Putative short chain dehydrogenase/reductase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta-ketoacyl-ACP reductase 2 - putative

Species:

Leishmania infantum

UniProt:

E9AH88_LEIIN

TriTrypDb:

LINF_240024100

Length:

501

Annotations

Annotations by Jardim et al.

Oxidoreductase, short chain dehydrogenase/reductase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 32
NetGPI	no	yes: 0, no: 33

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	16
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AH88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH88

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006633	fatty acid biosynthetic process	5	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0030497	fatty acid elongation	6	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0072330	monocarboxylic acid biosynthetic process	6	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0008667	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity	5	1
GO:0016491	oxidoreductase activity	2	4
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	1
GO:0004312	fatty acid synthase activity	5	3
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	5	3
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	3
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	3
GO:0016740	transferase activity	2	3
GO:0016746	acyltransferase activity	3	3
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	244	250	PF00089	0.279
CLV_NRD_NRD_1	136	138	PF00675	0.383
CLV_NRD_NRD_1	369	371	PF00675	0.558
CLV_PCSK_KEX2_1	136	138	PF00082	0.408
CLV_PCSK_KEX2_1	220	222	PF00082	0.286
CLV_PCSK_KEX2_1	369	371	PF00082	0.567
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.304
CLV_PCSK_PC7_1	216	222	PF00082	0.278
CLV_PCSK_SKI1_1	142	146	PF00082	0.381
CLV_PCSK_SKI1_1	242	246	PF00082	0.234
CLV_PCSK_SKI1_1	340	344	PF00082	0.499
CLV_PCSK_SKI1_1	56	60	PF00082	0.454
DOC_MAPK_HePTP_8	244	256	PF00069	0.401
DOC_MAPK_MEF2A_6	247	256	PF00069	0.462
DOC_PP4_FxxP_1	258	261	PF00568	0.509
DOC_USP7_MATH_1	194	198	PF00917	0.489
DOC_USP7_MATH_1	222	226	PF00917	0.511
DOC_USP7_MATH_1	28	32	PF00917	0.707
DOC_USP7_MATH_1	334	338	PF00917	0.518
DOC_USP7_MATH_1	341	345	PF00917	0.612
DOC_USP7_MATH_1	380	384	PF00917	0.797
DOC_USP7_UBL2_3	495	499	PF12436	0.380
DOC_WW_Pin1_4	177	182	PF00397	0.592
DOC_WW_Pin1_4	303	308	PF00397	0.541
DOC_WW_Pin1_4	406	411	PF00397	0.536
DOC_WW_Pin1_4	418	423	PF00397	0.567
DOC_WW_Pin1_4	43	48	PF00397	0.704
LIG_14-3-3_CanoR_1	349	353	PF00244	0.740
LIG_14-3-3_CanoR_1	402	410	PF00244	0.503
LIG_14-3-3_CanoR_1	48	57	PF00244	0.659
LIG_14-3-3_CanoR_1	64	69	PF00244	0.722
LIG_14-3-3_CanoR_1	79	83	PF00244	0.633
