Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein - putative

Species:

Leishmania infantum

UniProt:

E9AH82_LEIIN

TriTrypDb:

LINF_240023500

Length:

738

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AH82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH82

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.499
CLV_C14_Caspase3-7	366	370	PF00656	0.453
CLV_C14_Caspase3-7	572	576	PF00656	0.658
CLV_NRD_NRD_1	379	381	PF00675	0.519
CLV_NRD_NRD_1	705	707	PF00675	0.462
CLV_PCSK_KEX2_1	289	291	PF00082	0.538
CLV_PCSK_KEX2_1	379	381	PF00082	0.524
CLV_PCSK_KEX2_1	503	505	PF00082	0.479
CLV_PCSK_KEX2_1	704	706	PF00082	0.438
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.518
CLV_PCSK_PC1ET2_1	503	505	PF00082	0.405
CLV_PCSK_SKI1_1	290	294	PF00082	0.464
CLV_PCSK_SKI1_1	452	456	PF00082	0.418
CLV_PCSK_SKI1_1	520	524	PF00082	0.550
CLV_PCSK_SKI1_1	706	710	PF00082	0.525
DEG_APCC_DBOX_1	383	391	PF00400	0.406
DEG_APCC_DBOX_1	428	436	PF00400	0.547
DEG_SPOP_SBC_1	404	408	PF00917	0.607
DOC_ANK_TNKS_1	567	574	PF00023	0.611
DOC_CKS1_1	274	279	PF01111	0.583
DOC_CYCLIN_RxL_1	391	402	PF00134	0.529
DOC_MAPK_gen_1	379	387	PF00069	0.436
DOC_MAPK_MEF2A_6	384	392	PF00069	0.376
DOC_PP1_RVXF_1	392	399	PF00149	0.493
DOC_PP1_RVXF_1	413	420	PF00149	0.484
DOC_PP1_RVXF_1	58	64	PF00149	0.506
DOC_PP4_FxxP_1	274	277	PF00568	0.544
DOC_PP4_FxxP_1	658	661	PF00568	0.438
DOC_USP7_MATH_1	117	121	PF00917	0.718
DOC_USP7_MATH_1	131	135	PF00917	0.755
DOC_USP7_MATH_1	334	338	PF00917	0.509
DOC_USP7_MATH_1	370	374	PF00917	0.501
DOC_USP7_MATH_1	404	408	PF00917	0.628
DOC_USP7_MATH_1	507	511	PF00917	0.647
DOC_USP7_MATH_1	571	575	PF00917	0.663
DOC_USP7_MATH_1	595	599	PF00917	0.581
DOC_USP7_MATH_2	80	86	PF00917	0.691
DOC_USP7_UBL2_3	94	98	PF12436	0.696
DOC_WW_Pin1_4	118	123	PF00397	0.705
DOC_WW_Pin1_4	127	132	PF00397	0.603
DOC_WW_Pin1_4	198	203	PF00397	0.785
DOC_WW_Pin1_4	207	212	PF00397	0.750
DOC_WW_Pin1_4	229	234	PF00397	0.620
DOC_WW_Pin1_4	252	257	PF00397	0.707
DOC_WW_Pin1_4	273	278	PF00397	0.546
DOC_WW_Pin1_4	292	297	PF00397	0.526
DOC_WW_Pin1_4	405	410	PF00397	0.605
DOC_WW_Pin1_4	505	510	PF00397	0.623
DOC_WW_Pin1_4	554	559	PF00397	0.450
DOC_WW_Pin1_4	625	630	PF00397	0.547
LIG_14-3-3_CanoR_1	191	197	PF00244	0.692
LIG_14-3-3_CanoR_1	257	266	PF00244	0.553
LIG_14-3-3_CanoR_1	290	296	PF00244	0.544
LIG_14-3-3_CanoR_1	397	401	PF00244	0.425
LIG_14-3-3_CanoR_1	456	460	PF00244	0.368
LIG_Actin_WH2_1	384	399	PF00022	0.414
LIG_Actin_WH2_2	381	399	PF00022	0.503
LIG_Actin_WH2_2	440	458	PF00022	0.531
LIG_BIR_III_4	575	579	PF00653	0.751
LIG_BRCT_BRCA1_1	30	34	PF00533	0.648
LIG_BRCT_BRCA1_1	530	534	PF00533	0.466
LIG_Clathr_ClatBox_1	446	450	PF01394	0.467
LIG_FAT_LD_1	182	190	PF03623	0.599
LIG_FHA_1	11	17	PF00498	0.670
LIG_FHA_1	128	134	PF00498	0.757
LIG_FHA_1	211	217	PF00498	0.635
LIG_FHA_1	279	285	PF00498	0.563
LIG_FHA_1	521	527	PF00498	0.534
LIG_FHA_1	682	688	PF00498	0.514
