DUF4476 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AH87_LEIIN

TriTrypDb:

LINF_240024000

Length:

106

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0035869	ciliary transition zone	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AH87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH87

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	52	54	PF00675	0.625
CLV_PCSK_SKI1_1	101	105	PF00082	0.656
CLV_PCSK_SKI1_1	12	16	PF00082	0.488
DOC_USP7_MATH_1	23	27	PF00917	0.597
DOC_USP7_UBL2_3	50	54	PF12436	0.586
LIG_14-3-3_CanoR_1	10	18	PF00244	0.500
LIG_14-3-3_CanoR_1	53	62	PF00244	0.437
LIG_EVH1_1	83	87	PF00568	0.625
LIG_FHA_1	6	12	PF00498	0.494
LIG_LIR_Gen_1	42	51	PF02991	0.501
LIG_LIR_Gen_1	58	68	PF02991	0.462
LIG_LIR_Gen_1	72	83	PF02991	0.496
LIG_LIR_Nem_3	13	18	PF02991	0.486
LIG_LIR_Nem_3	42	46	PF02991	0.483
LIG_LIR_Nem_3	58	63	PF02991	0.477
LIG_LIR_Nem_3	72	78	PF02991	0.474
LIG_SH2_CRK	60	64	PF00017	0.396
LIG_SH2_NCK_1	60	64	PF00017	0.396
LIG_SH2_STAP1	60	64	PF00017	0.419
LIG_SH2_STAT5	75	78	PF00017	0.471
LIG_SH3_3	81	87	PF00018	0.573
MOD_GlcNHglycan	55	58	PF01048	0.460
MOD_GSK3_1	1	8	PF00069	0.575
MOD_GSK3_1	10	17	PF00069	0.485
MOD_PIKK_1	1	7	PF00454	0.581
MOD_PKA_1	53	59	PF00069	0.458
TRG_ENDOCYTIC_2	60	63	PF00928	0.399
TRG_ENDOCYTIC_2	75	78	PF00928	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBB6	Leptomonas seymouri	91%	100%
A0A0S4J366	Bodo saltans	60%	100%
A0A1X0NVT9	Trypanosomatidae	69%	98%
A0A3R7M555	Trypanosoma rangeli	68%	100%
A0A3S7WYM0	Leishmania donovani	100%	100%
A4HDP1	Leishmania braziliensis	95%	100%
C9ZWC2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9AX25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QAF1	Leishmania major	97%	100%