LIG_BIR_II_1	1	5	PF00653	0.581
LIG_BIR_III_1	1	5	PF00653	0.579
LIG_BIR_III_3	1	5	PF00653	0.579
LIG_BRCT_BRCA1_1	419	423	PF00533	0.641
LIG_CSL_BTD_1	304	307	PF09270	0.558
LIG_eIF4E_1	431	437	PF01652	0.293
LIG_FHA_1	139	145	PF00498	0.603
LIG_FHA_1	153	159	PF00498	0.481
LIG_FHA_1	263	269	PF00498	0.473
LIG_FHA_1	392	398	PF00498	0.703
LIG_FHA_1	79	85	PF00498	0.603
LIG_FHA_2	438	444	PF00498	0.330
LIG_HCF-1_HBM_1	72	75	PF13415	0.625
LIG_LIR_Apic_2	337	341	PF02991	0.666
LIG_LIR_Gen_1	210	218	PF02991	0.490
LIG_LIR_Gen_1	424	435	PF02991	0.402
LIG_LIR_Gen_1	81	90	PF02991	0.585
LIG_LIR_Nem_3	210	215	PF02991	0.466
LIG_LIR_Nem_3	311	316	PF02991	0.586
LIG_LIR_Nem_3	424	430	PF02991	0.364
LIG_Pex14_2	423	427	PF04695	0.457
LIG_Pex14_2	59	63	PF04695	0.580
LIG_PTAP_UEV_1	4	9	PF05743	0.583
LIG_PTB_Apo_2	456	463	PF02174	0.315
LIG_PTB_Phospho_1	456	462	PF10480	0.316
LIG_RPA_C_Fungi	125	137	PF08784	0.498
LIG_SH2_GRB2like	463	466	PF00017	0.363
LIG_SH2_PTP2	434	437	PF00017	0.483
LIG_SH2_SRC	432	435	PF00017	0.240
LIG_SH2_SRC	468	471	PF00017	0.485
LIG_SH2_STAP1	373	377	PF00017	0.720
LIG_SH2_STAT5	102	105	PF00017	0.391
LIG_SH2_STAT5	189	192	PF00017	0.304
LIG_SH2_STAT5	218	221	PF00017	0.384
LIG_SH2_STAT5	243	246	PF00017	0.220
LIG_SH2_STAT5	262	265	PF00017	0.384
LIG_SH2_STAT5	281	284	PF00017	0.349
LIG_SH2_STAT5	298	301	PF00017	0.396
LIG_SH2_STAT5	429	432	PF00017	0.296
LIG_SH2_STAT5	434	437	PF00017	0.273
LIG_SH3_1	54	60	PF00018	0.538
LIG_SH3_3	105	111	PF00018	0.445
LIG_SH3_3	2	8	PF00018	0.482
LIG_SH3_3	301	307	PF00018	0.494
LIG_SH3_3	54	60	PF00018	0.538
LIG_SUMO_SIM_anti_2	172	177	PF11976	0.386
LIG_SUMO_SIM_anti_2	228	233	PF11976	0.348
LIG_TYR_ITIM	430	435	PF00017	0.342
MOD_CDK_SPK_2	303	308	PF00069	0.443
MOD_CDK_SPK_2	43	48	PF00069	0.678
MOD_CK1_1	12	18	PF00069	0.584
MOD_CK1_1	225	231	PF00069	0.469
MOD_CK1_1	3	9	PF00069	0.725
MOD_CK1_1	344	350	PF00069	0.570
MOD_CK1_1	368	374	PF00069	0.660
MOD_CK1_1	383	389	PF00069	0.725
MOD_CK1_1	46	52	PF00069	0.629
MOD_CK2_1	383	389	PF00069	0.497
MOD_CK2_1	437	443	PF00069	0.401
MOD_CK2_1	64	70	PF00069	0.656
MOD_Cter_Amidation	134	137	PF01082	0.523
MOD_GlcNHglycan	108	111	PF01048	0.477
MOD_GlcNHglycan	11	14	PF01048	0.621
MOD_GlcNHglycan	155	158	PF01048	0.339
MOD_GlcNHglycan	28	31	PF01048	0.617
MOD_GlcNHglycan	284	287	PF01048	0.239
MOD_GlcNHglycan	299	302	PF01048	0.505
MOD_GlcNHglycan	370	373	PF01048	0.684
MOD_GlcNHglycan	385	388	PF01048	0.635
MOD_GlcNHglycan	41	44	PF01048	0.609
MOD_GlcNHglycan	423	426	PF01048	0.401
MOD_GlcNHglycan	5	8	PF01048	0.688
MOD_GlcNHglycan	87	90	PF01048	0.588
MOD_GSK3_1	102	109	PF00069	0.446
MOD_GSK3_1	12	19	PF00069	0.564