LIG_FHA_1	726	732	PF00498	0.546
LIG_FHA_2	230	236	PF00498	0.543
LIG_FHA_2	243	249	PF00498	0.677
LIG_FHA_2	259	265	PF00498	0.489
LIG_FHA_2	364	370	PF00498	0.454
LIG_FHA_2	510	516	PF00498	0.657
LIG_FHA_2	97	103	PF00498	0.691
LIG_GBD_Chelix_1	388	396	PF00786	0.373
LIG_HP1_1	334	338	PF01393	0.489
LIG_LIR_Gen_1	212	222	PF02991	0.603
LIG_LIR_Gen_1	458	467	PF02991	0.442
LIG_LIR_Gen_1	472	481	PF02991	0.480
LIG_LIR_Gen_1	684	692	PF02991	0.564
LIG_LIR_Nem_3	106	111	PF02991	0.694
LIG_LIR_Nem_3	212	217	PF02991	0.623
LIG_LIR_Nem_3	458	462	PF02991	0.370
LIG_LIR_Nem_3	463	468	PF02991	0.368
LIG_LIR_Nem_3	680	686	PF02991	0.500
LIG_LIR_Nem_3	710	714	PF02991	0.427
LIG_NRBOX	181	187	PF00104	0.578
LIG_NRBOX	386	392	PF00104	0.462
LIG_PCNA_yPIPBox_3	332	340	PF02747	0.510
LIG_PDZ_Class_2	733	738	PF00595	0.660
LIG_PTB_Apo_2	653	660	PF02174	0.551
LIG_Rb_LxCxE_1	463	485	PF01857	0.468
LIG_SH2_CRK	108	112	PF00017	0.697
LIG_SH2_NCK_1	643	647	PF00017	0.490
LIG_SH2_PTP2	686	689	PF00017	0.416
LIG_SH2_SRC	439	442	PF00017	0.527
LIG_SH2_STAT5	15	18	PF00017	0.578
LIG_SH2_STAT5	242	245	PF00017	0.692
LIG_SH2_STAT5	259	262	PF00017	0.502
LIG_SH2_STAT5	273	276	PF00017	0.462
LIG_SH2_STAT5	539	542	PF00017	0.383
LIG_SH2_STAT5	553	556	PF00017	0.419
LIG_SH2_STAT5	560	563	PF00017	0.512
LIG_SH2_STAT5	686	689	PF00017	0.419
LIG_SH2_STAT5	707	710	PF00017	0.442
LIG_SH3_3	494	500	PF00018	0.558
LIG_SH3_3	552	558	PF00018	0.433
LIG_SUMO_SIM_anti_2	261	267	PF11976	0.426
LIG_SUMO_SIM_anti_2	597	603	PF11976	0.642
LIG_SUMO_SIM_par_1	445	450	PF11976	0.565
LIG_TRAF2_2	54	59	PF00917	0.459
LIG_TYR_ITSM	682	689	PF00017	0.559
LIG_UBA3_1	387	394	PF00899	0.463
LIG_UBA3_1	601	607	PF00899	0.565
LIG_WRC_WIRS_1	347	352	PF05994	0.474
MOD_CDK_SPK_2	118	123	PF00069	0.705
MOD_CDK_SPK_2	198	203	PF00069	0.727
MOD_CDK_SPK_2	252	257	PF00069	0.702
MOD_CDK_SPxxK_3	118	125	PF00069	0.708
MOD_CK1_1	132	138	PF00069	0.763
MOD_CK1_1	142	148	PF00069	0.804
MOD_CK1_1	201	207	PF00069	0.641
MOD_CK1_1	29	35	PF00069	0.662
MOD_CK1_1	373	379	PF00069	0.474
MOD_CK1_1	4	10	PF00069	0.687
MOD_CK1_1	427	433	PF00069	0.468
MOD_CK1_1	482	488	PF00069	0.614
MOD_CK1_1	510	516	PF00069	0.621
MOD_CK1_1	72	78	PF00069	0.600
MOD_CK2_1	190	196	PF00069	0.685
MOD_CK2_1	209	215	PF00069	0.627
MOD_CK2_1	242	248	PF00069	0.604
MOD_CK2_1	280	286	PF00069	0.536
MOD_CK2_1	427	433	PF00069	0.538
MOD_CK2_1	435	441	PF00069	0.448
MOD_CK2_1	509	515	PF00069	0.614
MOD_CK2_1	566	572	PF00069	0.522
MOD_CK2_1	96	102	PF00069	0.690
MOD_CMANNOS	563	566	PF00535	0.580
MOD_Cter_Amidation	287	290	PF01082	0.535
MOD_GlcNHglycan	238	241	PF01048	0.704
MOD_GlcNHglycan	3	6	PF01048	0.650
MOD_GlcNHglycan	316	319	PF01048	0.640
MOD_GlcNHglycan	329	332	PF01048	0.634
MOD_GlcNHglycan	401	404	PF01048	0.515
MOD_GlcNHglycan	484	487	PF01048	0.673
MOD_GlcNHglycan	509	512	PF01048	0.629
MOD_GSK3_1	127	134	PF00069	0.710
MOD_GSK3_1	197	204	PF00069	0.713
MOD_GSK3_1	26	33	PF00069	0.687
MOD_GSK3_1	323	330	PF00069	0.687
