Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E9AH66_LEIIN

TriTrypDb:

LINF_240021400

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AH66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AH66

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.601
CLV_NRD_NRD_1	289	291	PF00675	0.623
CLV_NRD_NRD_1	330	332	PF00675	0.613
CLV_NRD_NRD_1	380	382	PF00675	0.843
CLV_NRD_NRD_1	449	451	PF00675	0.598
CLV_PCSK_FUR_1	378	382	PF00082	0.845
CLV_PCSK_KEX2_1	330	332	PF00082	0.613
CLV_PCSK_KEX2_1	377	379	PF00082	0.842
CLV_PCSK_KEX2_1	380	382	PF00082	0.797
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.842
CLV_PCSK_PC7_1	373	379	PF00082	0.842
CLV_PCSK_SKI1_1	132	136	PF00082	0.523
CLV_PCSK_SKI1_1	145	149	PF00082	0.328
CLV_PCSK_SKI1_1	24	28	PF00082	0.617
CLV_PCSK_SKI1_1	279	283	PF00082	0.651
CLV_PCSK_SKI1_1	294	298	PF00082	0.506
CLV_PCSK_SKI1_1	331	335	PF00082	0.594
CLV_PCSK_SKI1_1	357	361	PF00082	0.732
CLV_PCSK_SKI1_1	373	377	PF00082	0.594
CLV_PCSK_SKI1_1	444	448	PF00082	0.637
CLV_Separin_Metazoa	162	166	PF03568	0.572
DEG_APCC_DBOX_1	111	119	PF00400	0.553
DEG_APCC_DBOX_1	525	533	PF00400	0.608
DEG_APCC_DBOX_1	8	16	PF00400	0.589
DEG_Nend_UBRbox_2	1	3	PF02207	0.461
DEG_SCF_FBW7_1	511	517	PF00400	0.552
DEG_SPOP_SBC_1	423	427	PF00917	0.701
DOC_CKS1_1	511	516	PF01111	0.567
DOC_CYCLIN_RxL_1	142	151	PF00134	0.407
DOC_CYCLIN_yClb5_NLxxxL_5	521	527	PF00134	0.608
DOC_MAPK_gen_1	143	152	PF00069	0.477
DOC_MAPK_gen_1	521	529	PF00069	0.474
DOC_MAPK_MEF2A_6	143	152	PF00069	0.484
DOC_MAPK_MEF2A_6	165	174	PF00069	0.379
DOC_MAPK_NFAT4_5	143	151	PF00069	0.546
DOC_PP2B_LxvP_1	241	244	PF13499	0.533
DOC_PP2B_LxvP_1	34	37	PF13499	0.792
DOC_USP7_MATH_1	187	191	PF00917	0.711
DOC_USP7_MATH_1	298	302	PF00917	0.657
DOC_USP7_MATH_1	423	427	PF00917	0.697
DOC_USP7_MATH_1	44	48	PF00917	0.631
DOC_USP7_MATH_1	488	492	PF00917	0.622
DOC_WW_Pin1_4	29	34	PF00397	0.668
DOC_WW_Pin1_4	305	310	PF00397	0.778
DOC_WW_Pin1_4	397	402	PF00397	0.726
DOC_WW_Pin1_4	483	488	PF00397	0.801
DOC_WW_Pin1_4	492	497	PF00397	0.724
DOC_WW_Pin1_4	500	505	PF00397	0.587
DOC_WW_Pin1_4	510	515	PF00397	0.533
LIG_14-3-3_CanoR_1	122	131	PF00244	0.414
LIG_14-3-3_CanoR_1	149	153	PF00244	0.483
LIG_14-3-3_CanoR_1	343	349	PF00244	0.757
LIG_14-3-3_CanoR_1	357	364	PF00244	0.584
LIG_Actin_WH2_2	360	375	PF00022	0.756
LIG_Actin_WH2_2	8	26	PF00022	0.610
LIG_BIR_III_2	28	32	PF00653	0.460
LIG_BIR_III_4	396	400	PF00653	0.725
LIG_deltaCOP1_diTrp_1	166	175	PF00928	0.372
LIG_deltaCOP1_diTrp_1	205	210	PF00928	0.573
LIG_FHA_1	101	107	PF00498	0.665
LIG_FHA_1	413	419	PF00498	0.810
LIG_FHA_1	423	429	PF00498	0.708
LIG_FHA_1	511	517	PF00498	0.590
LIG_FHA_1	60	66	PF00498	0.552
LIG_FHA_2	200	206	PF00498	0.549
LIG_FHA_2	256	262	PF00498	0.545
LIG_FHA_2	463	469	PF00498	0.751
LIG_FHA_2	534	540	PF00498	0.660
LIG_FHA_2	97	103	PF00498	0.640
LIG_GBD_Chelix_1	50	58	PF00786	0.571
LIG_LIR_Apic_2	166	170	PF02991	0.381
LIG_LIR_Gen_1	204	215	PF02991	0.611
LIG_LIR_Gen_1	255	264	PF02991	0.408
LIG_LIR_Nem_3	166	172	PF02991	0.369
LIG_LIR_Nem_3	204	210	PF02991	0.612
LIG_LIR_Nem_3	255	260	PF02991	0.406
LIG_LYPXL_yS_3	19	22	PF13949	0.660
LIG_MYND_1	514	518	PF01753	0.614
LIG_NRBOX	11	17	PF00104	0.599
LIG_SH2_NCK_1	257	261	PF00017	0.628
LIG_SH2_STAT3	256	259	PF00017	0.617
LIG_SH2_STAT5	129	132	PF00017	0.560
LIG_SH2_STAT5	257	260	PF00017	0.464
