SpoU_methylase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

E9AH73_LEIIN

TriTrypDb:

Length:

518

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AH73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH73

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008173	RNA methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.369
CLV_C14_Caspase3-7	44	48	PF00656	0.524
CLV_NRD_NRD_1	14	16	PF00675	0.705
CLV_NRD_NRD_1	144	146	PF00675	0.412
CLV_NRD_NRD_1	160	162	PF00675	0.265
CLV_NRD_NRD_1	204	206	PF00675	0.528
CLV_NRD_NRD_1	30	32	PF00675	0.730
CLV_PCSK_FUR_1	28	32	PF00082	0.603
CLV_PCSK_KEX2_1	14	16	PF00082	0.699
CLV_PCSK_KEX2_1	160	162	PF00082	0.378
CLV_PCSK_KEX2_1	204	206	PF00082	0.512
CLV_PCSK_KEX2_1	30	32	PF00082	0.707
CLV_PCSK_KEX2_1	381	383	PF00082	0.250
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.303
CLV_PCSK_PC7_1	10	16	PF00082	0.601
CLV_PCSK_SKI1_1	205	209	PF00082	0.389
DEG_Nend_Nbox_1	1	3	PF02207	0.588
DEG_SCF_FBW7_2	120	125	PF00400	0.506
DEG_SCF_TRCP1_1	179	184	PF00400	0.334
DEG_SPOP_SBC_1	59	63	PF00917	0.602
DOC_CYCLIN_RxL_1	202	211	PF00134	0.349
DOC_CYCLIN_yCln2_LP_2	105	111	PF00134	0.521
DOC_CYCLIN_yCln2_LP_2	272	278	PF00134	0.623
DOC_CYCLIN_yCln2_LP_2	491	494	PF00134	0.432
DOC_MAPK_DCC_7	94	102	PF00069	0.434
DOC_MAPK_MEF2A_6	94	102	PF00069	0.434
DOC_MAPK_RevD_3	192	205	PF00069	0.489
DOC_PP2B_LxvP_1	233	236	PF13499	0.486
DOC_PP2B_LxvP_1	290	293	PF13499	0.446
DOC_PP2B_LxvP_1	366	369	PF13499	0.446
DOC_PP2B_LxvP_1	491	494	PF13499	0.455
DOC_PP4_FxxP_1	220	223	PF00568	0.342
DOC_SPAK_OSR1_1	382	386	PF12202	0.488
DOC_USP7_MATH_1	240	244	PF00917	0.775
DOC_USP7_MATH_1	246	250	PF00917	0.601
DOC_USP7_MATH_1	348	352	PF00917	0.538
DOC_USP7_MATH_1	367	371	PF00917	0.478
DOC_USP7_MATH_1	393	397	PF00917	0.587
DOC_USP7_MATH_1	404	408	PF00917	0.543
DOC_USP7_MATH_1	59	63	PF00917	0.662
DOC_USP7_MATH_1	92	96	PF00917	0.736
DOC_USP7_UBL2_3	142	146	PF12436	0.446
DOC_WW_Pin1_4	118	123	PF00397	0.430
DOC_WW_Pin1_4	196	201	PF00397	0.333
DOC_WW_Pin1_4	331	336	PF00397	0.460
DOC_WW_Pin1_4	513	518	PF00397	0.733
DOC_WW_Pin1_4	78	83	PF00397	0.753
LIG_14-3-3_CanoR_1	161	167	PF00244	0.442
LIG_14-3-3_CanoR_1	28	37	PF00244	0.680
LIG_14-3-3_CanoR_1	326	333	PF00244	0.478
LIG_14-3-3_CanoR_1	77	82	PF00244	0.624
LIG_Actin_WH2_2	16	32	PF00022	0.495
LIG_Actin_WH2_2	285	303	PF00022	0.538
LIG_AP2alpha_2	274	276	PF02296	0.522
LIG_DCNL_PONY_1	1	4	PF03556	0.538
LIG_EH1_1	278	286	PF00400	0.489
LIG_eIF4E_1	308	314	PF01652	0.538
LIG_FHA_1	115	121	PF00498	0.487
LIG_FHA_1	133	139	PF00498	0.291
LIG_FHA_1	148	154	PF00498	0.408
LIG_FHA_1	163	169	PF00498	0.442
LIG_FHA_1	182	188	PF00498	0.432
LIG_FHA_1	191	197	PF00498	0.372
LIG_FHA_1	229	235	PF00498	0.534
LIG_FHA_1	334	340	PF00498	0.467
LIG_FHA_1	393	399	PF00498	0.452
LIG_FHA_1	413	419	PF00498	0.345
LIG_FHA_1	444	450	PF00498	0.560
LIG_FHA_1	477	483	PF00498	0.443
LIG_FHA_1	59	65	PF00498	0.499
LIG_FHA_2	42	48	PF00498	0.657
LIG_FHA_2	495	501	PF00498	0.542
LIG_FHA_2	61	67	PF00498	0.481
LIG_Integrin_isoDGR_2	435	437	PF01839	0.252
LIG_LIR_Apic_2	219	223	PF02991	0.337
LIG_LIR_Gen_1	476	484	PF02991	0.416
LIG_LIR_Nem_3	476	481	PF02991	0.389
LIG_MYND_1	83	87	PF01753	0.604
LIG_PDZ_Class_1	513	518	PF00595	0.647
LIG_Pex14_1	438	442	PF04695	0.478
LIG_SH2_CRK	442	446	PF00017	0.503
LIG_SH2_CRK	93	97	PF00017	0.655
LIG_SH2_STAP1	216	220	PF00017	0.370
