Fatty acyl-CoA reductase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NAD dependent epimerase/dehydratase family/Male sterility protein - putative

Species:

Leishmania infantum

UniProt:

E9AH71_LEIIN

TriTrypDb:

LINF_240021900

Length:

579

Annotations

Annotations by Jardim et al.

Lipid Metabolism, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

E9AH71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH71

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006637	acyl-CoA metabolic process	4	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006790	sulfur compound metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0033865	nucleoside bisphosphate metabolic process	5	1
GO:0033875	ribonucleoside bisphosphate metabolic process	6	1
GO:0034032	purine nucleoside bisphosphate metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0035336	long-chain fatty-acyl-CoA metabolic process	6	1
GO:0035337	fatty-acyl-CoA metabolic process	5	1
GO:0035383	thioester metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901568	fatty acid derivative metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	4	12
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3	12
GO:0080019	alcohol-forming very long-chain fatty acyl-CoA reductase activity	5	12
GO:0102965	alcohol-forming long-chain fatty acyl-CoA reductase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	172	174	PF00675	0.311
CLV_NRD_NRD_1	318	320	PF00675	0.456
CLV_NRD_NRD_1	490	492	PF00675	0.314
CLV_NRD_NRD_1	51	53	PF00675	0.196
CLV_NRD_NRD_1	525	527	PF00675	0.337
CLV_PCSK_FUR_1	426	430	PF00082	0.438
CLV_PCSK_FUR_1	46	50	PF00082	0.270
CLV_PCSK_KEX2_1	172	174	PF00082	0.337
CLV_PCSK_KEX2_1	196	198	PF00082	0.337
CLV_PCSK_KEX2_1	318	320	PF00082	0.408
CLV_PCSK_KEX2_1	39	41	PF00082	0.230
CLV_PCSK_KEX2_1	428	430	PF00082	0.336
CLV_PCSK_KEX2_1	48	50	PF00082	0.190
CLV_PCSK_KEX2_1	490	492	PF00082	0.306
CLV_PCSK_KEX2_1	51	53	PF00082	0.166
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.337
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.235
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.295
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.225
CLV_PCSK_SKI1_1	12	16	PF00082	0.220
CLV_PCSK_SKI1_1	196	200	PF00082	0.193
CLV_PCSK_SKI1_1	25	29	PF00082	0.192
CLV_PCSK_SKI1_1	282	286	PF00082	0.319
CLV_PCSK_SKI1_1	30	34	PF00082	0.192
CLV_PCSK_SKI1_1	306	310	PF00082	0.209
CLV_PCSK_SKI1_1	51	55	PF00082	0.226
CLV_Separin_Metazoa	74	78	PF03568	0.337
DEG_APCC_DBOX_1	61	69	PF00400	0.337
DEG_SPOP_SBC_1	369	373	PF00917	0.504
DEG_SPOP_SBC_1	403	407	PF00917	0.294
DOC_CYCLIN_RxL_1	303	311	PF00134	0.218
DOC_MAPK_DCC_7	236	246	PF00069	0.337
DOC_MAPK_gen_1	236	245	PF00069	0.211
DOC_MAPK_gen_1	428	439	PF00069	0.378
DOC_MAPK_HePTP_8	233	245	PF00069	0.286
DOC_MAPK_MEF2A_6	133	140	PF00069	0.256
DOC_MAPK_MEF2A_6	236	245	PF00069	0.254
DOC_MAPK_MEF2A_6	342	350	PF00069	0.537
DOC_MAPK_MEF2A_6	432	441	PF00069	0.397
DOC_MAPK_MEF2A_6	456	463	PF00069	0.399
DOC_MAPK_NFAT4_5	133	141	PF00069	0.202
DOC_MAPK_RevD_3	160	173	PF00069	0.337
DOC_PP2B_LxvP_1	469	472	PF13499	0.378
DOC_PP4_FxxP_1	560	563	PF00568	0.308
DOC_USP7_MATH_1	200	204	PF00917	0.229
