Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Aminomethyltransferase folate-binding domain/Glycine cleavage T-protein C-terminal barrel domain containing protein - putative

Species:

Leishmania infantum

UniProt:

E9AH81_LEIIN

TriTrypDb:

LINF_240023400

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0005759	mitochondrial matrix	5	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

E9AH81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH81

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	1
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016226	iron-sulfur cluster assembly	4	1
GO:0022607	cellular component assembly	4	1
GO:0031163	metallo-sulfur cluster assembly	5	1
GO:0044237	cellular metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005542	folic acid binding	3	1
GO:0019842	vitamin binding	3	1
GO:0031406	carboxylic acid binding	4	1
GO:0033218	amide binding	2	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0043177	organic acid binding	3	1
GO:0072341	modified amino acid binding	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:0003824	catalytic activity	1	3
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0004047	aminomethyltransferase activity	5	1
GO:0016742	hydroxymethyl-, formyl- and related transferase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.629
CLV_C14_Caspase3-7	176	180	PF00656	0.754
CLV_NRD_NRD_1	14	16	PF00675	0.456
CLV_NRD_NRD_1	209	211	PF00675	0.498
CLV_NRD_NRD_1	283	285	PF00675	0.406
CLV_NRD_NRD_1	378	380	PF00675	0.512
CLV_NRD_NRD_1	96	98	PF00675	0.242
CLV_PCSK_KEX2_1	14	16	PF00082	0.456
CLV_PCSK_KEX2_1	209	211	PF00082	0.460
CLV_PCSK_KEX2_1	285	287	PF00082	0.363
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.363
CLV_PCSK_PC7_1	10	16	PF00082	0.470
CLV_PCSK_SKI1_1	14	18	PF00082	0.419
CLV_PCSK_SKI1_1	380	384	PF00082	0.494
DEG_SPOP_SBC_1	169	173	PF00917	0.623
DEG_SPOP_SBC_1	192	196	PF00917	0.603
DOC_ANK_TNKS_1	233	240	PF00023	0.486
DOC_CYCLIN_RxL_1	244	252	PF00134	0.405
DOC_MAPK_DCC_7	353	363	PF00069	0.526
DOC_MAPK_gen_1	284	292	PF00069	0.375
DOC_MAPK_gen_1	353	363	PF00069	0.369
DOC_MAPK_gen_1	95	102	PF00069	0.451
DOC_MAPK_MEF2A_6	284	292	PF00069	0.390
DOC_MAPK_MEF2A_6	356	363	PF00069	0.329
DOC_PP1_RVXF_1	257	264	PF00149	0.378
DOC_PP4_FxxP_1	155	158	PF00568	0.407
DOC_PP4_FxxP_1	164	167	PF00568	0.486
DOC_PP4_FxxP_1	221	224	PF00568	0.379
DOC_USP7_MATH_1	122	126	PF00917	0.680
DOC_USP7_MATH_1	134	138	PF00917	0.745
DOC_USP7_MATH_1	170	174	PF00917	0.751
DOC_USP7_MATH_1	177	181	PF00917	0.725
DOC_USP7_MATH_1	184	188	PF00917	0.652
DOC_USP7_MATH_1	368	372	PF00917	0.472
DOC_USP7_MATH_1	41	45	PF00917	0.448
DOC_USP7_UBL2_3	380	384	PF12436	0.464
DOC_USP7_UBL2_3	95	99	PF12436	0.510
DOC_WW_Pin1_4	137	142	PF00397	0.714
DOC_WW_Pin1_4	193	198	PF00397	0.687
DOC_WW_Pin1_4	199	204	PF00397	0.665
DOC_WW_Pin1_4	220	225	PF00397	0.508
DOC_WW_Pin1_4	364	369	PF00397	0.575
LIG_14-3-3_CanoR_1	135	140	PF00244	0.713
LIG_14-3-3_CanoR_1	150	158	PF00244	0.560
LIG_14-3-3_CanoR_1	284	289	PF00244	0.378
LIG_Actin_WH2_2	334	351	PF00022	0.409
LIG_APCC_ABBAyCdc20_2	97	103	PF00400	0.527
LIG_BRCT_BRCA1_1	247	251	PF00533	0.429
LIG_EVH1_2	203	207	PF00568	0.410
LIG_FHA_1	226	232	PF00498	0.514
LIG_FHA_1	285	291	PF00498	0.379
LIG_FHA_1	31	37	PF00498	0.469
LIG_FHA_1	312	318	PF00498	0.605
LIG_FHA_1	353	359	PF00498	0.524
LIG_FHA_1	51	57	PF00498	0.461
LIG_FHA_2	112	118	PF00498	0.536
LIG_FHA_2	144	150	PF00498	0.641
LIG_LIR_Apic_2	152	158	PF02991	0.431
LIG_LIR_Apic_2	161	167	PF02991	0.477
