Uncharacterized protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

E9AH67_LEIIN

TriTrypDb:

Length:

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote/Amastigote: 25

Expansion

Sequence features

E9AH67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH67

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.710
CLV_NRD_NRD_1	51	53	PF00675	0.719
CLV_PCSK_KEX2_1	16	18	PF00082	0.696
CLV_PCSK_KEX2_1	51	53	PF00082	0.688
DOC_WW_Pin1_4	22	27	PF00397	0.654
LIG_BIR_II_1	1	5	PF00653	0.693
LIG_FHA_2	56	62	PF00498	0.714
LIG_SH2_STAT5	57	60	PF00017	0.714
MOD_CDK_SPK_2	22	27	PF00069	0.567
MOD_CK1_1	34	40	PF00069	0.761
MOD_CK2_1	22	28	PF00069	0.580
MOD_CK2_1	7	13	PF00069	0.690
MOD_GlcNHglycan	33	36	PF01048	0.686
MOD_GlcNHglycan	9	12	PF01048	0.619
MOD_N-GLC_1	7	12	PF02516	0.619
MOD_NEK2_1	1	6	PF00069	0.637
MOD_PIKK_1	1	7	PF00454	0.686
MOD_PIKK_1	34	40	PF00454	0.649
MOD_ProDKin_1	22	28	PF00069	0.657
TRG_ER_diArg_1	15	17	PF00400	0.701
TRG_ER_diArg_1	50	52	PF00400	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WYK1	Leishmania donovani	100%	100%
A4HDM0	Leishmania braziliensis	74%	100%
E9AX05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QAH1	Leishmania major	94%	100%