Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Aminomethyltransferase folate-binding domain/Glycine cleavage T-protein C-terminal barrel domain containing protein - putative

Species:

Leishmania infantum

UniProt:

E9AH81_LEIIN

TriTrypDb:

LINF_240023400

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	11
GO:0005759	mitochondrial matrix	5	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

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Expansion

Sequence features

E9AH81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH81

Function

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Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	1
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016226	iron-sulfur cluster assembly	4	1
GO:0022607	cellular component assembly	4	1
GO:0031163	metallo-sulfur cluster assembly	5	1
GO:0032259	methylation	2	1
GO:0044237	cellular metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004047	aminomethyltransferase activity	5	1
GO:0005488	binding	1	1
GO:0005542	folic acid binding	3	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0016742	hydroxymethyl-, formyl- and related transferase activity	4	1
GO:0019842	vitamin binding	3	1
GO:0031406	carboxylic acid binding	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.629
CLV_C14_Caspase3-7	176	180	PF00656	0.754
CLV_NRD_NRD_1	14	16	PF00675	0.456
CLV_NRD_NRD_1	209	211	PF00675	0.498
CLV_NRD_NRD_1	283	285	PF00675	0.406
CLV_NRD_NRD_1	378	380	PF00675	0.512
CLV_NRD_NRD_1	96	98	PF00675	0.242
CLV_PCSK_KEX2_1	14	16	PF00082	0.456
CLV_PCSK_KEX2_1	209	211	PF00082	0.460
CLV_PCSK_KEX2_1	285	287	PF00082	0.363

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM11	Leptomonas seymouri	62%	89%
A0A0S4JL83	Bodo saltans	39%	100%
A0A1X0NVS6	Trypanosomatidae	42%	100%
A0A3Q8IEZ2	Leishmania donovani	98%	100%
A0A3R7K245	Trypanosoma rangeli	47%	100%
A4HDN4	Leishmania braziliensis	76%	100%
A4R8F9	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	27%	100%
C9ZWC9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AX19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q2H6N9	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	28%	89%

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