MOD_GSK3_1	369	376	PF00069	0.512
MOD_GSK3_1	399	406	PF00069	0.496
MOD_GSK3_1	480	487	PF00069	0.603
MOD_GSK3_1	505	512	PF00069	0.646
MOD_GSK3_1	554	561	PF00069	0.435
MOD_GSK3_1	584	591	PF00069	0.677
MOD_GSK3_1	631	638	PF00069	0.571
MOD_LATS_1	732	738	PF00433	0.618
MOD_N-GLC_1	649	654	PF02516	0.290
MOD_N-GLC_2	77	79	PF02516	0.661
MOD_NEK2_1	1	6	PF00069	0.695
MOD_NEK2_1	291	296	PF00069	0.532
MOD_NEK2_1	323	328	PF00069	0.710
MOD_NEK2_1	396	401	PF00069	0.445
MOD_NEK2_1	435	440	PF00069	0.556
MOD_NEK2_1	455	460	PF00069	0.370
MOD_NEK2_1	477	482	PF00069	0.474
MOD_NEK2_1	608	613	PF00069	0.691
MOD_NEK2_1	635	640	PF00069	0.587
MOD_NEK2_1	649	654	PF00069	0.527
MOD_NEK2_1	682	687	PF00069	0.581
MOD_NEK2_1	69	74	PF00069	0.460
MOD_NEK2_2	370	375	PF00069	0.525
MOD_PIKK_1	80	86	PF00454	0.663
MOD_PKA_2	145	151	PF00069	0.758
MOD_PKA_2	190	196	PF00069	0.735
MOD_PKA_2	396	402	PF00069	0.497
MOD_PKA_2	455	461	PF00069	0.368
MOD_Plk_1	631	637	PF00069	0.581
MOD_Plk_1	649	655	PF00069	0.483
MOD_Plk_2-3	190	196	PF00069	0.685
MOD_Plk_2-3	280	286	PF00069	0.536
MOD_Plk_4	280	286	PF00069	0.537
MOD_Plk_4	334	340	PF00069	0.495
MOD_Plk_4	460	466	PF00069	0.454
MOD_Plk_4	487	493	PF00069	0.686
MOD_Plk_4	558	564	PF00069	0.453
MOD_Plk_4	595	601	PF00069	0.657
MOD_Plk_4	64	70	PF00069	0.522
MOD_Plk_4	666	672	PF00069	0.542
MOD_Plk_4	682	688	PF00069	0.412
MOD_ProDKin_1	118	124	PF00069	0.707
MOD_ProDKin_1	127	133	PF00069	0.602
MOD_ProDKin_1	198	204	PF00069	0.784
MOD_ProDKin_1	207	213	PF00069	0.746
MOD_ProDKin_1	229	235	PF00069	0.627
MOD_ProDKin_1	252	258	PF00069	0.698
MOD_ProDKin_1	273	279	PF00069	0.539
MOD_ProDKin_1	292	298	PF00069	0.538
MOD_ProDKin_1	405	411	PF00069	0.596
MOD_ProDKin_1	505	511	PF00069	0.634
MOD_ProDKin_1	554	560	PF00069	0.450
MOD_ProDKin_1	625	631	PF00069	0.547
MOD_SUMO_rev_2	283	291	PF00179	0.515
MOD_SUMO_rev_2	575	585	PF00179	0.656
TRG_DiLeu_BaEn_1	280	285	PF01217	0.494
TRG_DiLeu_BaEn_1	383	388	PF01217	0.408
TRG_DiLeu_BaEn_1	450	455	PF01217	0.501
TRG_DiLeu_BaEn_3	286	292	PF01217	0.579
TRG_DiLeu_BaEn_3	472	478	PF01217	0.328
TRG_DiLeu_BaEn_4	177	183	PF01217	0.518
TRG_DiLeu_BaLyEn_6	167	172	PF01217	0.535
TRG_ENDOCYTIC_2	108	111	PF00928	0.697
TRG_ENDOCYTIC_2	474	477	PF00928	0.547
TRG_ENDOCYTIC_2	539	542	PF00928	0.468
TRG_ENDOCYTIC_2	686	689	PF00928	0.441
TRG_ENDOCYTIC_2	711	714	PF00928	0.515
TRG_ER_diArg_1	428	431	PF00400	0.507
TRG_ER_diArg_1	704	706	PF00400	0.503
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.740
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	706	710	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I099	Leptomonas seymouri	41%	100%
A0A3R7RB97	Trypanosoma rangeli	30%	100%
A0A3S7WYH5	Leishmania donovani	99%	100%
A4HDN5	Leishmania braziliensis	73%	100%
C9ZWC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AX20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QAF6	Leishmania major	90%	100%
V5CZP8	Trypanosoma cruzi	30%	100%