LIG_SH3_3	214	220	PF00018	0.594
LIG_SH3_3	266	272	PF00018	0.652
LIG_SH3_3	34	40	PF00018	0.664
LIG_SUMO_SIM_anti_2	193	198	PF11976	0.554
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.551
LIG_SUMO_SIM_par_1	78	84	PF11976	0.565
MOD_CDC14_SPxK_1	503	506	PF00782	0.639
MOD_CDK_SPxK_1	500	506	PF00069	0.641
MOD_CDK_SPxxK_3	399	406	PF00069	0.729
MOD_CDK_SPxxK_3	514	521	PF00069	0.636
MOD_CK1_1	190	196	PF00069	0.668
MOD_CK1_1	250	256	PF00069	0.580
MOD_CK1_1	347	353	PF00069	0.828
MOD_CK1_1	363	369	PF00069	0.565
MOD_CK1_1	384	390	PF00069	0.850
MOD_CK1_1	408	414	PF00069	0.772
MOD_CK1_1	483	489	PF00069	0.764
MOD_CK1_1	510	516	PF00069	0.592
MOD_CK2_1	255	261	PF00069	0.547
MOD_CK2_1	297	303	PF00069	0.801
MOD_CK2_1	383	389	PF00069	0.705
MOD_CK2_1	414	420	PF00069	0.851
MOD_CK2_1	462	468	PF00069	0.714
MOD_CK2_1	533	539	PF00069	0.662
MOD_CK2_1	75	81	PF00069	0.564
MOD_CK2_1	96	102	PF00069	0.628
MOD_CMANNOS	528	531	PF00535	0.673
MOD_GlcNHglycan	132	135	PF01048	0.457
MOD_GlcNHglycan	189	192	PF01048	0.692
MOD_GlcNHglycan	247	252	PF01048	0.556
MOD_GlcNHglycan	272	275	PF01048	0.573
MOD_GlcNHglycan	287	290	PF01048	0.470
MOD_GlcNHglycan	300	303	PF01048	0.642
MOD_GlcNHglycan	46	50	PF01048	0.638
MOD_GSK3_1	197	204	PF00069	0.572
MOD_GSK3_1	246	253	PF00069	0.538
MOD_GSK3_1	305	312	PF00069	0.812
MOD_GSK3_1	344	351	PF00069	0.831
MOD_GSK3_1	353	360	PF00069	0.690
MOD_GSK3_1	405	412	PF00069	0.812
MOD_GSK3_1	488	495	PF00069	0.681
MOD_GSK3_1	500	507	PF00069	0.712
MOD_GSK3_1	510	517	PF00069	0.666
MOD_GSK3_1	533	540	PF00069	0.553
MOD_GSK3_1	59	66	PF00069	0.551
MOD_GSK3_1	94	101	PF00069	0.582
MOD_N-GLC_1	344	349	PF02516	0.828
MOD_N-GLC_1	408	413	PF02516	0.806
MOD_N-GLC_1	504	509	PF02516	0.752
MOD_NEK2_1	130	135	PF00069	0.519
MOD_NEK2_1	148	153	PF00069	0.321
MOD_NEK2_1	206	211	PF00069	0.420
MOD_NEK2_1	246	251	PF00069	0.504
MOD_NEK2_1	297	302	PF00069	0.582
MOD_PIKK_1	122	128	PF00454	0.571
MOD_PIKK_1	255	261	PF00454	0.625
MOD_PIKK_1	357	363	PF00454	0.742
MOD_PK_1	63	69	PF00069	0.572
MOD_PKA_2	148	154	PF00069	0.485
MOD_PKA_2	270	276	PF00069	0.592
MOD_PKA_2	329	335	PF00069	0.650
MOD_PKB_1	120	128	PF00069	0.579
MOD_PKB_1	379	387	PF00069	0.848
MOD_Plk_1	292	298	PF00069	0.701
MOD_Plk_1	344	350	PF00069	0.829
MOD_Plk_1	45	51	PF00069	0.589
MOD_Plk_1	504	510	PF00069	0.721
MOD_Plk_1	59	65	PF00069	0.372
MOD_Plk_4	206	212	PF00069	0.609
MOD_Plk_4	424	430	PF00069	0.836
MOD_ProDKin_1	29	35	PF00069	0.672
MOD_ProDKin_1	305	311	PF00069	0.775
MOD_ProDKin_1	397	403	PF00069	0.725
MOD_ProDKin_1	483	489	PF00069	0.803
MOD_ProDKin_1	492	498	PF00069	0.721
MOD_ProDKin_1	500	506	PF00069	0.589
MOD_ProDKin_1	510	516	PF00069	0.524
MOD_SUMO_rev_2	400	408	PF00179	0.729
TRG_ENDOCYTIC_2	19	22	PF00928	0.660
TRG_ENDOCYTIC_2	257	260	PF00928	0.620
TRG_ER_diArg_1	142	145	PF00400	0.521
TRG_ER_diArg_1	378	381	PF00400	0.845
TRG_ER_diArg_1	523	526	PF00400	0.511
TRG_ER_diArg_1	543	546	PF00400	0.551
TRG_NES_CRM1_1	317	329	PF08389	0.640
TRG_NES_CRM1_1	56	71	PF08389	0.454
TRG_NLS_MonoCore_2	375	380	PF00514	0.842
TRG_NLS_MonoExtC_3	375	380	PF00514	0.842
TRG_NLS_MonoExtN_4	373	380	PF00514	0.843

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WYG0	Leishmania donovani	99%	100%
A4HDL9	Leishmania braziliensis	69%	100%
E9AX04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QAH2	Leishmania major	87%	100%