LIG_SH2_STAP1	308	312	PF00017	0.503
LIG_SH2_STAT5	11	14	PF00017	0.548
LIG_SH2_STAT5	174	177	PF00017	0.363
LIG_SH3_1	10	16	PF00018	0.601
LIG_SH3_3	10	16	PF00018	0.669
LIG_SH3_3	170	176	PF00018	0.330
LIG_SH3_3	234	240	PF00018	0.619
LIG_SH3_3	265	271	PF00018	0.535
LIG_SH3_3	442	448	PF00018	0.490
LIG_SUMO_SIM_par_1	106	113	PF11976	0.435
LIG_SUMO_SIM_par_1	420	427	PF11976	0.436
LIG_SUMO_SIM_par_1	479	485	PF11976	0.536
LIG_TRAF2_1	122	125	PF00917	0.612
LIG_TRAF2_1	319	322	PF00917	0.538
LIG_TRAF2_1	369	372	PF00917	0.538
LIG_TYR_ITIM	440	445	PF00017	0.503
MOD_CDK_SPxxK_3	331	338	PF00069	0.460
MOD_CK1_1	255	261	PF00069	0.598
MOD_CK1_1	328	334	PF00069	0.503
MOD_CK1_1	351	357	PF00069	0.526
MOD_CK1_1	396	402	PF00069	0.461
MOD_CK1_1	473	479	PF00069	0.543
MOD_CK2_1	372	378	PF00069	0.486
MOD_CK2_1	47	53	PF00069	0.720
MOD_CK2_1	59	65	PF00069	0.710
MOD_GlcNHglycan	156	159	PF01048	0.365
MOD_GlcNHglycan	179	182	PF01048	0.400
MOD_GlcNHglycan	208	211	PF01048	0.359
MOD_GlcNHglycan	257	260	PF01048	0.586
MOD_GlcNHglycan	261	264	PF01048	0.613
MOD_GlcNHglycan	32	35	PF01048	0.737
MOD_GlcNHglycan	374	377	PF01048	0.240
MOD_GlcNHglycan	398	401	PF01048	0.347
MOD_GlcNHglycan	472	475	PF01048	0.505
MOD_GlcNHglycan	484	487	PF01048	0.426
MOD_GSK3_1	114	121	PF00069	0.402
MOD_GSK3_1	177	184	PF00069	0.333
MOD_GSK3_1	206	213	PF00069	0.501
MOD_GSK3_1	242	249	PF00069	0.787
MOD_GSK3_1	251	258	PF00069	0.546
MOD_GSK3_1	291	298	PF00069	0.503
MOD_GSK3_1	348	355	PF00069	0.491
MOD_GSK3_1	392	399	PF00069	0.543
MOD_GSK3_1	443	450	PF00069	0.480
MOD_GSK3_1	453	460	PF00069	0.472
MOD_N-GLC_1	147	152	PF02516	0.417
MOD_N-GLC_1	457	462	PF02516	0.272
MOD_N-GLC_1	501	506	PF02516	0.505
MOD_NEK2_1	138	143	PF00069	0.403
MOD_NEK2_1	261	266	PF00069	0.601
MOD_NEK2_1	29	34	PF00069	0.717
MOD_NEK2_1	352	357	PF00069	0.523
MOD_NEK2_1	453	458	PF00069	0.501
MOD_PIKK_1	120	126	PF00454	0.574
MOD_PIKK_1	317	323	PF00454	0.538
MOD_PIKK_1	367	373	PF00454	0.460
MOD_PIKK_1	393	399	PF00454	0.539
MOD_PKA_1	30	36	PF00069	0.522
MOD_PKA_2	138	144	PF00069	0.386
MOD_PKA_2	29	35	PF00069	0.730
MOD_PKA_2	325	331	PF00069	0.436
MOD_PKA_2	470	476	PF00069	0.417
MOD_PKB_1	101	109	PF00069	0.446
MOD_PKB_1	28	36	PF00069	0.519
MOD_Plk_1	147	153	PF00069	0.503
MOD_Plk_1	228	234	PF00069	0.563
MOD_Plk_1	457	463	PF00069	0.488
MOD_Plk_2-3	47	53	PF00069	0.501
MOD_Plk_4	190	196	PF00069	0.420
MOD_Plk_4	295	301	PF00069	0.503
MOD_Plk_4	348	354	PF00069	0.538
MOD_Plk_4	461	467	PF00069	0.462
MOD_ProDKin_1	118	124	PF00069	0.430
MOD_ProDKin_1	196	202	PF00069	0.334
MOD_ProDKin_1	331	337	PF00069	0.460
MOD_ProDKin_1	78	84	PF00069	0.755
MOD_SUMO_rev_2	62	70	PF00179	0.545
TRG_ENDOCYTIC_2	442	445	PF00928	0.503
TRG_ENDOCYTIC_2	93	96	PF00928	0.663
TRG_ER_diArg_1	13	15	PF00400	0.682
TRG_ER_diArg_1	159	161	PF00400	0.378
TRG_ER_diArg_1	203	205	PF00400	0.374
TRG_ER_diArg_1	28	31	PF00400	0.710
TRG_ER_diArg_1	37	40	PF00400	0.717
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1U8	Leptomonas seymouri	63%	100%
A0A0S4JI78	Bodo saltans	42%	100%
A0A1X0NVU0	Trypanosomatidae	44%	100%
A0A3Q8IBF1	Leishmania donovani	99%	100%
A0A3R7R8W6	Trypanosoma rangeli	45%	100%
A4HDM6	Leishmania braziliensis	79%	100%
C9ZWD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AX11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QAG5	Leishmania major	91%	100%
V5BFK4	Trypanosoma cruzi	46%	100%