LIG_LIR_Apic_2	216	220	PF02991	0.552
LIG_LIR_Gen_1	225	232	PF02991	0.443
LIG_LIR_LC3C_4	108	111	PF02991	0.511
LIG_LIR_Nem_3	225	230	PF02991	0.399
LIG_LIR_Nem_3	44	49	PF02991	0.449
LIG_Pex14_1	217	221	PF04695	0.362
LIG_SH2_CRK	227	231	PF00017	0.527
LIG_SH2_STAP1	227	231	PF00017	0.437
LIG_SH2_STAT3	268	271	PF00017	0.365
LIG_SH2_STAT5	227	230	PF00017	0.454
LIG_SH2_STAT5	268	271	PF00017	0.365
LIG_SH2_STAT5	350	353	PF00017	0.412
LIG_SH2_STAT5	51	54	PF00017	0.510
LIG_SH3_3	138	144	PF00018	0.740
LIG_SH3_3	164	170	PF00018	0.634
LIG_SH3_3	198	204	PF00018	0.654
LIG_SH3_3	294	300	PF00018	0.626
LIG_SH3_3	316	322	PF00018	0.526
LIG_SUMO_SIM_anti_2	108	114	PF11976	0.476
LIG_SUMO_SIM_anti_2	277	283	PF11976	0.424
LIG_SUMO_SIM_par_1	108	114	PF11976	0.427
LIG_SUMO_SIM_par_1	314	321	PF11976	0.539
LIG_SUMO_SIM_par_1	74	81	PF11976	0.492
LIG_TRAF2_1	114	117	PF00917	0.531
LIG_TRAF2_1	146	149	PF00917	0.719
LIG_UBA3_1	345	353	PF00899	0.486
LIG_UBA3_1	87	95	PF00899	0.480
MOD_CK1_1	125	131	PF00069	0.726
MOD_CK1_1	137	143	PF00069	0.682
MOD_CK1_1	171	177	PF00069	0.714
MOD_CK1_1	180	186	PF00069	0.607
MOD_CK2_1	111	117	PF00069	0.573
MOD_CK2_1	143	149	PF00069	0.677
MOD_GlcNHglycan	127	130	PF01048	0.729
MOD_GlcNHglycan	175	178	PF01048	0.664
MOD_GlcNHglycan	186	189	PF01048	0.598
MOD_GlcNHglycan	324	327	PF01048	0.524
MOD_GlcNHglycan	81	85	PF01048	0.299
MOD_GSK3_1	111	118	PF00069	0.494
MOD_GSK3_1	123	130	PF00069	0.666
MOD_GSK3_1	168	175	PF00069	0.548
MOD_GSK3_1	180	187	PF00069	0.490
MOD_GSK3_1	226	233	PF00069	0.466
MOD_GSK3_1	280	287	PF00069	0.406
MOD_GSK3_1	303	310	PF00069	0.644
MOD_GSK3_1	364	371	PF00069	0.548
MOD_N-GLC_1	245	250	PF02516	0.542
MOD_NEK2_1	115	120	PF00069	0.506
MOD_NEK2_1	230	235	PF00069	0.407
MOD_NEK2_1	280	285	PF00069	0.431
MOD_NEK2_1	50	55	PF00069	0.442
MOD_NEK2_2	41	46	PF00069	0.510
MOD_PK_1	135	141	PF00069	0.747
MOD_PKA_1	284	290	PF00069	0.370
MOD_PKA_2	123	129	PF00069	0.726
MOD_PKA_2	134	140	PF00069	0.681
MOD_PKA_2	149	155	PF00069	0.592
MOD_PKA_2	19	25	PF00069	0.504
MOD_Plk_1	115	121	PF00069	0.558
MOD_Plk_1	245	251	PF00069	0.511
MOD_Plk_4	202	208	PF00069	0.498
MOD_Plk_4	226	232	PF00069	0.445
MOD_Plk_4	41	47	PF00069	0.449
MOD_Plk_4	71	77	PF00069	0.467
MOD_ProDKin_1	137	143	PF00069	0.714
MOD_ProDKin_1	193	199	PF00069	0.684
MOD_ProDKin_1	220	226	PF00069	0.502
MOD_ProDKin_1	364	370	PF00069	0.575
MOD_SUMO_rev_2	375	385	PF00179	0.432
MOD_SUMO_rev_2	89	96	PF00179	0.535
TRG_DiLeu_BaEn_1	381	386	PF01217	0.513
TRG_ENDOCYTIC_2	227	230	PF00928	0.383
TRG_ENDOCYTIC_2	46	49	PF00928	0.510
TRG_ER_diArg_1	14	16	PF00400	0.456
TRG_ER_diArg_1	17	20	PF00400	0.535
TRG_ER_diArg_1	208	210	PF00400	0.404
TRG_ER_diArg_1	346	349	PF00400	0.379
TRG_NLS_MonoExtN_4	95	101	PF00514	0.474
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM11	Leptomonas seymouri	62%	89%
A0A0S4JL83	Bodo saltans	39%	100%
A0A1X0NVS6	Trypanosomatidae	42%	100%
A0A3Q8IEZ2	Leishmania donovani	98%	100%
A0A3R7K245	Trypanosoma rangeli	47%	100%
A4HDN4	Leishmania braziliensis	76%	100%
A4R8F9	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	27%	100%
C9ZWC9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AX19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q2H6N9	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	28%	89%
Q4P7A4	Ustilago maydis (strain 521 / FGSC 9021)	27%	97%
Q4QAF7	Leishmania major	86%	94%
Q54NS1	Dictyostelium discoideum	27%	96%
Q6C8Y7	Yarrowia lipolytica (strain CLIB 122 / E 150)	27%	81%
Q7RYZ1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	31%	89%
V5AJ90	Trypanosoma cruzi	47%	100%