DOC_USP7_MATH_1	207	211	PF00917	0.121
DOC_USP7_MATH_1	324	328	PF00917	0.488
DOC_USP7_MATH_1	340	344	PF00917	0.355
DOC_USP7_MATH_1	369	373	PF00917	0.659
DOC_USP7_MATH_1	403	407	PF00917	0.291
DOC_USP7_MATH_1	462	466	PF00917	0.319
DOC_USP7_UBL2_3	306	310	PF12436	0.210
DOC_USP7_UBL2_3	428	432	PF12436	0.361
DOC_WW_Pin1_4	329	334	PF00397	0.576
DOC_WW_Pin1_4	376	381	PF00397	0.516
DOC_WW_Pin1_4	472	477	PF00397	0.452
DOC_WW_Pin1_4	67	72	PF00397	0.226
LIG_14-3-3_CanoR_1	111	115	PF00244	0.214
LIG_14-3-3_CanoR_1	342	350	PF00244	0.493
LIG_14-3-3_CanoR_1	411	415	PF00244	0.425
LIG_14-3-3_CanoR_1	416	422	PF00244	0.383
LIG_14-3-3_CanoR_1	526	532	PF00244	0.248
LIG_14-3-3_CterR_2	575	579	PF00244	0.327
LIG_AP2alpha_2	257	259	PF02296	0.337
LIG_BIR_II_1	1	5	PF00653	0.316
LIG_BRCT_BRCA1_1	69	73	PF00533	0.207
LIG_CaM_IQ_9	308	323	PF13499	0.329
LIG_CaM_NSCaTE_8	262	269	PF13499	0.192
LIG_deltaCOP1_diTrp_1	506	511	PF00928	0.185
LIG_EH1_1	298	306	PF00400	0.203
LIG_FHA_1	11	17	PF00498	0.287
LIG_FHA_1	164	170	PF00498	0.221
LIG_FHA_1	18	24	PF00498	0.237
LIG_FHA_1	273	279	PF00498	0.211
LIG_FHA_1	369	375	PF00498	0.642
LIG_FHA_1	380	386	PF00498	0.605
LIG_FHA_1	417	423	PF00498	0.365
LIG_FHA_2	389	395	PF00498	0.500
LIG_FHA_2	501	507	PF00498	0.226
LIG_GBD_Chelix_1	300	308	PF00786	0.207
LIG_LIR_Apic_2	254	258	PF02991	0.226
LIG_LIR_Apic_2	557	563	PF02991	0.307
LIG_LIR_Gen_1	496	504	PF02991	0.314
LIG_LIR_Gen_1	506	517	PF02991	0.246
LIG_LIR_Gen_1	82	92	PF02991	0.305
LIG_LIR_Nem_3	165	171	PF02991	0.207
LIG_LIR_Nem_3	34	38	PF02991	0.252
LIG_LIR_Nem_3	413	417	PF02991	0.304
LIG_LIR_Nem_3	496	502	PF02991	0.314
LIG_LIR_Nem_3	506	512	PF02991	0.246
LIG_LIR_Nem_3	528	534	PF02991	0.311
LIG_LIR_Nem_3	535	541	PF02991	0.256
LIG_LIR_Nem_3	70	76	PF02991	0.215
LIG_LIR_Nem_3	82	88	PF02991	0.192
LIG_MYND_1	563	567	PF01753	0.327
LIG_PCNA_yPIPBox_3	302	316	PF02747	0.276
LIG_PDZ_Class_1	574	579	PF00595	0.338
LIG_Pex14_1	507	511	PF04695	0.213
LIG_SH2_CRK	29	33	PF00017	0.337
LIG_SH2_CRK	509	513	PF00017	0.257
LIG_SH2_CRK	541	545	PF00017	0.259
LIG_SH2_GRB2like	168	171	PF00017	0.194
LIG_SH2_GRB2like	56	59	PF00017	0.286
LIG_SH2_NCK_1	541	545	PF00017	0.226
LIG_SH2_PTP2	460	463	PF00017	0.313
LIG_SH2_SRC	545	548	PF00017	0.257
LIG_SH2_SRC	56	59	PF00017	0.325
LIG_SH2_STAP1	534	538	PF00017	0.235
LIG_SH2_STAP1	541	545	PF00017	0.173
LIG_SH2_STAT5	168	171	PF00017	0.204
LIG_SH2_STAT5	223	226	PF00017	0.192
LIG_SH2_STAT5	255	258	PF00017	0.191
LIG_SH2_STAT5	299	302	PF00017	0.395
LIG_SH2_STAT5	42	45	PF00017	0.193
LIG_SH2_STAT5	453	456	PF00017	0.351
LIG_SH2_STAT5	460	463	PF00017	0.305
LIG_SH2_STAT5	541	544	PF00017	0.276
LIG_SH2_STAT5	56	59	PF00017	0.197
LIG_SH3_3	374	380	PF00018	0.660
LIG_SH3_3	560	566	PF00018	0.290
LIG_SUMO_SIM_anti_2	370	379	PF11976	0.505
LIG_SUMO_SIM_anti_2	64	70	PF11976	0.257
LIG_SUMO_SIM_par_1	272	277	PF11976	0.320
LIG_SUMO_SIM_par_1	346	351	PF11976	0.511
LIG_SUMO_SIM_par_1	370	379	PF11976	0.505
LIG_TYR_ITAM	444	463	PF00017	0.259
LIG_TYR_ITIM	27	32	PF00017	0.311
LIG_TYR_ITIM	450	455	PF00017	0.334
LIG_UBA3_1	27	33	PF00899	0.193
LIG_UBA3_1	304	310	PF00899	0.246
MOD_CDC14_SPxK_1	475	478	PF00782	0.459
MOD_CDK_SPK_2	472	477	PF00069	0.444