MOD_GSK3_1	138	145	PF00069	0.534
MOD_GSK3_1	149	156	PF00069	0.310
MOD_GSK3_1	24	31	PF00069	0.660
MOD_GSK3_1	341	348	PF00069	0.649
MOD_GSK3_1	39	46	PF00069	0.511
MOD_GSK3_1	417	424	PF00069	0.460
MOD_N-GLC_1	225	230	PF02516	0.494
MOD_N-GLC_2	138	140	PF02516	0.340
MOD_N-GLC_2	450	452	PF02516	0.333
MOD_NEK2_1	126	131	PF00069	0.418
MOD_NEK2_1	417	422	PF00069	0.456
MOD_NEK2_1	423	428	PF00069	0.327
MOD_NEK2_1	473	478	PF00069	0.572
MOD_NEK2_1	85	90	PF00069	0.511
MOD_PIKK_1	380	386	PF00454	0.735
MOD_PIKK_1	442	448	PF00454	0.320
MOD_PKA_2	138	144	PF00069	0.480
MOD_PKA_2	222	228	PF00069	0.386
MOD_PKA_2	348	354	PF00069	0.681
MOD_PKA_2	368	374	PF00069	0.700
MOD_PKA_2	401	407	PF00069	0.391
MOD_PKA_2	78	84	PF00069	0.537
MOD_PKA_2	85	91	PF00069	0.447
MOD_Plk_1	171	177	PF00069	0.332
MOD_Plk_1	225	231	PF00069	0.462
MOD_Plk_4	294	300	PF00069	0.438
MOD_Plk_4	423	429	PF00069	0.402
MOD_Plk_4	444	450	PF00069	0.330
MOD_Plk_4	485	491	PF00069	0.289
MOD_Plk_4	64	70	PF00069	0.649
MOD_ProDKin_1	177	183	PF00069	0.487
MOD_ProDKin_1	303	309	PF00069	0.420
MOD_ProDKin_1	406	412	PF00069	0.417
MOD_ProDKin_1	418	424	PF00069	0.450
MOD_ProDKin_1	43	49	PF00069	0.643
MOD_SUMO_for_1	498	501	PF00179	0.486
TRG_ENDOCYTIC_2	432	435	PF00928	0.366
TRG_ER_diArg_1	136	139	PF00400	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S7	Leptomonas seymouri	33%	97%
A0A0N1HZ81	Leptomonas seymouri	69%	90%
A0A0S4IWT0	Bodo saltans	32%	100%
A0A0S4IZG2	Bodo saltans	35%	100%
A0A0S4J1I6	Bodo saltans	43%	100%
A0A1X0NVT8	Trypanosomatidae	36%	100%
A0A1X0NVV6	Trypanosomatidae	51%	97%
A0A3Q8ID46	Leishmania donovani	34%	99%
A0A3Q8IM89	Leishmania donovani	29%	100%
A0A3R7K071	Trypanosoma rangeli	51%	100%
A0A3R7N7S2	Trypanosoma rangeli	26%	100%
A0A3S5H7D5	Leishmania donovani	99%	100%
A0A3S7X986	Leishmania donovani	24%	100%
A0A422N2B6	Trypanosoma rangeli	34%	100%
A4HDP2	Leishmania braziliensis	86%	100%
A4HDP3	Leishmania braziliensis	32%	98%
A4HMN7	Leishmania braziliensis	27%	100%
C9ZWC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZWC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
C9ZZF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AF41	Leishmania major	22%	100%
E9AH89	Leishmania infantum	33%	99%
E9AHV6	Leishmania infantum	29%	100%
E9AHV8	Leishmania infantum	24%	100%
E9AX26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AX27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B694	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B696	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
Q4QAE9	Leishmania major	34%	100%
Q4QAF0	Leishmania major	93%	100%
V5BAF4	Trypanosoma cruzi	34%	100%
V5BNY6	Trypanosoma cruzi	28%	100%