC_1 34 39 PF02516 0.334
MOD_N-GLC_2 453 455 PF02516 0.461
MOD_NEK2_1 123 128 PF00069 0.573
MOD_NEK2_1 153 158 PF00069 0.385
MOD_NEK2_1 22 27 PF00069 0.668
MOD_NEK2_1 29 34 PF00069 0.648
MOD_NEK2_1 324 329 PF00069 0.209
MOD_NEK2_1 364 369 PF00069 0.417
MOD_NEK2_1 413 418 PF00069 0.327
MOD_NEK2_1 427 432 PF00069 0.383
MOD_NEK2_1 494 499 PF00069 0.345
MOD_NEK2_1 59 64 PF00069 0.620
MOD_NEK2_2 86 91 PF00069 0.736
MOD_PIKK_1 445 451 PF00454 0.249
MOD_PKA_1 325 331 PF00069 0.311
MOD_PKA_1 48 54 PF00069 0.549
MOD_PKA_2 162 168 PF00069 0.335
MOD_PKA_2 251 257 PF00069 0.233
MOD_PKA_2 324 330 PF00069 0.228
MOD_PKA_2 396 402 PF00069 0.410
MOD_PKA_2 456 462 PF00069 0.380
MOD_PKA_2 47 53 PF00069 0.689
MOD_Plk_1 98 104 PF00069 0.591
MOD_Plk_2-3 215 221 PF00069 0.240
MOD_Plk_4 117 123 PF00069 0.562
MOD_Plk_4 155 161 PF00069 0.422
MOD_Plk_4 251 257 PF00069 0.255
MOD_Plk_4 427 433 PF00069 0.430
MOD_Plk_4 447 453 PF00069 0.244
MOD_Plk_4 74 80 PF00069 0.611
MOD_ProDKin_1 240 246 PF00069 0.525
MOD_SUMO_rev_2 477 485 PF00179 0.292
MOD_SUMO_rev_2 89 98 PF00179 0.625
TRG_DiLeu_BaEn_1 353 358 PF01217 0.259
TRG_DiLeu_BaEn_2 216 222 PF01217 0.316
TRG_DiLeu_BaLyEn_6 25 30 PF01217 0.567
TRG_ENDOCYTIC_2 121 124 PF00928 0.498
TRG_ENDOCYTIC_2 139 142 PF00928 0.278
TRG_ENDOCYTIC_2 180 183 PF00928 0.278
TRG_ENDOCYTIC_2 194 197 PF00928 0.261
TRG_ENDOCYTIC_2 390 393 PF00928 0.326
TRG_ENDOCYTIC_2 501 504 PF00928 0.393
TRG_ER_diArg_1 127 129 PF00400 0.417
TRG_ER_diArg_1 27 29 PF00400 0.639
TRG_ER_diArg_1 388 390 PF00400 0.323
TRG_ER_diArg_1 6 9 PF00400 0.670
TRG_ER_FFAT_2 60 68 PF00635 0.538

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2S7 Leptomonas seymouri 80% 99%
A0A0N1HZ81 Leptomonas seymouri 32% 91%
A0A0S4IWT0 Bodo saltans 46% 100%
A0A0S4IZG2 Bodo saltans 30% 100%
A0A0S4J1I6 Bodo saltans 31% 100%
A0A1X0NVT8 Trypanosomatidae 65% 100%
A0A3Q8ID46 Leishmania donovani 99% 100%
A0A3Q8IM89 Leishmania donovani 28% 100%
A0A3R7K071 Trypanosoma rangeli 32% 100%
A0A3R7N7S2 Trypanosoma rangeli 26% 100%
A0A3S5H7D5 Leishmania donovani 33% 100%
A0A3S7WQY1 Leishmania donovani 27% 100%
A0A422N2B6 Trypanosoma rangeli 63% 100%
A4H5Z1 Leishmania braziliensis 24% 100%
A4HDP2 Leishmania braziliensis 33% 100%
A4HDP3 Leishmania braziliensis 87% 100%
A4HMN7 Leishmania braziliensis 29% 100%
A4HUB6 Leishmania infantum 27% 100%
C9ZWC0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
C9ZWC1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZZF3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9AF39 Leishmania major 29% 100%
E9AH88 Leishmania infantum 33% 100%
E9AHV6 Leishmania infantum 29% 100%
E9AN15 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AX26 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9AX27 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9B694 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
Q4QAE9 Leishmania major 92% 100%
Q4QAF0 Leishmania major 34% 100%
Q4QHL1 Leishmania major 28% 100%
Q803A8 Danio rerio 26% 100%
Q92247 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 25% 100%
V5BAF4 Trypanosoma cruzi 64% 100%
V5BJC7 Trypanosoma cruzi 25% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS