Thioredoxin-like_fold domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AH69_LEIIN

TriTrypDb:

LINF_240021700

Length:

353

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	8
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AH69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH69

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006626	protein targeting to mitochondrion	5	1
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.329
CLV_C14_Caspase3-7	346	350	PF00656	0.490
CLV_NRD_NRD_1	188	190	PF00675	0.431
CLV_NRD_NRD_1	24	26	PF00675	0.357
CLV_NRD_NRD_1	51	53	PF00675	0.424
CLV_NRD_NRD_1	80	82	PF00675	0.497
CLV_PCSK_KEX2_1	150	152	PF00082	0.524
CLV_PCSK_KEX2_1	188	190	PF00082	0.417
CLV_PCSK_KEX2_1	239	241	PF00082	0.538
CLV_PCSK_KEX2_1	26	28	PF00082	0.313
CLV_PCSK_KEX2_1	272	274	PF00082	0.521
CLV_PCSK_KEX2_1	326	328	PF00082	0.519
CLV_PCSK_KEX2_1	51	53	PF00082	0.413
CLV_PCSK_KEX2_1	79	81	PF00082	0.518
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.524
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.493
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.313
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.521
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.519
CLV_PCSK_SKI1_1	201	205	PF00082	0.460
CLV_PCSK_SKI1_1	26	30	PF00082	0.512
CLV_PCSK_SKI1_1	273	277	PF00082	0.412
CLV_PCSK_SKI1_1	326	330	PF00082	0.473
CLV_PCSK_SKI1_1	72	76	PF00082	0.589
DEG_APCC_DBOX_1	13	21	PF00400	0.555
DEG_APCC_DBOX_1	79	87	PF00400	0.271
DEG_Nend_UBRbox_1	1	4	PF02207	0.681
DOC_ANK_TNKS_1	50	57	PF00023	0.404
DOC_CYCLIN_RxL_1	270	279	PF00134	0.243
DOC_CYCLIN_RxL_1	323	331	PF00134	0.326
DOC_CYCLIN_yCln2_LP_2	291	297	PF00134	0.302
DOC_MAPK_gen_1	236	243	PF00069	0.300
DOC_MAPK_gen_1	79	85	PF00069	0.304
DOC_MAPK_MEF2A_6	92	100	PF00069	0.324
DOC_MAPK_RevD_3	226	239	PF00069	0.289
DOC_PP1_RVXF_1	199	205	PF00149	0.243
DOC_PP1_RVXF_1	338	344	PF00149	0.456
DOC_PP2B_LxvP_1	137	140	PF13499	0.204
DOC_PP2B_LxvP_1	291	294	PF13499	0.274
DOC_PP4_FxxP_1	99	102	PF00568	0.257
DOC_USP7_MATH_1	13	17	PF00917	0.637
DOC_USP7_MATH_1	171	175	PF00917	0.346
DOC_USP7_MATH_1	245	249	PF00917	0.392
DOC_USP7_MATH_1	30	34	PF00917	0.716
DOC_USP7_UBL2_3	34	38	PF12436	0.594
DOC_WW_Pin1_4	101	106	PF00397	0.303
DOC_WW_Pin1_4	108	113	PF00397	0.265
DOC_WW_Pin1_4	44	49	PF00397	0.633
LIG_14-3-3_CanoR_1	188	192	PF00244	0.299
LIG_14-3-3_CanoR_1	240	250	PF00244	0.303
LIG_14-3-3_CanoR_1	273	281	PF00244	0.304
LIG_14-3-3_CanoR_1	327	336	PF00244	0.316
LIG_14-3-3_CanoR_1	340	348	PF00244	0.463
LIG_14-3-3_CanoR_1	72	77	PF00244	0.382
LIG_APCC_ABBAyCdc20_2	272	278	PF00400	0.243
LIG_BRCT_BRCA1_1	70	74	PF00533	0.390
LIG_EH1_1	192	200	PF00400	0.212
LIG_eIF4E_1	193	199	PF01652	0.212
LIG_FHA_1	214	220	PF00498	0.368
LIG_FHA_2	113	119	PF00498	0.285
LIG_FHA_2	280	286	PF00498	0.203
LIG_FHA_2	308	314	PF00498	0.326
LIG_FHA_2	73	79	PF00498	0.314
LIG_IRF3_LxIS_1	215	222	PF10401	0.382
LIG_LIR_Gen_1	305	316	PF02991	0.278
LIG_LIR_Gen_1	65	74	PF02991	0.407
LIG_LIR_Gen_1	94	105	PF02991	0.273
LIG_LIR_Nem_3	143	149	PF02991	0.303
LIG_LIR_Nem_3	244	249	PF02991	0.342
LIG_LIR_Nem_3	305	311	PF02991	0.243
LIG_LIR_Nem_3	65	70	PF02991	0.427
LIG_LIR_Nem_3	71	77	PF02991	0.360
LIG_LIR_Nem_3	94	100	PF02991	0.364
LIG_MYND_1	108	112	PF01753	0.298
LIG_Pex14_2	6	10	PF04695	0.612
LIG_SH2_CRK	200	204	PF00017	0.321
LIG_SH2_CRK	246	250	PF00017	0.305
LIG_SH2_CRK	289	293	PF00017	0.231
LIG_SH2_CRK	308	312	PF00017	0.111
LIG_SH2_CRK	67	71	PF00017	0.446
LIG_SH2_GRB2like	320	323	PF00017	0.311
LIG_SH2_NCK_1	308	312	PF00017	0.317
LIG_SH2_STAP1	233	237	PF00017	0.347
LIG_SH2_STAP1	284	288	PF00017	0.197
LIG_SH2_STAP1	289	293	PF00017	0.197
LIG_SH2_STAP1	308	312	PF00017	0.111
LIG_SH2_STAT3	149	152	PF00017	0.243
LIG_SH2_STAT5	274	277	PF00017	0.287
LIG_SH2_STAT5	320	323	PF00017	0.233
LIG_SH2_STAT5	5	8	PF00017	0.585
LIG_SH3_3	99	105	PF00018	0.296
LIG_TYR_ITIM	126	131	PF00017	0.405
LIG_TYR_ITIM	198	203	PF00017	0.253
LIG_UBA3_1	317	326	PF00899	0.410
MOD_CDK_SPxxK_3	44	51	PF00069	0.552
MOD_CK1_1	174	180	PF00069	0.300
MOD_CK1_1	248	254	PF00069	0.472
MOD_CK1_1	342	348	PF00069	0.544
MOD_CK1_1	44	50	PF00069	0.551
MOD_CK2_1	112	118	PF00069	0.365
MOD_CK2_1	72	78	PF00069	0.361
MOD_GlcNHglycan	304	307	PF01048	0.400
MOD_GlcNHglycan	313	316	PF01048	0.303
MOD_GlcNHglycan	333	336	PF01048	0.372
MOD_GSK3_1	108	115	PF00069	0.405
MOD_GSK3_1	183	190	PF00069	0.347
MOD_GSK3_1	241	248	PF00069	0.452
MOD_GSK3_1	276	283	PF00069	0.283
MOD_GSK3_1	302	309	PF00069	0.367
MOD_GSK3_1	327	334	PF00069	0.405
MOD_GSK3_1	339	346	PF00069	0.447
MOD_GSK3_1	62	69	PF00069	0.421
MOD_N-GLC_1	279	284	PF02516	0.242
MOD_NEK2_1	172	177	PF00069	0.332
MOD_NEK2_1	219	224	PF00069	0.540
MOD_NEK2_1	241	246	PF00069	0.399
MOD_NEK2_1	276	281	PF00069	0.281
MOD_NEK2_1	343	348	PF00069	0.680
MOD_PIKK_1	256	262	PF00454	0.351
MOD_PKA_2	13	19	PF00069	0.456
MOD_PKA_2	187	193	PF00069	0.374
MOD_PKA_2	30	36	PF00069	0.627
MOD_PKA_2	322	328	PF00069	0.302
MOD_PKA_2	339	345	PF00069	0.478
MOD_PKA_2	91	97	PF00069	0.434
MOD_Plk_1	172	178	PF00069	0.447
MOD_Plk_1	191	197	PF00069	0.195
MOD_Plk_1	279	285	PF00069	0.297
MOD_Plk_4	245	251	PF00069	0.491
MOD_ProDKin_1	101	107	PF00069	0.377
MOD_ProDKin_1	108	114	PF00069	0.325
MOD_ProDKin_1	44	50	PF00069	0.556
TRG_DiLeu_BaEn_1	143	148	PF01217	0.297
TRG_DiLeu_BaEn_2	92	98	PF01217	0.349
TRG_DiLeu_BaLyEn_6	194	199	PF01217	0.253
TRG_ENDOCYTIC_2	128	131	PF00928	0.383
TRG_ENDOCYTIC_2	200	203	PF00928	0.367
TRG_ENDOCYTIC_2	246	249	PF00928	0.386
TRG_ENDOCYTIC_2	289	292	PF00928	0.234
TRG_ENDOCYTIC_2	308	311	PF00928	0.111
TRG_ENDOCYTIC_2	67	70	PF00928	0.349
TRG_ER_diArg_1	151	154	PF00400	0.297
TRG_ER_diArg_1	187	189	PF00400	0.282
TRG_ER_diArg_1	224	227	PF00400	0.384
TRG_ER_diArg_1	25	28	PF00400	0.451
TRG_ER_diArg_1	51	53	PF00400	0.550
TRG_ER_diArg_1	79	81	PF00400	0.401
TRG_NLS_MonoExtC_3	149	155	PF00514	0.297
TRG_NLS_MonoExtN_4	236	242	PF00514	0.327
TRG_Pf-PMV_PEXEL_1	273	278	PF00026	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM13	Leptomonas seymouri	65%	80%
A0A0N1PD54	Leptomonas seymouri	31%	100%
A0A0S4JQS8	Bodo saltans	30%	100%
A0A1X0NVR0	Trypanosomatidae	33%	100%
A0A1X0NVT0	Trypanosomatidae	26%	76%
A0A3S5H7D4	Leishmania donovani	100%	100%
A0A422N8G9	Trypanosoma rangeli	29%	100%
A0A422N8I7	Trypanosoma rangeli	32%	88%
A4HDM2	Leishmania braziliensis	81%	100%
C9ZWE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AX07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QAG9	Leishmania major	91%	100%
Q95RI5	Drosophila melanogaster	22%	84%
V5BK31	Trypanosoma cruzi	29%	100%
V5DBK9	Trypanosoma cruzi	31%	86%