Uncharacterized protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM - RBD - or RNP domain)/RNA recognition motif (a.k.a. RRM - RBD - or RNP domain) - putative

Species:

Leishmania infantum

UniProt:

E9AH86_LEIIN

TriTrypDb:

LINF_240023900

Length:

245

Annotations

Annotations by Jardim et al.

Nucleic acid binding, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

E9AH86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH86

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	135	139	PF00082	0.339
CLV_PCSK_SKI1_1	230	234	PF00082	0.443
DEG_Nend_UBRbox_2	1	3	PF02207	0.601
DOC_CKS1_1	88	93	PF01111	0.728
DOC_MAPK_MEF2A_6	208	216	PF00069	0.547
DOC_USP7_MATH_1	107	111	PF00917	0.679
DOC_WW_Pin1_4	119	124	PF00397	0.703
DOC_WW_Pin1_4	146	151	PF00397	0.485
DOC_WW_Pin1_4	216	221	PF00397	0.568
DOC_WW_Pin1_4	82	87	PF00397	0.727
LIG_BRCT_BRCA1_1	218	222	PF00533	0.603
LIG_BRCT_BRCA1_1	76	80	PF00533	0.734
LIG_CtBP_PxDLS_1	154	158	PF00389	0.474
LIG_EH_1	77	81	PF12763	0.734
LIG_FHA_1	120	126	PF00498	0.613
LIG_FHA_1	182	188	PF00498	0.480
LIG_FHA_1	209	215	PF00498	0.474
LIG_FHA_1	216	222	PF00498	0.475
LIG_FHA_2	150	156	PF00498	0.474
LIG_LIR_Gen_1	184	194	PF02991	0.474
LIG_LIR_Nem_3	184	189	PF02991	0.474
LIG_PAM2_1	78	90	PF00658	0.726
LIG_RPA_C_Fungi	6	18	PF08784	0.624
LIG_SH2_STAT3	96	99	PF00017	0.732
LIG_SH2_STAT5	186	189	PF00017	0.339
LIG_SH2_STAT5	192	195	PF00017	0.339
LIG_SH2_STAT5	223	226	PF00017	0.508
LIG_SH3_3	51	57	PF00018	0.646
LIG_SH3_3	66	72	PF00018	0.641
LIG_SH3_3	73	79	PF00018	0.645
LIG_SH3_3	83	89	PF00018	0.649
LIG_TRAF2_1	153	156	PF00917	0.339
LIG_TYR_ITIM	221	226	PF00017	0.431
LIG_WRC_WIRS_1	125	130	PF05994	0.539
MOD_CK1_1	129	135	PF00069	0.477
MOD_CK1_1	3	9	PF00069	0.637
MOD_CK2_1	149	155	PF00069	0.339
MOD_GlcNHglycan	109	112	PF01048	0.555
MOD_GlcNHglycan	4	8	PF01048	0.635
MOD_GSK3_1	129	136	PF00069	0.472
MOD_GSK3_1	146	153	PF00069	0.339
MOD_N-GLC_1	168	173	PF02516	0.339
MOD_N-GLC_1	82	87	PF02516	0.727
MOD_NEK2_1	168	173	PF00069	0.280
MOD_NEK2_1	207	212	PF00069	0.339
MOD_NEK2_1	224	229	PF00069	0.553
MOD_NEK2_1	49	54	PF00069	0.734
MOD_NEK2_1	64	69	PF00069	0.673
MOD_PIKK_1	36	42	PF00454	0.501
MOD_PIKK_1	64	70	PF00454	0.654
MOD_PIKK_1	94	100	PF00454	0.659
MOD_PKA_2	143	149	PF00069	0.377
MOD_PKA_2	175	181	PF00069	0.339
MOD_Plk_1	168	174	PF00069	0.339
MOD_Plk_1	190	196	PF00069	0.406
MOD_Plk_4	168	174	PF00069	0.335
MOD_Plk_4	208	214	PF00069	0.339
MOD_Plk_4	42	48	PF00069	0.557
MOD_ProDKin_1	119	125	PF00069	0.702
MOD_ProDKin_1	146	152	PF00069	0.354
MOD_ProDKin_1	216	222	PF00069	0.577
MOD_ProDKin_1	82	88	PF00069	0.725
MOD_SUMO_rev_2	175	184	PF00179	0.339
TRG_ENDOCYTIC_2	186	189	PF00928	0.339
TRG_ENDOCYTIC_2	192	195	PF00928	0.329
TRG_ENDOCYTIC_2	223	226	PF00928	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IMV3	Leishmania donovani	98%	100%
A0A3R7NAM0	Trypanosoma rangeli	50%	100%
A4HDP0	Leishmania braziliensis	80%	100%
E9AX24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QAF2	Leishmania major	91%	98%