MOD_CDK_SPxK_1	472	478	PF00069	0.452
MOD_CK1_1	10	16	PF00069	0.251
MOD_CK1_1	372	378	PF00069	0.551
MOD_CK1_1	379	385	PF00069	0.543
MOD_CK1_1	388	394	PF00069	0.572
MOD_CK1_1	525	531	PF00069	0.319
MOD_CK2_1	372	378	PF00069	0.580
MOD_CK2_1	403	409	PF00069	0.480
MOD_CK2_1	500	506	PF00069	0.226
MOD_CK2_1	565	571	PF00069	0.390
MOD_Cter_Amidation	426	429	PF01082	0.365
MOD_Cter_Amidation	46	49	PF01082	0.286
MOD_GlcNHglycan	209	212	PF01048	0.319
MOD_GlcNHglycan	326	329	PF01048	0.539
MOD_GlcNHglycan	343	346	PF01048	0.572
MOD_GlcNHglycan	364	367	PF01048	0.665
MOD_GlcNHglycan	387	390	PF01048	0.638
MOD_GlcNHglycan	567	570	PF01048	0.420
MOD_GSK3_1	10	17	PF00069	0.245
MOD_GSK3_1	219	226	PF00069	0.192
MOD_GSK3_1	368	375	PF00069	0.495
MOD_GSK3_1	433	440	PF00069	0.461
MOD_LATS_1	430	436	PF00433	0.374
MOD_N-GLC_1	10	15	PF02516	0.383
MOD_N-GLC_1	512	517	PF02516	0.213
MOD_NEK2_1	124	129	PF00069	0.219
MOD_NEK2_1	151	156	PF00069	0.311
MOD_NEK2_1	272	277	PF00069	0.192
MOD_NEK2_1	308	313	PF00069	0.230
MOD_NEK2_1	385	390	PF00069	0.693
MOD_NEK2_1	437	442	PF00069	0.358
MOD_NEK2_1	500	505	PF00069	0.282
MOD_NEK2_2	433	438	PF00069	0.333
MOD_PIKK_1	308	314	PF00454	0.254
MOD_PIKK_1	539	545	PF00454	0.256
MOD_PKA_2	110	116	PF00069	0.263
MOD_PKA_2	246	252	PF00069	0.201
MOD_PKA_2	341	347	PF00069	0.672
MOD_PKA_2	410	416	PF00069	0.439
MOD_PKA_2	525	531	PF00069	0.376
MOD_PKA_2	554	560	PF00069	0.355
MOD_Plk_1	10	16	PF00069	0.372
MOD_Plk_1	369	375	PF00069	0.505
MOD_Plk_1	500	506	PF00069	0.337
MOD_Plk_1	512	518	PF00069	0.337
MOD_Plk_1	97	103	PF00069	0.345
MOD_Plk_2-3	493	499	PF00069	0.257
MOD_Plk_4	246	252	PF00069	0.199
MOD_Plk_4	372	378	PF00069	0.673
MOD_Plk_4	417	423	PF00069	0.473
MOD_ProDKin_1	329	335	PF00069	0.581
MOD_ProDKin_1	376	382	PF00069	0.516
MOD_ProDKin_1	472	478	PF00069	0.452
MOD_ProDKin_1	67	73	PF00069	0.226
MOD_SUMO_rev_2	34	41	PF00179	0.313
MOD_SUMO_rev_2	349	354	PF00179	0.481
TRG_DiLeu_BaEn_1	209	214	PF01217	0.263
TRG_DiLeu_BaEn_2	394	400	PF01217	0.458
TRG_ENDOCYTIC_2	29	32	PF00928	0.240
TRG_ENDOCYTIC_2	42	45	PF00928	0.138
TRG_ENDOCYTIC_2	447	450	PF00928	0.348
TRG_ENDOCYTIC_2	452	455	PF00928	0.314
TRG_ENDOCYTIC_2	460	463	PF00928	0.214
TRG_ENDOCYTIC_2	509	512	PF00928	0.257
TRG_ENDOCYTIC_2	541	544	PF00928	0.260
TRG_ENDOCYTIC_2	547	550	PF00928	0.239
TRG_ER_diArg_1	171	173	PF00400	0.337
TRG_ER_diArg_1	318	321	PF00400	0.429
TRG_ER_diArg_1	448	451	PF00400	0.375
TRG_ER_diArg_1	489	491	PF00400	0.288
TRG_ER_diArg_1	49	52	PF00400	0.223
TRG_NES_CRM1_1	493	506	PF08389	0.288
TRG_NLS_MonoExtC_3	47	52	PF00514	0.255
TRG_NLS_MonoExtN_4	172	177	PF00514	0.257
TRG_NLS_MonoExtN_4	46	52	PF00514	0.254
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.226

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I721	Leptomonas seymouri	72%	100%
A0A0S4ILT5	Bodo saltans	43%	100%
A0A1X0NVR7	Trypanosomatidae	49%	100%
A0A3Q8ICX8	Leishmania donovani	100%	100%
A0A422N8G4	Trypanosoma rangeli	49%	98%
A4HDM4	Leishmania braziliensis	86%	100%
C9ZWE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	93%
E9AX09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QAG7	Leishmania major	95%	100%
Q9LXN3	Arabidopsis thaliana	27%	100%
V5AVK6	Trypanosoma cruzi	50%	98%